Nature Communications
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2026
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IF 18.1
Shaojie Chen,Hao Tang,Xiaoliang Fan,Bohan Li,Yaomin Wang,Wei Zhou,Xiaoyu Jiang,Xiaomin Dong,Yanyi Wang,Peng Zhao,Tianwen Ye,Bolin An,Yijun Zheng,Chao Zhong
Bacterial cellulose possesses excellent biocompatibility and mechanical strength but lacks the bioactivity needed for many biomedical and healthcare applications. To address this limitation, we develop a metabolic glycoengineering–click chemistry strategy that enables in situ incorporation of azide groups into bacterial cellulose, followed by mild and selective conjugation of alkyne-bearing functional molecules. This approach avoids harsh chemical treatments, preserves the native properties of bacterial cellulose, and supports stable attachment of diverse bioactive agents, including antibacterial porphyrins, arginine-glycine-aspartic acid peptides, and recombinant proteins with fluorescent or enzymatic functions. As a proof-of-concept, a cascade catalytic system comprising glucose oxidase and superoxide dismutase is immobilized onto azide-modified bacterial cellulose, yielding a multifunctional wound dressing designed to address hyperglycemia and oxidative stress—key barriers to chronic wound healing. In male diabetic mice, this glucose oxidase/superoxide dismutase-integrated bacterial cellulose dressing (low endotoxin <0.1 EU/mL) accelerates wound closure to 92.1% by day 14, significantly outperforming the controls. Our strategy highlights a scalable and bio-orthogonal route for enhancing bacterial cellulose with user-defined bioactivities, thereby expanding its utility in advanced biomaterials development. Bacterial cellulose (BC) possesses excellent biocompatibility and mechanical strength but lacks the bioactivity needed for many biomedical applications. Here the authors use glycoengineering–click chemistry to incorporate azide groups into BC in situ, and show enhanced BC-mediated wound healing.
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高影响因子
Journal of Advanced Research
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2026
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IF 17.1
Weichen Dong,Wenxin Zhang,Li Huang,Lulu Xiao,Yuanfei Luo,Linying Yuan,Yike Jiang,Anyu Liao,Hongting Zhao,Zhihui Liu,Jia Wang,Ying Zhao,Yulong Cai,Mengna Peng,Dong Yang,Yi Xie,Kuanyu Li,Wusheng Zhu
Introduction Cardiolipins (CLs) are mitochondria-specific phospholipids critically involved in neurological disorders. However, their role in cerebral ischemia/reperfusion (I/R) injury remains largely underexplored. Objectives This study aimed to characterize CL alterations following cerebral I/R injury, identify potential mechanisms underlying CL loss, and investigate the pathophysiological effects of these changes. Methods Ischemic stroke was modeled by using middle cerebral occlusion/reperfusion (MCAO/R) in mice and oxygen-glucose deprivation/reoxygenation (OGD/R) in vitro . CL alterations following cerebral I/R injury were evaluated through lipidomic analysis and fluorescent staining. The role of extracellular vesicles (EVs) in CL release was investigated. The effects of CL-targeting peptide SS-31 on CL release and homeostasis were assessed, and underlying mechanisms were explored by analyzing neuronal autophagy and ferroptosis. Plasma CL levels in stroke patients were also measured to elucidate clinical relevance. Results Significant CL depletion and acyl chain remodeling were observed in peri -infarct brain tissues. EV-mediated release was identified as one of the mechanisms of CL loss, and inhibiting EV release restored neuronal CL levels. SS-31 inhibits CL release, preserves CL content, and subsequently restores CL homeostasis. Restoring CL homeostasis attenuated cerebral I/R injury by suppressing neuronal ferroptosis. Mechanistically, SS-31 downregulated autophagy-associated genes, with ATG5 identified as the crucial target. Activating autophagy or overexpressing ATG5 reversed the protective effects of SS-31. Clinically, plasma CL levels in patients undergoing endovascular treatment correlated with 90-day functional outcomes. Conclusion Our findings establish CL preservation as a novel neuroprotective strategy, in which SS-31 mitigates I/R injury by restoring CL homeostasis and ameliorating ATG5-mediated autophagy-dependent neuronal ferroptosis, offering a novel therapeutic avenue for stroke.
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CHINESE JOURNAL OF CHEMICAL ENGINEERING
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2026
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IF 3.5
Minghong Feng,Teng He,Haiqian Zhao,Tao Chen,Wenjing Lin,Chufen Yang
To address the challenges of poor stability and weak targeting capability in polymeric micelles, which negatively impact controlled drug release performance, pH-responsive polymers PCL-PDEAEMA-PHEMA-PPEGMA (P1, P2, and P3) with distinct block lengths were designed and synthesized in this work. These copolymers were rigorously characterized using 1 H NMR, FT-IR, and GPC. Subsequently, polymer P3 was selected for modification based on comparative analyses of critical micelle concentrations (CMC) and drug-loading performance. Polymer P3 underwent esterification with lipoic acid (LA) and folic acid (FA) to yield LA-P3 and FA-P3, respectively. These derivatives were blended at a mass ratio of 1:1 (LA-P3:FA-P3), and dithiothreitol was employed to initiate self-crosslinking, resulting in the preparation of actively targeted crosslinked mixed micelles (C-MIX). The results revealed that C-MIX@PTX drug-loaded micelles prepared at a feeding ratio of 15 mg PTX/30 mg polymer exhibited a smaller size (134.7 nm) compared to non-crosslinked micelles, with a drug-loading content of 15.31 ± 1.79% and an encapsulation efficiency of 38.42 ± 5.22%. In vitro release studies demonstrated that under neutral conditions, C-MIX@PTX achieved a cumulative drug release of 16.8% at 120 h, significantly lower than non-crosslinked micelles. Under acidic/reductive conditions, C-MIX@PTX showed a cumulative drug release of 77.1% at 120 h, slightly lower compared to non-crosslinked micelles. Cytotoxicity assays confirmed that both MIX and C-MIX were biocompatible low-toxicity carrier materials, while LA-P3@PTX, FA-P3@PTX, MIX@PTX, and C-MIX@PTX exhibited inhibitory effects on HepG2 cells, FA-P3@PTX with folate-modified demonstrated enhanced efficacy.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Yulin Jiang,Xiaoqiao Yang,Changshun Xu,Xuetong Liu,Tong Ye,Zheng Xi,Jing Gao,Haihang Ye,Tingrui Pan
The ability to monitor cholesterol in biofluids is essential for health management, including the prevention of chronic diseases. Wearable sweat biosensors offer a noninvasive and continuous means of monitoring disease biomarkers, however, the inherently low cholesterol concentration in sweat poses a significant challenge for sensitive detection. In this study, a wearable cholesterol biosensor combining cholesterol oxidase with Pd Ir nanozymes as a cascade sensing unit was developed for continuous monitoring of cholesterol in sweat. The Pd Ir nanozyme, synthesized via seed-mediated growth and selective etching, has a unique icosahedral hollow cage structure and exhibits peroxidase-mimicking activity with catalytic efficiency much higher than its core-shell and natural counterparts. A detection limit of 0.22 μM with a dynamic range of 0–15.5 μM was achieved by the developed cholesterol biosensor in artificial sweat, covering the physiological range in human sweat. Furthermore, the integrated device was validated through volunteer testing after dietary cholesterol intake and exercise, confirming its effectiveness for real-time, dynamic monitoring of sweat cholesterol during daily activities. The wearable sensing strategy based on coupling the nanozyme and enzymes holds great promise for noninvasive and sensitive lipid monitoring and personalized health management across a range of physiological and pathological conditions.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Weidong Li,Hanwen Ge,Sen Ma,Lei Liu,Lin Luo,Zihao Qin,Aiyong He,Chao Wang,Xianhai Zeng
This study developed a technology for pretreating bamboo biomass using a synergistic system of 4-hydroxybenzoic acid (4-HA) and formic acid (FA). By optimizing reaction temperature, reaction time, and acid concentration parameters, the bamboo hemicellulose removal yield of 99.53% was achieved, whilst glucose and lignin removal yield were only 9.28% and 9.69%, respectively. Characterization results indicated that the surface morphology of the pretreated solid residue exhibited disordered features, with significantly enhanced crystallinity and thermal stability. Subsequent experiments with model lignin compounds confirmed that 4-HA addition effectively inhibited lignin degradation. Nuclear magnetic resonance (NMR) analysis indicated reductions in S and G units alongside an increase in H units. Combining density functional theory (DFT) calculations with molecular dynamics simulations (MDS) elucidated the synergistic mechanism of 4-HA and FA in hemicellulose removal and lignin depolymerization inhibition. Enzymatic hydrolysis achieved separation of the three major components. This strategy offered novel insights for precise hemicellulose removal during biorefinery.
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Nutrients
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2026
·Vol. 18
·期 6
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IF 5.8
Warren Chanda,He Jiang,Shuang-Jiang Liu
Background/Objectives: Cholesterol is an essential lipid required for membrane structure and normal physiological functions. However, dysregulation of cholesterol homeostasis, manifesting as hypercholesterolemia, can precipitate a range of metabolic and cardiovascular diseases.Blautiaspecies are important gut commensals, but their role in cholesterol metabolism remains poorly defined.Methods: A total of 63Blautiastrains isolated from human fecal samples were screened for cholesterol conversion using the o-phthalaldehyde colorimetric assay in cholesterol-containing media with or without oxgall. Cholesterol removal by live and heat-inactivated cells was compared. Metabolomic, transcriptomic, and proteomic analyses were employed to investigate molecular mechanisms and involved genes.Results: Nine strains significantly lowered cholesterol levels (live cells: 31–78%; heat-inactivated cells: 8–64%), with theB. hominisstrain HA2291, theBlautiasp. strain HA3515, and theB. coccoidesstrain HA4419 showing the strongest activity. Oxgall increased cholesterol removal by live cells to 74–83%, indicating bile-tolerant metabolism activity. Metabolomic profiling revealed thatB. hominisHA2291 transformed cholesterol into cholest-4-en-3-one and epicholestanol. An SCP2-like protein, RS03310, was identified as a candidate cholesterol-interacting factor; its recombinant form catalyzed measurable NAD+-dependent cholesterol oxidation in vitro.Conclusions:Blautia hominisHA2291 may employ multiple in vitro strategies for cholesterol-lowering, including cell-surface adsorption (heat-inactivated cells), bile-enhanced removal (oxgall effect), and enzymatic transformation, with the gene RS03310 implicated as the main contributor. These findings provide in vitro mechanistic insights intoBlautia-mediated cholesterol metabolism, highlight RS03310 as a candidate gene associated with cholesterol biotransformation, and advance our understanding of the potential role ofBlautiain host cholesterol homeostasis.
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Gels
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2026
·Vol. 12
·期 3
·221
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IF 6.4
Huixiang Wang,Kaiquan Zhang,Ya Lu
Flexible supercapacitors have attracted significant attention as promising power sources for portable and wearable electronic devices. However, achieving simultaneous high power density, energy density and long-term cyclic stability in a simple device configuration remains a critical challenge. Herein, we report an all-solid-state flexible planar supercapacitor based on hierarchically structured cellulose nanofiber-carbon nanotube@manganese dioxide (CNF-CNT@MnO2) composite aerogels. The electrode architecture is rationally designed by first dispersing CNTs within a hydrophilic CNF scaffold to form a conductive three-dimensional network, followed by in situ oxidative polymerization of MnO2onto the CNF-CNT fibrous skeleton. The hydrophilic CNFs network ensures thorough electrolyte penetration, the interconnected CNTs facilitate rapid electron transport, and the uniformly coated MnO2layer provides substantial pseudocapacitance. The aerogel electrode with a low density of 14.6 mg cm−3and a high specific surface area of 214.4 m2g−1delivers a specific capacitance of 273.0 F g−1at 0.4 A g−1. The assembled planar supercapacitor, incorporating gel electrolyte and a flexible hydrogel substrate, achieves an impressive areal capacitance of 885.0 mF cm−2at 2 mA cm−2, energy density of 122.9 μWh cm−2and corresponding power density of 1000.0 μW cm−2. The device exhibits excellent electrochemical stability, retaining 83.3% capacitance after 2500 charge–discharge cycles, and outstanding mechanical flexibility, with 96.3% capacitance retention after 200 repeated bending cycles. Furthermore, multiple devices can be connected in series or parallel to proportionally increase output voltage or current, meeting the practical power requirements of electronic applications. This work offers a viable pathway toward high-performance, durable energy storage solutions for next-generation wearable electronics.
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ADVANCED FUNCTIONAL MATERIALS
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2026
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IF 19.9
Jiahui Song,Yutao Ni,Chaoqi Han,Huiying Lan,Xue Jing,Mengxue Huang,Lifang Chen,Qi Wang,Wenwen Shi,Ruimin Ding,Xi Yin
Rational carbon support engineering is a critical yet underexplored strategy for modulating the activity and durability of Pt-based oxygen reduction reaction (ORR) electrocatalysts in proton exchange membrane fuel cells (PEMFCs). Here, we show that dual-atom-site-rich carbon supports constitute an unique and highly promising architecture, playing a decisive role in electronic metal-support interactions (EMSI) and catalyst stability. Comparing single-atom-site-rich (M-NC, M = Co or Fe) and dual-atom-site-rich (CoFe-NC) supports for PtZn intermetallic nanoparticles (iNPs) reveals that conventional M-NC suffers from metal leaching, whereas cooperative CoFe-N 8 sites remain intact, enabling strong and persistent EMSI. Density functional theory (DFT) calculations reveal that the dual-atom-site configuration promotes electron donation to Pt, downshifts the Pt d -band center, reduces the kinetic barrier for the final * OH desorption step, and reinforcing nanoparticle anchoring, collectively enhancing ORR activity and stability. Consequently, PtZn@CoFe-NC catalyst achieves a mass activity of 1.93 A mg Pt −1 at 0.9 V vs. RHE in rotating disc electrode (RDE) tests. Membrane electrode assembly (MEA) delivers peak power density 2.18 W cm −2 (H 2 ─O 2 ), retaining ∼95% performance after 30k cycles accelerated stress test (AST). This work highlights that dual-atom-site-rich support engineering can serve as an effective approach to enhance performance of PtZn catalysts.
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Advanced Materials Technologies
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2026
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IF 6
Rui Dai,Jiapeng Zheng,Hui Yang,Xi Chen
Two-terminal optoelectronic synapses have garnered great attention in neuromorphic computing due to their advantages in structural simplicity and energy efficiency. However, the device's operational flexibility is fundamentally limited by its spectral and electrical characteristics, which fail to tune photoresponses with wavelength selectivity and voltage modulation. Here, a MoS 2 /Au nanoparticle two-terminal optoelectronic synapse is presented that simultaneously achieves wavelength selectivity and voltage-modulated memory control. Adjusting the morphology of Au nanoparticles enables selective maximum photoresponses across the green and red wavelength regions, and voltage modulation induces switching between short-term and long-term memory states, thereby enhancing functional versatility. Based on this tunable photoresponse of the synapse, wavelength-selective image denoising and recognition tasks are demonstrated, achieving a maximum classification accuracy of 98.03% at 520 nm across the visible wavelength range. A wavelength-selective and voltage-modulated task for road condition classification is also implemented, incorporating an artificial neural network to track color-coded vehicles and classify their movement trajectories with precise directional recognition (96.67% accuracy). This work demonstrates a highly tunable optoelectronic synapse that achieves concurrent wavelength selectivity and voltage modulation in a single device, enabling neuromorphic computing and providing a practical strategy for developing highly efficient, multifunctional neuromorphic architectures.
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Advanced Science
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2026
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IF 14.1
Xiaokai Li,Yonghui Zhang,Yongxin Li,Jiahao Zhang,Yuheng Li,Zhengyu Li,Jianwu Wang,Yaochen Lv,Yanan Wang,Jiyu Liu,Xin Liu,Huanxi Zheng
Underwater smart adhesives with switchable adhesion have attracted significant attention for applications in marine engineering and biomedical fields. However, achieving both robust adhesion and rapid on-demand detachment in aquatic environments remains a critical challenge. Inspired by the diving bell spider, we propose a design strategy based on heterogeneous wettability surfaces to achieve switchable adhesion between two surfaces. The heterogeneous wettability surface design confines the oil phase within air cavities formed in superhydrophobic (lipophilic) regions, thereby creating annular oil rings, which establish stable oil/water interfaces that spatially isolate the internal water bridge from the external aquatic environment. The Laplace pressure difference generated at the oil/water interfaces induces robust adhesion between surfaces. In addition, the adhesion strength can be linearly enhanced by constructing multiple, uniformly arranged oil/water interfaces. Rapid on-demand separation can also be achieved through controlled electrolysis of the internal water bridge by applying voltage between the surfaces. Finally, we demonstrate the practical applicability of this adhesive by integrating it into an unmanned underwater vehicle (UUV) for efficient underwater anchoring and ship-hull hitchhiking, highlighting its broad application potential in underwater engineering scenarios.
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WATER SCIENCE AND TECHNOLOGY
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2026
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IF 2.8
Wu Wei,Ma Xiaoqian,Wang Rui,Hao Mengqi
View large Download slide View large Download slide Close modal This paper delves into the impact of electrostatic interaction and wettability of MNPs on the efficiency of demulsifiers. Fe 3 O 4 magnetic nanocomposites (Fe 3 O 4 /HA/PDDA/OLA MNPs, S1–S5) were synthesized with varying wettability and zeta potential by adjusting the surface modification ratio of poly-dimethyl-diallyl-ammonium chloride (PDDA) and oleylamine (OLA). S1–S5 were then used to demulsify O/W (hexadecane) nanoemulsions. The oil/water separation efficiency (SE) initially increased (S1–S4) and then decreased (S4–S5) with their increasing water contact angles (WCA). S4 with a WCA about 90° exhibited the maximum SE, although S4 has a negative charge and shows electrostatic repulsion with oil droplets, indicating that the wettability of MNPs, rather than electrostatic interaction, played a dominant role in demulsification. Adsorption energy of S1–S5 at the water–oil interface aligned with the variation in their demulsification efficiency. Based on previous reports, a possible demulsification mechanism was proposed. Hydrogen bond and hydrophobic long chains present in PDDA and OLA increased the interfacial activity of S4, which facilitated the spontaneous migration of MNPs to the interface of oil and water. With oil droplet aggregation by magnetic recovery, a good oil–water separation performance was achieved. The study provides a theoretical foundation for the design and synthesis of magnetic demulsifiers. Wettability of MNPs plays a crucial role in demulsification performance. Surface charge of MNPs shows less function than wettability. MNPs with a WCA of approximately 90° showed the maximum demulsification efficiency. The study provides a theoretical foundation for the design and synthesis of magnetic demulsifiers.
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ACS Applied Electronic Materials
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2026
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IF 4.7
Qinghu Guo,Ting Wang,Mengchen Yao,Shangshu Li,Yiren Liu,Weiping Gong,Hua Hao
The demand for advanced microwave dielectric ceramics for 5G base station filters drives the need for materials combining moderate permittivity, high quality factor (Q × f), and near-zero temperature stability (τf). This work investigates Ga2O3-doped SrTiO3–NdAlO3 (ST-NA) ceramics. The optimal base composition (0.5ST-0.5NA) achieves εr = 40.2, Q × f = 12,729 GHz, τf = 5.89 ppm/°C. To further enhance the microwave dielectric performance, Ga2O3 doping was introduced into the ST-NA ceramics. The substitution of Ga3+ for Ti4+ not only induces associated oxygen vacancy formation but also effectively suppressed the reduction of Ti4+ to Ti3+ during sintering, thereby reducing conduction loss, while the dielectric constant remained relatively stable. Consequently, 1.5% Ga2O3-doped ST-NA ceramic exhibited excellent overall microwave dielectric properties, with εr = 40.7, Q × f = 21,441 GHz, τf = 1.78 ppm/°C. These results demonstrate that Ga2O3-doped ST-NA ceramics are promising candidates for temperature-stable, low-loss microwave components in 5G and other high-frequency communication systems.
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