Journal of Materials Chemistry A
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2025
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IF 9.5
Weiguang Hu,Qinghua Xia,Lian Ying Zhang,Jianguo Lu,Qinggang He,Weiyong Yuan
Amorphous MOFs (a-MOFs) could be highly promising cocatalysts of 3-D α-Fe2O3 to greatly improve its photoelectrochemical oxygen evolution performance, but their effective synthesis and assembly on 3-D α-Fe2O3 presents formidable challenges. A conformal and ultrathin layer of amorphous Co–TDPAT (a-Co–TDPAT) MOF cocatalyst has been in situ self-assembled on an α-Fe2O3 nanosheet array (NSA) by employing 5,5′,5″-(1,3,5-triazine-2,4,6-triyl)tris(azanediyl)triisophthalic acid (H6TDPAT) as the organic ligand. The obtained α-Fe2O3 NSA@a-Co–TDPAT core–shell NSA exhibits a photocurrent density of 1.54 mA cm−2 (1.23 V), onset potential of ∼0.48 V, and photoconversion efficiency of 0.25%, 6.2 times higher, 290 mV lower, and 12.5 times higher, respectively, than those of the α-Fe2O3 NSA. The photocurrent density and the photoconversion efficiency are among the highest reported for photoanodes based on the FTO-supported α-Fe2O3 NSA without addition of noble metals, and the onset potential is the lowest among those of FTO-supported α-Fe2O3-based photoanodes reported. It is discovered that a-Co–TDPAT significantly enhances charge separation and accelerates charge transport and transfer for a fast oxygen evolution reaction, thus greatly boosting PEC oxygen evolution. This work not only provides a novel strategy to produce highly efficient, highly stable, low-cost, and earth-abundant core–shell water splitting photoanodes via in situ self-assembly of conformal, ultrathin a-MOFs on an α-Fe2O3 NSA, but sheds light on the mechanisms for controlled self-assembly of MOFs and PEC performance enhancement of α-Fe2O3-based photoelectrodes.
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
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2025
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IF 3.5
Bing-Rui Liu,Wen-Xiang Hu,Hai-Jie Li,Jian-Kun Yan,Xi-Tong Zhang,Chu Chu,Yan-Shu Zhang
BACKGROUND The rhizome of Alpinia officinarum Hance, considered as a medicinal and edible plant, is gathering increasing attention as a natural source for exploring dietary α-glucosidase inhibitors. Magnetic beads-based ligand fishing has shown great promise for accelerating identification of bioactive constituents from complex plant extracts. However, immobilization efficiency and stability when using different aldehyde-activated magnetic beads is still unclear. Moreover, non-specific binding hampers characterization of inhibitory ligands. RESULTS Immobilized enzymes on 3-carbon linker length (AG NTC - 3 MB) and 21-carbon linker length (AG NTC - 21 MB) supports were synthesized, respectively. The highest immobilization efficiency of 91.13 ± 0.40% was observed when the mass ratio of MBs-C21 to α-glucosidase was 10:1. The catalytic activity of AG NTC - 21 MB was four- to eight-fold higher than that of AG NTC - 3 MB. Additionally, after 56 days, the catalytic activity of AG NTC - 21 MB retained 73.4–90.3% activity – more stable than AG NTC - 3 MB (18.2–32.2%). In a proof-of-concept study, AG NTC - 21 MB-based ligand fishing led to the identification of 12 ligands. Among them, two flavonoids – kaempferol ( 1 ), galangin ( 6 ) – and three diarylheptanoids – 7-(4-hydroxyphenyl)-1-phenyl-4-hepten-3-one ( 9 ), 7-(4-hydroxy-3-methoxyphenyl)-1-henylhept-4-en-3-one ( 11 ), and 1,7-diphenyl-4-hepten-3-one ( 15 ) – exhibited significant α-glucosidase inhibitory activity, with IC 50 values in the range of 23.6 ± 0.7 to 146.2 ± 3.8 μmol L −1 , and showing a mixed-type behavior with K i values ranging from 42.6 ± 2.0 to 786.0 ± 13.9 μmol L −1 . Molecular docking showed compounds 6 , 9 , 11 , and 15 bind with α-glucosidase by H-bonds, electrostatic and hydrophobic interactions. CONCLUSION Aldehyde-activated magnetic beads with 21-carbon linker length and AG NTC - 21 MB are superior to AG NTC - 3 MB in terms of immobilized efficiency, enzymatic activity, and stability. AG NTC - 21 MB-based ligand fishing combined with high-performance liquid chromatography–quadrupole time-of-flight–mass spectrometry and molecular docking constitute an effective and robust bioanalytical technology platform for analyzing antidiabetic composition in A . officinarum . Flavonoids and diarylheptanoids are responsible for the α-glucosidase inhibitory effect of the methanolic A . officinarum extract. The pharmacological and chemical profiles support further research with the aim of developing A. officinarum into functional food for prevention and management of type 2 diabetes and related complications. © 2025 Society of Chemical Industry.
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BIOELECTROCHEMISTRY
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2024
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IF 4.8
Zhihao Xu,Zhixiang Lv,Huijiao Yang,Jiashuo Zhang,Zijie Sun,Dawei He,Ruijiang Liu
A label-free electrochemical DNA detection strategy based on self-assembled α-Fe 2 O 3 /Fe 3 O 4 nanosheets with PNA-DNA hybridization process was developed for ultrasensitive detection of APOE ε4 gene, one of the most robust genetic risks for Alzheimer’s Disease (AD). In this work, magnetic α-Fe 2 O 3 /Fe 3 O 4 heterogeneous nanosheets were prepared by hydrothermal-calcined reduction method and loaded with Au nanoparticles (AuNPs) on their surfaces. The magnetic α-Fe 2 O 3 /Fe 3 O 4 @Au nanocomposites significantly enhanced the electrochemical response as a signal amplification matrix and were able to bind to the magnetic glassy carbon electrode (MGCE) surface by magnetic self-assembly. Moreover, owing to the high specificity and stable binding capacity of PNA with respect to the target DNA, the biosensor not only enabled accurate (the limit of detection was estimated to be 0.147 pM) and rapid detection of the APOE ε4 gene, but also exhibited excellent specificity, stability and regeneration capability. Additional, the satisfactory recoveries were also obtained in real samples of human serum, ranging from 92.83 % to 106.22 % with relative standard deviation (RSD) between 0.25 % and 1.85 %. The results possessed important reference value for exploring the application of DNA biosensor technology in the diagnosis of APOE gene mutation.
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Food Bioscience
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2024
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IF 4.8
Jinzhe Li,QiuWan Jiang,Ruyi Zhang,Shiyi Guo,Zhanmei Jiang,Juncai Hou
Due to uneven distribution amino acid residues of α-lactalbumin (αLA) at oil-water interface, some measurement should be adopted to improve its interfacial behavior and emulsion stability. Therefore, this study focused on the mechanism of synergy of ultrasound and high pressure homogenization on the emulsion stability and interfacial behaviors of α-lactalbumin with mogroside V (MGV). Four treatments were adopted: ultrasound (US), high pressure homogenization (HPH) and combined treatment (US-HPH and HPH-US). Primarily, emulsion stability of αLA/MGV was analyzed. US-HPH or HPH-US exhibited better emulsion stability than US or HPH. Especially, HPH-US-αLA/MGV emulsion was not stratified at the given time (45 d), which was the most stable emulsion. Moreover, the micromorphology of emulsion showed that MGV and UH/HPH treatment suppressed the aggregation of αLA emulsion droplet. In addition, interfacial adsorption mass and viscoelasticity of physical treated αLA was improved with MGV in the order of HPH-US > US-HPH > US > HPH, specifically, frequency shift (ΔF) and dissipation shift (ΔD) of HPH-US-αLA/MGV was 42.2% and 32.5% higher than that without MGV. This finding may provide a potential approach for obtaining natural and high-efficient protein-based emulsifier in food industry.
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CARBOHYDRATE POLYMERS
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2024
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IF 10.7
Hongcai Li,Weiteng Tan,Mengxin Hou,Shuang Yang,Caiyun Liu,Mengzhen Han,Jingjing Liang,Zhenpeng Gao
Developing multifunctional films with antibacterial, antioxidant, and sustained-release properties is a robust strategy for preventing contamination of perishable fruits by foodborne microorganisms. This study engineered a sustained-release biodegradable antibacterial film loaded with EGCG (Pickering emulsion (PE)/α-Cyclodextrin (α-CD)/Konjac glucomannan (KGM)) through multi-strategy cross-linking for fruit preservation. EGCG is stabilized using PE and incorporated into the α-CD/KGM inclusion compound; the unique structure of α-CD enhances EGCG encapsulation, while KGM provides the film toughness and surface adhesion. The composite film's physicochemical properties, antioxidant, bacteriostatic and biodegradability were studied. Results showed that Pickering emulsions with 3 % oil phase exhibited excellent stability. Moreover, α-CD introduction increased the loading and sustained release of EGCG from the film, and its concentration significantly affected the light transmission, thermal stability, mechanical strength, mechanical characteristics and antioxidant capacity of the composite membrane. Antioxidant and antimicrobial activities of the composite film increased significantly with increasing α-CD concentration. Application of the film to tomatoes and strawberries effectively inhibited Escherichia coli and Staphylococcus aureus growth, prolonging the shelf-life of the fruits. Notably, the composite film exhibits superior biodegradability in soil. This EGCG-loaded PE/α-CD/KGM composite film is anticipated to be a multifunctional antimicrobial preservation material with sustained-release properties and biodegradable for perishable food applications.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2018
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IF 3.909
Huizhu Wang,Yan Li,Zhihui Ren,Zhongcheng Cong,Mengjie Chen,Lin Shi,Xu Han,Jin Pei
An extraction assay applying microwave-assisted enzymatic treatment for polysaccharides in Rosa roxburghii was developed using response surface methodology. The process parameters were optimized using Plackett-Burman (PB) design and central composite design to enhance the Rosa roxburghii polysaccharide extraction yield. Specific conditions (microwave power, 575 W; microwave time, 18 min; liquid-to-material ratio, 13.5:1 mL/g; and enzyme dose, 6.5 g/mL) generated an experimental yield of 36.21 ± 0.62%, which closely agreed with the predicted value of 35.75%. Purification with a DEAE-52 cellulose column generated two fractions, PR-1 (from 6.2 × 10 3 to 7.4 KDa) and PR-2 (from 559.8 to 106.6 KDa). Subsequently, the antioxidant activity and α- d -glucosidase inhibitory activity of the two polysaccharide fractions were assessed; PR-1 exhibited stronger antioxidant activity and α- d -glucosidase inhibitory activity than PR-2. Finally, the monosaccharide composition of PR-1 was determined by HPLC using a 1-phenyl-3-methyl-5-pyrazolone precolumn derivatization method. The result showed that PR-1 contained mannose , ribose , rhamnose , glucosamine hydrochloride, glucuronic acid , galacturonic acid, glucose, galactose , arabinose and fucose with molar percentages of 2.1%, 0.54%, 2.1%, 0.26%, 1.5%, 22.7%, 24.0%, 26.4%, 19.6% and 0.89%, respectively.
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Frontiers in Pharmacology
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2018
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IF 3.831
Tsai Hsiang-I,Jiang Lijuan,Zeng Xiaowei,Chen Hongbo,Li Zihuang,Cheng Wei,Zhang Jinxie,Pan Jie,Wan Dong,Gao Li,Xie Zhenhua,Huang Laiqiang,Mei Lin,Liu Gan
The clinical applications of platinum-based antitumor agents are still largely limited by severe side effects as well as multidrug resistance (MDR). To solve these problems, we developed an 1,2-diaminocyclohexane-platinum(II) (DACHPt)-loaded nanoparticle (NP-TPGS-Pt) by self-assembly of poly(amidoamine)-polyglutamic acid-b-D-α-tocopheryl polyethylene glycol 1000 succinate (PAM-PGlu-b-TPGS) and DACHPt. NP-TPGS-Pt showed robust stability and pH-responsive DACHPt release profile in vitro similar to the PEG-containing nanoparticle (NP-PEG-Pt). Meanwhile, in contrast with NP-PEG-Pt, NP-TPGS-Pt exhibited efficient nanoparticle-based cellular uptake by the Pt-resistant A549/DDP human lung cancer cells and caused much more cytotoxicity than free Oxaliplatin and NP-PEG-Pt. Finally, this NP-TPGS-Pt was proved to perform outstanding inhibition of Pt-resistant tumor growth, much superior than free Oxaliplatin and NP-PEG-Pt. Thus, this NP-TPGS-Pt provides a novel powerful nanomedicine platform for combatting multidrug resistant cancer.
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Natural Product Communications
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2024
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IF 1.5
Hui-Peng Song,Ming-Yue Zhao,Zhi-Li Xu,Jia-Nuo Zhang,Wen-Yu Wang,Zi-Xuan Ding,Ying Wang,Li-Bin Zhan,Xi Chen,Ruo-Nan Li,Yue-Hua Chen
ObjectivesThe aim is to discover α-glucosidase/acetylcholinesterase inhibitors as lead compounds from a traditional herbal prescription of Qi-Li-Qiang-Xin capsule (QLQX).MethodsA novel strategy combining time-based fractionation, LC-QTOF-MS, enzymatic activity assay, molecular docking and component-target association analysis was performed to discover α-glucosidase/acetylcholinesterase inhibitors from QLQX. Time-based fractionation combined with enzymatic activity assay was used to find the distribution period of active compounds in the herbal prescription. LC-QTOF-MS was used to analyze the structure of active compounds. Molecular docking was applied to explore the interaction between active compounds and targets.ResultsAccording to time-based fractionation, the active components of QLQX for acetylcholinesterase were primarily concentrated in the highly polar region, whereas the active components for α-glucosidase were predominantly found in the moderately polar area. A total of 33 compounds were identified by comparing with chemical reference substances. Dihydrotanshinone Ⅰ (16.98 µM), hydroxysafflor yellow A (84.57 µM), salvianolic acid A (76.62 µM) and cryptotanshinone (112.68 µM) were identified as acetylcholinesterase inhibitors from QLQX. Similarly, rosmarinic acid (62.29 µM), isochlorogenic acid A (17.95 µM), 4,5-dicaffeoylquinic acid (117.93 µM), danshensu (207.88 µM), salvianolic acid A (1.31 µM), 3,4-dicaffeoylquinic acid (91.71 µM), formononetin (67.26 µM), ginsenoside Rd (3.43 µM), ginsenoside Rb1 (26.37 µM) and ginsenoside F1 (18.79 µM) were discovered as α-glucosidase inhibitors. Notably, salvianolic acid A inhibited both acetylcholinesterase and α-glucosidase. The results of molecular docking indicated that hydrogen bonds, hydrophobic interactions and Pi-Pi T-shaped interactions were crucial for inhibiting acetylcholinesterase. Meanwhile, hydrogen bonds, hydrophobic interactions and Pi-Pi stacked interactions were significant in suppressing α-glucosidase.ConclusionQLQX contains numerous acetylcholinesterase and α-glucosidase inhibitors, demonstrating its potential therapeutic benefits for Alzheimer's disease and diabetes.
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FOOD CHEMISTRY
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2024
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IF 8.5
Shenling Wang,Xiaofeng Hu,Wenqin Wu,Du Wang,Peiwu Li,Zhaowei Zhang
The coexistence of multiple contaminates in the environment and food is of growing concern due to their extremely hazard as a well-known class I carcinogen, like aflatoxin B1 (AFB1) and benzo(α)pyrene (BaP). AFB1 and BaP are susceptible to coexistence in environmental water and edible oil , posing a significant potential risk to environmental monitoring and food safety. The remaining challenges in detecting multiple contaminates include unsatisfied sensitivity, insufficient targets selectivity , and interferences in complex matrices. Here, we developed dual-template magnetic molecularly imprinted polymers (DMMIPs) for selective extraction of dual targets in complex matrices from the environment and food. The DMMIPs were fabricated by surface imprinting with vinyl-functionalized Fe 3 O 4 as carrier, 5,7-dimethoxycoumarin and pyrene as dummy templates, and methacrylamide as functional monomer . The DMMIPs showed excellent adsorption ability (12.73–15.80 mg/g), imprinting factors (2.01–2.58), and reusability of three adsorption-desorption cycles for AFB1 and BaP . The adsorption mechanism including hydrogen bond , electrostatic interaction and van der Waals force was confirmed by physical characterization and DFT calculation. Applying DMMIPs in magnetic solid phase extraction (MSPE) followed by high-performance liquid chromatography (HPLC) analysis enabled detection limits of 0.134 μg/L for AFB1 and 0.107 μg/L for BaP. Recovery rates for water and edible oil samples were recorded as 86.2%–110.3% with RSDs of 4.1%–11.9%. This approach demonstrates potential for simultaneous identification and extraction of multiple contaminants in environmental and food.
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ADVANCED FUNCTIONAL MATERIALS
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2024
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IF 18.5
Yu Bing,Zhao Song,Hongtao Jiang,Xiaoyi Xu,Zhongzheng Yu,Tingting Zhou,Tong Zhang
Water competitive adsorption and limited reaction sites on the micro-scale sensing area of micro-electro-mechanical system (MEMS) sensors are two bottleneck problems that restrict the detection of trace indoor polluted gases, leading to drifting and weak signals. To address this, a “duet-insurance” sensing strategy is proposed to protect and amplify the sensing signal. For the first-level protection, the well-designed double-layer structure consisting of Janus TpMa covalent organic framework (COF)/Eu-doped α-Fe 2 O 3 can resist diffusion of water molecules and facilitate the electron transfer from formaldehyde (CH 2 O) to sensing layers, benefiting from the outer hydrophobic character of Janus TpMa and the strong CH 2 O adsorption capacity of Eu-doped Fe 2 O 3 . For the second-level amplification, the unique variable temperature excitation facilitates the deep penetration of CH 2 O into the active sites across COF layers, enabling signal amplification through thermally actuated carrier modulation. The sensor demonstrates high sensing ability to the CH 2 O, with an ultra-low limit of detection of 794 ppt. Leveraging the novel sensing strategy, a multi-functional, visual sensing system is designed to identify multi-indoor pollution gases by feature signal encoding and color mapping, showcasing the promising potential for MEMS sensors based on Janus TpMa COF/Eu-doped α-Fe 2 O 3 materials.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2025
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IF 6.3
Ligang Ma,Yihuan Ding,Chao Lin,Tingting Chen,Xinlan Li,Shun Yan,Xiang Song,Xiaoqian Ai,Xiaoshan Wu
Photocatalytic water splitting represents a sustainable pathway for hydrogen production, yet the development of efficient and cost-effective photocatalysts remains challenging. Herein, we report the in situ construction of a noble-metal-free coaxial core-shell 1D/3D heterojunction composed of paraotwayite-type α -Ni(OH) 2 nanowire (NIOH) and ZnIn 2 S 4 (ZIS) for significantly enhanced photocatalytic hydrogen evolution. The unique 1D/3D architecture of NIOH@ZIS synergistically combines the advantages of both components: the 1D NIOH nanowires suppress charge recombination by shortening in-plane migration distances, while the 3D ZIS nanoflowers provide abundant active sites and prevent structural aggregation. Under full-spectrum irradiation, the optimized NIOH@ZIS-3 heterojunction achieves an exceptional hydrogen production rate of 7.682 mmol·g⁻¹ ·h⁻¹ , 7.8 times higher than pristine ZIS. Mechanistic studies reveal that the pn heterojunction charge transfer pathway, driven by the built-in electric field at the NIOH/ZIS interface, facilitates efficient separation and utilization of photogenerated carriers. Furthermore, the heterojunction exhibits robust stability over four photocatalytic cycles without performance degradation. This work provides a rational design strategy for high-performance, low-cost photocatalysts through structural and interfacial engineering.
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JOURNAL OF ETHNOPHARMACOLOGY
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2020
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IF 3.69
Yaxin Zhang,Yuyan Gu,Yihao Chen,Zhiyong Huang,Mei Li,Weihao Jiang,Jiahui Chen,Wenting Rao,Shangfei Luo,Yuyao Chen,Junqi Chen,Lijun Li,Yuhua Jia,Menghua Liu,Fenghua Zhou
Ethnopharmacological relevance Dingxin Recipe (DXR) is a traditional Chinese medicine formula that has been reported to be effective and safe treatment for cardiovascular diseases, such as arrhythmias, coronary heart disease. Dingxin Recipe IV (DXR IV) was further improved from the DXR according to the traditional use. However, the mechanism of DXR IV in atherosclerosis is unclear. Aim of the study This study aimed to illustrate whether DXR IV improve atherosclerosis through modulating the lipid metabolism and gut microbiota in atherosclerosis mice. Materials and methods 40 male ApoE -/- mice were fed on HFD for 12 weeks and were then treated with DXR IV (1.8, 0.9, or 0.45 g/kg/d) for another 12 weeks. The decroation of DXR IV contains four traditional Chinese medicines: the dried rhizome of Coptis chinensis Franch. (15.09%), the root of Salvia miltiorrhiza Bunge (28.30%), the seed of Ziziphus jujuba Mill. (37.74%) and the fruiting body of Ganoderma lucidum (Leyss.ex Fr.) Karst. (18.87%). 8 male c57BL/6 mice fed a normal diet served as control group. The atherosclerotic plaque was quantified by oil-red O staining and masson trichrome staining. Mice feces were collected. The gut micobiota were detected by 16S rRNA gene sequencing and fecal metabolites were analyzed by 1 H NMR spectroscopy. The effect of DXR IV on blood lipids (TG, TC, LDL-C, HDL-C) was investigated. The lipid metabolism related genes were determined by RT-qPCR and western blotting respectively. Results DXR IV exerted the anti-atherosclerosis effect by inhibiting the excessive cholesterol deposition in aorta and regulating the level of TG, TC, LDL-C and HDL-C. The composition of gut microbiota was changed. Interestingly, the relative abundance of Muribaculaceae and Ruminococcaceae increased after DXR IV administration, whereas the abundance of Erysipelotrichaceae decreased, which have been beneficial to lipid metabolism. Nine potential metabolic biomarkers, including acetate, butyrate, propionate, alanine, succinate, valerate, xylose, choline, glutamate, were identified, which were related to fatty acid metabolism. Further, the pathway of fatty acid was detected by the RT-qPCR and western blotting. Compared with model group, the level of LXR-α and SREBP1 decreased significantly in DXR IV group while LXR-β, SREBP2 showed no statistical significance. It indicated that DXR IV modulated lipid metabolism by LXR-α/SREBP1 but not LXRβ and SREBP2. Conclusions DXR IV exhibits potential anti-atherosclerosis effect, which is closely related to lipid metabolism and the gut microbiota. This study may provide novel insights into the mechanism of DXR IV on atherosclerosis and a basis for promising clinical usage.
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