MOLECULAR DIVERSITY
·
2024
·Vol. 28
·期 6
·3713-3737
·
IF 3.9
Zhang Minjie,Chen Guifen,Chen Yafang,Sui Yi,Zhang Yan,Yang Wude,Yu Xiang
In order to develop new natural product-based anticancer agents, a series of 1,3,4-oxadiazole analogues based on petiolide A were prepared and evaluated for their anticancer activities by MTT method. The structures of all analogues were characterized by various spectral analyses, and B9 was further confirmed by X-ray crystallography. Among all the synthesized compounds, B1 displayed the most promising growth inhibitory effect on colon cancer cells (HCT116) with the IC 50 value of 8.53 μM. Flow cytometric analysis exhibited that B1 arrested the cell cycle at G2 phase and induced apoptosis. Additionally, network pharmacology analysis calculated that B1 might target several key proteins, including AKT serine/threonine kinase 1 (AKT1), SRC proto-oncogene, non-receptor tyrosine kinase (SRC) and epidermal growth factor receptor (EGFR). Furthermore, molecular docking study indicated that B1 had potentially high binding affinity to these three target proteins. Given these results, analogue B1 could be deeply developed as potential anticancer agents.
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2023
·Vol. 34
·期 28
·1-15
·
IF 2.8
Wang Jia-Wei,Meng Tian-Li,Ma Ying-Xia,Lei Lei,Li Jing,Ran Fen
Metal–organic frameworks (MOFs) have low conductivity, which is not conducive to further application. To address the issue, in this work, using carboxylation multiwall carbon nanotubes (MWCNTs-COOH) as carbon materials, benzene-1,4-dicarboxylic acid (PTA) as organic ligands, nickel nitrate hexahydrate (Ni(NO 3 ) 2 ·6H 2 O) as transition metal ions precursors, MWCNTs decorated with nickel MOFs (Ni-MOFs/MWCNTs) nanohybrids were fabricated via in situ growth by a one-pot solvothermal method. The electrochemical properties of the Ni-MOFs/MWCNTs nanohybrids obtained by adjusting the dosage of MWCNTs-COOH and the experimental conditions as electrode materials for supercapacitors (SCs) were investigated. The results showed that the Ni-MOFs nanoflowers self-assembled by nanorods were in situ growth on the MWCNTs, which could avoid the agglomeration of Ni-MOFs and MWCNTs, enhance the specific surface area, and expose more active sites to improve the electrochemical properties. The specific capacity of the Ni-MOFs/MWCNTs nanohybrids as electrode materials obtained at the optimal experimental conditions was 749.6 C g −1 at 1.0 A g −1 .
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2024
·Vol. 35
·期 6
·1-13
·
IF 2.8
Li Zezhong,Xu Jing,Ma Yongqiang,Ma Yue,Liu Zhenlu
Photocatalytic hydrogen production is one of the effective ways of global energy conservation and emission reduction. Herein, we report the successful embedding of flower ball MoS 2 into Sm 2 WO 6 using the hydrothermal method, and p-n heterojunction is obtained successfully. Due to the narrow band gap of MoS 2 , the Sm 2 WO 6 / MoS 2 composite photocatalyst effectively improves the photogenerated carrier separation. The better redox capacity of Sm 2 WO 6 itself also promotes the reduction capacity of Sm 2 WO 6 /MoS 2 . The petals on MoS 2 are closely bound to Sm 2 WO 6 , which enhances the electron transport efficiency and is one of the main factors for improving photocatalytic hydrogen evolution (HER). To explore the performance of Sm 2 WO 6 / MoS 2 by various means of representation. And the HER performance of Sm 2 WO 6 / MoS 2 is evaluated using eosin Y (EY) as sensitizer and TEOA as sacrifice agent. Compared with pure Sm 2 WO 6 , Sm 2 WO 6 / MoS 2 has improved HER performance, and its optimal activity is 142.7 µmol, which is nearly 140 times that of pure Sm 2 WO 6 . This study demonstrates a novel morphology design strategy for composite photocatalysts to promote efficient photocatalytic hydrogen production.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2022
·Vol. 29
·期 57
·86651-86664
·
IF 5.19
Li Caidan,Wang Jing,Jiang Yue,Bai Yilin,Cheng Liu
Pollution of municipal sewage sludge with heavy metals (HMs) inevitably causes secondary contamination, threatening ecosystems and human health. Dissolved organic matters (DOM) would serve as HMs carriers or ligands, directly influencing the transport and distribution. So it is of essential importance to simultaneously evaluate the release characteristics of HMs and DOM from MSS. In this paper, we investigated leaching characteristics of HMs (Cd, Cr, Cu, Zn, Ni, and Mn) and DOM from raw sewage sludge (RSS) and lime-conditioned sewage sludge (LCSS) under simulated rain with different acidities (pH 6.5 and 2.9) via column leaching experiments. The results showed the release of HMs could be divided into two distinct stages, a rapid decreasing changes in the early stage and a slow and steady change in the later stages with a slight increase in the middle of time. At the early stage, DOM was dominated by protein-like components (tryptophan-like, tyrosine-like). As time passed, protein-like components decreased while humic-like components (fulvic acid and humic acid) increased gradually. Protein-like components showed significant positive correlations with HMs, while humic acid-like components showed strong negative correlations with them. Moreover, the leaching efficiencies of Cd, Zn and Mn at pH 2.9 was about 1.5 times higher than that at 6.5, and the fluorescence intensity of humic-like components at pH 2.9 was higher than that at pH 6.5, suggesting that acid rain accelerated the release of HMs and the humification of DOM. Compared with the RSS, the DOM of LCSS showed noticeable differences, especially an obvious increase of the fulvic acid component. And the leaching efficiencies of Cd, Cr, Cu, Ni, and Mn in LCSS were much lower than that in RSS, indicating lime treatment retarded the release of HMs. Thus, our findings will be a guide to the treatment of HMs contaminants in MSS.
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IONICS
·
2024
·Vol. 30
·期 8
·4479-4486
·
IF 2.4
Tang Anping,Chen Juedong,Xu Guorong,Song Haishen,Wang Jinglun,Chen Hezhang
Non-intercalation cathode materials based on nanocomposites of lithium fluoride and Li-free transition metal compounds have drawn attention as materials for fabricating the cathode of lithium ion batteries owing to their high theoretical specific capacities and high redox voltages. In the present study, a nanocomposite of MnO-LiF was in situ synthesized by a quick annealing at 500 °C for just 5 min using a mixture of ammonium fluoride, manganese acetate, and lithium acetate as precursor. The synthesized composite is investigated by X-ray diffraction, scanning electron microscopy, nitrogen sorption, and charge-discharge measurements. As a lithium-ion battery cathode, it delivers respectively an initial discharge-specific capacity of 170 mAh g −1 and a discharge-specific capacity of 137 mAh g −1 in the 50th cycle at a current rate of C/20, which is equivalent to a moderate capacity retention rate of 80.6%. The novel synthesis approach proposed offers access to electrochemically active composites of lithium fluoride and Li-free transition metal oxides.
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Carbon Letters
·
2020
·Vol. 30
·期 6
·657-665
·
IF 1.992
Li Jiajia,Hu Jiajun,Wang Kai,Xia Hongyan
Effective processing and use of coal slime is of great significance to protect the environment and save resources. Different coal slimes (untreated with 43 wt% ash content, crushed and flotation treated with 10 wt% ash content, and pre-carbonized) were activated with KOH to prepare porous activated carbon. The results show the activated carbon prepared from coal slime with 10 wt% ash had high specific surface area (3037 m 2 /g) and pore volume (1.66 cm 3 /g), which was ascribed to the suitable contents of minerals as template and oxygen-containing functional groups. Electrochemical measurements exhibited the best specific capacitance of 220 F/g at 0.1 A/g and the cycle stability of over 100% capacitance retention after 1000 cycles at 5 A/g in 6 M KOH solution. Due to the high specific surface area, superior electrochemical performance, and facile and low cost, developing highly porous activated carbon for supercapacitors is one alternative way for effective use of coal slime waste.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2024
·Vol. 35
·期 1
·1-12
·
IF 2.8
Lu Xi,Meng Yanshuang,Wang Xin,Xiao Mingjun,Xu Yishan,Zhu Fuliang
Uniformly distributed NiCo 2 S 4 nanoparticles on hollow carbon spheres were prepared by carbonisation and in-situ vulcanisation methods as a positive electrode host for lithium–sulphur batteries. Among them, carbon hollow spheres can provide a huge internal cavity, which prevents volume expansion during the charge and discharge process. At the same time, the physically limit the dissolution of polysulfides in the electrolyte and can also provide high conductivity. The NiCo 2 S 4 nanoparticles on the surface can establish a specific polar environment for charge and discharge and can interact with polysulfides to mitigate the loss of active materials through chemical adsorption. Under the synergistic effect of NiCo 2 S 4 and carbon hollow spheres, the electrode with a special structure of NiCo 2 S 4 /carbon hollow spheres as sulfur host exhibits excellent long cycle performance. At a current density of 335 mA g −1 , it still has a high discharge specific capacity of 526 mAh g −1 after 500 cycles.
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Biomass Conversion and Biorefinery
·
2023
·Vol. 15
·期 2
·2603-2617
·
IF 4
Yang Xiaojian,An Mengmeng,Han Nannan,Zhang Shu,Rong Qianqian,Lu Hui
The adsorption and removal of chlortetracycline (CTC) from water on peanut shells decorated with magnetic particles under ultrasonic were studied. The morphology, components, functional groups, magnetic properties and BET surface area of peanut shells before and after decorated with magnetic particles were characterized. Further, the effects of contact time, temperature and initial pH value on adsorption were investigated. Meanwhile, the adsorption kinetics and regeneration performance were studied. The CTC adsorption of magnetic peanut shells can reach 82.96%, and the adsorption behavior of CTC by magnetic peanut shells can be described using pseudo-second-order kinetics model. Finally, the adsorption capacity of CTC merely decreases by 9.52% after recycling five times, and solid-liquid separation can be easily achieved under magnetic field applied. Graphical
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WATER AIR AND SOIL POLLUTION
·
2024
·Vol. 235
·期 1
·1-15
·
IF 3.8
Wang Tingting,Zhang Lucheng,Zhang Mingqing,Yang Fang,Wu Shilong
The widespread use of cyanidation in gold beneficiation leads to a large amount of SCN − in the gold extract tail solution, which poses a threat to the environment and human health. The present study successfully synthesized octadecyltrimethylammonium bromide/bentonite/titanium dioxide (OTAB/Bt/TiO 2 ) photocatalysts through a sol–gel hydrothermal approach. Evaluation of the BET specific surface area, X-ray diffraction (XRD) analysis, UV–vis diffuse reflectance spectroscopy, and zeta potential experiments unveiled the beneficial impact of incorporating OTAB. This inclusion led to an enlargement of the pore size and layer spacing of Bt, broadening the range of photoresponses. Additionally, it effectively neutralized the negative charge residing on the surface of Bt. Consequently, these enhancements contributed to the improved performance of the photocatalytic material in terms of adsorption and catalytic degradation of SCN − . The degradation rate of SCN − reached 98.78% under the reaction conditions of initial SCN − concentration of 50 mg/L, OTAB/Bt/TiO 2 dosage of 0.8 g/L, pH = 8, and reaction time of 300 min. The degradation of the SCN − composite through the OTAB/Bt/TiO 2 photocatalytic process followed a zero-order kinetic model with a calculated rate constant ( k value) of 0.1148 min −1 . Notably, this rate constant was 1.9 times greater than the degradation rate observed in the pure TiO 2 system. The free radical quenching test showed that h + , ∙OH and ∙O 2− were the main oxidizing substances for photocatalytic degradation. The identification of intermediates proved that the complete mineralization of SCN − could be achieved by OTAB/Bt/TiO 2 adsorption and photocatalytic degradation without generating the highly toxic intermediate CN − . Overall, this study provides guidance for the development of more photocatalysts with strong adsorption properties and more effective removal of SCN − from gold extraction tailings.
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RARE METALS
·
2024
·Vol. 43
·期 4
·1747-1757
·
IF 9.6
Jiang Ming-Ji,Zhang Ya-Na,Meng Ling-Shen,Kang Jing,Li Yong-Jun,Dong Alideertu
Based on the in-situ self-reduction and chemical stability, graphdiyne (GDY) and graphdiyne oxide (GDYO) are used as trapping agents to investigate the ability for recovering Au 3+ , Ag + , and Pd 2+ under different pH values and interfering ions. Under strong acidity at pH = 1, these two agents demonstrate high select recovery towards the three precious metal ions, which could be in-situ reduced to nanoparticles (NPs). In addition, superparamagnetic Fe 3 O 4 NPs are deposited on the surfaces of GDY and GDYO. The magnetic responses enable GDY-Fe 3 O 4 to recover precious metals conveniently and efficiently by the aid of an external magnetic field. This study also confirms the antibacterial activity of the as-recovered NPs deposited on GDY and GDYO against Escherichia coli and Staphylococcus aureus (1 × 10 5 colony-forming unit (CFU)·ml −1 ) , and the antibacterial rates are 100%. This strategy of recovering precious metals and subsequently reusing to combat pathogens will be of great significance for environmental remediation and biomedical applications. Graphical abstract
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高影响因子
INTERNATIONAL OPHTHALMOLOGY
·
2024
·Vol. 44
·期 1
·1-10
·
IF 1.4
Fu Miao,Chen Yuanyuan,Yang Anhuai
Purpose Ochratoxin A (OTA) contamination of food and feed is a serious problem worldwide. OTA is considered a carcinogen and immunotoxic, nephrotoxic, and neurotoxic mycotoxin. The present study aims to determine the toxic effects of OTA on retinal ganglion cells (RGCs) and assess the resulting impairment of retinal function in mice. Methods RGC-5 cells were exposed to OTA (100 and 200 μg/L) for 3 days, and the mice were fed OTA-contain (100 and 200 μg/kg) diets for 4 weeks. Antioxidant indices were detected by spectrophotometer. The apoptosis of RGC-5 cells was determined by flow cytometry. Mitochondrial morphology and mitochondrial membrane potential were detected by immunofluorescence. RGC survival was determined by immunofluorescence staining with Brn3a. Flash electroretinography (ERG) was conducted to assess visual function. Results The oxidative-antioxidant balance suggested that OTA-induced severe oxidative stress, including increased reactive oxygen species (ROS) and malondialdehyde (MDA) levels in the OTA-exposed RGC-5 cells, and the reduced activity of superoxide dismutase (SOD) and glutathione-S-transferase (GST) in the OTA exposed group. Furthermore, OTA exposure led to remarkable apoptosis in RGC-5 cells. The mitochondrial detection showed that OTA caused significant mitochondrial membrane potential reduction and mitochondrial fragmentation, which may be the cause of apoptosis of RGC-5 cells. Additionally, in vivo experiments demonstrated that OTA resulted in significant death of RGCs and subsequent retinal dysfunction in mice. Conclusion Ochratoxin A induces mitochondrial dysfunction, oxidative stress, and RGCs death in mice.
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MICROCHIMICA ACTA
·
2023
·Vol. 190
·期 8
·1-11
·
IF 5.7
Zhang Ziyi,Liu Dan,Zhang Xiaoshuo,Luo Xueli,Lin Wanmei,Li Zhonghong,Huang Jihong
Novel methods for high-performance detection of Hg 2+ in seafood are critical for ensuring food safety and human health. Herein, Ag nanoparticles (Ag NPs) were successfully deposited on carbon microspheres (CMs) to form Ag NPs-CMs nanocomplex. The proposed Ag NPs-CMs could oxidize colorless 3,3′,5,5′-tetramethylbenzidine (TMB) to blue oxidation state TMB (oxTMB) in the presence of hydrogen peroxide (H 2 O 2 ) and had a significant UV–vis absorption peak at 652 nm. The excellent peroxidase-like activity was attributed to the increased electrostatic attraction of CMs and the catalytic synergistic effect. After adding Hg 2+ , the catalytic activity of Ag NPs-CMs was specifically enhanced and the Michaelis–Menten constant ( K m ) decreased from 0.067 to 0.052 mmol/L due to the formation of Ag-Hg amalgam which produced more superoxide anions (O 2 •− ) and hydroxyl radicals (•OH). The linear response ranges for Hg 2+ were 2~833 nmol/L and 2.5~40 μmol/L, with the low detection limit of 1.10 nmol/L. This method was applied to detect Hg 2+ in seafood with satisfactory recoveries of 95.65~106.56%. A hydrogel kit was designed for portable detection of Hg 2+ , and the response range was 0.5~5 μmol/L. This work provides a reliable method for visual Hg 2+ detection in seafood as well as a feasible strategy for the design of high-performance nanozymes. Graphical
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