JOURNAL OF FOOD PROCESSING AND PRESERVATION
·
2016
·Vol. 41
·期 5
·e13126
·
IF 0.894
L. Xu,W.X. Cai,B.J. Xu
This study aimed to provide comprehensive health beneficial profiles of fermented soy products and further provide reference values of vitamin B 2 and B 12 and GABA enrichment products. High performance liquid chromatography (HPLC) analyses were applied to systemically investigate the vitamins and GABA. The highest vitamin B 2 content of 6.06 μg g −1 was detected in “Wangzhihe” sufu. All natto samples showed relatively higher vitamin B 2 content with an average value of 3.35 μg g −1 compared to the other fermented soy products. “Liubiju” dry yellow soybean paste was detected with the highest vitamin B 12 content of 732.94 ng g −1 . All sufu samples presented relatively higher GABA levels with an average value of 11.58 mg g −1 . Fermented soy products could be used as supplements of vitamins and bioactive substances such as GABA. It can be concluded that fermentation can be used as an alternative method to chemical synthesis of vitamin B 12 and GABA. Practical Applications Presented information will guide consumers to choose fermented soy product to gain health benefit components, especially for vegetarian to find food sources of vitamin B 12 . The study will help food manufacturers to understand secondary metabolites production through fermentation. Current results make food industry commercially feasible to produce special amino acids (such as GABA) and vitamins B 2 and B 12 .
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高影响因子
JOURNAL OF ETHNOPHARMACOLOGY
·
2020
·
IF 3.69
Hai-Lian Yuan,Yun-Li Zhao,Cai-Feng Ding,Pei-Feng Zhu,Qiong Jin,Ya-Ping Liu,Zhong-Tao Ding,Xiao-Dong Luo
Ethnopharmacological relevance “Curcumae Radix”, the dried rhizomes of Curcuma kwangsiensis documented in Chinese pharmacopoeia, has been traditionally used for the treatment of inflammatory and pain diseases, such as jaundice and red urine, cleaning the heart-fire and depression, arthralgia , and dysmenorrhea . However, according to literature surveys, anti-inflammatory and antinociceptive studies of C. kwangsiensis have been seldom reported so far. Aim of the study The current study focuses on the anti-inflammatory and antinociceptive effects of C. kwangsiensis and discovering the bioactive compounds for its traditional usages both in vivo and in vitro , which could provide scientific justification about its traditional use. Material and methods The anti-inflammatory and antinociceptive assays of various layers (ME, EA , AQS) from C. kwangsiensis were achieved by carrageenan-induced paw edema and acetic acid-induced writhing animal models, respectively. The most bioactive part, EA layer was further phytochemically investigated by multiple step chromatography techniques. The structures of these isolates were unambiguously elucidated by means of extensive spectroscopic and chemical methods, and comparison with corresponding data of the reported literature. Four major sesquiterpenoids ( 4 , 6 , 14 , and 15 ) were achieved for their anti-inflammatory and antinociceptive assays by the two aforementioned animal models in vivo . All the isolated compounds were evaluated for their anti-inflammatory effects via detecting inflammatory mediator releases (COX-2, IL-1 β , and TNF- α ) in RAW 264.7 macrophage cells induced by LPS . Results The ME and EA layers significantly alleviated the paw edema caused by carrageenan and decreased the number of writhes induced by acetic acid at the dose of 200 and/or 100 mg/kg in comparison to the control group ( p < 0.01 / 0.05), and the EA layer exhibited better activity than that of ME layer. Subsequent phytochemical investigation on EA layer of C. kwangsiensis exhibited that three new terpenoid compounds ( 1 – 3 ), identified as (12 Z ,14 R )-7 β -hydroxylabda-8(17),12-diene-14,15,16-triol ( 1 ), (12 Z ,14 S )- 7 β -hydroxlabda-8(17),12-diene-14,15,16-triol ( 2 ), and (4 S )-hydroxy-(8)-methoxy-(5 S )-(H)-guaia1(10),7(11)-dien-12,8-olide ( 3 ), together with twenty-two known analogs were isolated. Furthermore, four major sesquiterpenoids ( 4 , 6 , 14 , and 15 ) significantly relieved the paw edema and number of writhes at 100 and/or 50 mg/kg ( p < 0.05/0.01). Likewise, the majority of sesqui- and diterpenoids isolated could remarkably inhibited the secretion of inflammatory mediators (COX-2, IL-1 β , and TNF- α ) in LPS-stimulated RAW 264.7 macrophages cells at the concentration of 20 μ g/mL, comparable to DXM used as the positive control. All the results suggested that EA layer from C. kwangsiensis possessed the anti-inflammatory and antinociceptive activities , and these sesqui- and diterpenoids could be the effective constituents responsible for relieving inflammation. Conclusion The present studies undoubtedly determined the anti-inflammatory and antinociceptive material basis of C. kwangsiensis , including the EA layer and its precise components, which presented equivalent or better anti-inflammatory effects than that of positive control (ASP/DXM) in vivo and in vitro . These results not only would account for scientific knowledge for traditional use of C. kwangsiensis , but also provide credible theoretical foundation for the further development of anti-inflammatory and antinociceptive agents.
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PubMed
高影响因子
PLANT SCIENCE
·
2022
·
IF 5.363
Kamran Shah,Mengxue Wang,Xiaolong Li,Wei Shang,Shujin Wang,Mingyu Han,Xiaolin Ren,Jianwen Tian,Na An,Libo Xing
In the apple tree, insufficient flower bud production is an intractable challenge, and very little information is available in this field due to the fact that research done in this sector is very rare owing to its extended life cycles and low rate of genetic transformation. Here we display novel changes and events in spur buds of Malus × domestica trees after they were exposed to salicylic acid (SA) treatment during the flower induction period. We found a significant increase in morphological indexes, followed by a wider and well-defined shoot apical meristem in SA-treated spur buds. Additionally, we observed increased oxidative stress markers and enzymatic antioxidants in control-treated buds during the flower induction period, while non-enzymatic antioxidants were recorded higher in SA-treated buds. Maximum flowering was observed in SA-treated trees in the next year. Furthermore, ultra-high-performance liquid chromatography (u-HPLC) analysis displays that SA treatment enhances SA and indole acetic acid (IAA), while having an antagonistic effect on gibberellin (GA). At different time points, transcriptome analysis was conducted to analyze the transcriptional response of CK and SA treated buds. Pathway enrichment was detected in differentially expressed genes (DEGs). Agamous ( AGL ) and SQUAMOSA-promoter binding protein-like ( SPL ) family related flowering genes display a positive signal for the increased flowering in SA-treated trees, which confirms our findings. As far as we know, there is no report available on the response of spur buds to SA treatment during the flower induction period. This data provides a new theoretical reference for the management of apple tree flowering and also provides an essential basis for future analysis of the regulation and control of flowering in M. domestica .
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PubMed
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2018
·
IF 2.297
Xiaoxia Sheng,Jingjing Tang,Jiayin Bao,Xiangjun Shi,Weike Su
In the present study, a febuxostat (FEB) solid dispersion was prepared via the solvent evaporation method, and the dispersion's solubility, dissolution rate and oral bioavailability were investigated. To select the appropriate carriers for the FEB solid dispersion, series of preliminary trials were performed on d-α-tocopherol polyethylene glycol 1000 succinate (TPGS), HPMC, PEG4000, PEG6000, Eudragital, PVA, PVP K30, poloxamer188 and poloxamer407. Based on the preliminary trials, TPGS and poloxamer188 were selected as the carriers for the FEB solid dispersion preparation. In addition, a mixture of FEB:poloxamer188:TPGS (1:5:1) exhibited outstanding characteristics; its saturation solubility was 7.31 times (in water), 17.67 times (in pH 1.2), 17.22 times (in pH 4.5), 3.60 times (in pH 6.0) and 1.99 times (in pH 6.8) higher than that of pure crystalline FEB. In an in vitro drug dissolution study, the mixture exhibited a drug release rate that was 1.94 times that of the FEB API. Meanwhile, oral bioavailability, C max and AUC, as evaluated in an in vivo pharmacokinetic study, also showed a notable enhancement.
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ACS Applied Nano Materials
·
2021
·
IF 5.097
Xiuli Zhang,Weiyan Liu,Hailong Li,Shuixin Xia,Chia-Kuang Tsung,Hao Liu,Wei Liu,Yi Yu
Understanding the sintering kinetics of nanoparticles is important for their applications, such as printable nanoinks and wearable devices. However, it is challenging to in situ study the sintering process at nanoscale in a liquid environment. In this work, in situ investigation of the thermal sintering of gold nanoparticles is performed using liquid cell transmission electron microscopy. We have observed the unique sintering process of two nanoparticles in the liquid phase. By heating the gold nanoparticle solution in a liquid cell, a neck formed between the two nanoparticles at the initial sintering stage, followed by a rapid increase of neck size accompanied by a more rounded surface, and finally, the as-formed gold dimer shrank to a short nanorod. The sintering observations are dominated by two different surface diffusion paths and grain boundary diffusion. Furthermore, the high surface energy of small nanoparticles results in a higher shrinkage ratio in sintering. This insight of the kinetics of nanoparticle sintering provided by in situ characterization offers guidance for the future applications such as ink-jet printing.
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FOOD CONTROL
·
2021
·
IF 5.548
Dan Xu,Mengqi Wei,Shurui Peng,Haizhen Mo,Lin Huang,Lishan Yao,Liangbin Hu
The contamination of food with Aspergillus flavus has caused serious economic losses and posed a great threat to human and animal health. Cumin , a condiment and flavoring in many dishes, was showed to have great potential to prevent A. flavus contamination in the present study. By using cumin essential oil (CEO), the occurrence of A. flavus contamination on peanuts was prevented during the storage period even up to 9 months. We further identified cuminaldehyde as the predominant component in CEO with great inhibitory activity to both the growth of A. flavus and aflatoxin B 1 (AFB 1 ) biosynthesis. The data showed that the minimum inhibitory concentration (MIC) of cuminaldehyde to conidial growth was 0.64 μL/mL, and the mycelia exposed to 0.80 μL/mL cuminaldehyde reduced AFB 1 production by more than 99% in comparison to the control. RNA-Seq profiles showed that some genes, involving the synthesis pathway of ergosterol and AFB 1 , were significantly down-regulated in the transcription by cuminaldehyde. Further investigation confirmed a significantly reduced cellular ergosterol content in the presence of cuminaldehyde, and the qRT-RCR results were also in agreement with that by RNA-Seq, indicating down-regulated expressions of those genes involving ergosterol and AFB 1 synthesis. Taken together, our study strongly supported cuminaldehyde as a potential agent for the prevention of A. flavus contamination.
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Inorganic Chemistry Frontiers
·
2024
·Vol. 11
·期 11
·3323-3333
·
IF 6.1
Shunqin Zeng,Meinan Zhao,Chen Xie,Jianhui Li,Xiaoli Ding,Liqing He,Yongtao Li,Qingan Zhang,Hai-Wen Li
Developing composite solid electrolytes (CSEs) represents a promising avenue for advancing commercial viability of all-solid-state batteries because none of the single electrolytes can meet the application requirements. However, the correlation of interfacial reconstruction among more than two composite solid electrolytes with property enhancements still remains unclear. In this study, lithium-based hydride-oxide solid electrolytes are chosen as a model to explore in situ interfacial reactions between these composites, with the goal of innovating design of electrolytes for all-solid-state batteries. Our research reveals the formation of dual core–shell-structured electrolytes with LiBO2 as the intermediate layer and LiBH4 as the outer layer embedded with LixM intermediates, resulting in the in situ reactions of LiBH4 and LixMOy (M = N, P, S) composites. These composites exhibit continuous conductive networks and demonstrate a high Li+ conductivity of ∼1.9 × 10−4 S cm−1 at 75 °C. This impressive conductivity enables stable cycling of Li–Li symmetric cells for 650 h. Moreover, the critical current density can reach about 2.3 mA cm−2, and the electrochemical window extends from −0.5 to 6 V. Notably, the reversible specific capacity attains 225.1 mA h g−1 for Li‖TiS2 batteries with an initial coulombic efficiency of 95.4%. This work provides valuable insights into the design and performance of composite solid electrolytes, offering a promising approach for the development of high-performance all-solid-state batteries.
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JOURNAL OF MEMBRANE SCIENCE
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2024
·
IF 8.4
Wangwang Guan,Hao Zhang,Jingguo She,Jiahui Li,Haifu Gao,Ziping Song,Le Shi,Hongjin Yan,Zhiyao Du,Li Ding,Chunrui Wu,Xiaolong Lu
In this paper, a novel polyvinylidene fluoride (PVDF) hollow fiber membrane with uniform pore size and hydrophilic cross-linked network in membrane matrix was developed by non‐solvent induced phase separation method. The dual role mechanism of in-situ cross-linking in regulating molecular chain arrangement during phase separation and preventing deterioration of membrane mechanical properties were analyzed. The results demonstrated that the cross-linked network formed by in-situ crosslinking entangled with PVDF molecular chains which improved the regularity of PVDF molecular chains, increasing the uniformity of the pore size distribution, the percentage of the most probable pore size of the modified membrane increased to 93.25 %. The cross-linked network was immobilized in the membrane which formed semi-interpenetrating structure, maintaining the mechanical properties of the membrane. The permeation flux of the modified membrane increased by 24.1 times to 477.7 L m −2 h −1 compared to the original PVDF membrane. The rejection of BSA was maintained at 98.5 %, with the tensile strength increased to 2.52 MPa. The modified membrane exhibited persistent hydrophilicity in 21 days washing experiment with improved antifouling performance.
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高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Yi Wang,Mengyuan Guo,Peipei Wu,Chong Chen,Weibo Zhang,Fazheng Ren,Pengjie Wang,Shouyun Wu,Jianhuan Wei,Jie Luo,Jinghua Yu
This study provides insights into the composition and in-situ structures of the milk fat globule membrane (MFGM) in buffalo milk with different fat globule sizes (0.55 μm and 8.04 μm). Small fat globules contained a higher amount of MFGM proteins and polar lipids, while the content of MFGM components (except for ADPH) was greater per unit membrane area in large fat globules. A total of 386 differentially expressed proteins were identified, with many of the most differentially expressed proteins being associated with human diseases, such as cancer and elderly diseases. The coverage of sphingomyelin and certain MFGM proteins (BTN and PAS 6/7) on large fat globules was higher, potentially linked to the presence of larger, irregular lipid rafts and patch-shaped glycocalyxes, respectively. These findings suggest that small fat globules are suitable for nutritional fortification of buffalo milk, while large fat globules are appropriate for the preparation of functional dairy-based ingredients.
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高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Rui Xu,Bowen Xiao,Ce Xuan,Shuyu Gao,Jingchao Chai,Shujian Liu,Yang Chen,Yun Zheng,Xin Cheng,Qingzhong Guo,Zhihong Liu
All-solid-state polymer electrolytes can improve the safety of lithium batteries. However, the common Bellcore polymer electrolyte technology faces several issues such as wasting a mass of solvent, high manufacturing cost, and poor interfacial compatibility between polymer electrolytes and electrodes. Herein, we propose an in situ polymerization technique to synthesize all-solid-state polymer electrolytes by a thiol-Michael addition click reaction. The alternating copolymer is made from the Michael addition reaction of ethylene glycol dimethacrylate (EGDMA) and 1,2-ethane dithiol (EDT). At ambient temperature, the obtained composite polymer electrolyte displays an ionic conductivity of 3.02 × 10–5 S/cm, an electrochemical window of 4.5 V, and a lithium-ion transference number of 0.45. In light of this unique polymerization process, the traditional fabrication method of liquid electrolyte-based lithium batteries can be adopted in the current study for the preparation of all-solid-state Li/LiFePO4 batteries. It was found that the assembled all-solid-state Li/LiFePO4 batteries exhibited superior charging/discharging performance and preferable safety. Thus, this facile and powerful in situ polymerization strategy may open up a new approach for the design and fabrication of all-solid-state batteries with desirable performances.
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高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2021
·Vol. 168
·期 1
·016504
·
IF 4.316
Haomin Jiang,Yujuan Cheng,Zhaohui Wang,Zhiqun Bai,Yang Tang,Yanzhi Sun,Pingyu Wan,Yongmei Chen
The cleavage of the linkage bonds among the C9 units in lignin molecules via selective oxidation method to obtain small-weight aromatic compounds is an important way to lignin valorisation. In this study, the cleavage pathways of bonds in a lignin model compound, GGE (guaiacylglycerol-β-guaiacyl ether), by the reactive oxygen species (ROS) in situ generated through electrochemical oxygen reduction reaction (ORR) in an aprotic ionic liquid ([BMIM]BF4) was investigated. The results indicated that when the main ROS was ·OOH, coniferyl alcohol, guaiacol and vanillin were detected as the degradation products which is supposed to be caused by β-O-4 bonds cleavage; Otherwise, when HO2− was the main ROS, coniferyl alcohol could not be detected and the degradation reaction is believed to be trigerred by Cα-Cβ bonds cleavage.
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高影响因子
BIORESOURCE TECHNOLOGY
·
2012
·
IF 4.98
Fengcheng Li,Shuangfeng Ren,Wei Zhang,Zhengdan Xu,Guosheng Xie,Yan Chen,Yuanyuan Tu,Qing Li,Shiguang Zhou,Yu Li,Fen Tu,Lin Liu,Yanting Wang,Jianxiong Jiang,Jingping Qin,Shizhong Li,Qiwei Li,Hai-Chun Jing,Fasong Zhou,Neal Gutterson,Liangcai Peng
Xylans are the major hemicelluloses in grasses, but their effects on biomass saccharification remain unclear. In this study, we examined the 79 representative Miscanthus accessions that displayed a diverse cell wall composition and varied biomass digestibility . Correlation analysis showed that hemicelluloses level has a strong positive effect on lignocellulose enzymatic digestion after NaOH or H 2 SO 4 pretreatment. Characterization of the monosaccharide compositions in the KOH-extractable and non-KOH-extractable hemicelluloses indicated that arabinose substitution degree of xylan is the key factor that positively affects biomass saccharification. The xylose/arabinose ratio after individual enzyme digestion revealed that the arabinose in xylan is partially associated with cellulose in the amorphous regions, which negatively affects cellulose crystallinity for high biomass digestibility. The results provide insights into the mechanism of lignocellulose enzymatic digestion upon pretreatment, and also suggest a goal for the genetic modification of hemicelluloses towards the bioenergy crop breeding of Miscanthus and grasses.
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高影响因子
危险品化学品经营许可证（带存储）