FREE RADICAL BIOLOGY AND MEDICINE
·
2026
·
IF 8
Hao Lei,Zhongxue Lin,Xin Chen,Kuanhou Mou,Feng Xu,Yan Zheng,Lei Xie
Psoriasis, a globally prevalent immune-mediated dermatosis, requires novel therapeutic strategies that address its multifactorial pathogenesis, involving oxidative stress, cell-free DNA (cfDNA)-driven inflammation, and keratinocyte hyperproliferation. Here, we presented a pH-responsive two-dimensional (2D) MXene nano-scavenger integrating Ti 3 C 2 T x -mediated antioxidant activity, polyethylenimine (PEI)- facilitated cfDNA scavenging, and 2,3-dimethylmaleic anhydride (DMMA)-induced charge reversal for targeted ATIC inhibitor delivery. Comprehensive material characterization confirmed pH-dependent charge reversal and sustained drug release. In vitro, the MXene-based platform (MPDA) exhibited superior reactive oxygen species (ROS) scavenging (superior to Trolox at the same concentration) and cfDNA adsorption (3-fold higher than pure MXene), while in vivo administration in imiquimod-induced psoriatic mice markedly alleviated disease severity (PASI score reduction of approximately 50%), reduced epidermal thickness (37% decrease compared to the IMQ group), and suppressed inflammatory cytokines—significantly outperforming monotherapies. Transcriptomic analysis further revealed that MPDA cooperatively inhibited multiple inflammatory pathways, including the TNF and IL-17 signaling, thereby effectively disrupting the self-perpetuating inflammatory cycle of psoriasis. This work establishes a promising paradigm for combinatorial nanotherapy in psoriasis treatment.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Yi-Lin Liu,Changgui Guo,Ping Cao,Qingyan Zhang,Ling Wang,Qingyi Zeng
The rapid development of the nuclear industry has made the efficient treatment of uranium-containing wastewater a significant challenge in environmental radiochemistry. This study aimed to develop a high-performance adsorbent for the removal of UO 2 2+ from water. A series of MIL-125/Ti 3 C 2 nanocomposites were successfully constructed via an in-situ solvothermal method, by integrating two-dimensional Ti 3 C 2 MXene with rich surface functional groups and porous MIL-125(Ti) MOF. The composite material not only retained the regular pore structure of MIL-125 but also exposed a greater number of active sites, exhibiting optimal adsorption performance. Under neutral conditions (pH = 7), the adsorption of U(VI) onto MIL-125/Ti 3 C 2 –2 followed the pseudo-second-order kinetic model and reached equilibrium within 50 min, with a remarkable maximum adsorption capacity of 661.07 mg/g, clear superior to most reported adsorbents. The adsorption isotherm fitted the Langmuir model, indicating monolayer chemisorption. Furthermore, the material demonstrated excellent anti-interference ability and selectivity in the presence of various coexisting ions (except for Cu 2+ and Ca 2+ ) and humic acid, along with satisfactory regeneration performance (85.6% retention after 5 cycles). The adsorption mechanism involves strong coordination interactions between surface functional groups (-NH 2 , -OH) and UO 2 2+ , while the potential reducing ability of MXene also facilitates the partial reduction of U(VI) to the more stable U(IV), forming a dual fixation mechanism of ‘synergistic adsorption-reduction’. This work provides new insights and experimental evidence for designing efficient and stable MOF/MXene adsorbents for treating actual uranium-containing wastewater.
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Sustainable Materials and Technologies
·
2026
·
IF 9.7
Wenjuan Zhang,Zhongliang Li,Yezhi Ding,Panpan Zhang,Yongqiang Wan,Qiaohong Zhang,Jinyuan Ma,Youliang Wang
The development of iron-based heterogeneous Fenton catalysts is often hindered by challenges including slow Fe 3+ /Fe 2+ cycling, limited interfacial electron transfer kinetics, and inefficient mass transport, leading to suboptimal catalytic efficiency. In this work, three distinct assembly strategies—hydrogen bonding, electrostatic self-assembly, and solvothermal methods—were utilized to fabricate MCuFe-MOF/PMMA@MXene (denoted as MPM) microspheres for the photo-Fenton degradation of methylene blue (MB). Notably, the microspheres fabricated via electrostatic self-assembly (designated E -MPM) exhibited a unique three-dimensional (3D) microsphere architecture. This structure significantly enhanced the adsorption capacity for pollutants and improved mass transfer, concurrently broadening the visible-light absorption range. The well-defined interfaces within the E -MPM microspheres facilitate the formation of multiple heterojunctions with favorable band alignment, which effectively promotes the generation and separation of photogenerated electron-hole pairs. Consequently, highly reactive free radicals are efficiently generated through the photo-Fenton process, the E -MPM microspheres demonstrated high catalytic activity, achieving a remarkable MB degradation efficiency of approximately 91.9% within 60 min at 4 g/L MB under visible-light irradiation. This study not only provides a fundamental insight into the design of bimetallic MOF/MXene-derived heterogeneous photocatalysts, but also broadens the application scope of MXene-based materials in advanced water treatment technologies.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.5
Jian Mu,Tianlu Dong,Fanyan Zhou,Xiao-kun Ouyang,Nan Wang
Chronic diabetic wounds pose a major clinical challenge due to impaired healing, persistent infections, and disrupted bioelectrical signaling. In this study, a multifunctional hydrogel dressing was developed by incorporating tannic acid-modified MXene (TA@MXene) into a polysaccharide dual-crosslinked network formed by oxidized alginate (OSA) and carboxymethyl chitosan (CMC). The hydrogel combines dynamic Schiff base bonds and Fe 3+ coordination, endowing it with self-healing properties and tissue-like mechanical strength. The incorporated MXene not only provides high electrical conductivity (0.55 S/m) suitable for electrical stimulation but also confers near-infrared-triggered photothermal antibacterial activity, enabling localized heating above 50 °C. In vitro assays demonstrated broad-spectrum antibacterial efficacy (> 90% inhibition) and promoted endothelial cell migration. In diabetic mouse models, the hydrogel accelerated wound closure, achieving 98% healing within 14 days, through a combination of infection control, attenuation of oxidative stress, and electrical stimulation. This work offers a promising strategy for diabetic wound management by integrating the multifunctionality of MXene with dynamic polysaccharide networks.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 13.2
Hao-wen Zhang,Xiang Xu,Jie Lu,Wei-jin Li,Aming Xie,Hao Chen,Yang-sheng Wang,Ying Zhi,Zhe-sheng Feng,Yan Wang
With excellent conductivity, large specific surface area, and tunable surface properties, MXene is regarded as a promising material for research in humidity sensing technologies. Nevertheless, achieving the high response intensity, excellent response sensitivity, structural stability, and oxidation resistance in the MXene-based humidity sensors remains a formidable challenge. Herein, this work presents a NiFe layered double hydroxide modified MXene composite material as the humidity sensing material with superior sensing performance. By adding the composite material to the carboxymethyl cellulose solution, a humidity-sensitive functional ink was prepared with favorable printability. Besides, the screen-printing process was successfully adapted to prepare the mass-producible humidity sensor. Experimental results indicate that the humidity sensor in this research possesses exceptional sensitivity (1.10 s/7.89 s for response/recovery time) and satisfactory response intensity (90,843% at 97% RH), along with favorable physicochemical stability and functional durability. Eventually, the function of the humidity sensor for skin humidity sensing, real-time respiration monitoring, soil moisture, and temperature visualization has been evaluated, revealing significant potential in meteorological monitoring, industrial production, intelligent home, and personalized healthcare management.
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Environmental Science-Nano
·
2026
·
IF 5.1
Xuanxiu Da,Miao Zhou,Bolu Sun,Haoye Zou,Wenya Wang,Zhen Liu,Hongxia Shi,Jia Zhou,Lin Yang,Yonggang Wang
As a key compound widely used in textile, cosmetic, fire protection, and packaging industries, perfluorooctane sulfonic acid (PFOS) pollutes the environment via the hydrological cycle and enters the human body through the food chain, causing severe toxicity to reproductive, endocrine, and liver systems. Thus, highly sensitive detection of trace PFOS in water is crucial for protecting life and health. Based on this, a molecularly imprinted electrochemical sensor based on a chitosan/MXene/gold nanoparticle (CS/MXene/AuNPs) composite was developed for ultra-trace PFOS detection. MXene, with a high specific surface area and excellent conductivity, served as the substrate, enhancing electron transport via in situ AuNP reduction, while CS improved interfacial stability. Using PFOS as a template and pyrrole as the functional monomer, specific imprinted sites were constructed on the electrode via electropolymerization. Synergistic effects of MXene (conductive framework), AuNPs (catalyzing redox), and CS (immobilizing imprinted layer) boosted sensitivity. Results showed a linear range of 1.0 × 101–1.0 × 109 pg mL−1, detection limit of 7.9 pg mL−1 (S/N = 3), and 98.02–102.04% recovery in spiked samples. This strategy provides a selective and low-cost paradigm for monitoring persistent organic pollutants. Furthermore, it holds significant potential for supporting global environmental safety networks, aiding in pollution-induced disease control, and safeguarding ecological security, human health, and sustainable development.
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ACS Applied Nano Materials
·
2026
·
IF 5.5
Jeremiah Hao Ran Huang,Yu-Hsuan Chang,I-Wen Peter Chen
MXenes are promising materials for energy storage due to their high electrical conductivity and unique layered structure. This study demonstrates the dual role of 1-Butyl-3-methylimidazolium tetrafluoroborate (BMImBF4) as both an etching agent and an intercalation medium for synthesizing Ti3C2Tx MXene with enhanced electrochemical performance. In-situ Raman and XRD analyses show that BMIm+ ions intercalate between MXene layers, stabilizing the nanoscale (002) interlayer spacing, preventing restacking and improving ion transport. When tested in the H2SO4–BMImBF4 hybrid electrolyte, the Ti3C2Tx MXene delivers a capacitance of 228.7 F g–1 at a scan rate of 1 mV s–1, compared to 179.9 F g–1 in pure H2SO4, measured on the same batch of materials. This demonstrates that incorporating BMImBF4 into H2SO4 significantly enhances the charge storage capability of Ti3C2Tx MXene. These findings highlight the effectiveness of BMImBF4 in optimizing charge storage and reinforce the potential of ionic liquids for advanced MXene-based energy storage systems.
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COMPOSITES PART B-ENGINEERING
·
2023
·
IF 13.1
Anchalee Duongthipthewa,Hanmo Zhou,Qingqing Wang,Limin Zhou
Two-dimensional (2D) nanosheets are promising nanomaterials that can be used as sensing elements in numerous applications such as wearable devices , machine tools, and aircraft; however, challenges remain in achieving high sensitivity, wide frequency sensing range, and reliability after long cyclic loading. Suitable ink formulations and preparation parameters for embedded sensors while retaining the structural integrity of the host structure should be determined. In this work, we demonstrated a synergistic combination of l -cysteine-reduced graphene oxide and MXene (LGM) inks in the absence of an additional polymer matrix to establish noninvasive conditions for embedding sensors in prepreg fiberglass/epoxy for smart composites with sensing capabilities. This sensor offers a high gauge factor of 47–1400 in different tensile strain ranges, with unnoticeable changes in the outstanding mechanical properties of the host glass fiber-reinforced polymer (GFRP) laminate. Long-term fatigue three-point bending tests were performed at different frequencies and bending angles, demonstrating excellent durability and stability. The corresponding sensors can also capture vibration signals in the low-high-frequency ranges. The nonintrusive embedment of sensors in GFRP laminates using the new coated non-additive polymer matrix LGM ink successfully preserves the mechanical properties of the host, including its structural integrity, with outstanding sensing performance for low-to-high-frequency signals.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2021
·
IF 5.316
Haiguang Gao,Rui Shi,Yuting Shao,Yana Liu,Yunfeng Zhu,Jiguang Zhang,Xiaohui Hu,Liquan Li,Zhixin Ba
Self-assembly of TiO 2 nanoparticles (M-TiO 2 , 15–20 nm in size) on few layer Ti 3 C 2 T x (FL-Ti 3 C 2 T x ) are conducted via simple one-step ultrasound method at room temperature, in which van der Waals interactions act as the driving force. After introduced into MgH 2 system, M-TiO 2 /FL-Ti 3 C 2 T x heterostructure with mass ratio of 60: 40 (6 M-TiO 2 /FL-Ti 3 C 2 T x ) shows the best catalytic activity. The one-step self-assembly preparation can alleviate the restacking of FL-Ti 3 C 2 T x and the agglomeration of M-TiO 2 nanoparticles to a certain extent, which can generate lots of interfaces between M-TiO 2 and FL-Ti 3 C 2 T x . The rich interfaces can not only act as hydrogen diffusion channels, but also the electron transfer on the interfaces can enhance the catalytic activity of the whole heterostructure. Besides, abundant electrons from multiple valence Ti (Ti 4+ , Ti 3+ , Ti 2+ , Ti 0 ) can effectively promote the reversible reaction between MgH 2 and Mg, H 2 . The facile preparation method facilitates the understanding of MXene heterostructure catalysts, without the influence of particle growth and impurities. These findings provide new insights to design heterostructure with high catalytic activity and guide the understanding of its catalytic mechanism.
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ELECTROCHIMICA ACTA
·
2026
·
IF 5.6
Yu-hang Ma,Yi-feng Ding,Liu-hong Yang,Jing Wen,Ke-fan Duan,Ge Dai,Feng-Feng Mo,Jia-feng Wang
The simultaneous monitoring of lactate and potassium ions (K⁺) in blood is critical for the management of critical conditions like crush syndrome, yet it remains a significant challenge. Herein, we present a novel integrated microfluidic electrochemical sensor for the dual-mode detection of these biomarkers. The sensor leverages a synergistic composite of Ti 3 C 2 T x MXene and electrodeposited gold nanoparticles (AuNPs) to create a highly sensitive sensing interface. The microfluidic chip, fabricated with polymethylmethacrylate (PMMA), incorporates two independent detection chambers functionalized with lactate oxidase (LOx) and a valinomycin-based ion-selective membrane, respectively. This design enables specific and parallel detection from a single sample. The fabricated sensor demonstrated excellent performance. In a KCl solution, the sensor exhibited a linear range of 1 μM to 10 mM and a low LOD of 1 μM. In the 1 × PBS configuration of lactate solution, the sensor showed a linear range of 10 μM to 16 mM and an LOD of 10 μM. When applied to the analysis of rat plasma samples, the sensor showed strong correlation with a commercial hematology analyzer, confirming its accuracy and practical utility. This work provides a promising platform for point-of-care testing, offering a fast, convenient, and reliable method for simultaneous biomarker monitoring.
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JOURNAL OF MEMBRANE SCIENCE
·
2026
·
IF 8.8
Dandan Zhao,Yuchun Ren,Chen Fu,Yiqing Liu,Dongmei Wang,Zhengjun Gong,How Yong Ng
The rapid expansion of the shale gas industry has led to the production of large volumes of wastewater containing valuable lithium resources. Although various lithium-ion sieve (LIS) materials have been developed for selective lithium recovery from shale gas wastewater (SGW), their adsorption capacity and selectivity are severely limited under natural near-neutral conditions. Here, a polydopamine (PDA)-modified Ni–H 2 TiO 3 (HTO)/MXene/polysulfone (PSF) composite membrane was developed for sustainable and selective lithium recovery from real SGW at its natural pH of 7.92. Surface polymerization of dopamine modulated the zeta potential of the membrane, effectively enhancing its Li + adsorption performance. The PDA/Ni-HTO/MXene/PSF membrane achieved a high adsorption capacity of 38.31 mg g −1 within 2 h, while maintaining excellent cycling stability and fouling resistance. Mechanistic analyses revealed that the synergistic effects between PDA and MXene enhanced the electronic capture ability of Ti–O and C–O coordination sites and activated interfacial π-electronic structures and charge redistribution, thereby promoting Li + adsorption and transport. The integrated membrane-based approach couples lithium recovery with wastewater treatment, offering a pathway for simultaneous resource recovery with reduced chemical input and secondary salinity loading.
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RSC Advances
·
2026
·Vol. 16
·期 16
·14159-14169
·
IF 6.1
Qiujiang Wei,Fuhuan Chu,Chunyan Tian,Hua Ke,Xiya Wang,Xiaomin Chen,Linhui Qiang,Shiqi Xu
Although flexible hydrogel sensors hold great promise in health monitoring, their reliability in long-term wearable scenarios is severely compromised by intrinsic hydrophilicity-induced uncontrollable swelling and signal drift. To address this critical bottleneck, we developed an MXene-poly(acrylic acid) (PAAc)-gelatin (MPG) composite hydrogel featuring superior anti-swelling properties. By incorporating Zr4+ coordination crosslinking, a robust “covalent-physical-coordination” triple network was constructed. This design not only endows the hydrogel with excellent mechanical toughness but also significantly restricts water uptake, achieving an ultralow 30-day cumulative swelling degree of 1.74%, thereby ensuring structural stability in humid environments. Based on this advanced material, a smart insole sensing system was fabricated. Benefiting from the high signal-to-noise-ratio and temporal stability of the MPG sensors, the proposed CNN-LSTM hybrid deep-learning model effectively extracts spatiotemporal features from complex gait signals. The system achieves a gait phase recognition accuracy of 88.0%, significantly outperforming conventional machine learning algorithms. This work demonstrates that the integration of high-performance anti-swelling materials with advanced deep learning algorithms represents an effective strategy for achieving next-generation precision wearable diagnostics.
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