MOLECULAR CARCINOGENESIS
·
2024
·
IF 3
Junyi Jin,Yihui Wang,Yaoyuan Hu
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. STAM binding protein-like 1 (STAMBPL1), a key member of the COP9 signalosome subunit 5/serine protease 27/proteasome 26S subunit non-ATPase 7 (JAMM) family, is closely associated with tumor development. In this work, data from GSE101728 and GSE84402 chips were analyzed, and STAMBPL1 was selected as the target factor. This study aimed to reveal the potential function of STAMBPL1 in HCC. Clinical results showed that STAMBPL1 was significantly increased in tumor tissues of HCC patients, and its expression was strongly associated with tumor size and TNM stage. Furthermore, STAMBPL1-overexpressed Hep3B2.1-7 cell line or STAMBPL1-silenced SNU-182 cell line were established using lentivirus carrying cDNA encoding STAMBPL1 mRNA or shRNA targeting STAMBPL1, respectively. STAMBPL1-overexpressed cells exhibited a pronounced enhancement of proliferation in vitro and in vivo. Exogenous expression of STAMBPL1 increased the percentage of cells in the S phase and upregulated the expressions of CyclinD1 and Survivin. As expected, STAMBPL1 knockdown exhibited completely opposite effects, resulting in impaired tumorigenicity in vitro and in vivo. Mechanistically, STAMBPL1 activated Wnt/β-catenin pathway and increased the expression of downstream cancer-promoting genes. Interestingly, we found that STAMBPL1 was transcriptionally regulated by sterol regulatory element-binding protein 1 (SREBP1), a modulator of lipid metabolism, as evidenced by luciferase reporter and chromatin-immunoprecipitation (Ch-IP) assays. Notably, STAMBPL1 overexpression increased lipid accumulation in HCC cells and xenograft tumors. Totally our findings suggest that STAMBPL1 plays a vital role in the tumorigenicity of HCC cells. Modulation of Wnt/β-catenin and lipid metabolism may contribute to its pro-cancer effects. STAMBPL1 may serve as a therapeutic target of HCC.
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DOI
PubMed
高影响因子
iScience
·
2023
·
IF 5.8
Luxian Guo,Yangming Ding,Hua Wang,Yuxuan Liu,Qian Qiang,Qi Luo,Fei Song,Changzhi Li
The catalytic conversion of lignin into N-containing chemicals is of great significance for the realization of value-added biorefinery concept. In this article, a one-pot strategy was designed for the transformation of lignin β-O-4 model compounds to imidazo[1,2-a]pyridines in yields up to 95% using 2-aminopyridine as a nitrogen source. This transformation involves highly coupled cleavage of C-O bonds, sp 3 C-H bond oxidative activation, and intramolecular dehydrative coupling reaction to construction of N-heterobicyclic ring. With this protocol, a wide range of functionalized imidazo[1,2-a]pyridines sharing the same structure skeleton as those commercial drug molecules, such as Zolimidine, Alpidem, Saripidem, etc., were synthesized from different lignin β-O-4 model compounds and one β-O-4 polymer, emphasizing the application feasibility of lignin derivatives in N-heterobicyclic pharmaceutical synthesis.
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DOI
高影响因子
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
·
2021
·Vol. 25
·期 2
·131-137
·
IF 2.016
Jing Cheng,Chaoyang Ren,Renli Cheng,Yunning Li,Ping Liu,Wei Wang,Li Liu
Aging is the process spontaneously occurred in living organisms. Cardiac fibrosis is a pathophysiological process of cardiac aging. Mangiferin is a well-known C-glucoside xanthone in mango leaves with lots of beneficial properties. In this study, rat model of cardiac fibrosis was induced by injected with 150 mg/kg/d D-galactose for 8 weeks. The age-related cardiac decline was estimated by detecting the relative weight of heart, the serum levels of cardiac injury indicators and the expression of hypertrophic biomakers. Cardiac oxidative stress and local inflammation were measured by detecting the levels of malondialdehyde, enzymatic antioxidant status and proinflammatory cytokines. Cardiac fibrosis was evaluated by observing collagen deposition via masson and sirius red staining, as well as by examining the expression of extracellular matrix proteins via Western blot analysis. The cardiac activity of profibrotic TGF-β1/p38/MK2 signaling pathway was assessed by measuring the expression of TGF-β1 and the phosphorylation levels of p38 and MK2. It was observed that mangiferin ameliorated D-galactose-induced cardiac aging, attenuated cardiac oxidative stress, inflammation and fibrosis, as well as inhibited the activation of TGF-β1/p38/MK2 signaling pathway. These results showed that mangiferin could ameliorate cardiac fibrosis in D-galactose-induced aging rats possibly via inhibiting TGF-β/p38/MK2 signaling pathway.
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DOI
高影响因子
INORGANIC CHEMISTRY
·
2022
·
IF 5.436
Yulin Xie,Man Wang,Qianqian Sun,Dongmei Wang,Shuiping Luo,Chunxia Li
Combined photothermal/photodynamic therapy is a promising strategy to achieve an enhanced anticancer effect. However, hypoxia is one of the representative characteristics of the microenvironment of solid tumors, which not only attenuates the therapeutic effects but also promotes tumor invasion and metastasis. Herein, a PtBi-β-CD-Ce6 nanoplatform for the generation of sustained O2 was constructed for more effective tumor therapy. In detail, the catalase (CAT)-like nanozyme, PtBi, which could decompose H2O2 to produce O2, was modified with β-cyclodextrin (β-CD). O2 would be converted into 1O2 by PtBi-β-CD-Ce6 for enhanced photodynamic therapy (PDT) under 650 nm laser irradiation. In addition, by reason of excellent absorption in the near-infrared-II (NIR-II) region, PtBi-β-CD-Ce6 was used for photoacoustic imaging (PA) and photothermal imaging (PT)-guided photothermal therapy (PTT) in the NIR-II biowindow. Furthermore, PtBi-β-CD-Ce6 could be elected to serve as a contrast agent for X-ray computed tomography (CT) imaging due to the apparent X-ray attenuation capability of the Pt and Bi elements themselves. Therefore, by integrating the advantages of overcoming the hypoxia function and photothermal effect into a single nanoplatform, PtBi-β-CD-Ce6 showed an immense possibility in multimodal imaging-guided combined PDT/PTT.
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DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2020
·
IF 5.065
Shuang Gao,Jingyu Jiang,Xiaoming Li,Yanyan Liu,Lixia Zhao,Ying Fu,Fei Ye
Cyanazine is usually dissolved in organic reagents during use due to the poor solubility in water. However, cyanazine residues in the environment may cause serious harm to the soil, water and human body, etc. In this study, clathrate of cyanazine-beta-cyclodextrin (cyanazine- β -CD) clathrate was synthesized via co-precipitation to enhance the water solubility, thermostability and herbicidal activity of cyanazine. Moreover, the X-ray diffraction, scanning electron microscope and Fourier transform infrared spectroscopy techniques were used to examine the clathrate. Results proved that cyanazine successfully entered the cyclodextrin cavity. Clathrate of cyanazine and β -CD was synthesized in a 1:1 stoichiometric ratio explored using the study of inclusion ratios. Besides, clathrate improved the water solubility of cyanazine, which was proved by the phase solubility study. The improvement of thermal stability was confirmed by thermogravimetric analysis. Furthermore, the biological activity studies indicated the clathrate had better herbicidal activity than cyanazine.
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DOI
高影响因子
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
·
2020
·
IF 1.431
Yudong Gao
A glassy carbon electrode (GCE) modified with simultaneous electropolymerisation of L-lysine (L-lys) and β-cyclodextrin (β-CD) film (P-β-CD-L-lys/GCE) is proposed as a novel electrochemical platform for the detection of pymetrozine. The electrochemical activity of P-β-CD-L-lys/GCE towards pymetrozine was investigated using cyclic voltammetry experiments in 0.1 M H2SO4. The potential utility of the sensor was demonstrated by applying it to the analytical determination of pymetrozine concentration using linear sweep voltammetry. The linear in the range of 4.0 × 10−8 to 1.0 × 10−6 mol L−1. The detection limit of pymetrozine was found to be 1.3 × 10−8 mol L−1 (S/N = 3). Using this method, we successfully got satisfactory results of pymetrozine in real sample analysis. This work promoted the potential applications of amino acid materials and β-cyclodextrin in environmental analytical chemistry.
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DOI
高影响因子
CHEMOSPHERE
·
2022
·
IF 8.943
Boyin Yan,Songxue Wang,Zhiquan Liu,Da Wang,Wenxin Shi,Fuyi Cui
In this work, the UV 254 /H 2 O 2 process was utilized to remove β-N-methylamino- l -alanine (BMAA), a kind of cyanobacteria neurotoxin, and the influence of reaction parameters and environmental factors on the degradation of BMAA has been systematically investigated. The results showed that BMAA could be effectively removed in the UV 254 /H 2 O 2 system compared to UV or H 2 O 2 alone and OH was confirmed as the main ROS to degrade BMAA. The degradation rate of BMAA increased first and then decreased with the increase of pH and the maximum k obs was 0.1545 min −1 obtained at pH 9. The removal of BMAA in the UV 254 /H 2 O 2 system was inhibited in actual water, while the degradation rate of BMAA in actual water could still exceed 90% by appropriately extending the reaction time. The decrease in the degradation efficiency of BMAA in actual water was primarily due to the ultraviolet light absorption and competition effects of NOM, and anions (Cl − and HCO 3 − ) would also inhibit the degradation of BMAA. Five by-products ([M − H] - = 118, 103, 88, 87 and 59) were identified in this study and the degradation pathways of BMAA were proposed. The production of by-products was attributed to the fracture of the C–N bond and hydroxylation reaction. This study is worthwhile to deepen the understanding of the degradation mechanism of BMAA in the UV 254 /H 2 O 2 system.
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DOI
高影响因子
Journal of Materials Chemistry A
·
2020
·Vol. 9
·期 1
·349-357
·
IF 11.301
Wei Ping Wang,Le Xin Song,Yao Li,Yue Teng,Juan Xia,Fang Wang,Nan Ning Liu
Here we report a novel synthesis of hollow high-quality β-Ga2O3 nanorings based on an interesting structural evolution from concave Ga-MOF nanodisks. The concave low-crystallinity nanodisks were constructed by non-classical crystallization with particle attachment aid. Further, we propose the evolution mechanism from the Ga-MOF nanostructure to the gallium oxide nanostructure based on the outward contraction of nanoparticles. This synthesis method is highly straightforward and provides high yields. It is important to note that the β-Ga2O3 nanorings exhibit good heterogeneous catalytic activity for epoxidation of alkenes. A new oxygen transfer pathway was illustrated to describe the catalytic process based on density functional theory.
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DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2021
·Vol. 32
·期 11
·15046-15058
·
IF 2.478
Zhong Yue,Chen Zhou,Chen Gui,Luo Yang,Zhang Lizhong,Hua Bin,Li Jianhui,Sun Yifei
The development of an efficient synthesis process for carbon-based supercapacitor electrodes is highly appreciated for its practical application. In this work, using β-cyclodextrin (O and C sources), melamine (C and N sources) and zinc chloride (active agent) as affordable precursors, we proposed a cost-efficient route integrating one-pot hydrothermal treatment and in situ carbonization/activation to obtain a N/O co-doped hierarchically porous carbon sheets and employ them as a potential electrode for supercapacitor. The β-cyclodextrin with abundant hydrophobic cavity assists the formation of porous architecture with a large specific surface area (SSA) of 1427 m 2 g −1 . The materials are systematically characterized using various technologies including SEM, XRD, Raman, TEM and XPS measurements. Further, the supercapacitor performances are analyzed using cyclic voltammetry at different scan rates, ac impedance and galvanostatic charge/discharge measurement. A specific capacitance of 240 F g −1 (at 0.5 A g −1 ) and 120 F g −1 (at 0.3 A g −1 ) could be obtained in three-electrode system and symmetric two-electrode full device measurements, respectively. This work points out a new avenue for the fabrication of carbon-based high-performance supercapacitors.
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DOI
高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2022
·
IF 6.364
Qiang Zhi,Shan Zhao,Nan-Long Zhang,Bao-Qiang Hou,Bo Wang,Jian-Feng Yang
The directional freezing of β-Si 3 N 4 whiskers suspensions followed by high-temperature sintering was employed for fabricating novel highly porous fibrous Si 3 N 4 three-dimensional (3D) scaffolds. A honeycomb-like structure was achieved, in which the directionally aligned lamellar walls were composed of the oriented fibrous Si 3 N 4 grains and bridged by the transverse grains. Ultrahigh porosities ranging from 97.8% to 90.2% and rather low densities from 0.073 to 0.320 g cm −3 could be obtained by controlling the Si 3 N 4 contents from 1.5 to 7.5 vol%. The longitudinal compressive strength was superior to the transverse and increased obviously from 0.19 to 3.7 MPa as the porosity decreased. The superior compressive strength was due to the excellent resistance to bucking-induced elastic instability for the lamellar fibrous Si 3 N 4 walls. Meanwhile, the dielectric constant and loss were decreased to 1.08 and 6.6 × 10 −4 , respectively. This study provides a strategy for fabricating porous Si 3 N 4 ceramics with ultrahigh porosities and improved strength.
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DOI
高影响因子
Journal of Materials Research and Technology-JMR&T
·
2019
·
IF 3.327
Yinxin Yang,Lingyun Huang,Quanquan Dai,Long Cui,Shijun Liu,Yanlong Qi,Wei Dong,Jianyun He,Chenxi Bai
In this work, hexagonal boron nitride ( h BN) was modified to introduce hydroxyl groups. The abundant hydroxyl groups in β-cyclodextrin (βCD) provide many reactive sites to form covalent links with epoxy groups in epoxy butadiene rubber (EBR). Therefore, we propose the utilization of biological βCD as a novel interfacial crosslinker, assisting in the dispersion of the hydroxylated h BN ( m BN) via hydrogen bonding, to prepare EBR/βCD/ m BN nanocomposites. Such interfacial interactions not only effectively promote the homogeneous dispersion of m BN in the matrix, but also enhance the mechanical property of nanocomposites. Meanwhile, a high thermal conductivity of 0.187 W/m K was obtained by introducing m BN (4 wt%), reaching 2.83 times of the value for the vulcanized butadiene rubber (BR, 0.066 W/m K). The promising mechanical and thermal conductivity properties of our new materials, and the environmentally friendly curing agent makes them attractive for thermal management application, the tread and sidewall compound of tire.
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DOI
高影响因子
JOURNAL OF SEPARATION SCIENCE
·
2017
·Vol. 40
·期 18
·3718-3724
·
IF 2.557
Xu Ling,Li Zou,Zilin Chen
A polymeric column that contains multiwalled carbon nanotubes-β-cyclodextrin composite was developed. The composite was wrapped into the poly(butyl methacrylate-ethylene dimethacrylate) monolith column (0.76 mm id and 10 cm in length). The column was then applied for the online solid-phase microextraction of psoralen and isopsoralen from Fructus Psoraleae. Following microextraction, the coumarins were quantified by high-performance liquid chromatography with C 18 separation column and UV detection. The effects of sample flow rate, sample volume, and pH value were optimized. The method showed low limits of detection (20 pg/mL, S/N = 3) for both psoralen and isopsoralen. Finally the method was successfully applied to the determination of psoralen and isopsoralen in spiked herb extracts and rat plasma where it gave recoveries that ranged between 93.2 and 102.1%. The empty hydrophobic cavities of β-cyclodextrin and the hydrophobicity of multiwalled carbon nanotubes provided specific extraction capability for psoralen and isopsoralen.
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DOI
高影响因子
危险品化学品经营许可证（带存储）