JOURNAL OF BIOMATERIALS APPLICATIONS
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2024
·
IF 2.3
Dandan Niu,Danyang Zhou,Mengke Zhan,Lijing Lei,Jinhua Zhu,Xiuhua Liu
γ-Cyclodextrin-based metal-organic frameworks (γ-CD-MOF) were successfully synthesized using the solvent diffusion method and applied as carriers for trans-N-p-coumaroyltyramine (N-p-t-CT, NCT) to study the solubability, stability, sustained release and inhibitory activity against α-glucosidase. The solubilization effect of γ-CD-MOF on N-p-t-CT was performed using impregnation (NCT@CD-MOF-1) and co-crystallization (NCT@CD-MOF-2) methods. X-ray diffraction, scanning electron microscope (SEM), fourier transform infrared spectrometer (FTIR), and N2 adsorption/desorption were used to characterize the MOFs before and after loading NCT. The results showed that NCT@CD-MOF-2 had a better solubability for N-p-t-CT, 145.03 μg/mg of drug loading capacity could be achieved, and the solubility of NCT@CD-MOF-2 in water was 366 times higher than free N-p-t-CT. In addition, the stabilities of N-p-t-CT under temperature, UV light and pH conditions were greatly improved after encapsulation in γ-CD-MOF. Furthermore, NCT@CD-MOFs had a sustained release of N-p-t-CT over an extended period in vitro due to the primary encapsulation in pore structures. Notably, γ-CD-MOF loaded with N-p-t-CT showed superior inhibitory activity against α-glucosidase compared to free N-p-t-CT. Cytotoxicity studies demonstrated that NCT@CD-MOF-2 had low toxicity in vitro and perfect biocompatibility with HL-7702 cells, and γ-CD-MOF could reduce the toxicity of free N-p-t-CT at higher concentrations.
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高影响因子
Chinese Physics C
·
2023
·Vol. 47
·期 3
·034001
·
IF 3.6
Long He,Junhua Luo,Li Jiang
Measurement of the cross-sections of the 79Br(n, 2n)78Br, 81Br(n, p)81mSe, 81Br(n, α)78As, and 79Br(n, α)76As reactions was performed at specific neutron energies, precisely, 13.5±0.2, 14.1±0.2, 14.4±0.2, and 14.8±0.2 MeV, relative to the standard 93Nb(n, 2n)92mNb and 27Al(n, α)24Na reference reactions using offline γ-ray spectrometry and neutron activation. Monoenergetic neutrons were generated at the China Academy of Engineering Physics via a 3H(d, n)4He reaction using the K-400 Neutron Generator equipped with a solid 3H-Ti based target. The activity of the reaction produce was obtained using a high-purity germanium detector. The cross-sections of the (n, 2n), (n, p), and (n, α) reactions on the bromine isotopes were measured in the 13–15 MeV neutron energy range. The covariance analysis approach was employed for a thorough inspection of any uncertainties within the measured cross-section data. A discussion and comparison of the observed outcome were carried out with previously published data, especially with the results of the JENDL-4.0, JEFF-3.3, TENDL-2019, and ENDF/B-VIII.0 data libraries, along with the theoretical excitation function curve derived by employing the TALYS-1.95 program. Improved cross-section restrictions for the investigated processes in the 13–15 MeV neutron energy range will be obtained using the current findings, which will help to raise the caliber of associated databases. Furthermore, the parameters of relevant nuclear reaction models can be verified using this data.
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JOURNAL OF CATALYSIS
·
2021
·
IF 7.92
Ye Yuan,Jia Hu,Yu Wang,Leilei Huang,Jiayun Zheng,Yufeng Zhao,Yiyun Chen,Cheng Chen,Francis Verpoort
α-Hydroxy ketones are important building blocks in biological, pharmaceutical and synthetic chemistry. In this work, diverse α-hydroxy ketones were efficiently constructed through the CO 2 -promoted hydration process of propargyl alcohols, which was catalyzed by a system consisted of economical CuSO 4 ·5H 2 O and a green 1-butyl-3-methylimidazolium acetate ionic liquid. Particularly, this catalytic system exhibited excellent activity under atmospheric CO 2 or even mimetic flue gas (20 vol% of CO 2 ). Moreover, this system employed the lowest metal loading ever reported (0.004–0.25 mol%) meanwhile reached the highest turnover number (11700) for the target hydration reaction. Additionally, this is the first reported Cu catalytic system with reliable recyclability, which could be easily reused at least 6 times with yields higher than 85%.
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PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
·
2016
·Vol. 15
·期 8
·1046-1053
·
IF 2.235
Zhang Guangshan,Wang Qiao,Zhang Wen,Li Tian,Yuan Yixing,Wang Peng
This work investigated the effects of organic acids and initial solution pH on the photodegradation of BPA in a photo-Fenton-like process using α-FeOOH as a catalyst. The results showed that the addition of different organic acids affected the formation of the ferric-carboxylate complexes and free radicals, which in turn varied the photodegradation efficacy. Compared with the other acids, oxalic acid (OA) was found to be the most effective in enhancing the photodegradation of BPA, which strongly depends on the OA concentration. Particularly, the addition of OA could significantly extend the working pH from an acidic to a neutral range for the photocatalytic process and thus the acidification pretreatment may not be needed. A high photocatalytic degradation of BPA occurred at pH 6.0, due to the formation of ferric-oxalate complexes and ˙OH radicals in the synergistic interactions of OA and α-FeOOH. This finding highlights that the oxalate-promoted photo-Fenton-like process using the α-FeOOH catalyst may be used for wastewater treatment without pH adjustment.
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高影响因子
Nanoscale
·
2015
·Vol. 8
·期 5
·3100-3118
·
IF 7.394
Di Jiang,Xiaoling Gao,Ting Kang,Xingye Feng,Jianhui Yao,Mengshi Yang,Yixian Jing,Qianqian Zhu,Jingxian Feng,Jun Chen
Drug resistance is the major reason for therapeutic failure during cancer treatment. Chemo-photodynamic combination therapy has potential to improve the treatment efficiency in drug-resistant cancers, but is limited by the incompatible physical properties of the photosensitizer with a chemo-drug and poor accumulation of both drugs into the inner areas of the tumor. Herein, a novel drug delivery system was designed by incorporating the photosensitizer, chlorine 6, chemically in the shell and the chemo-drug, doxorubicin, physically in the core of D-α-tocopheryl polyethylene glycol 1000 succinate-poly(lactic acid) (TPGS-PLA) nanoparticles with a targeting ligand, tLyp-1 peptide, decorated over the surface (tLyp-1-NP). This nanoparticle with a high drug loading capacity of both the photosensitizer and chemo-drug is expected to realize chemo-photodynamic combination therapy of drug-resistant cancer and simultaneously achieve the specific deep penetration and accumulation of drugs into the inner areas of tumor. tLyp-1-NP was prepared via a nanoprecipitation method and it exhibited a uniformly spherical morphology with a size of approximately 130 nm. After appropriate irradiation, tLyp-1-NP showed high cellular uptake and strong cytotoxicity in both human umbilical vein endothelial cells (HUVEC cells) and doxorubicin-resistant human breast adenocarcinoma cells (MCF-7/ADR cells) in vitro. After intravenous administration, compared with the unmodified NPs, tLyp-1-NP was found to have superior tumor targeting ability and more potent reversion of doxorubicin-resistant cancer. The terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling and the hematoxylin and eosin staining of the treated tumors further demonstrated the anti-tumor efficacy of tLyp-1-NP in the presence of a laser. These observations collectively suggest the potential of tLyp-1-NP for the actively targeting chemo-photodynamic combination therapy of drug-resistant cancer.
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高影响因子
RSC Advances
·
2019
·Vol. 9
·期 11
·5978-5986
·
IF 3.049
Shunyou Hu,Linlin Wang,Xiaopeng Chen,Xiaojie Wei,Zhangfa Tong,Lijiang Yin
The concept of a solid catalyst coated with a thin ionic liquid layer (SCILL) was applied to the stereoselective hydrogenation of α-pinene. Nickel, a non-noble metal, was supported on a discarded fluid catalytic cracking catalyst (DF3C) and then modified with different loadings of the ionic liquid 1-ethanol-3-methylimidazolium tetrafluoroborate ([C2OHmim][BF4]). The resulting catalysts showed a range of conversions and selectivities for the hydrogenation of α-pinene. The SCILL catalysts afforded cis-pinane with high selectivity and their activity depended on the ionic liquid loading. For an ionic liquid loading of 10 wt%, although the catalytic activity was suppressed, the selectivity and conversion could reach above 98% and 99%, respectively. In addition, the catalyst remained stable after 13 runs and the activity was almost unchanged with the conversion maintained at approximately 99%. Thus, the ionic liquid layer not only improved the selectivity for cis-pinane but also protected the active site of the catalyst and prolonged the service lifetime of the catalyst. The SCILL catalytic system provides an example of an ionic liquid catalytic system which eliminates organic solvents from the catalytic process.
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Phytochemistry Letters
·
2024
·
IF 1.3
Yu-Fei Hou,Lu Bai,Shao-Jing Liu,Sen Guo,Ya-Long Wang,Chi-Tang Ho,Nai-Sheng Bai
A. arguta leaves, as an important by-product during the ripening of A. arguta fruits, are usually discarded. It contains numerous flavonoid components. In the present research, a simple and reproducible HPLC-DAD method was established and verified for simultaneous identification and quantification analysis of 25 flavonoid components in A. arguta leaves. The findings indicated that the highest concentration of flavonoid compounds in A. arguta leaves was quercetin ( 2 ), with a content of 8.97 ± 0.09 mg/g. The content of flavonoids in samples from different cultivation bases was different, indicating that the varied flavonoid contents are possibly determined by geographical variance. This method can be used for the quality control of Actinidia arguta . The 25 flavonoids showed good α-glucosidase inhibitory activity with IC 50 values ranging from 0.35 to 4.15 mM, and the activity difference varied with the different structures. 2"- O -galloylhyperin ( 18 ) showed the best antihyperglycemic action (IC 50 = 0.35 ± 0.01 mM), followed by quercetin ( 2 , IC 50 = 0.38 ± 0.01 mM), quercetin 4′- O -galactoside ( 19 , IC 50 = 0.41 ± 0.01 mM), kaempferol ( 3 , IC 50 = 0.42 ± 0.01 mM), and kaempferol-3-rutinoside ( 6 , IC 50 = 0.53 ± 0.01 mM). Molecular docking analysis demonstrated that the interaction modes of these five stronger inhibitors with α-glucosidase were mainly hydrogen bonding and hydrophobic interaction. The results showed that compounds with different structural skeletons interacted with different amino acid residues and exerted different degrees of α-glucosidase inhibition. Therefore, A. arguta leaves and their flavonoids may be beneficial against diabetes, and higher levels of flavonoids are considered to have greater potential for medicinal use.
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高影响因子
ADVANCED POWDER TECHNOLOGY
·
2012
·
IF 1.612
Hongtao Cui,Yan Liu,Wanzhong Ren
With same procedure and same starting materials, nearly monodispersed α-Fe 2 O 3 , γ-Fe 2 O 3 and Fe 3 O 4 nanoparticles were synthesized on an large scale of about 60 g in a single reaction through a low temperature sol–gel route. The simple preparation process includes the reactions between FeCl 2 and propylene oxide in ethanol solution at boiling point to form a sol and the following drying of the sol. The different iron oxide phases can be obtained just by changing of the drying conditions for the sol solution. The strategy developed in this study offers important advantages over the conventional routes for the synthesis of α-Fe 2 O 3 , γ-Fe 2 O 3 and Fe 3 O 4 nanoparticles , showing potential for its application in industrial production of iron oxides.
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CARBOHYDRATE POLYMERS
·
2026
·
IF 13.2
Yiping Chen,Keqian Xu,Xin Guo,Wen Xu,Qian Cao,Dong Xu,Aiqing Yu,Zhenbo Cheng,Jiawei Liang,Feiyang Jiang
Polysaccharide hydrogels are promising for coupled Cr(VI) adsorption and photocatalytic reduction, but conventional co-loaded designs provide limited control over functional-domain organization and catalyst–carrier contact. Here, we constructed a dual-carrier polysaccharide hydrogel (SH-3) in which two TEMPO-oxidized cellulose nanofibril (TOCNF) populations independently host the photocatalyst and electron-mediator domains. α-FeOOH was grown in situ on one TOCNF population through Fe 3+ /carboxylate-guided hydrothermal nucleation, while chitosan-derived carbon dots (CS-CDs) were covalently grafted onto a second population by amide coupling. The two functionalized carriers were co-incorporated into a three-dimensional porous network, placing the two functional domains on distinct TOCNF populations while enabling their functional coupling. SH-3 achieved a Langmuir Q max of 176.1 mg g −1 for total-Cr uptake from Cr(VI)-containing solution and an apparent Cr(VI) depletion rate constant of 0.1341 min −1 , outperforming the physically co-mixed control and literature-derived benchmark. Spectroscopic and electrochemical analyses indicated improved charge separation, electron/•O 2 − -mediated Cr(VI) reduction, and partial solid-phase retention of generated Cr(III). These results identify carrier-level organization of functionalized TOCNF populations as a design variable for coupling adsorption and photocatalysis within a polysaccharide hydrogel. Download: Download high-res image (492KB) Download: Download full-size image
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高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Zeyi Cheng,Jingling Lu,Wang Ran,Shaopeng Rong
Formaldehyde (HCHO), a ubiquitous gaseous pollutant in indoor environments, threatens human health under long-term exposure, necessitating its effective elimination. Due to its advantages in enhancing mass transfer and effectively exposing active sites, aerogels with a three-dimensional (3D) interconnected network structure are expected to achieve efficient and stable decomposition of HCHO at ambient temperature. However, how to realize the self-assembly of transition metal oxides to construct high-purity 3D network aerogels is still a huge challenge. Herein, the cation-induced self-assembly strategy was developed to construct high-purity self-standing 3D network manganese dioxide aerogels. The interaction between cations and the surface groups of nanowires is crucial for successful self-assembly, which leads to the cross-winding of nanowires with each other, forming a 3D-structured network. The K+-induced 3D-MnO2 exhibited excellent catalytic performance for HCHO, which could continuously and steadily decompose HCHO into CO2 and H2O at ambient temperature. Thanks to the 3D interconnected network structure, on the one hand, it provides a large specific surface area and porosity, reducing mass transfer resistance and promoting the adsorption of HCHO and O2 molecules. On the other hand, it is more important to fully expose the active sites, which can generate more surface active oxygen species and achieve effective recycling and regeneration. Importantly, 3D-MnO2 has a strong ability to capture and activate water molecules in the atmosphere, which could be further involved in the replenishment of the consumed hydroxyl groups. This study proposes a strategy for self-assembly of transition metal oxides through cation-induction, which provides a new catalyst design approach for the room temperature decomposition of VOCs.
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高影响因子
Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 5
·123628
·
IF 7.5
Yan Wang,Jiang Meng,Siyao Wang,Yuzi Yin,Tianyi Huang,Yue Wang,Jianyu Han
The development of efficient photocatalysts for antibiotic removal remains constrained by the lack of well-defined active sites and severe charge recombination. Herein, a nitrogen-vacancy-rich carbon nitride coupled with mixed-phase bismuth oxide (α-Bi 2 O 3 /β-Bi 2 O 3 /g-C 3 N 4 -nitrogen vacancies, denoted as N V -αβBO) was rationally constructed via NaBH 4 -assisted defect engineering and in-situ phase transformation. The optimized N V -αβBO-4 shows significantly enhanced photocatalytic performance under visible light and rapidly removes tetracycline hydrochloride (TCH). Systematic characterizations show that nitrogen vacancies facilitate O 2 adsorption and activation. Meanwhile, the interfacial coupling among α-Bi 2 O 3 , β-Bi 2 O 3 and defective g-C 3 N 4 (N V -CN-10) promotes directional charge transfer and suppresses carrier recombination. More importantly, a dual S-scheme charge-transfer pathway is established. This pathway preserves photogenerated electrons and holes with strong redox capability, thereby promoting reactive oxygen species (ROS) generation. This work demonstrates a synergistic strategy by integrating defect engineering with phase-junction construction, providing new insights into the design of high-performance photocatalysts for antibiotic wastewater treatment.
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高影响因子
PHYTOMEDICINE
·
2026
·
IF 11.3
Yuting Yi,Dongdong Li,Yuan Li,Haotong Wang,Daxin Yang,Simin Yang,Shangping Xing,Shanshan Wei,Jie Yang,Hongwei Guo,Zhuo Luo
ACP-A1, a novel an α-glucan-like Polysaccharide from Abrus cantoniensis , is structurally resolved for the first time. • ACP-A1 reshapes gut microbiota and triggers the FFAR2/MAVS/IFN-β antiviral circuit. • Microbiota-driven IFN-β signaling underpins ACP-A1 protection against H1N1 influenza. Background The gut microbiota is critical for host defense against influenza. Polysaccharides are known for their microbiota-modulating and immunomodulatory activities; however, the anti-influenza efficacy of homogeneous Abrus cantoniensis polysaccharides (ACP) remains unexplored. Purpose The present study seeks to clarify the protective role of ACP in influenza and explore its underlying molecular mechanisms. Methods Initially, crude polysaccharides were extracted via ethanol precipitation and subsequently purified by gel chromatography. Systematic structural characterization of ACP was then performed using carbohydrate chemistry techniques, including scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), ultraviolet (UV) spectroscopy, and nuclear magnetic resonance (NMR). The therapeutic efficacy of ACP was assessed by monitoring various indicators such as body weight, survival rate, viral load, and pulmonary pathological changes in mouse models. Furthermore, to elucidate the biological mechanism underlying ACP’s anti-influenza activity via regulation of pulmonary interferon-beta (IFN-β) immune networks by intestinal acetate-producing microbiota, multi-omics analyses integrating metagenomics, metabolomics, gene knockout, immunofluorescence, and Western blot were conducted. Finally, the potential anti-influenza effects of ACP via the gut-lung axis were evaluated based on in vivo and in vitro detection of protein expression of IFN-β, free fatty acid receptor 2 (FFAR2), and mitochondrial antiviral signaling protein (MAVS), as well as antiviral interferon-stimulated genes (ISGs). Results In this study, we purified a novel polysaccharide, ACP-A1, with a backbone of→4)-α-D-Glc p -(1→,→4)-β-D-Gal p -(1→, and →4,6)-α-D-Glc p -(1→ linkages and α-D-Glc p -(1→ branches at O-6. In H1N1-infected mice, oral ACP-A1 alleviated weight loss, increased survival, and reduced lung inflammation and viral load. Metagenomic and targeted metabolomic analyses showed that ACP-A1 enriched Limosilactobacillus reuteri and elevated acetate levels. Fecal microbiota transplantation, FFAR2 inhibition, and MAVS knockout experiments demonstrated that ACP-A1 enhances the FFAR2/MAVS/IFN-β antiviral pathway via microbial-derived acetate. Conclusion Collectively, our findings elucidate that ACP mitigates influenza virus-induced lung dysfunction by promoting the proliferation of acetate-producing gut microbiota, particularly Limosilactobacillus reuteri , and activating the FFAR2/MAVS/IFN-β antiviral axis in pulmonary immune cells. These findings establish ACP-A1 as a natural polysaccharide regulating IFN-β homeostasis, highlighting its potential for influenza prevention. Download: Download high-res image (323KB) Download: Download full-size image
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