RSC Advances
·
2011
·Vol. 1
·期 7
·1220-1227
·
IF 0
Chang-Dong Gu,Jiang-Ping Tu
Novel non-aqueous thermochromic solutions were facilely prepared by dissolving transition metal chlorides, such as NiCl2·6H2O, CrCl3·6H2O, FeCl3, and CoCl2·6H2O, in an inexpensive, widely available ionic liquid analogous deep eutectic solvent (DES). It was found that only the NiCl2·6H2O dissolved choline chloride-based DES exhibited a stable and significant thermochromic behavior over a wide working temperature ranging from room temperature to about 150 °C. Typically, the colour of the 0.1 M NiCl2·6H2O dissolved DES solution changed in this order from pale green (room temperature), spring green (∼70 °C), to blue (∼120 °C). An effective strategy was proposed to produce more thermochromic solutions by mixing Ni(II) with other metal ions in the choline chloride-based DES. The thermochromic PVDF composite film was demonstrated by incorporating DES-based Ni(II) solution into the microporous PVDF film. The preliminary results are expected to stimulate interest of the development of high performance thermochromic materials for the facile fabrications from DESs.
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AAPS PHARMSCITECH
·
2016
·Vol. 18
·期 3
·586-594
·
IF 1.954
Wang Yuanwen,Wang Shicheng,Firempong Caleb Kesse,Zhang Huiyun,Wang Miaomiao,Zhang Ya,Zhu Yuan,Yu Jiangnan,Xu Ximing
This study was aimed at preparing orally administered naringenin-loaded liposome for pharmacokinetic and tissue distribution studies in animal models. The liposomal system, consisting of phospholipid, cholesterol, sodium cholate, and isopropyl myristate, was prepared using the thin-film hydration method. Physicochemical characterization of naringenin-loaded liposome such as particle size, zeta potential, and encapsulation efficiency produced 70.53 ± 1.71 nm, −37.4 ± 7.3 mV, and 72.2 ± 0.8%, respectively. The in vitro release profile of naringenin from the formulation in three different media (HCl solution, pH 1.2; acetate buffer solution, pH 4.5; phosphate buffer solution, pH 6.8) was significantly higher than the free drug. The in vivo studies also revealed an increase in AUC of the naringenin-loaded liposome from 16648.48 to 223754.0 ng·mL −1 h as compared with the free naringenin. Thus, approximately 13.44-fold increase in relative bioavailability was observed in mice after oral administration. The tissue distribution further showed that the formulation was very predominant in the liver. These findings therefore indicated that the liposomal formulation significantly improved the solubility and oral bioavailability of naringenin, thus leading to wider clinical applications.
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MOLECULES
·
2019
·Vol. 24
·期 10
·1893
·
IF 3.06
Jia-Li Yan,Gang-Qin Shao,Shu-Hao Fan,Can Zhu,Yong Zhang,Jun Wang,Qi Liu
Solid-solution Li-ion cathode materials transform through a single-phase reaction thus leading to a long-term structural stability and improved cyclability. In this work, a two- to single-phase Li+-extraction/insertion mechanism is studied through tuning the stoichiometry of transition-metal Fe/V cations to trigger a transition in the chemical reactivity path. Tavorite triclinic-structured LiFe1−xVxPO4F (x= 0, 0.1, 0.3, 0.5, 0.7, 0.9, 1) solid-solution powders were prepared by a facile one-step solid-state method from hydrothermal-synthesized and commercial raw materials. The broad shape of cyclic voltammetry (CV) peaks, sloping charge/discharge profiles and sloping open-circuit voltage (OCV) profiles were observed in LiFe1−xVxPO4F solid-solution cathodes while 0
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JOURNAL OF HAZARDOUS MATERIALS
·
2019
·
IF 7.65
Chaolei Yuan,Fangbai Li,Wenhua Cao,Zi Yang,Min Hu,Weimin Sun
We successfully accounted for the dynamics of cadmium (Cd) solubility in paddy soil that contained a realistically low total Cd concentration (0.36 mg kg −1 ) after submergence and redrying by monitoring multiple chemical and microbial soil properties. The addition of rice straw promoted greater microbial iron reduction and induced a greater increase in soil pH after submergence, compared to the control and treatments with added gypsum or hematite. Consequently, dissolved Cd decreased to under the detection limit in one week in the straw-amended treatment but remained high even after eight weeks in the other three treatments. The Cd solubility strongly correlated with soil pH and was unlikely to decrease due to Cd precipitation in secondary iron minerals. After five weeks of redrying, the dissolved Cd content was still the lowest, and the putative iron-reducing bacteria Geobacter remained the most abundant in the straw-amended soil. The results suggest that the addition of organic matter can efficiently immobilize soil Cd at an environmentally realistic concentration by stimulating the microbial reduction of native oxidized soil components after submergence, while adding extra iron oxide or sulfate alone is not effective because it does not eliminate the limitation imposed by electron donors on microbial reduction.
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高影响因子
Frontiers in Psychiatry
·
2024
·
IF 3.2
Gu Tengyu,Dong Jing,Ge Jing,Feng Jialu,Liu Xiaoliu,Chen Yun,Liu Jianfeng
The claustrum (CLA), a subcortical area between the insular cortex and striatum, innervates almost all cortical regions of the mammalian brain. There is growing evidence that CLA participates in many brain functions, including memory, cognition, and stress response. It is proposed that dysfunction or malfunction of the CLA might be the pathology of some brain diseases, including stress-induced depression and anxiety. However, the role of the CLA in fear memory and anxiety disorders remains largely understudied. Here, we evaluated the influences of neurotoxic lesions of the CLA on auditory-cued fear memory and anxiety-like behaviors in rats.We found that lesions of anterior CLA (aCLA) but not posterior CLA (pCLA) before fear conditioning attenuated fear retrieval, facilitated extinction, and reduced freezing levels during the extinction retention test. Post-learning lesions of aCLA but not pCLA facilitated fear extinction and attenuated freezing behavior during the extinction retention test. Lesions of aCLA or pCLA did not affect anxiety-like behaviors evaluated by the open field test and elevated plus-maze test.These data suggested that aCLA but not pCLA was involved in fear memory and extinction.Future studies are needed to further investigate the anatomical and functional connections of aCLA subareas that are involved in fear conditioning, which will deepen our understanding of CLA functions.
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2019
·
IF 14.229
Bingbing Hu,Maocong Hu,Qiang Guo,Kang Wang,Xitao Wang
In this work, a series of In(OH) 3 with abundant indium vacancies were synthesized by hydrothermal method using mixed solvent of ethylenediamine(En) and water for photocatalytic reduction of CO 2 with H 2 O vapor. The morphology, particle size, crystallinity, pore structure, and vacancy concentration of photocatalysts were successfully regulated by adjusting the ratio of En and water in mixed solvent, which were characterized by XRD, FT-IR, TG-DTA, SEM, HRTEM, UV–vis DRS, PL spectra, XPS, and EPR. Moreover, the effect of En/water ratio on the adsorption capacity to CO 2 and photo-electrical properties of In(OH) 3 were further investigated by in-situ FTIR, PL spectra, UV–vis DRS, CV, and EIS. In(OH) 3 prepared in mixed solution exhibited much higher photocatalytic activity for CO 2 reduction with H 2 O vapor compared to that prepared with water only solvent. The enhanced photocatalytic performance can be attributed to the special morphology, smaller particle size, larger BET surface area, and especially generated indium vacancies creating defect energy levels in the bandgap, which improved visible light absorption, carrier separation, and CO 2 chemisorption. This work paves the way to enable a non-visible-light response material with high visible-light photocatalytic activity by regulating vacancy concentration via a facile method.
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Frontiers in Chemistry
·
2022
·
IF 5.545
Tian Xiaoran,Yu Qian,Kong Xianming,Zhang Miao
The colloidal polystyrene (PS) was synthesized and decorated with silver nanoparticles (Ag NPs). The plasmonic Ag@PS nanocomposite was prepared by loading Ag NPs on PS microsphere through a seed-mediated in situ growth route. The property of Ag NPs deposited on the PS microsphere could be precisely controlled by adjusting the concentration of the chemicals used in the growth medium. The growth step is only limited by the diffusion of growing species in the growth media to the surface of the Ag seed. The Ag@PS prepared via the in situ growth method exhibited two advantages compared with the self-assembled PS/Ag. First, the high-density of Ag NPs were successfully deposited on the surface of PS as the electroless-deposited Ag seed process, which brings nearly three times SERS enhancement. Second, the rapid preparation process for in situ growth method (half an hour, 10 h for the self-assembled method). The PS/Ag could detect Nile blue A (NBA) down to 10–7 M by SERS. Furthermore, the plasmonic Ag@PS SERS substrate was used for pesticide identification. The on-site monitoring malachite green (MG) from fish was achieved by portable Raman spectrometer, and the limit of detection (LOD) was 0.02 ppm. The Ag@PS substrate has also shown capability for simultaneously sensing multiple pesticides by SERS.
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PubMed
高影响因子
Current Drug Delivery
·
2024
·
IF 2.8
Liu JiaYan,Guo Song,Hong Shuai,Piao Jingshu,Piao Mingguan
Background: Linagliptin (LNG) exhibits poor bioavailability and numerous side effects,
significantly limiting its use. Transdermal drug delivery systems (TDDS) offer a potential solution to
overcome the first-pass effect and gastrointestinal reactions associated with oral formulations.
Objective: The aim of this study was to develop LNG microparticle gels to enhance drug bioavailability
and mitigate side effects.
Methods: Linagliptin hyaluronic acid (LNG-HA) microparticles were prepared by spray drying
method and their formulation was optimized via a one-factor method. The solubility and release were
investigated using the slurry method. LNG-HA microparticle gels were prepared and optimised using
in vitro transdermal permeation assay. The hypoglycaemic effect of the LNG-HA microparticle gel
was examined on diabetic mice.
Results: The results indicated that the LNG-HA microparticle encapsulation rate was 84.46%. Carbomer
was selected as the gel matrix for the microparticle gels. Compared to the oral API, the microparticle
gel formulation demonstrated a distinct biphasic release pattern. In the first 30 minutes,
only 43.56% of the drug was released, followed by a gradual release. This indicates that the formulation
achieved a slow-release effect from a dual reservoir system. Furthermore, pharmacodynamic
studies revealed a sustained hypoglycemic effect lasting for 48 hours with the LNG microparticle gel
formulation.
Conclusion: These findings signify that the LNG microparticle gel holds significant clinical value
for providing sustained release and justifies its practical application.
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PubMed
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2022
·
IF 7.139
Wenhui Zou,Yingcen Liu,Caicheng Song,Hua Lin,He Huang,Wanyue Ye,Rongwen Lu,Shufen Zhang
A series of PdO@MCM-41-x was in situ synthesized by a facile one-pot method, and their catalytic performance for dehydrogenation of formic acid was investigated. The PdO nanoparticles were immobilized in MCM-41 channel with small size of 2.2–2.5 nm due to the confinement of mesoporous silica . The initial turnover frequency (TOF) of as-prepared catalyst can reach 1096 h −1 at 323 K with 100% hydrogen selectivity. The hydrogen production activity was better than that of catalyst priorly reduced by hydrogen because of the gradual reduction of PdO nanoparticles and generation of fresh Pd(0) during the formic acid dehydrogenation process, which was confirmed by XPS characterization and catalytic system monitoring. It provides a new way for the preparation of simple and efficient catalysts for hydrogen production , which has great application potential.
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HYDROMETALLURGY
·
2021
·
IF 4.156
Xiaocong Zhong,Zhencong Lin,Chen Chen,Ruixiang Wang,Shuiping Zhong,Zhifeng Xu
The nonferrous metal electrowinning process is energy intensive due to the sluggish dynamics of the oxygen evolution reaction (OER) on the anode. Developing novel anode materials with high OER activity and stability is imperative. Herein, we propose a novel Pb-ceramic composite anode by introducing ZnFe 2 O 4 . In this work, Pb-ZnFe 2 O 4 and PS-Pb anodes were prepared through powder pressing and sintering processes. The effects of ZnFe 2 O 4 particles on the phase composition, surface morphology and inner structure of the oxide layer formed on Pb-ZnFe 2 O 4 anodes were investigated. Furthermore, the role of ZnFe 2 O 4 in the anodic potential and stability of Pb-ZnFe 2 O 4 anodes was discussed. The results show that as the ZnFe 2 O 4 content increases, the oxide layer formed on Pb-ZnFe 2 O 4 anodes exhibits higher surficial compactness, higher integrity, and much smaller thickness. ZnFe 2 O 4 exhibits a trivial impact on the oxygen evolution dynamics. However, the anodic potential of the Pb-ZnFe 2 O 4 anode declines as the ZnFe 2 O 4 content increases, which could be attributed to the higher compactness and smaller thickness of the oxide layer. As the ZnFe 2 O 4 content increases, the weight loss of the Pb-ZnFe 2 O 4 composite anode increases, suggesting the unsatisfactory stability of Pb-ZnFe 2 O 4 , which could be attributed to the inevitable dissolution of ZnFe 2 O 4 particles, smaller thickness of the oxide layer and larger porosity of the substrate. Although Pb-ZnFe 2 O 4 composite anodes have the potential to reduce energy consumption, their unsatisfactory stability limits the feasibility of Pb-ZnFe 2 O 4 anodes in the electrowinning industry.
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高影响因子
PROGRESS IN ORGANIC COATINGS
·
2022
·
IF 6.206
Jingxia Yang,Bingjie Zou,Qing Fang,Jinjie Wang,Lidong Wang
To figure out the behavior of benzotriazole (BTA) loaded in CeO 2 nanocontainers during long term anticorrosion, three kinds of CeO 2 spheres were used: hollow spheres ( HS s), double-shell hollow spheres ( DHS s), and solid-mesoporous spheres ( SS s). The BTA loading and releasing situations were checked, and CeO 2 - HS s exhibited the largest BTA loading amount of 12.5 wt%, forming by both chemical and physical adsorption. The highest BTA loading in CeO 2 - HS s may be attributed to its hollow structure and more Ce 3+ sites (39 %) for BTA anchoring. Thus, CeO 2 - HS s@BTA exhibited an excellent long-term anticorrosion in epoxy coating for low carbon steel protection, showing no rusting after 40 days of salt spray experiment.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Qinglin Lu,Hao Zhang,Jinrui Du,Jiachen Huang,Rong Fan,Weiqing Zhou,Xiangming Na,Caiyun Wang,Yinhua Wan,Jianquan Luo
Protein-based therapeutics, including monoclonal antibodies, enzymes, and cytokines, often require concentration to achieve clinical efficacy, improve stability and administration efficiency. Ultrafiltration (UF) is the mainstream technique for protein concentration, but its efficiency remains limited by severe flux decline and protein loss. This study demonstrates that, during the re-concentration process, fouling resistance arising from severe concentration polarization and cake layer formation, rather than the intrinsic membrane resistance, is the primary determinant of filtration flux. To alleviate this resistance, nano-protrusion arrays are patterned on the UF membrane via co-assembly of glutaraldehyde (GA) and hydroxypropyl cellulose (HPC), which act as a turbulence promoter to enhance localized shear forces while minimizing mechanical damage to proteins in the bulk solution. This approach effectively inhibits the formation of the cake layer and alleviated concentration polarization during protein concentration. Compared to the pristine membrane, the as-prepared membrane exhibits great anti-fouling performance with a 40.5 % increase in average permeate flux and a 57.0 % reduction in permeability decline after protein concentration. This work proposes an insightful approach to protein concentration and designing an anti-fouling UF membrane with a gentler filtration process, which holds promise for reducing protein denaturation and minimizing energy consumption by mitigating bulk turbulence.
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