DYES AND PIGMENTS
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2026
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IF 3.9
Weidong Yu,Jialing Tan,Chen Zhang,Daokun Tian,Hao Li,Cheng Zeng,Chaoxia Wang
Positive/negative thermochromic dyes achieved via hydrogen bond competition. • Adjustable phase change behavior controlled by long alkyl chain integration. • Thermochromic fabrics changed at 47°C (white to red) and 35°C (red to white). Thermochromic ternary complexes relying on phase change materials to switch color currently lack effective measures to regulate their color-changing direction. In this work, a brominated fluorane dye (BDF) was synthesized via condensation reaction and subsequently incorporated with dodecyl gallate (DG, color developer) and 1-tetradecanol (TD, phase change solvent) to form a positive thermochromic ternary complex. The DG participated in the melting and crystallization process of the phase change solvent due to the presence of multiple phenolic hydroxyl groups and long alkyl chains (C12), thereby generating a distinct colorless-to-colored transition upon heating. The positive thermochromic fabric prepared via dip-coating exhibited excellent thermal cycling stability. In contrast, a negative thermochromic complex was constructed with BDF, bisphenol A (BPA, color developer), and TD. Because BPA lacks long alkyl chains to integrate into the phase change process of TD, this negative complex altered its color from red to colorless upon heating. To stabilize the negative thermochromic ternary complex and address phase separation, melamine-urea-formaldehyde (MUF) resin was employed as a protective shell to provide nanoscale spatial confinement for the phase-changing process. The thermochromic capsules (TC) prepared via in situ polymerization exhibited an average diameter of 536 nm, a well-defined core-shell structure, and superior thermochromic reversibility. The reflectance difference of the microcapsules reached approximately 20%, enabling distinct optical color changes. This regulatory mechanism for controlling color-changing direction and stabilizing phase separation through nanoscale confinement effects provides a promising approach for developing high-performance thermochromic textiles. Download: Download high-res image (408KB) Download: Download full-size image
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高影响因子
Metabolites
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2026
·Vol. 16
·期 8
·549
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IF 4.5
Dandan Xia,Liubao Gu,Lei Yang,Jiaojiao Hu,Xiaowei Xu,Dechen Jiang,Qiuling Zheng,Bing Wan
Background/Objectives: Human islet amyloid polypeptide (IAPP) aggregation plays a critical role in the pathogenesis of type 2 diabetes mellitus (T2DM). Although metabolic alterations are a hallmark of T2DM, the functional roles of differential metabolites in regulating disease-associated molecular processes remain largely unexplored. This study aimed to establish a metabolomics-guided strategy for identifying endogenous metabolites with anti-amyloid activity and to investigate their underlying chemical interactions with IAPP.Methods: Untargeted metabolomic profiling of clinical samples from T2DM patients, obesity patients and healthy controls was performed to identify differential metabolites. Candidate metabolites were subsequently screened for their ability to modulate IAPP aggregation. Transmission electron microscopy (TEM), thioflavin T (ThT) fluorescence assays, and cell viability measurements were employed to evaluate their effects on fibril formation and cytotoxicity. Mass spectrometry was further used to characterize metabolite–IAPP interactions.Results: Metabolomic analysis identified 3-hydroxypyruvic acid (also known as β-hydroxypyruvic acid, hereafter referred to as HPA) as a significantly altered endogenous metabolite associated with T2DM and a candidate regulator of IAPP aggregation. Functional assays demonstrated that HPA effectively inhibited amyloid fibril formation, as evidenced by the absence of typical fibrillar structures and a prolonged lag phase during aggregation. HPA also significantly alleviated IAPP-induced cytotoxicity. Mass spectrometric analysis revealed the formation of HPA–IAPP oligomer complexes (n< 4), suggesting that HPA directly interacts with early oligomeric intermediates and interferes with their progression toward mature fibrils.Conclusions: This work demonstrates that untargeted metabolomics of clinical samples can serve as an effective strategy for discovering bioactive endogenous metabolites involved in disease-related molecular processes. The identification of HPA as a potential endogenous inhibitor of IAPP aggregation provides new chemical insight into the relationship between metabolic dysregulation and amyloidogenesis and highlights endogenous metabolites as a valuable source of potential therapeutic lead compounds.
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ADVANCED MATERIALS
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2026
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IF 29.1
Renjie Zhang,Yuemei Han,Huiying Huang,Wei Li,Yajia Wang,Ruixiang Chen,Jiaying Yang,Jiang Chen,Wenxin Hong,Quankui Lin
Phacoemulsification followed by intraocular lens (IOL) implantation is currently the only effective treatment for cataracts. However, conventional IOLs exhibit limited biological adaptability and fixed or discontinuous focal properties, preventing restoration of the natural lens's continuous accommodation and often causing postoperative visual disturbances and complications. Herein, we report an injectable multifunctional hydrogel-based biomimic lens that simultaneously reconstructs optical–mechanical properties and dynamically modulates the postoperative lenticular microenvironment. Through multilayered dynamic crosslinking and micro-capsulorhexis-assisted in situ gelation within the capsular bag, the hydrogel forms a biomimic lens with continuous refractive characteristics. Meanwhile, its drug-loading capability enables the incorporation of multifunctional components for early postoperative antibacterial, anti-inflammatory, and antifibrotic effects. In addition, after inflammation subsides, the loaded photocatalytic elements induce the orderly clearance of residual lens epithelial cells, enabling comprehensive restoration of microenvironmental homeostasis within the capsular bag. In a rabbit model, this hydrogel lens demonstrates effective refractive reconstruction and sustained suppression of postoperative complications, highlighting its potential as a next-generation intraocular lens.
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Science China-Life Sciences
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2026
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IF 9.6
Liu Zichao,Yang Huai,Zhang Zenan,Kuang Chenke,Deng Liyong,Li Yueyong,Jin Linyuan,Nie Hongjun,Wang Guihua,Du Meng,Chen Zhiyi
The limited therapeutic efficacy of radiotherapy (RT) in breast cancer is closely linked to hypoxia, which is caused by structurally abnormal vascular networks in the tumor microenvironment (TME). Tumor vascular normalization has emerged as a promising strategy to enhance radiosensitization by alleviating hypoxia. However, current vascular normalization methods face critical limitations, including off-target effects and inadequate spatiotemporal precision. Therefore, developing precise and efficient vascular normalization strategies is crucial for improving RT efficacy. In this study, we developed a tumor vascular normalization strategy based on ultrasound-targeted cavitation for radiosensitization. We synthesized VEGFR2-targeted microbubbles (MB@VEGFR2) to selectively accumulate on tumor vascular endothelial cells. Ultrasound-targeted cavitation enhanced local tumor blood perfusion, increased vascular diameter and maturity, and effectively alleviated hypoxia. By monitoring the time window of vascular normalization and administering RT within this period, tumor growth was significantly suppressed, with a 2.5-fold reduction in tumor volume compared to RT alone. Mechanistically, ultrasound-targeted cavitation promoted ATP release from endothelial cells, activating the PI3K/AKT/eNOS pathway to elevate nitric oxide (NO) production by 4-fold, thereby inhibiting abnormal vascular formation. This study demonstrates that ultrasound-targeted cavitation precisely achieves tumor vascular normalization, effectively improving RT efficacy.
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高影响因子
Small
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2026
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IF 11.8
Jiaofan Sun,Yuanyuan Rao,Xin Zhang,Jing Liu,Shasha Feng,Yutang Kang,Sheng Wang,Yicheng Wang,Kai Yuan,Daoming Xu,Lanying Liu,Zhaoxiang Zhong,Weihong Xing
As one of the most distinctive therapeutic methods in traditional Chinese medicine, moxibustion therapy has garnered significant attention for its analgesic, anti-inflammatory, and anti-tumor effects. However, traditional moxibustion therapy lacks portability, generates substantial harmful gas emissions during combustion, and exhibits uncontrollable burning temperatures, which lead to unstable therapeutic outcomes. In this work, a smart thermo-responsive and sustained-release dressing with a three-layer structure is developed. Within this design, the electrothermal carbon fiber layer is responsible for heat generation, while the thermochromic nanofiber membrane layer enables temperature visualization. The core functional layer is a polylactic acid/hollow carbon nanosphere/mugwort essential oil nanofiber membrane fabricated via electrospinning. Leveraging its hierarchical porous structure and the microencapsulation effect of the hollow carbon nanospheres, the membrane achieves a high mugwort essential oil loading capacity of 164.32%, effectively maintaining sustained release over 10 days. The dressing exhibits excellent temperature responsiveness and reusability, maintaining accurate temperature control even after 200 consecutive cycles. Experiments using a porcine skin model demonstrated that the active components of the essential oil can penetrate into both the stratum corneum and stratum corneum-removed tissue, with thermotherapy significantly enhancing their transdermal absorption. This study provides a green, safe, and convenient solution for modernizing traditional moxibustion therapy.
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PubMed
高影响因子
ANALYTICA CHIMICA ACTA
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2026
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IF 6.1
Xiping Cui,Qiyi He,Huiyi Yang,Mingxia Lin,Suqing Zhao,Yunping Mu
Background Measurement of cortisol levels is still a complex multi-step process in immunoassay. The isolation of single-chain variable fragment (scFv) from phage-display library is an effective approach to generate antibody-enzyme fusion protein, which can be used to improve the performance of immunoassay. Results In this work, the specific scFv against cortisol was isolated from native chicken-derived phage display library by the stringent bio-panning strategy. The obtained scFv was further fused with nanoluciferase (Nluc), named scFv-Nluc. Compared with scFv-based enzyme-linked immunosorbent assay (ELISA), the bioluminescent enzyme immunoassay (BLEIA) based on scFv-Nluc was conducted in one-step strategy, which could reduce the assay time. The half maximal inhibitory concentration (IC 50 ) of the one-step BLEIA was calculated to be 203 ng/mL, which was 5-fold lower than the scFv-based ELISA (IC 50 of 1139 ng/mL). When the BLEIA and ELISA are applied to serum samples subjected to 200-fold dilution, the corresponding original-serum equivalent IC 50 values are 41 μg/mL for BLEIA and 228 μg/mL for ELISA, respectively. The established BLEIA exhibited excellent selectivity for cortisol among the analogues, while the satisfactory recoveries between 85.1 % and 120.1 % were obtained. Significance The results above demonstrated that both scFv and scFv-Nluc could be utilized as useful reagents for immunoassay, but the scFv-Nluc-based BLEIA could further enhance the performance of immunoassay, which may represent the promising method for cortisol analysis.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Dan Wu,Yanni Lang,Liang Xu,Qiyuexin Wang,Qiu Fu,Bingli Li,Xinye Zhao,Zhaoyi Yin,Yongjin Li,Dacheng Zhou,Yangke Cun,Zhiguo Song,Yugeng Wen,Yong Yang,Jin Han,Jianbei Qiu
The circular dichroism (CD) signal of D-BiOBr/Bi 0.3 g flipped and intensified. • The nanosheets of D-BiOBr/Bi 0.3 g were arranged in a spiral (counterclockwise) manner, forming petal-shaped nanospheres. • 0.3 g D-BiOBr/Bi exhibits a CO production rate of 84.27 μmol・g −1 h −1 , 3.34 times the value of D-BiOBr and 4.00 times that of 0.3 g pristine BiOBr/Bi sample. • LSPR boosts the migration of spin−down polarized electrons and improves the separation efficiency of photogenerated electron−hole pairs. Chiral inorganic nanomaterials have shown considerable promise in photocatalysis, owing to their distinctive optical activity and asymmetric interfacial effects. Metallic bismuth (Bi) exhibits a localized surface plasmon resonance (LSPR) effect, which markedly enhances both the generation and separation efficiencies of photogenerated electron-hole pairs. By employing D-sorbitol as a chiral inducer, we successfully synthesized chiral D-BiOBr/Bi nanocomposites. We propose that the synergistic integration of metallic Bi and chiral BiOBr enables effective modulation of chirality-induced spin selectivity (CISS), thereby enhancing spin polarization and promoting CO production from CO 2 reduction. Among the prepared samples, D-BiOBr/Bi 0.3 g exhibited the highest photocatalytic CO 2 reduction activity, selectively converting CO 2 to CO. The CO production rate of D-BiOBr/Bi 0.3 g was 84.27 μmol g −1 h −1 , which was 4.00 times and 3.34 times that of BiOBr/Bi 0.3 g and D-BiOBr respectively. Furthermore, magnetic conductive atomic force microscopy (Mc-AFM) measurements revealed that D-BiOBr/Bi 0.3 g generated the strongest tunneling current with an opposite polarity compared to its controls, providing indirect evidence for CISS-associated spin-selective charge transport. Collectively, our findings demonstrate a strong coupling between the LSPR of metallic Bi and structural chirality, which cooperatively boosts spin-polarized electron generation, accelerates electron-hole pair separation, and significantly improves photocatalytic CO 2 reduction performance.
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高影响因子
RARE METALS
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2026
·Vol. 45
·期 8
·e70441
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IF 12.1
Mengya Li,Ruimei Jin,Shengxi Zhou,Jingan Li,Kun Zhang
en This link goes to a English section zh This link goes to a Chinese section Esophageal cancer is the seventh leading cause of cancer death, and the energy depletion in cancer cells can be achieved through synergistic therapy. The integration of sonodynamic therapy and chemotherapy offers a promising comprehensive treatment strategy for esophageal cancer. However, a significant challenge lies in the efficient delivery of sound sensitizers and therapeutic agents. Herein, we present an energy-depleting biomimetic Zeolitic imidazolate framework-8 (ZIF-8) nanoparticle with high encapsulation efficiencies for the sonosensitizer Indocyanine green (ICG) and the chemotherapeutic agent Doxorubicin (DOX). By coating the nanoplatform with esophageal cancer cell membranes, we achieve enhanced homologous targeting to esophageal cancer cells, termed ICG/DOX/ZIF-8@M. In vitro and in vivo experiments demonstrated significant inhibition of tumor growth when treated with ICG/DOX/ZIF-8@M and ultrasonic stimulation. Single-cell RNA sequencing and mechanistic studies further elucidated the downregulation of energy metabolism-related pathways, including glutamine metabolism and glycolysis, which contribute to the enhanced efficacy of the combined therapy. Targeting and energy-depleting biomimetic ICG DOX/ZIF-8@M nanoparticles represent a promising strategy for esophageal cancer therapy. 摘要 en This link goes to a English section zh This link goes to a Chinese section 声动力疗法与化疗协同治疗策略可显著实现肿瘤能量耗竭, 抑制肿瘤生长, 是治疗食管鳞癌的一种前景广阔的策略。然而, 如何实现声敏剂和和化疗药物的高效递送仍然是一个重大挑战。为此, 我们开发了一种能量耗竭型仿生ZIF-8纳米颗粒(ICG/DOX/ZIF-8@M), 对声敏剂吲哚菁绿和化疗药物多柔比星具有极高的包封率, 采用食管癌细胞膜包覆可以通过同源靶向作用实现药物高效递送。体外和体内实验结果表明, ICG/DOX/ZIF-8@M联合超声处理显著抑制肿瘤生长。单细胞RNA测序与分子水平研究表明, ICG/DOX/ZIF-8@M显著下调谷氨酰胺代谢和糖酵解等能量代谢相关通路, 实现肿瘤能量耗竭。综上, 靶向能量耗竭型仿生ICG/DOX/ZIF-8@M纳米颗粒为食管癌治疗提供了一种富有前景的治疗策略。
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高影响因子
ACTA PHARMACOLOGICA SINICA
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2026
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IF 10.4
Yuan Man-man,Zheng Bing-feng,Wang Jing-lin,Xu Shuai-qi,Wang Sheng-lan,Tan Yang,Feng Yong,Dong Xian-chi,Zhu Qi-hua,Yan Jie,Xu Qiang,Wu Xing-xin
Hepatic stellate cells (HSCs) and macrophages are key regulators of liver fibrosis, yet their direct communication during fibrogenesis remains incompletely characterized. We showed that genetic deletion of folate receptor beta ( Folr2 ) significantly attenuated experimental liver fibrosis in mice. In both human and murine fibrotic livers, FOLR2 + macrophages are frequently juxtaposed with activated HSCs. Functionally, FOLR2 expressed by reparative, but not M1 or scar-associated, macrophages promotes HSC activation in a contact-dependent manner. Mechanistically, FOLR2 binds to transforming growth factor beta receptor II (TGFβRII) on HSCs, sustaining transforming growth factor beta 1 (TGF-β1) signaling and driving fibrogenesis. Finally, the natural compound fraxinellone targets FOLR2, disrupts its interaction with TGFβRII, and attenuates HSC activation and liver fibrosis. These findings identify the FOLR2-TGFβRII intercellular interaction as a critical mediator of macrophage-HSC crosstalk and highlight its disruption as a promising therapeutic strategy against liver fibrosis.
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PubMed
高影响因子
BMEMat
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2026
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IF 17.2
Siyu Pan,Xuanyi Lu,Wenjie Yang,Yunhui Peng,Lingfu Deng,Shuai Zha,Xueyang Fang,Guochen Bao,Lijun Jiang
Intratumoral L-lactate represents a valuable biomarker for both prognosis and therapy response, underscoring the importance of its accurate detection. However, traditional L-lactate assays rely on indirect hydrogen peroxide readouts and often compromise the accuracy and specificity. Herein, we report an aptamer-based nanoprobe (UCNP-Apt-Act) that allows direct L-lactate detection. Aptamers offer high specificity for L-lactate but suffer from poor cellular uptake and premature activation by extracellular L-lactate. To overcome this, we introduced lanthanide-doped upconversion nanoparticles (UCNPs) to enable spatially controlled unlocking by near-infrared (NIR) light for intratumoral L-lactate detection. The nanoprobe remains “locked” during delivery via an engineered actuator, preventing premature response to extracellular L-lactate. Upon 980 nm excitation, UCNPs convert NIR to UV emission, photocleaving the actuator linker and unlocking the aptamer. Notably, the UCNP carriers enhanced cellular uptake by 41 times through overcoming membrane barriers. The unlocked nanoprobe shows a 46-fold fluorescence enhancement in the presence of L-lactate, with an exceptional selectivity against a broad range of molecules and biological ions and metabolites. It enables specific detection of L-lactate in cancer cells, colorectal tumors, and diverse real samples, with excellent recoveries of 95.0%–110.0%. This strategy establishes a robust approach for endogenous small-molecule sensing and provides a versatile platform for biomedical applications.
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高影响因子
ACS Applied Materials & Interfaces
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2026
·Vol. 18
·期 30
·40218-40231
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IF 7.8
Xu Tianyu,Zhong Jun,Dai Chengbai,Du Yimin,Lyu Xinzhe,Ma Tian,Zhang Panpan,Zhu Xiaojia,Li Zheng,Quan Cheng,Hu Yuting
Osteoarthritis (OA) is a chronic degenerative disease causing bone and cartilage deterioration, joint deformity, and functional loss. The initiation and progression of OA are primarily driven by oxidative stress and the abnormal activation of the Wnt/β-catenin signaling pathway. This study involved loading Resveratrol (Res) and platinum (Pt) nanozymes, which exhibit superoxide dismutase (SOD) and catalase (CAT), onto a metal-organic framework (MOF) due to its distinctive porosity and high loading capacity. The system was further modified with hyaluronic acid (HA) to synthesize Pt-MOF/Res@HA (PMRH) nanoparticles. The PMRH nanoparticles improve early OA prevention and treatment by concurrently inhibiting the Wnt/β-catenin signaling pathway and eliminating reactive oxygen species (ROS). Experimental results, both in vitro and in vivo, indicate that PMRH nanoparticles efficiently scavenge ROS within the OA microenvironment. The PMRH nanoparticles inhibit the overactive Wnt/β-catenin signaling pathway in chondrocytes affected by osteoarthritis. This dual-target approach, which addresses oxidative stress and inhibits the Wnt/β-catenin signaling pathway, shows promising therapeutic potential for OA.
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高影响因子
Petroleum Science
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2026
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IF 6.4
Jia-Ning He,Yang Bai,Tuo-Ming Zhang,Deng Gu,Rui-Fang Wang
A composite plugging agent, glucose-derived carbon spheres grafted with poly(methyl methacrylate-co-octadecyl methacrylate-co-styrene) (GCS-g-PMOS), was synthesized by grafting an oil-absorbing polymer onto glucose-derived carbon spheres through suspension polymerization for application in oil-based drilling fluids. This material was designed to overcome the limited adaptability of conventional rigid plugging agents by integrating the structural support of carbon spheres with the swelling and filling capabilities of the polymer phase. Response surface methodology was used to optimize the preparation parameters, and the optimum formulation was determined to be 0.75 wt% glucose-derived carbon spheres, 1.5 wt% N , N ′-methylenebisacrylamide, and 2.0 wt% benzoyl peroxide. Under these conditions, the oil absorption capacity reached 9.02 g/g. Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and wettability analyses confirmed successful grafting of the polymer phase and showed that the composite possessed good thermal stability and strong oil affinity. After aging at 160 °C, the addition of 6 wt% GCS-g-PMOS reduced the American Petroleum Institute (API) filtrate loss from 4.4 to 2.4 mL and decreased the filter cake thickness from 2.0 to 0.9 mm. The material also exhibited effective plugging performance in media of different scales and reduced the permeability of the filter cake, with a maximum permeability reduction rate of 63.53%. These results demonstrate that the integration of rigid carbon spheres and an oil-absorbing polymer is beneficial for forming a dense sealing structure and enhancing fluid-loss control in oil-based drilling fluids under high temperature conditions.
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