CELL RESEARCH
·
2022
·Vol. 32
·期 7
·638-658
·
IF 46.297
Wang Xiaomin,Chen Ziqi,Xu Jun,Tang Shuai,An Nan,Jiang Lei,Zhang Yixiang,Zhang Shaoying,Zhang Qingli,Shen Yanyan,Chen Shijie,Lan Xiaojing,Wang Ting,Zhai Linhui,Cao Siyuwei,Guo Siqi,Liu Yingluo,Bi Aiwei,Chen Yuehong,Gai Xiameng,Duan Yichen,Zheng Ying,Fu Yixian,Li Yize,Yuan Liang,Tong Linjiang,Mo Kun,Wang Mingcheng,Lin Shu-Hai,Tan Minjia,Luo Cheng,Chen Yi,Liu Jia,Zhang Qiansen,Li Leping,Huang Min
Mutant isocitrate dehydrogenase 1 (mIDH1) drives tumorigenesis via producing oncometabolite R-2-hydroxyglutarate (R-2-HG) across various tumor types. However, mIDH1 inhibitors appear only effective in hematological tumors. The therapeutic benefit in solid tumors remains elusive, likely due to the complex tumor microenvironment. In this study, we discover that R-2-HG produced by IDH1-mutant tumor cells is preferentially imported into vascular endothelial cells and remodels mitochondrial respiration to promote tumor angiogenesis, conferring a therapeutic vulnerability in IDH1-mutant solid tumors. Mechanistically, SLC1A1, a Na + -dependent glutamate transporter that is preferentially expressed in endothelial cells, facilitates the influx of R-2-HG from the tumor microenvironment into the endothelial cells as well as the intracellular trafficking of R-2-HG from cytoplasm to mitochondria. R-2-HG hijacks SLC1A1 to promote mitochondrial Na + /Ca 2+ exchange, which activates the mitochondrial respiratory chain and fuels vascular endothelial cell migration in tumor angiogenesis. SLC1A1 deficiency in mice abolishes mIDH1-promoted tumor angiogenesis as well as the therapeutic benefit of mIDH1 inhibitor in solid tumors. Moreover, we report that HH2301, a newly discovered mIDH1 inhibitor, shows promising efficacy in treating IDH1-mutant cholangiocarcinoma in preclinical models. Together, we identify a new role of SLC1A1 as a gatekeeper of R-2-HG-mediated crosstalk between IDH1-mutant tumor cells and vascular endothelial cells, and demonstrate the therapeutic potential of mIDH1 inhibitors in treating IDH1-mutant solid tumors via disrupting R-2-HG-promoted tumor angiogenesis.
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FIBERS AND POLYMERS
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2025
·
IF 2.3
Zhou Siqi,Guo Yangfeng,Zhang Tingting,Ding Kangjia,Wang Dongfang,Li Zihui,Li Qian
The fabrication of PTFE micron filaments with superior mechanical properties remains both a key research focus and a considerable challenge in the field of engineering technology. In this study, the PTFE micron filaments were successfully prepared via wet spinning and molding process by optimizing the concentration of the carrier polyethylene oxide (PEO) aqueous solution, molecular weight of the coagulation bath poly-(ethylene glycol) PEG, mass ratio of PTFE to PEO, and sintering temperature. Due to its higher hygroscopicity and surface tension compared to the spinning solution, PEG provided favorable conditions for the solidification of the PTFE/PEO primary filaments. Elemental analysis results confirmed the complete removal of PEO and PEG from the PTFE fibers after sintering. When the mass fraction of PEO is 4%, the mass ratio of PTFE to PEO is 4:1, PEG molecular weight is 200 Da, and the sintering temperature is 370 ℃, the resulting PTFE fibers display a smooth and compact Surface, with a diameter of 27.50 ± 0.66 μm. Furthermore, tensile testing reveals that the PTFE filaments achieved a tensile strength of 133.02 ± 5.39 MPa and an elongation at break of 567.77 ± 93.67%. These findings demonstrate a feasible and efficient approach for the fabrication of high-performance PTFE micron filaments.
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
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2025
·
IF 1.6
Tao Qinqin,Wang Yusheng,Chen Chuanhong,Dai Ying
This study investigates the role of hydrogen bonding in Hydrogen-Bonded Complex Extractants (HBCEs) for uranium extraction from wastewater. Through integrated experimental and theoretical approaches including electrostatic potential (ESP) analysis, molecular binding energy calculations, Atoms in Molecules (AIM) theory, and spectroscopic characterization, we reveal how structural variations (carbon chain length, unsaturation degree, spatial configuration, and functional groups) modulate hydrogen bond characteristics. Results show that extending carbon chains enhances hydrogen bond strength (TBPO-18: -24.28 kcal/mol binding energy), while increasing unsaturation initially weakens then strengthens interactions. Linear structures exhibit superior hydrogen bonding versus cyclic configurations (TBPO-OH vs TBPO-HOH: 18.60 vs 14.47 kcal/mol). Extraction performance correlates with hydrogen bond stability, where TBPO-12 achieves maximum capacity (40.55 mg/L) due to optimal acid resistance. Mechanistic studies via 31 P NMR titration confirm a two-step process: initial \({\text{UO}}_{2}^{2 + }\) complexation with TBPO’s P = O group, followed by hydrogen bond formation with HBDs. This work provides fundamental insights for rational design of high-efficiency HBCEs, highlighting hydrogen bond engineering as a key strategy for nuclear wastewater treatment.
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Nature Energy
·
2025
·
IF 60.1
Wang Jinlin,Meng Fanqi,Lou Licheng,Yin Kang,Xu Xiao,Jiao Menghan,Zhang Bowen,Li Yiming,Shi Jiangjian,Wu Huijue,Luo Yanhong,Li Dongmei,Meng Qingbo
Atomic disorder is a widespread issue in multi-element crystalline materials and poses a critical challenge to the performance of Cu 2 ZnSn(S, Se) 4 (CZTSSe) photovoltaic devices. In particular, Cu–Zn disorder is prevalent in CZTSSe due to its low formation energy, leading to the formation of high-concentration deep defects and severe charge loss. The regulation of this disorder remains challenging because of the trade-off between the thermodynamics of the disorder–order phase transition and the kinetics of atom interchange. Here we introduce additional vacancy defects at the CZTSSe surface via magnesium doping to reduce the energy barrier for atom interchange. This vacancy-assisted approach enhances the kinetics of Cu–Zn ordering, thereby reducing charge loss in the device. As a result, we achieve a power conversion efficiency of 14.9% certified by the Chinese National PV Industry Measurement and Testing Center in CZTSSe solar cells, marking an advancement in the development of emerging inorganic thin-film photovoltaics.
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Signal Transduction and Targeted Therapy
·
2025
·Vol. 10
·期 1
·1-17
·
IF 52.7
Tang Yu,Luo Zhiyuan,Ma Zhanni,Han Lingling,Zhou Yurong,Liang Tianci,Yang Kangsen,Zhao Lei,Chen Xiaoyuan,Zhang Pengfei
The variety and functionality of current clinical vaccine adjuvants remain limited. Conventional aluminum-based adjuvants predominantly induce Th2-biased humoral immunity but exhibit a limited capacity to elicit Th1-mediated cellular immune responses, particularly tumor antigen-specific cytotoxic CD8 + T lymphocytes (CTLs), which are essential for effective cancer vaccine performance. Inspired by natural biomolecular condensates, we developed a versatile noncovalent protein self-assembly strategy distinct from traditional approaches requiring structural domain modifications or bifunctional crosslinkers. Our methodology employs amphiphilic molecules (sodium myristate/SMA and sodium dodecyl thiolate/SDT) as molecular bridges to mediate protein‒protein interactions through hydrophobic forces and disulfide bond formation. This process generates nanoscale protein condensate (PCD) vaccines with exceptional stability. As a novel adjuvant system, these synthetic condensates significantly enhance antigen cross-presentation by optimizing key parameters: antigen loading capacity, lymph node targeting, cytosolic delivery, and lysosomal escape. Consequently, they induce robust antigen-specific CTL responses and humoral immunity, demonstrating potent antitumor efficacy. Importantly, we found that the synthetic protein condensate (PCD) alone can act as a nanoadjuvant. By increasing mitochondrial membrane permeability, PCD induces mitochondrial DNA leakage into the cytosol, activating the cGAS‒STING pathway and promoting DC maturation. This safe and scalable platform eliminates the need for complex covalent modifications or genetic engineering, and it facilitates the design of diverse modular antigens, including neoantigens and viral antigens. Given its straightforward manufacturing process and superior immunogenicity, this synthetic PCD vaccine adjuvant has significant potential for clinical application and translation.
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Signal Transduction and Targeted Therapy
·
2025
·Vol. 10
·期 1
·1-19
·
IF 52.7
Wang Baile,Liu Jie,Wang Qin,Arhatte Malika,Cheong Lai Yee,Glogowska Edyta,Jiang Xue,Chung Sookja Kim,Jin Leigang,Hu Qianxing,Wang Yu,Honoré Eric,Xu Aimin
With aging or osteoporosis, bone marrow adipogenesis is increased and inversely correlates with the loss of bone mass. Bone marrow adipocytes are derived from multipotent bone marrow mesenchymal stem cells (BMMSCs), which can differentiate into either fat or bone. BMMSCs are mechanosensitive cells, but how mechanical loading is implicated in the in vivo regulation of bone marrow adipogenesis and its impact on bone remodeling remain poorly understood. Here, we identify the mechanosensitive cationic channel Piezo1 in BMMSCs as a key suppressor of bone marrow adipogenesis by preventing local inflammation, thereby enhancing osteoblast differentiation and bone formation. Mice with a specific Piezo1 invalidation in BMMSCs exhibit osteoporosis and marrow adiposity, together with resistance to the beneficial effects of exercise on bone health. Accordingly, Piezo1-deficient BMMSCs in vitro preferentially differentiate into adipocytes rather than osteoblasts. Invalidation of Piezo1 in BMMSCs enhances the autocrine activation of CCR2 by Ccl2, which further induces lipocalin-2 (Lcn2) production via NF-κB activation, thereby promoting adipocyte differentiation. Conversely, Piezo1 opening induces Klf2 expression through CaMKII, preventing c-Jun activation, Ccl2 production and bone marrow adipogenesis. These findings demonstrate that Piezo1 activation in BMMSCs suppresses bone marrow adipogenesis to maintain bone strength by preventing the Ccl2-Lcn2 inflammatory autocrine loop, thus uncovering a previously unrecognized link between mechanotransduction, inflammation, and cell fate determination.
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Nature Electronics
·
2025
·
IF 40.9
He Jing,Ge Jifeng,Xue Junying,Xia Tingyi,Dai Yongping,Wang Shengqi,Li Wenjie,Lin Zhaoyang
Solution-processed two-dimensional semiconductors could be used to create electronic devices on large scales and at low cost. However, the electronic performance of devices based on such materials is typically below that of devices based on materials grown via high-temperature chemical vapour deposition. Here we report the fabrication of indium selenide (InSe) semiconductor thin films using a colloidal solution of monolayer nanosheets (monolayer purity more than 98%). The InSe thin films are assembled on 4-inch wafers with conformal and intimate van der Waals contacts between the monolayer building blocks. We use the solution-processed films to fabricate InSe transistors that exhibit electron mobilities of 90–120 cm 2 V −1 s −1 , current on/off ratios of up to 10 7 and a small current hysteresis. We also show that InSe transistors with oxide encapsulation can remain stable in air for 3 months.
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NATURE MATERIALS
·
2025
·Vol. 24
·期 11
·1716-1725
·
IF 38.5
Zhang Zhi,Zhang Yuwei,Lu Kangjun,Zhang Jun-Jie,Zhang Nannan,Feng Rui,Ye Haoran,Zhou Xiaoli,Li Linglong,Wan Dongyang,Lu Junpeng,Ni Zhenhua,Wang Jinlan,Chen Qian,Lu Jiong,Li Zejun
Rolling two-dimensional materials into one-dimensional nanoscrolls introduces curvature, chirality and symmetry breaking, enabling emergent properties. Conventional methods relying on external driving forces, however, exhibit poor control, low yield and limited reproducibility. Here we report spontaneous scrolling in polar van der Waals materials via an electrochemical intercalation/exfoliation process, enabling scalable nanoscroll production. This self-rolling is driven intrinsically by out-of-plane electric polarization ( P ⊥ ), where the magnitude of P ⊥ is modulated by the intercalant size. Validated across eight polar materials, this approach achieves virtually 100% yield and reproducibility with defined scrolling direction, surpassing external driving force limitations. The nanoscrolls exhibit layer-independent inversion symmetry breaking and coherently enhanced second-harmonic generation, exceeding two-dimensional flakes by ~100-fold and rivalling leading two-dimensional nonlinear materials. Electrochemical initiation further facilitates metal-ion co-intercalation, yielding ten hybrid nanoscroll architectures. These findings establish a scalable route to create one-dimensional nanostructures and hybrid heterostructures, paving the way for designer quantum solids and van der Waals superlattices in quantum nanodevices.
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Nano-Micro Letters
·
2025
·Vol. 17
·期 1
·1-14
·
IF 36.3
Yin Guang,Wu Jing,Qi Chengzhang,Zhou Xinfeng,Yu Zhong-Zhen,Zhang Hao-Bin
A versatile surfactant-free emulsion construction strategy is proposed to customize functional hydrogels.
The synergistic emulsification mechanism between amphiphilic polymers and MXene is comprehensively elucidated.
Programmable functional structures confer hydrogels with excellent EMI shielding and water evaporation performance.
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Nano-Micro Letters
·
2025
·Vol. 17
·期 1
·1-28
·
IF 36.3
Shi Tao,Gao Xing,Liu Huan,Wang Xiaodong
A “five-in-one” multifunctional phase-change composite is developed for magnetothermal, electrothermal, solar-thermal, and thermoelectric energy conversion and electromagnetic shielding applications.
The developed composite is based on an innovative combination of carbonized polyimide/Kevlar/graphene oxide@ZIF-67 complex aerogel as a supporting material and paraffin wax as a phase-change material.
The developed composite exhibits excellent solar-thermal, thermoelectric, electrothermal, and magnetothermal energy conversion performance along with high electromagnetic interference shielding effectiveness.
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RESEARCH ON CHEMICAL INTERMEDIATES
·
2025
·
IF 3.5
Han Lijuan,Chai Keyi,Du Xinyu,Wang Xiangtong,Zhang Ping,Wang Xiaotian
Tetracycline poses a serious threat to the ecosystems even if the concentration is very low due to its structural stability. In this work, a series of magnetic separable Fe 3 O 4 /ZnO/g-C 3 N 4 composite with excellent degrading tetracycline performance were prepared. And, repeated calcination method was used to strengthen the bonding effect of single component improving the formation of heterojunction. Electrochemical analysis confirmed that the ZnO/g-C 3 N 4 and Fe 3 O 4 /ZnO/g-C 3 N 4 heterojunctions were generated, effectively accelerating the electron separation and transfer in photocatalytic process. The characterization results also showed that ZnO and Fe 3 O 4 nanoparticles are evenly distributed on the surface of g-C 3 N 4 . With the increase of the loading mass concentration of ZnO/g-C 3 N 4 , the degradation rate of tetracycline on Fe 3 O 4 /ZnO/g-C 3 N 4 composite increased and then decreased. The degradation rate of tetracycline on optimal Fe 3 O 4 /ZnO/g-C 3 N 4 composite reached to 94.50% while the TC mineralization rate reached to 61.61% under visible light irradiation for 120 min, exhibiting excellent photocatalytic performance. Due to the effect of Fe 3 O 4 , Fe 3 O 4 /ZnO/g-C 3 N 4 materials exhibited good magnetic property, which is beneficial to separation and recovery of photocatalysts. The reusability experiment showed that the degradation rate of tetracycline was 80.66% after five cycles, displaying good reusability.
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Journal of Food Measurement and Characterization
·
2025
·
IF 3.3
Lv Junli,Ren Zhilong,Niu Jianjiao,Lian Guohua
Pepsin is a crucial digestive enzyme in the human body. However, its hyperactivity can readily contribute to the development of gastrointestinal disorders. Research has indicated that certain phenolic acids can bind to pepsin, thereby attenuating its activity, which may be affected by the molecular weight and conformation of phenolic acids. Nonetheless, there are few reports in the literature regarding comparative studies on the inhibition of pepsin by various phenolic acids. Hence, three phenolic acids—ferulic acid, chlorogenic acid, and gallic acid—were selected for investigation in this study. A combination of spectroscopic experiments, molecular docking simulations, and antioxidant tests were employed to elucidate the interactions and mechanisms between these phenolic acids and pepsin. The findings demonstrated that the interaction between the three phenolic acids and pepsin occurred via a static quenching mechanism. Notably, chlorogenic acid exhibited the most pronounced impact on the fluorescence of pepsin. At temperatures of 298 K and 310 K, the fluorescence intensity of pepsin was reduced by 75.23% and 76.17% at a concentration of 0.6 × 10 −3 mol/L, respectively. Furthermore, thermodynamic parameter analysis indicated that the interaction between the polyphenols and pepsin was a spontaneous process, primarily driven by van der Waals forces and hydrogen bonding interactions. Molecular docking results corroborated the thermodynamic analysis, highlighting hydrogen bonding as the predominant force. Through an analysis of binding free energy, it was determined that the binding affinity of phenolic acids to pepsin follows the order: chlorogenic acid > gallic acid > ferulic acid. Furthermore, upon interaction with pepsin, the DPPH radical scavenging activity of these phenolic acids was diminished. The findings of this study may enhance the understanding of the health implications of phenolic acids in future research.
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