GREEN CHEMISTRY
·
2015
·Vol. 17
·期 8
·4206-4216
·
IF 8.02
Jinxia Zhou,Zhi Xia,Tingyu Huang,Peifang Yan,Wenjuan Xu,Zhanwei Xu,Jianji Wang,Z. Conrad Zhang
Increasing the glucose loading in the 1-butyl-3-methylimidazolium chloride ([BMIM]Cl) ionic liquid containing a dissolved CrCl3 catalyst system led to excessive formation of humins and a serious decrease in the 5-hydroxymethylfurfural (5-HMF) yield. A biphasic system containing glycol dimethyl ether (GDE) as the extraction phase, and [BMIM]Cl/CrCl3/glucose in combination with a partitioned amount of GDE and an appropriate amount of water as the reaction phase was found to be highly efficient for the reaction; CrCl3 catalyzed the formation of 5-HMF in 64.5 mol% yield from a very high glucose concentration (80 wt% with respect to the ionic liquid) at 108 °C. This 5-HMF yield in the [BMIM]Cl–GDE–H2O ternary biphasic system nearly doubled that obtained in the single [BMIM]Cl/CrCl3/glucose reaction phase. Importantly, the GDE phase contained about 56% of the generated 5-HMF without detectable contamination by the ionic liquid or carbohydrates. GDE served multiple functions: as a hydrogen-bond acceptor, it exhibited excellent extraction performance for 5-HMF; due to its low boiling point and suitable solubility saturation point in the ionic liquid, a sustained GDE bubbling phenomenon in the ionic liquid phase was observed that promoted the rate of inter-phase mass-transfer of 5-HMF in reactions; and GDE mediated the [BMIM]Cl phase to a reduced viscosity. In addition, an appropriate amount of water in the ternary system promoted the extraction efficiency of 5-HMF and also lowered the viscosity of [BMIM]Cl/glucose. The ionic liquid–organics–water ternary biphasic system has been demonstrated for high 5-HMF productivity and separation efficiency.
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Analytical Methods
·
2015
·Vol. 7
·期 5
·1971-1976
·
IF 1.821
Yahong Chen,Gongke Li,Yufei Hu
In this paper, a novel electrochemical method is proposed for the determination of 5-hydroxytryptophan (5-HTP) based on a carbon nanosheets (CNSs)-modified electrode. The CNSs were prepared by a one-step flowing electrolysis using a home-made device. The surface morphology and composition of the CNSs were characterized by scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy. The cyclic voltammetry method was used to study the electrochemical behavior of 5-HTP on the CNSs-modified electrode. The results suggested that the modified electrode exhibited high electrocatalytic activity, and that the anodic peak current of 5-HTP was significantly enhanced on the modified electrode. A differential pulse voltammetry method was developed for the determination 5-HTP at the modified electrode. In the optimum experimental conditions, the linear calibration range varied from 5 × 10−8 mol L−1 to 1 × 10−6 mol L−1, with a detection limit of 3 × 10−8 mol L−1. The proposed method was further successfully applied for the determination of 5-HTP in rats' brain tissue samples, with the recovery ranging from 90.3% to 98.0%.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2024
·Vol. 35
·期 19
·1-11
·
IF 2.8
Shen Xuri,Kong Jinfang,Wang Fengchao,Zhang Canyun,Li Lan,Chen Jin,Yang Jing,Sun Yu
Two-dimensional (2D) Cu 2+ –Mn 2+ co-doped CsPb 2 (ClBr) 5 nanocrystals (NCs) with various Cu/Mn molar ratios were synthesized by a simple one-pot method at room temperature. Additionally, we encapsulated C 3 H 9 SiCl to protect the co-doped CsPb 2 (ClBr) 5 NCs from moisture. The analysis of the structure and composition confirmed the phase and chemical composition of the 2D co-doped CsPb 2 (ClBr) 5 NCs. Steady-state and time-resolved photoluminescence (PL) spectroscopy revealed the enhanced optical properties of the 2D co-doped CsPb 2 (ClBr) 5 NCs. Meanwhile, the optical properties of Cu 2+ –Mn 2+ co-doped NCs presented the good thermal stability even after 36 days. The photoluminescence quantum yields (PLQYs) related to the Mn 2+ emission of the 2D co-doped CsPb 2 (ClBr) 5 NCs increased to 97.36% at a Cu/Mn molar ratio of 0.05/1. Furthermore, a prototype white light-emitting device (WLED) was successfully assembled by combining orange‒red Cu 2+ –Mn 2+ co-doped CsPb 2 (ClBr) 5 NCs, a CsPbBr 3 film, and a 365 nm commercial UV chip; this prototype confirms its potential for a wide range of applications in general lighting.
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Biomass Conversion and Biorefinery
·
2025
·
IF 4.1
Mubashir Tayyaba,Farrukh Aftab,Hassan Najam Ul,Mahmood Rashid,Nasir Zonaira,Tahir Mudassir Hussain
This study investigates the effectiveness of a two-stage process aimed at achieving sustainable aromatic production through the co-pyrolysis of biomass and plastic, followed by catalytic reforming utilizing an Fe-modified ZSM-5 catalyst. To characterize the thermal decomposition behavior and monitor the progression of volatile compounds during the co-pyrolysis process, we employed thermogravimetric analysis (TGA) in conjunction with Fourier transform infrared (FTIR) spectroscopy and gas chromatography-mass spectrometry (GC–MS). Additionally, we conducted a compositional analysis of the resultant bio-oil. This study demonstrates that the co-pyrolysis process, employing a catalyst-to-feedstock ratio of 1:1 with the 10Fe/ZSM-5 catalyst (10 wt.% Fe loading), significantly increases the yield of aromatic hydrocarbons to 67.38%. This yield is markedly higher compared to the aromatic hydrocarbon yield of 55.37% obtained from catalytic pyrolysis of biomass alone. Moreover, these findings highlight the potential of this integrated methodology as a promising pathway for transforming waste materials into value-added chemicals, thereby improving bio-oil quality through the enrichment of aromatic compounds.
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CHEMICAL ENGINEERING JOURNAL
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2025
·
IF 13.2
Hong Tian,Huimin Mao,Jiawei Wang,Yi Cheng
The HZSM-5 zeolite was modified through alkali treatment (NaOH) and metal loading (Ga, Ni), followed by constructing an MCM-41 layer to create a core–shell molecular sieve catalyst. With the feedstock of wheat straw, this work investigated the effects of various catalysts on pyrolysis product distribution and bio-oil composition with a tubular furnace and Py-GC/MS. The results showed that with the alkali-treated HZSM-5, the yield of monocyclic aromatic hydrocarbons (MAHs) in the bio-oil reached 40.35%, with an overall bio-oil yield of 21.16%. Metal-modified zeolites, exhibiting enhanced acidity, further optimized the bio-oil composition, producing an MAH yield of 61.48% and 27.31% bio-oil yield. Bimetal loading with Ga and Ni further enhanced MAH selectivity, delivering an MAH yield of 69.48% and a bio-oil yield of 27.79%. The synergy between Ga and Ni suppressed excessive aromatization and polymerization into polycyclic aromatic hydrocarbons (PAHs), favouring MAH formation. Constructing an MCM-41 layer further promotes the selectivity of MAHs. Compared to uncoated catalysts, those coated with MCM-41 significantly improved monocyclic aromatic yields, achieving the highest MAH yield of 83.61%.
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JOURNAL OF LOSS PREVENTION IN THE PROCESS INDUSTRIES
·
2024
·
IF 3.6
Shuna Zhao,Mi Li,Lin Jiang
5-Aminotetrazole (5AT) is widely used as a green gas-generating agent in fire extinguishers, but it exhibits low combustion stability. To enhance its combustion rate and modify gas production performance, this study investigated the catalytic effects of adding different metal oxides (Bi 2 O 3 , PbO, TiO 2 , and CoO) on its pyrolysis process and decomposition mechanism. The pyrolysis behavior and pyrolysis products of 5AT were studied by simultaneous thermal analyzer (thermogravimetry - differential thermal analysis, TG-DTA) and TG-FTIR/MS (mass spectrometry and fourier transform infrared spectroscopy) hyphenated instrument. Isoconversional methods were used to calculated kinetic parameters, and reaction mechanism was also speculated by combining the experimental and calculational results. The experimental results indicated that Bi 2 O 3 , PbO, TiO 2 and CoO have minimal impact on the ring opening reaction process of 5AT, but they catalyzed the polymer decomposition process of 5AT, especially CoO. Consequently, the addition of metal oxides as catalysts to 5AT holds significant potential for improving its thermal safety and enhancing its suitability as a solid propellant gas generator.
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MATERIALS & DESIGN
·
2024
·
IF 7.6
Yanyan Meng,Shaoqing Chen,Pengyin Li,Cheli Wang,Xinye Ni
Melanoma is a highly invasive and lethal skin cancer with a strong tendency to metastasize and has a poor prognosis. Radiotherapy is one of the important treatments for melanoma. In this study, monoglyceride solid lipid nanoparticles (MG SLNs) were wrapped with the B16-F10 cell membrane (B16 CM) for the fabrication of B16@MG. B16@MG had low toxicity and specifically targeted B16-F10 cells. B16-F10 tumor–bearing mouse model showed that indocyanine green (ICG) -loaded B16@MG achieved long-term accumulation in the tumor and facilitated the localization of the tumor boundary. MG SLNs were encapsulated with methyl 5-aminolevulinate (MLA) and desferrioxamine (DFO), and B16 CM was wrapped around their surfaces to obtain B16@MG–MLA–DFO.MLA was metabolized to protoporphyrin IX (PpIX) in the cells and DFO reduced the content of iron ion in the cells, blocked the biotransformation of PpIX, and promoted the accumulation of PpIX in the cells. The results of mitochondrial reactive oxygen species (ROS) and membrane potential detection showed that PpIX enhanced the generation of ROS, caused DNA and mitochondrial damage, and led to the apoptosis of tumor cells under radiotherapy. In B16-F10 tumor–bearing mice, B16@MG–MLA–DFO can improve the efficacy of radiotherapy and allow the integration of diagnosis and treatment.
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FUEL
·
2024
·
IF 6.7
Hongli He,Jie Yang,Bo Kang,Mingxin Lv,Enhui Du,Zhilin Chen,Weiping Xie,Liyuan Huai,Hualei Hu,Chunlin Chen,Jian Zhang
Catalytic performances of supported metal catalysts are highly affected or even dominated by supports. Here, the manganese oxide octahedral molecular sieves (OMS-2) supported Pt nanoparticles (Pt/OMS-2) show specific selectivity in the hydrogenation of 5-hydroxymethylfurfural to 2,5-bis(hydroxymethyl)furan (BHMF) in liquid water, without ring-hydrogenation or ring-opening, even under harsh conditions. a 97.6 ± 2.1 % yield of BHMF was obtained over Pt/OMS-2 within 2 h at 30 °C and 1.5 MPa H 2 . This specific selectivity was attributed to a vertical adsorption model of BHMF at the interface, where an O atom and H atom of hydroxyl attached to the Mn and O 2− sites. The hydrogenation of the C O bond followed hydroxy routes through a water-mediated mechanism. Specifically, a water molecule facilitated the transfer of hydrogen atoms between the carbonyl group and the Pt surface, with the cleavage of O H bonds being a key step in the overall process.
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高影响因子
Journal of Energy Storage
·
2024
·
IF 8.9
Jinping Mu,Xiaohui Li,Rui He,Lijing Sun,Xue Bai,Lihui Zhang,Peng Liu,Zhenfa Liu,Jing Gao,Aijia Wei
High-voltage lithium-ion batteries (LIBs) with LiNi 0.5 Mn 1.5 O 4 (LNMO) cathode are considered promising energy sources due to their high energy density . However, enhancing the stability of the electrode/electrolyte interface remains critical for the practical application of LIBs. In this work, lithium-containing inorganic phosphates (LiPO 3 , Li 3 PO 4 , and LiH 2 PO 4 ) were used as multifunctional inorganic additives to improve the stability of the electrode/electrolyte interface in 5.0 V, LNMO-based LIBs with carbonate-based electrolytes. Based on theoretical calculations and experimental evaluations of the electrochemical performance , LiPO 3 was selected as the optimal additive for further study in LNMO/Li and LNMO/Li 4 Ti 5 O 12 cells. The LNMO/Li half-cells with LiPO 3 delivered an initial discharge capacity of 108.8 mAh∙g −1 and retained a capacity of 94.9 % after 500 cycles at 5C, compared to 75.1 mAh∙g −1 and 79.4 % for the standard electrolyte. The increased cycling stability was ascribed to the ability of the multifunctional, film-forming LiPO 3 additive to form stable interfacial films on both the cathode and anode , thus, inhibiting side reactions between the electrodes and electrolyte. Moreover, as an HF scavenger, LiPO 3 reduced the HF content in the electrolyte to ensure the structural integrity of LNMO and inhibit the dissolution of transition metal ions . In the LNMO/Li 4 Ti 5 O 12 full cells, the addition of LiPO 3 effectively enhanced the cycling performance, and the capacity retention after 400 cycles at 5C was 79.1 %, compared to only 12.3 % for the standard electrolyte. Considering its simplicity, low cost, and feasibility, the addition of LiPO 3 as a multifunctional electrolyte additive showed excellent prospects for commercial applications.
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Advanced Healthcare Materials
·
2024
·
IF 10
Zongpu Han,Yixiong Lin,Xinyu Guo,Jieyun Xu,Xiaomeng Gao,Ruihan Yang,Yuan Zhao,Mixiao Gui,Linjun Zhang,Yuanlong Guo,Zetao Chen
The strategy of re-organogenesis provides an optimal framework for restoring complex organ structures and functions in adult damage. While the focus has often been on restoring organogenesis stem cells, there is limited investigations of reverting the environmental niche to support this approach. The guiding principle of “Nature selects the fittest to survive” drives the intricate dynamic changes in cellular events within the niche environment, especially through immune surveillance. The extracellular matrix (ECM) serves as the “self-associated molecular patterns” of the niche, containing extensive data on cell-niche reaction data and acting as the active tuner of immune surveillance. In this study, hyaluronic acid (HA) is identified as a unique component of the ECM in cranial osteo-organogenesis. Mechanistically, HA activates the Cluster of Differentiation 44 (CD44)-Mitogen-Activated Protein Kinase (MAPK)/Extracellular Signal-Regulated Kinase (ERK)-Ets Variant 1/5 (ETV1/5)- Mannose Receptor C-Type 1 (MRC1) axis in macrophages, establishing a distinct immune surveillance during osteo-organogenesis. Furthermore, HA is utilized as a novel engineered material for an “Osteo-organogenesis niche”, restoring immune surveillance and synergistically regulating stem cells to achieve re-osteo-organogenesis in cranial defects of rats. Taken together, the study unveils a previously unknown strategy for leveraging re-organogenesis by utilizing “organogenesis niche” ECM engineered materials to manipulate immune surveillance, thereby comprehensively regulating stem cells and other tissue cells effectively for re-organogenesis.
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PubMed
高影响因子
Drug Delivery and Translational Research
·
2024
·
IF 5.7
Chen Siwei,Huang Hongwu,Li Qi,Cai Jia,Miao Zhuolin,Xie Peikang,Tang Shengsong,He Dongxiu
5-Fluorouracil (5-FU) is commonly used as a chemotherapeutic drug for advanced HCC. However, the effectiveness of 5-FU is limited by the emergence of resistance and poor targeting efficiency. Combining 5-FU with natural compounds has shown promise in HCC treatment. In this study, we prepared carrier-free nanoparticles (GEN-Cu-GEN@FUA) containing 5-FU and genistein (GEN) in a synergistic ratio via a green synthesis procedure. The resulting GEN-Cu-GEN@FUA nanoparticles had a spherical or near spherical shape, a dynamic size of 129.3 ± 40.1 nm, and a high drug loading content of approximately 21.40% (5-FU) and 61.48% (GEN). These nanoparticles exhibited approximately 3.6-fold lower IC50 value than 5-FU alone in Bel-7402 cells and resulted in a 3.7-fold greater reduction in tumor weight compared to 5-FU alone in Bel-7402 tumor-bearing BALB/c mice. Importantly, the nanoparticles showed negligible systemic toxicity due to their synergistic effect on cancer cell dysfunction and significant amplification of intracellular glutathione consumption. Our findings suggest that the developed carrier-free nanomedicines offer a highly promising platform for the co-delivery of genistein (GEN) copper(II) complexes and 5-FU, with easy fabrication and great potential for clinical translation in HCC synergistic therapy. Graphical abstract
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PubMed
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FUEL
·
2025
·
IF 7.5
Huiyu Liu,Ying Qiu,Rui Shan,Jun Zhang,Haoran Yuan,Yong Chen
Catalytic fast pyrolysis (CFP) using bimetallic modified ZSM-5 enables efficient upcycling of polyethylene (PE). The present study demonstrates that alkaline sites significantly enhanced the mass transfer capacity of catalysts through generating fragmented structures, thus contributing to the selective regulation of thermal decomposition behavior of PE. Specifically, CuZn/ZSM-5 reduced decomposition temperature range by > 100 °C via enhanced chain-cracking and product transport. The synergistic effects of Cu 0 and alkaline sites derived from Zn species facilitated the cleavage of C–C bonds under a high heating rate, thereby accelerating the formation of olefin intermediates as well as promoting the aromatization within ZSM-5 channels. CuZn/ZSM-5 optimally combined highly dispersed metal sites, abundant strong alkaline sites, moderate acidic sites, and reinforced diffusion capacity, boosting low-temperature aromatics selectivity by 29.7 %, particularly for monocyclic aromatic hydrocarbons (MAHs). Despite the highest alkalinity of CuMg/ZSM-5, the permanent loss of weak alkaline sites at high temperatures resulted in weak capacity for aromatization. In addition, the plausible pathway for fast pyrolysis of PE into aromatics over CuZn/ZSM-5 was proposed.
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