APPLIED ORGANOMETALLIC CHEMISTRY
·
2017
·Vol. 32
·期 3
·e4201
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IF 2.319
Mengqiu Huang,Jiasheng Fang,Yiwei Zhang,Chao Zhang,Yuming Zhou,Shuo Zhao,Yan Gao,Xiaoli Sheng
A novel magnetic binary-metal-oxide-coated nanocataly composing of a hollow Fe 3 O 4 core and CeO 2 -La 2 O 3 shells with Au nanoparticles encapsulated has been created in this work. The structural features of catalysts were characterized by several techniques, including SEM, TEM, UV-vis, FTIR, XRD, XPS and TGA analyses. After the coating of CeO 2 -La 2 O 3 layer, CeO 2 -La 2 O 3 /Au/C/Fe 3 O 4 microspheres showed a superior thermal stability and catalytic reactivity compared with a pure CeO 2 or La 2 O 3 layer. Accompanied by the burning of carbon layer, the specific surface could be increased by the formation of double-shelled structure. Besides, the desired samples could be separated by magnet, implying the superior recycle performance. Using the reduction of 4-nitrophenol by NaBH 4 as a model reaction, the microspheres exhibited highly reusability, superior catalytic activity, thermal stability, which are attributed to the unique double-shelled structure of the support, uniform distribution of Au nanoparticles, the highly thermal stability of CeO 2 -La 2 O 3 layer and mixed oxide synergistic effect. As a consequence, the unique nanocatalyst will open a promising way in the fabrication of the double-shelled hollow binary-metal-oxide materials for future research and has great potential in other applications.
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MATERIALS CHEMISTRY AND PHYSICS
·
2018
·
IF 2.21
Jianwei Fu,Shaomin Wang,Jianhua Zhu,Kai Wang,Meng Gao,Xuzhe Wang,Qun Xu
Highly dispersed Au-Ag bimetallic nanoparticles were facilely synthesized on the multi-amino poly(cyclotriphosphazene-co-polyethyleneimine) (PCP) microspheres through in situ co-reduction method and then used as catalysts for the reduction of 4-nitrophenol (4-NP). Characterization results showed that the as-synthesized PCP microspheres possessed regular spherical morphology and relatively smooth surface, which could be well modified by highly dispersed Au-Ag bimetallic nanoparticles with size of 2–4 nm. For the reduction of 4-NP, it was found that the as-synthesized PCP@Au-Ag composites showed much better catalytic activity than PCP microspheres supported monometallic counterparts, which could be ascribed to a synergistic effect between Au and Ag in Au-Ag bimetals . For the PCP@Au-Ag catalysts, the rate constant k and intrinsic activity parameter κ of the reaction could be up to 2.87 × 10 −3 s −1 and 144 s −1 g −1 , respectively, and the conversion of the 4-NP could still reach 83% after six cycles. In addition, the possible catalytic mechanism of PCP@Au-Ag composites towards the reduction of 4-AP was also proposed.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2017
·
IF 3.133
Hongying Liu,Mingru Jiao,Chunchuan Gu,Mingzhen Zhang
In this research, [email protected] x OS yolk-shell nanomaterials with porous shells were prepared by an ion-exchange route and characterized by scanning electron microscopy (SEM) as well as transmission electron microscopy (TEM). Then, the as-prepared [email protected] x OS yolk-shell nanomaterials were proposed as an outstanding peroxidase-like mimic for the first time, which could be used as a colorimetric probe for the determination of H 2 O 2 . The enhanced intrinsic peroxidase mimic activity was much higher than that of horseradish peroxidase (HRP), Au nanoparticles , and [email protected] 2 O core-shell nanomaterials due to the special yolk-shell structure and the synergistic cooperation between the AuNP core and the CuxOS shells. The catalytic property of the resulting nano-alloy followed a symbolical Michaelis–Menten model. Further studies also exhibited a ping-pong mechanism of the enzyme catalytic reaction. Under the optimized conditions, colorimetric determination for H 2 O 2 was carried out and the results showed a linear response range from 0.1 to 32 μM along with a limit of detection of 0.03 μM (S/N = 3). Due to the high catalytic activity, this assay promised wide application in clinical diagnosis, food safety, and environmental monitoring.
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JOURNAL OF MOLECULAR LIQUIDS
·
2024
·
IF 5.3
Xinrong Li,Shuliang Chen,Xianzhi Hu,Futing Zi
Thiosulfate as a green and environmentally friendly lixiviant has received great attention in the field of gold extraction. However, the problem of gold ion recovery in thiosulfate gold leaching solution has hindered the large-scale application of this technology. Here, tri-n-butylphosphine (TBUP) was used as a functional monomer to prepare an adsorbent (CTS-TBUP) with abundant pores through the ion crosslinking reaction of chitosan, which was used to recover Au(I) from Au[(S 2 O 3 ) 2 ] 3− solution with high efficiency and large capacity. CTS-TBUP exhibited good potential for industrial applications with a gold loading capacity of 46.34 mg/g. CTS-TBUP exhibited a similar gold recovery performance for all pH ranges from 6 to 11, and the adsorption process of Au(I) on CTS-TBUP was well described by pseudo-second-order kinetics and Langmuir isothermal model. The mechanism by which CTS-TBUP adsorbs gold ions involves ligand exchange between TBUP and Au[(S 2 O 3 ) 2 ] 3− . In addition, Au(I) on CTS-TBUP will be reduced to elemental gold by TBUP in CTS-TBUP. The mechanism of Au(I) adsorption by CTS-TBUP was also confirmed by density functional theory calculations, and confirmed the rationality of forming a complex with a coordination ratio of 2:1 between TBUP and Au(I) at the theoretical level. CTS-TBUP has a good affinity for gold ions in thiosulfate solution, which provides a new idea for the preparation of gold adsorbent.
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Analytical Methods
·
2024
·Vol. 17
·期 1
·84-91
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IF 2.7
Miaowen Xu,Gaoyang Chen,Yong Huang,Hangyu Song,Zheng Wu,Fengjuan Jiang,Lei Fu,Caili Bi,Xiaowei Cao,Wei Wei
This paper presents functionalized magnetic nanoparticles (Fe3O4@Au MNPs) combined with the surface-enhanced Raman spectroscopy (SERS) technique for sensitive detection of colorectal cancer (CRC) protein biomarker carbohydrate antigen 19-9 (CA19-9). Fe3O4@Au MNPs were constructed by the PEI-mediated seed growth method. Then, the signal molecule 5-5′-dithiobis (succinimidyl-2-nitrobenzoic acid) was used as a bridging agent to link CA19-9 antibody, and the SERS sensor was prepared. Using this sensor, detection of CA19-9 can be realized with only a one step sampling reaction. Fe3O4@Au MNPs combine the advantages of magnetic materials and noble metal nanoparticles, effectively amplifying the signal by creating numerous “hot spots” within the Au particle gaps and enhancing magnetic enrichment. Consequently, this approach lowers the detection limit (LOD) and enhances detection sensitivity. The ratio of characteristic peak intensities I1392/I1069 was selected for calculation, and a linear equation was constructed with a LOD as low as 0.27 U mL−1 by quantitative detections of the standard antigen. Finally, the sensor was used to analyze the clinical serum samples from CRC patients and healthy individuals, and the detection results were consistent with the actual results. This method exhibits notable advantages, including simplicity, high sensitivity, specificity, stability and reproducibility. It is expected to provide a new promising analytical method for clinical CA19-9 immunoassay.
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
·
2012
·
IF 2.484
Da-Quan Sun,Ying Wang,Ding-Gan Liu
AU-rich elements are functional motifs in the 3′untranslated region of mRNA and are binding sites for the RNA binding protein HuR, an mRNA stabilizer and translation enhancer implicated in carcinogenesis. It is not clear whether, and, if so, how the AU-rich elements function in cells when they are separated from their mRNA and form an independent RNA species. Here, we show that a short RNA with AU-rich elements derived from C/EBPβ 3′UTR suppressed growth in a human liver cancer cell line. It specifically bound HuR, and it competed with C/EBPβ mRNA in order to bind to HuR. Our results provide evidence that the cancer cell growth suppression by this 62nt RNA containing AU-rich elements may be due to competitive binding to HuR. This work may open new options for the development of novel anti-cancer drugs.
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ANALYTICAL CHEMISTRY
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2009
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IF 5.712
Jingming Gong,Ting Zhou,Dandan Song,Lizhi Zhang,Xianluo Hu
A new, highly sensitive and selective sensor for the electrochemical assay of Hg(II) by anodic stripping voltammetry has been developed, whereby a glassy carbon electrode is modified with a novel inorganic−organic hybrid nanocomposite, namely, bimetallic Au−Pt nanoparticles/organic nanofibers (labeled as Au−PtNPs/NFs). The sensor possesses a three-dimensional (3D) porous network nanoarchitecture, in which the bimetallic Au−Pt NPs serving as metal NP-based microelectrode ensembles are homogenously distributed in the matrix of interlaced organic NFs. The surface structure and composition of the sensor were characterized by scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS). Its electrochemical performance was systematically investigated. Our results show that such a newly designed, Au−PtNPs/NF nanohybrid modified electrode provides remarkably improved sensitivity and selectivity for the stripping assay of Hg(II). The detection limit is found to be as low as 0.008 ppb (S/N = 3) that is much below the guideline value from the World Health Organization (WHO). Interferences from other heavy metal ions such as Cu(II), Cr(III), Co(II), Fe(II), Zn(II), and Mn(II) ions associated with mercury analysis are effectively inhibited. Toward the goal for practical applications, the sensor was further evaluated by monitoring Hg(II) in tap and river water specimens.
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MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 11
·1-17
·
IF 5.3
Liang Jintao,Liang Jianlu,Xiao Xinkai,Guo Fei,Zhan Yulian,Zhou Xueqing,Zhou Zhide,Li Guiyin
A sandwich-type electrochemical aptasensor for ultrasensitive detection of glypican-3 (GPC3) was constructed using GPC3 aptamer (GPC3 Apt ) labelled reduced graphene oxide-cerium oxide-gold nanoparticles (RGO-CeO 2 -Au NPs) as the signal probe and the same GPC3 Apt as the capture probe. The electrochemical redox properties of CeO 2 (Ce 3+ /Ce 4+ ) in the RGO-CeO 2 -Au NPs indicate the electrochemical signals. When the target GPC3 was present, an “aptamer-protein-aptamer” sandwich structure was formed on the sensing interface due to the specific binding between the protein and aptamers, resulting in an increased electrochemical redox signal detected by differential pulse voltammetry (DPV) technique. Under optimal conditions, the established aptasensor exhibited a logarithmic linear relationship between the current response and GPC3 concentration in the range 0.001–100.0 ng/mL, with a minimum detection limit of 0.74 pg/mL. Using the spike-recovery tests for measurement of the human serum samples, the recovery was from 99.26 to 114.01%, and the RSD range was 3.04 to 5.34%. Furthermore, the sandwich-type electrochemical aptasensor exhibited excellent performance characteristics such as good stability, high specificity, and high sensitivity, demonstrating effective detection of GPC3 in human serum samples and can be used as a clinical detection tool for GPC3. Graphical Abstract
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International Journal of Nanomedicine
·
2024
·
IF 6.6
Yaxu Feng,Qing Sun,Pei Liu,Wei Fan,Bing Fan
Background Enterococcus faecalis (E. faecalis) is one of the main pathogens responsible for refractory root canal infections in the teeth and shows resistance against various antibacterial managements. Effective control of E. faecalis infection is a prerequisite for successful treatment of refractory apical periodontitis. This study aimed to analyze the antibacterial activity and mechanisms of Au@Ag nanoparticles (NPs) combined with photothermal therapy (PTT) against the original and Ag+-resistant E. faecalis.Methods Au@AgNPs with optimal shell thicknesses were synthesized and characterized. The antibacterial activity of Au@AgNPs with PTT against the original or Ag+-resistant E. faecalis was evaluated, and the antibiofilm activity was tested on E. faecalis biofilm on the dentin of teeth. The potential antibacterial mechanisms of Au@AgNPs combined with PTT against E. faecalis have also been studied. Moreover, its influence on dentin microhardness and cytotoxicity was assessed.Results This study revealed that Au@AgNPs combined with PTT showed enhanced antibacterial and antibiofilm effects, no negative effects on dentin microhardness, and low cytotoxicity toward human periodontal ligament cells (hPDLCs). Moreover, Au@AgNPs combined with PTT effectively inhibited the growth of Ag+-resistant E. faecalis. Its antibacterial effects may be exerted through the release of silver ions (Ag+), destruction of the cell membrane, production of reactive oxygen species (ROS) and inhibition of adenosine triphosphate (ATP) production. Hyperthermia generated by Au@AgNPs with PTT reduced membrane fluidity and enhanced Ag+ sensitivity by downregulating fabF expression. The upregulated expression of heat shock genes demonstrated that the Ag+ released from Au@AgNPs compromised the heat adaptation of E. faecalis.Conclusion PTT significantly enhanced Ag+ sensitivity of the original and Ag+-resistant E. faecalis. Au@AgNPs combined with PTT may have the potential to be developed as a new antibacterial agent to control E. faecalis infections in teeth.
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Food Bioscience
·
2025
·
IF 5.9
Tao Lu,Zhiguang Suo,Min Wei,Huali Jin,Yong Liu,Baoshan He,Renyong Zhao
β-lactoglobulin (β-LG) is a major allergen in milk what can provoke intense allergic reactions. Therefore, an accurate and efficient method is required for sensitive detection of β-LG. A label-free electrochemical aptasensor utilizing Au/Ag@ZIF-8 and dual amplification strategy has been designed for the detection of β-LG. Au/Ag@ZIF-8 nanocomposite is used as the electrode modification material, which has abundant relative surface area and exceptional conductivity behavior, and it can also serve to immobilize DNA strands. By combining RecJf exonuclease and hybridization chain reaction (HCR) dual amplification strategy, an apparent enhancement of electrochemical signal is obtained. β-LG undergoes target cycling in the effect of RecJf exonuclease, which dislodges complementary strand cDNA and further triggers HCR to provide a large number of sites for methylene blue embedding. The detection range of this aptasensor is 0.01–1000 ng/mL in the optimal detection conditions, with a limit of detection (LOD) of 5.37 pg/mL. The constructed electrochemical aptasensor possesses the superiorities of good specificity, preeminent accuracy and satisfied stability in the detection of β-LG. Moreover, it also demonstrates satisfactory detection performance in the detection of real samples, which indicates that the electrochemical aptasensor has a broad application prospect in protecting food safety and health.
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Analytical Methods
·
2024
·
IF 2.7
Taohong Zhou,Jin Lin,Fengmei Jin,Yanxing Yao,Zhihao Li,Lihua Wang
Cr(VI) is one of the most typical heavy metal contaminants and rapid detection of Cr(VI) is highly important in food control and public health. Herein, a core–shell Au@Pt nanozyme-based colorimetric assay was developed for the rapid and sensitive detection of Cr(VI). The monodispersed Au@Pt core–shell nanoparticles exhibited high peroxidase-mimicking activity and can catalyze colorless TMB into blue-colored oxidized oxTMB. After the addition of Cr(VI), the oxTMB molecules can be reduced into colorless TMB. The ultrathin Pt shell can prevent the Pt component from aggregation, thus improving the catalytic activity of Au@Pt nanozyme. These Au@Pt nanozyme-based Cr(VI) assays exhibited high sensitivity and selectivity and displayed satisfactory recoveries in practical samples. Our work highlights opportunities for the development of core–shell nanozymes with extensive applications in food safety, biomedicine, and environmental monitoring.
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Journal of Materials Chemistry C
·
2024
·
IF 5.7
Jiahao Pan,Yuchen Zhang,Zhentao Pang,Yu Deng,Zhenda Lu
This work presents a high-content platform for investigating the critical interplay between the nanoparticle cluster size, structure, and plasmon-enhanced fluorescence at a single particle level. The platform enables the controlled assembly of pre-synthesized, bio-conjugatable Ag@Au nanocubes into clusters with varying sizes and configurations, ultimately arranged in an array pattern. Notably, the platform statistically reveals that Ag@Au nanocubes achieve over two orders of magnitude greater fluorescence enhancement compared to Au nanoparticles alone. Moreover, it identifies a crucial size regime for maximizing fluorescence enhancement. Clusters containing 1–4 nanocubes exhibit a direct correlation between the fluorescence intensity and the number of particles, as well as cluster configuration. Compact clusters display a significantly stronger fluorescence response compared to loosely packed configurations. This high-content platform offers a powerful approach for the rapid, simultaneous characterization of multiple nanoparticles, paving the way for efficient, large-scale fluorescence-based detection.
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