SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Zheng Zhang,Jinfeng Zhang,Zhihua Zhang,Xiao Du,Xiaogang Hao,Xiaowei An,Guoqing Guan,Jun Li,Zhong Liu
A novel physically blended polyvinylidene fluoride (PVDF) and polyacrylic acid (PAA) composite binder enhanced LiMn 2 O 4 /C (carbon black) film based electrode was successfully fabricated, and applied in an electrochemically switched ion exchange (ESIX) process for selective extraction of Li + from high Mg/Li ratio brine. The multifunctional composite binder system enabled the obtained LiMn 2 O 4 /C/PVDF- b -PAA film coated electrode to exhibit superior mechanical, hydrophilic and electrochemical properties compared with the LiMn 2 O 4 /C/PVDF film coated electrode. Based on the density functional theory (DFT) calculations, the ion exchange interaction between H + of –COOH groups in PAA and Li + facilitated the transport of Li + at the electrode interface, which enhanced lithium extraction performance of the film coated electrode. For treating the simulated brine (Mg/Li: ∼500), the intercalation capacity of Li + was about 15.1 mg g −1 , and the total extraction efficiency of lithium reached up to 62.8% after two electrochemical intercalation tests. Moreover, the film coated electrode displayed excellent selectivity towards Li + ions even in pre-treated actual brine (Mg/Li: ∼292.2). The Mg/Li mass ratio in the recovery solution could decrease to 0.46, and the calculated Li + /Mg 2+ separation coefficient reached as high as 631.08. In particular, the highly stable and scalable electroactive film could be prepared effectively, thus increasing its applicability. It is expected that such a LiMn 2 O 4 /C/PVDF- b -PAA film coated electrode could be a promising candidate for the selective extraction of Li + from high Mg/Li mass ratio brines.
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PHYSIOLOGIA PLANTARUM
·
2024
·Vol. 176
·期 1
·e14194
·
IF 5.4
Kai Su,Jing Yuan,Ran Wang,Lanlan Huang,Jian Zhan,Xueqiong Zhang,Shanping Wan,Xinhua He,Hans Lambers,Fuqiang Yu,Yanliang Wang
Ectomycorrhizal (EM) fungi play important roles in nutrient cycling and plant community establishment in forest ecosystems. Effects of EM formation on global alterations of the transcriptome and metabolome during plant-fungal interaction and the key metabolites involved in EM development are largely unknown. Here, dual RNA-Seq and untargeted metabolomic analyses were used to reveal stage-specific and core responses of Pinus yunnanensis and Lactarius deliciosus during mycorrhizal colonization. We found that L. deliciosus colonization in P. yunnanensis roots induced different transcriptional changes across three interaction stages, with a small core of genes consistently regulated at all stages. Concentrations of retinol (vitamin A) and retinoic acid increased while that of B group vitamins decreased during EM formation, which was coordinately regulated by these two plant-fungus partners, with L. deliciosus possibly playing a dominant role. Exogenous retinol altered the diameter and mantle thickness of P. yunnanensis - L. deliciosus EM tips and affected host plant growth and phosphorus acquisition . In the absence of L. deliciosus, exogenous retinol increased the root diameter and the number of root tips of P. yunnanensis . Furthermore, the concentration of auxin increased, but that of abscisic acid decreased during EM formation, and the genes involved in plant hormone signal transduction were gradually activated, and auxin and cytokinin signal transduction potentially played a positive role in this EM symbiosis. In conclusion, we propose that the interaction of P. yunnanensis and L. deliciosus alters vitamin metabolism, which may further affect plant hormone biosynthesis and signal transduction, modulating root morphology and EM traits.
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Current Pharmaceutical Analysis
·
2020
·Vol. 16
·期 6
·763-773
·
IF 0.923
Yaro Peter,Nie Jing,Xu Mingcheng,Zeng Kui,Zeng Su
Background: Terpene lactones are major components of ginkgo biloba extract which are used in cardiovascular and degenerative diseases. To study the involvement of transporters in the transport/disposition of ginkgolides A, B, C, and bilobalide, a bioanalytical assay was developed by
LCMS/ MS system for the quantitation of intracellular levels of terpene lactones in cells expressing organic cation transporter 2 (OCT2). Methods: The assay involved an optimized simple sample handling with methyl tert-butyl ether for liquid-liquid extraction and reconstitution in modified
dissolution solution. Pretreatment of samples with 50 μM ascorbic acid and the addition of ascorbic acid and formic acid in dissolution solution significantly reduced matrix effect and stabilized the postpreparative samples. Separations were performed by Zobrax RRHD column (extend-C18 1.8μm,
3.0 x 100mm) and acetonitrile gradient elution. The analysis was carried out in the negative ion scan mode using multiple reaction monitoring. Results: The method was validated for linearity (concentration range of 20-5000nM), accuracy (±13.1%), precision (<11.0%), recovery
(94.31–105.9%), matrix effect (93.8-111.0%) and stability. Finally, the method was applied in the determination of intracellular concentrations of ginkgolides A, B, C, and bilobalide in Madin-Darby canine kidney (MDCK-mock) and MDCK-OCT2 cells in uptake study. Conclusion: The developed
method was successfully validated. Results suggest that OCT2 is involved in the renal disposition of ginkgolide A, B, and bilobalide. This method would foster the study of transport mediated activity via the interaction of ginkgolides and bilobalide with cellular systems.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yating Hou,Mengmeng Wang,Xinru Wei,Yunmei Du,Dehong Chen,Ruiyong Zhang,Lei Wang
Developing an effective strategy to controllably construct phosphate shells on phosphides remains a challenge because of the sluggish kinetics of the oxygen evolution reaction (OER). In this work, Ni(PO x )@B-Ni 2 P/NF electrodes with an amorphous phosphate shell were fabricated using a phosphorization–quenching strategy. Remarkably, Ni(PO x )@B-Ni 2 P/NF requires only 81 mV and 1.333 V to deliver a current density of 100 mA cm −2 for the hydrogen evolution reaction (HER) and urea oxidation reaction (UOR), respectively—outperforming Pt/C@NF and previously reported Ni-based electrodes. The self-assembled Ni(PO x )@B-Ni 2 P/NF(+)||Ni(PO x )@B-Ni 2 P/NF(−) configuration achieves 1 A cm −2 at only 1.414 V for urea-assisted water splitting, indicating strong potential for industrial application. In situ Raman spectroscopy, combined with theoretical calculations, reveals that the amorphous phosphate shell, which exhibits strong urea adsorption capacity, optimizes the electronic configuration of the Ni(PO x )@B-Ni 2 P heterointerface. It also suppresses the peroxidation of internal Ni active sites into Ni–OOH by-products with high *COO adsorption energy. The resulting low-valent Ni O active species reduce the *COO adsorption energy and promote C N bond cleavage in urea, thereby accelerating UOR kinetics. These findings offer new design strategies for phosphate@phosphide electrodes tailored for industrial hydrogen production coupled with urea degradation.
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JOURNAL OF SOLID STATE CHEMISTRY
·
2026
·
IF 3.2
Yuye Li,Tianao Liu,Tingting Du,Congzhi Hu,Youyong Pang,Yongping Liu,Botian Liu,Ling Li,Huidan Lu,Bin Huang
Dyes and antibiotics possess high stability and are resistant to microbial degradation, leading to their persistence in the natural environment. Photocatalysis is an effective and green degradation method. In this work, a novel Ag/AgCl/NH 2 -MIL-53(Fe) (AAF) heterojunction photocatalyst was prepared using a solvothermal method, precipitation method, and photochemical reduction method, which effectively promotes the separation of photogenerated charge carriers. The study shows that the composite consisting of 95 wt% Ag/AgCl/NH 2 -MIL-53(Fe) (AAF-95) can photocatalytically degrade 99.4% of RhB within 15 min and 82.4% of TC within 12 min, achieving higher photocatalytic degradation activity than the individual materials. The main active species involved in the degradation are h + and •O 2 - . Based on Mott-Schottky tests, radical trapping experiments, and UV-vis DRS, a possible photocatalytic degradation mechanism and the advantages are proposed: AAF-95 broadens the light absorption range, and the NH 2 -MIL-53(Fe) increases the specific surface area, thereby enhancing the catalytic reaction activity. The coupling between the heterojunction and the SPR effect promotes the separation of photogenerated charge carriers and lowers the catalytic reaction barrier. These are the reasons for the enhanced photocatalytic degradation capability of the composite.
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 5
·352
·
IF 5.4
Zhang Yanmei,Jiang Rui,Yang Hongze,Zhou Cheng,Sun Mengxi,Chen Hong,Lin Donghai,Huang Liming,Chen Guosong
A near-infrared (NIR)-excitable ratiometric fluorescent nanosensor, CS-UCNP@mSiO 2 –RBPA, was developed for the selective and sensitive detection of Hg 2+ . The nanosensor is constructed by grafting a rhodamine B-derived probe (RBPA) onto mesoporous silica-coated core–shell NaYF 4 :Yb,Er upconversion nanoparticles (UCNPs). Upon 980 nm excitation, the UCNPs exhibit characteristic green emission at ~ 543 nm and red emission at ~ 655 nm. In the presence of Hg 2+ , the spirolactam ring of RBPA opens specifically, producing a yellow-emitting species that enables efficient Förster resonance energy transfer (FRET) from the UCNP donor. This leads to a Hg 2+ concentration-dependent quenching of green emission and a synchronous enhancement of yellow fluorescence at ~ 584 nm, with the red emission acting as a stable internal reference. The nanosensor shows outstanding selectivity toward Hg 2+ against other competing metal ions and performs optimally at neutral pH. It presents a good linear response in the Hg 2+ concentration range 0–70 µM via UV–vis absorption, and achieves an ultra-low detection limit of 14 nM based on the ratiometric fluorescence signal (I 584 /I 655 ). Benefiting from NIR excitation, ratiometric self-calibration and excellent specificity, this fluorescent nanoplatform holds great potential for practical applications in environmental monitoring and biological analysis.
Section
Graphical
The alternative text for this image may have been generated using AI.
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CELLULAR AND MOLECULAR LIFE SCIENCES
·
2026
·Vol. 83
·期 1
·76
·
IF 6.2
Feiyu Lu,Shengnan Wang,Mengru Zhu,Kuo Qu,Tong Zhu,Hong Wang,Yongli Yu,Liying Wang
The imbalanced expression of interferon regulatory factor (IRF) 4 and IRF8 in activated B cells significantly influences their differentiation and promotes the development of immune-related diseases. Restoring abnormal B cells to appropriate responses may treat these diseases. In this study, an oligodeoxynucleotide (ODN) S2, designed according to the consensus sequence recognized by IRFs in interferon-stimulated response elements, was used as an immunomodulator to investigate its effects on mouse splenic B cells stimulated with the TLR9 agonist CpG ODN, either alone or in combination with antigen, and to explore its underlying mechanisms. The results showed that S2 had a significant negative regulatory effect on CpG ODN induced B cell activation. It also significantly downregulated the production of IL-6 and the percentage of IL-6 + B cells in splenocytes stimulated by CpG ODN, but significantly upregulated the percentage of IL-10 + B cells. Interestingly, S2 impaired antibody production both in vitro and in vivo, but rescued mice from lethal inflammatory responses. Further studies showed that S2 could bind IRF4 and IRF8 with high affinity, slightly upregulate phosphorylated IRF4, reduce the expression and nuclear translocation of IRF8, and alter the proportion of IRF4 + , IRF8 + or double-positive B cells in spleen cells induced by CpG ODN. These results suggest that S2 acts as a decoy directing some B cells to differentiate into IL-10-producing Breg-like cells rather than plasma cells by restoring the TLR9 signal-induced IRF4 and IRF8 ratio imbalance. This indicates its potential as an immunomodulator for the treatment of diseases associated with B-cell abnormalities.
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CATALYSIS LETTERS
·
2019
·Vol. 149
·期 6
·1690-1700
·
IF 2.372
Xiong Xingquan,Yi Chao,Liao Xu,Lai Shilin
A simple, highly efficient and green route for the synthesis of 2-amino-4 H -benzo[ b ]pyrans and 1,4-dihydropyridines has been developed by using γ-cyclodextrin (γ-CD) as catalyst in deep eutectic solvent (DES) of urea-choline chloride (urea-ChCl), for the first time, accomplished via a one-pot, three-component strategy. All the reactions were successfully carried out under mild conditions and gave good to excellent yields (86–98%) in 8–28 min in the presence of 5 mol% of the γ-CD catalyst. The short reaction time, green reaction medium, moderate reaction conditions, simple work-up procedure and use of easily available reagents are the attractive features of this novel synthetic method. More importantly, the urea-ChCl-γ-CD catalytic system was regenerated and reused up to 6 times with a slight drop in the product yields. Graphical
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Surfaces and Interfaces
·
2025
·
IF 6.3
Chun Yu,Liangzhen Zhu,Yanjin Lu,Yi Zhao
CoCr-based alloys are widely utilized in dental implants and serve as metallic frameworks for porcelain-fused-to-metal (PFM) restorations, owing to their cost-effective, excellent wear and corrosion. However, interfacial failure between the base alloy and the porcelain arose over extended periods of use in oral environments. Therefore, establishing a reliable metal-porcelain interface is of critically importance. This study investigates how the addition of boron impacts the pre-oxidation scale and its mechanical properties of Co-Cr-W-Cu-Si-(0, 0.5, 1.1 wt.%) B alloys at 928 °C for 10 mins in air. Surface analysis indicated that Si and B stabilized Cr 2 O 3 scale grown on the surface of CoCr based alloys. As the B concentration increased, the scale became thinner, and its morphology transformed from Cr 2 O 3 to a combination of outer CoCr 2 O 4 spinel and inner Cr 2 O 3 . Amorphous SiO₂ was detected along the scale-alloy interface together with B 2 O 3. The mechanical stability of the scale along with its adhesion to the matrix increases with increasing B concentration. The synergistic impact of Si and B is probably due to the amorphous innerlayer playing as an effective barrier to the transportation of reactants and slow down the oxide scale growth. Meanwhile, the morphology of pining-like arrangement for amorphous SiO 2 layer increases the factual contact area between the oxide scale and matrix, rendering it less susceptible to fracture.
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POLYMERS FOR ADVANCED TECHNOLOGIES
·
2022
·Vol. 34
·期 4
·1209-1219
·
IF 3.348
Wenju Hu,Haozhi Sun,Lixia Pan,Chaoqun Zhang,Xin Shen,Feng Su,Jie Song
The encapsulation and release of hydrophobic drugs from polymersomes are of great importance in drug delivery. A significant challenge is to enhance the encapsulation capacity of finding better drug-polymer compatibility. Herrin, poly(trimethylene carbonate)-b-poly(ethylene glycol) (PTMC-PEG) diblock copolymers were successfully synthesized by ring opening polymerization of trimethylene carbonate using monomethoxy poly(ethylene glycol) (mPEG) as macro-initiator and stannous octoate as catalyst. The resulting diblock copolymer were characterized by 1 H NMR, FTIR, GPC, and DSC techniques. Blank and paclitaxel (PTX) loaded micelles was prepared by co-solvent evaporation method and characterized by transmission electron microscope (TEM) and dynamic light scattering (DLS). The influence of hydrophilic/hydrophobic segment length to drug loading and release was explored. All micelles have the sustained hydrophobic drug release properties of the micelles. Moreover, the cytotoxicity of micelles was evaluated by MTT and live-dead cell staining assay using L929 cell lines, showing the good biocompatibility. Therefore, PTMC-PEG micelles could be a suitable material for the loading and releasing of hydrophobic drugs.
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MICROCHEMICAL JOURNAL
·
2022
·
IF 5.304
Jiangru Wang,Qirui Shen,Xifeng Yu,Qi Kang,Dazhong Shen
Multi-signal assays offer the advantage to improve the accuracy and diversity by integrating the merits of each output. In the widely used colorimetric and fluorometric dual-mode, the fluorescent intensity and absorbance signals are usually measured by a lab spectrofluorometer and a spectrophotometer. Herein, a smartphone-based device which is able to measure simultaneously the ratiometric fluorescence and absorbance signals was designed. Its analytical performance is demonstrated by the determination of Rhodamine B (Rh B). In a three-channel cuvette, the detection cell (with test solution) was sandwiched between two light intensity measurement cells (with Rh B standard solution). Under the irradiation of the excitation light of 550 nm, the fluorescent images of the three cells were captured by the camera in a smartphone. The ratiometric fluorescence at 590 nm and the absorbance at 550 nm are obtained according to the brightness ratio of the middle cell and the third cell to the first one, respectively. The dual-mode of fluorescence and absorbance can widen the detection range, with the limit of detection for Rh B of 3.2 nM in ratiometric fluorescence mode and 0.38 μM in absorbance outputs, respectively. Importantly, the possible inner filter effect at the excitation wavelength of the fluorescence can be corrected according to the absorbance signal, improving the accuracy of determination. The dual-mode portable device was used to determine Rh B in combination with differential molecularly imprinting strategy to improve further the anti-interference ability.
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2022
·
IF 5.999
Yongli Shi,Xueyan Hou,ShaSha Yu,Xiaofei Pan,Mingbo Yang,Jie Hu,Xiao Wang
Doxorubicin (DOX) is widely used in the treatment of many tumors, but the dose-dependent toxicity limits its further application. In this study, a unique strategy was developed to improve the anti-tumor effects of free DOX and lower its in vivo toxicity by constructing novel glutathione (GSH)-sensitive poloxamer188-b-polycaprolactone-S-S-doxorubicin nanoparticles (PPSSD NPs). After uptake by tumor cells, the disulfide bonds in the PPSSD NPs would be cloven by reacting with GSH. Then, a lethal dose of DOX was released in tumor cells. The uptake of PPSSD NPs by 4T1 cells was proved using fluorescence microscopy by co-localization of PPSSD NPs and 4′, 6-diamidino-2-phenylindole (DAPI). Cell tests suggested that the PPSSD NPs showed high anti-tumor cells (4T1) activity but low cytotoxicity against normal cells (293 t). The in vivo toxicity and anti-tumor effects of the PPSSD NPs were studied with Kunming and Balb/c mice as models, respectively. The H&E slices, blood routine and biochemistry indexes of the PPSSD NPs treated mice indicated that the PPSSD NPs did not induce obvious in vivo toxicity. The PPSSD NPs showed higher in vitro anti-4T1 cells activity than free DOX. Furthermore, the in vivo anti-tumor study, TUNEL and H&E slices suggested that the PPSSD NPs exhibited excellent anti-tumor effects. In a word, the novel PPSSD NPs did not only improve the anti-tumor effect of DOX, but also decrease its cytotoxicity to normal tissues.
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