Colloid and Interface Science Communications
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2022
·
IF 5.633
Tiantang Fan,Yujue Zhang,Xiao Meng,Yangcui Qu,Ying Wang,Qing Liu,Guannan Wang
Biocompatible porous scaffolds with adjustable degradation rate and mechanical properties have attracted increasing interest in tissue engineering. 3D printing technology is an effective method for the rapid preparation of bone tissue engineering scaffolds. In this study, bone conductive poly( l -lactide- ran -p-dioxanone- ran -glycolide) (PLPG)/nano-hydroxyapatite (nHAP) (P/H) composites are prepared by solution blending method, which are used to fabricate P/H scaffolds by 3D printing technology. The physicochemical properties of the P/H composites are examined by DSC, XRD, and contact angle goniometry. Furthermore, the surface morphology, mechanical properties, biodegradation ability, and in vitro biocompatibility of the P/H scaffolds are investigated. The results indicate the PLPG copolymers have a highly printability with nHAP, and the mechanical and biodegradation properties of the P/H scaffolds can be tuned by adjusting the ratio of PLPG and nHAP. The in vitro biological experiments show that the P/H scaffolds are excellent substrates for the adhesion, growth, and proliferation of MC3T3-E1.
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ADVANCED ENGINEERING MATERIALS
·
2023
·Vol. 26
·期 2
·2301381
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IF 3.6
Wenqiang Guo,Beibei Zhou,Yulong Zou,Xili Lu
Near-infrared (NIR) light-responsive shape-memory polymers have drawn increasing attention because NIR light is safe and easy to perform in biological applications. Herein, a novel NIR light-responsive shape-memory polymer composite is developed, which comprises poly( l -lactide) (PLLA) matrix and surface-modified magnesium oxide (MgO) nanoparticles by ferric chloride (FeCl 3 ) and tannic acid (TA) (FeCl 3 –TA/MgO). This design can fully combine the printability and shape-memory effect of PLLA, the excellent bioactivity, and the outstanding photothermal effect of MgO nanoparticles modified by FeCl 3 –TA. The PLLA/(FeCl 3 –TA/MgO) composite scaffolds with a homogeneously porous structure are further fabricated by 4D printing. The synergetic presence of components and fabrication process can endow the prepared composite scaffolds with enhanced mechanical properties and stable NIR light-induced shape-memory effect, as well as antibacterial and antioxidant properties. With 5 wt% FeCl 3 –TA/MgO particles, the scaffold not only has a compress modulus of 0.93 MPa, which is 4 times that of a pristine PLLA scaffold, but also achieves a shape fixation ratio of 95.7% and a shape recovery ratio of 80.9% under NIR light irradiation at 2 w cm −2 . The PLLA/(FeCl 3 –TA/MgO) composites have great potential for application in the field of bone tissue engineering scaffolds.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2014
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IF 2.235
Peng Xie,Xuan Liu,Ru Cheng,Youping Wu,Jianping Deng
Both chiral hydrogels and pH-sensitive hydrogels have received considerable attention in recent years. In the present study, we combined the two intriguing concepts, i.e., chirality and pH sensitivity, in one single hydrogel. Such hydrogels were prepared via free radical copolymerization using chiral N-acryloyl-l-alanine (NAA) as monomer, the inclusion complex of glycidyl methacrylate (GMA) and hydroxypropyl-β-cyclodextrin (HP-β-CD) as comonomer, N,N′-methylenebis(acrylamide) as cross-linking agent, and K2S2O8 as initiator. The hydrogels were successfully obtained and exhibited remarkable swelling in water and pH responsivity. The hydrogels were characterized by circular dichroism and UV–vis absorption spectroscopies, demonstrating the optical activity of the hydrogels. The hydrogels performed chiral recognition and enantiodifferentiating release abilities toward proline enantiomers, in which l-proline was preferentially adsorbed whereas d-proline was preferentially released. The present study established a platform for preparing versatile, in particular, optically active hydrogels. Noticeably, the hydrogels are expected to find practical applications as novel materials for chiral drugs delivery.
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Environmental Science and Ecotechnology
·
2024
·
IF 14
Chang Liu,Lin Li,Linji Xu,Tanglong Zhang,Qiang He,Xiaodong Xin
N,N bis(carboxymethyl)- l -glutamate (GLDA) is an eco-friendly chelating agent that effectively extracts multivalent metal ions from waste activated sludge (WAS) flocs, which could potentially alter their structure. However, the effect of GLDA on the production of volatile fatty acids (VFAs) from WAS is not well known. Here, we demonstrate that pretreatment with GLDA at a concentration of 200 mmol per kg VSS results in a significant increase of 142 % in extractable extracellular polymeric substances and enhances the total VFAs yield by 64 % compared to untreated samples. We reveal GLDA's capability to mobilize organic-binding multivalent metal ions within sludge flocs. Specifically, post-pretreatment analyses showed the release of 69.1 mg L −1 of Ca and 109.8 mg L −1 of Fe ions from the flocs, leading to a more relaxed floc structure and a reduced apparent activation energy (10.6 versus 20 kJ mol −1 ) for WAS solubilization. Molecular dynamic simulations further demonstrate GLDA's preferential binding to Fe 3+ and Ca 2+ over Mg 2+ . Our study suggests that GLDA pretreatment causes minimal disruption to reactor stability, thereby indicating the stability of microbial community composition. GLDA has emerged as a viable pretreatment agent for enhancing volatile fatty acids production from waste activated sludge.
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Journal of Materials Chemistry B
·
2025
·
IF 5.7
Lunjie Zhao,Jianyou Xia,Congcong Yang,Jianping Tao,Shanfu Zhang,Wentao Hu,Chen Zhang,Jiuwu Zhang,Qiang Li,Yujie Xu
When the bladder is affected by factors such as tumors, tuberculosis, and trauma, its normal structure and function will be damaged inescapably. At this point, bladder replacement or enlargement surgery becomes necessary to restore its structure and improve the patient's quality of life. Traditional bladder reconstruction surgery, specifically ileum augmentation cystoplasty, has a complex surgical process, along with relatively large operative wounds and intestinal obstruction complications. There is an urgent need for bladder replacement material. Over the past decade, synthetic bladder scaffolds have emerged as alternatives; however, most fail to simultaneously address postoperative fibrosis and bacterial infection. To overcome these challenges, we developed an electrospinning poly (L-lactic acid)/gelatin (PLLA/GEL) microfiber membrane loaded with mitomycin C (MMC). By optimizing the PLLA/GEL ratio (7:3), the membrane had both good rigidity and excellent elasticity. The MMC-loaded fibers demonstrated sustained drug release, effectively inhibiting E. coli and S. aureus in vitro. In rat partial cystectomy models, the PLLA/GEL/MMC group showed reducing collagen III deposition through TGF-β/Smad2 pathway inhibition, enhancing urothelium regeneration and promoting angiogenesis. Notably, the membrane-maintained cell viability for both urothelial cells and smooth muscle cells over 7 days, confirming biocompatibility. These findings highlight a promising potential of the PLLA/GEL/MMC microfiber membrane not only as a material for bladder tissue engineering but also as a tool for therapeutic intervention that addresses multiple facets of bladder healing and regeneration.
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Food Bioscience
·
2025
·
IF 5.9
Chunying Li,Jiahui Gong,Mengfei Tian,Hongying Ge,Xiaofei Xie,Qi Liang,Ying Yang,Chunjian Zhao,Ying Liu
The typical phytochemical emodin (ED) found in Rumex acetosa L. is extensively utilized in traditional medicine and demonstrates substantial pharmacological effects. However, Rumex acetosa L. is frequently regarded as a weed and discarded, leading to the underutilization of this valuable resource. In this work, a polydopamine molecularly imprinted resin (PDA@MIR) was successfully synthesized for the selective recognition and isolation of ED. The PDA@MIR is fabricated using macroporous resin X-5 as the carrier, dopamine as the green functional monomer, and emodin as the template molecule. The PDA@MIR displays excellent adsorption capacity (41.55 mg⋅g −1 ) for ED and adsorption affinity (IF = 3.19). Meanwhile, even after going through 10 cycles of adsorption-desorption tests, it demonstrates consistent adsorption efficacy and reusability. Moreover, the PDA@MIR can serve as the innovative column filler in solid-phase extraction (SPE) for applying to the separation of ED from Rumex acetosa L. roots extracts. The adsorption recovery rate of ED reaches 90.95%, while the effective adsorption recovery rate is 85.33%. The DFT simulation and NMR analysis reveales that the recognition mechanism of PDA@MIR is attributed to interactions involving hydrogen bonds and Van der Waals forces. Furthermore, this study provides valuable insights into the design of molecularly imprinted resin materials, which possess superior recognition capabilities and exceptional selectivity for the specific separation and recognition of phytochemicals from plant extracts.
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GREEN CHEMISTRY
·
2024
·
IF 9.3
Lin Fan,Shangshang Sun,Zhidan Zhang,Yanmei Qin,Peter Ruhdal Jensen,Chun You
In conjunction with the pressing global issue of climate change and the associated concern over global warming, increasing interest has emerged in the exploration of carbon dioxide (CO2) as a resource for the generation of a diverse array of products intended to serve societal needs. This study presents the development of an ATP-free and NAD-balanced in vitro synthetic enzymatic biosystem (ivSEB), which comprises only five cascade thermophilic enzymes, designed for the synthesis of L-malate through CO2 fixation powered by the utilization of D-glucose as a substrate. This designed ivSEB yields two moles of L-malate from one mole of D-glucose and two moles of CO2. Through meticulous refinement of reaction conditions and enzyme loading amounts, this ivSEB has demonstrated its capability to produce 6.85 mM of L-malate via CO2 fixation from an initial 5 mM of D-glucose with a molar product yield of 68.5%, and 2.45 mM of L-lactate as a byproduct. In the pursuit of assessing the industrial feasibility of this ivSEB, the study further subjected the system to the utilization of a high concentration (45.70 mM) of D-glucose. Although this endeavor necessitates additional optimization for enhanced efficiency, the present findings herald the emergence of an alternative avenue for the sustainable production of L-malate through CO2 fixation, thus bearing substantial promise for addressing ecological and industrial imperatives.
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Nano Energy
·
2025
·
IF 17.1
Xiuzi Che,Huiqing Fan,Jiahao Cao,Yongbo Fan,Yuxin Jia,Yidi Duan,Qinghua Guo,Yafei Feng,Weijia Wang
Piezoelectric biomaterials can convert mechanical energy into electricity, which make them attractive for implant applications, such as sensing, energy harvesting, and medical devices. The β-glycine has excellent piezoelectric performance, but their practical use is hindered by instable crystal phase and water solubility. Here, we present a simple method for preparing poly L-lactide (PLLA) composite fibers encapsulating β-glycine nano crystals via coaxial electrospinning. The formation of β-glycine crystals is the synergistic outcome of the ionization of glycine solution under the electric field and the confinement of external PLLA solution, which enhances the piezoelectric performance of the film. The V oc , I sc , and power density of composite film reach 14 V, 0.94 μA, and 0.92 mW/cm 2 , respectively. In addition, PLLA shell stabilizes β-glycine, leading to a stable piezoelectric performance for device applications. The composite film can be ultrasonically driven to generate electric signals, and therefore functions well in promoting cell proliferation and bone tissue repairing in vivo . Moreover, the film can be naturally degraded after long-term implantation. This study provides a strategy to deal with the instability of β-glycine-based biodegradable piezoelectric films, and promotes the implant applications.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·Vol. 142
·期 14
·e56682
·
IF 2.8
Huili Liu,Luyao Su,Ruihan Li,Liting Wang,Dongyu Bai
In this article, poly(ethylene glycol)-poly( d -lactide) (PEG-PDLA) block copolymers with different PEG chain lengths were synthesized and melt-mixed with poly( l -lactide) (PLLA) and rubber nanoparticles. The role of PEG-PDLA block copolymers in tailoring the microstructures and performances of PLLA/rubber blend were investigated in detail. It was found that high contents of stereocomplex (SC) crystals were generated in PLLA/rubber/PEG-PDLA copolymer blends, which induced rubber nanoparticles to agglomerate and form network-like structures. The size of rubber aggregates and continuity of rubber network-like structures first increased and then declined significantly as the PEG chain length increased. Resultingly, the impact toughness of PLLA/rubber/PEG-PDLA copolymer blends first remarkably increased to 74.1 kJ/m 2 and then decreased to 30.6 kJ/m 2 . Meanwhile, the elongation at break increased with increasing PEG chain length and little loss of tensile strength happened, revealing good stiffness-toughness balance performances of PLLA/rubber/PEG-PDLA copolymer blends. Moreover, the matrix crystallization rate of PLLA/rubber/PEG-PDLA copolymer blends could be greatly increased by increasing PEG chain length and the PLLA/rubber/PEG-PDLA copolymer blends exhibited much higher Vicat softening temperatures than PLLA/rubber blend, which confirmed the excellent heat resistance of PLLA/rubber/PEG-PDLA copolymer blends. These interesting findings suggested that PEG-PDLA block copolymers were highly conducive to prepare PLLA materials with outstanding comprehensive performances.
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PHYSIOLOGY AND MOLECULAR BIOLOGY OF PLANTS
·
2025
·
IF 3.3
Wu Mengyao,Wang Haiou,Wang Wenxuan,Ren Xiaoyu,Zhang Juming
Hydroponic experiments and computational simulations were conducted to investigate the changes in the gene expression, structure, and binding mode of the rice transporter protein OsTIL to OPEs by the presence of Cd 2+ and Zn 2+ . OPEs and Zn 2+ were observed to promote seedling growth and OPEs alleviated the suppressive effect of Cd 2+ on seedlings. Usually, Cd 2+ and Zn 2+ inhibited the accumulations of OPEs in plants accompanied by the decrease of RCF (root concentration factor) and TF (transport coefficient). In particular, Zn 2+ promoted TDCPP accumulation only in roots accompanied by the increase of RCF and the decrease of TF. Furthermore, Cd 2+ and Zn 2+ affected the gene expressions of OPEs transporter-OsTIL response in the accumulation of OPEs in both single and compound pollution. After molecular dynamics simulation analysis, RMSD of the protein backbone, binding pocket, and ligand only in TDCPP-OsTIL complex also were significantly affected by two metal ions. Furthermore, two metal ions can press the interaction of OPEs and OsTIL by reducing the stability of protein structure and the numbers of HB (hydrogen bonds) and enlarging the pocket. However, Zn 2+ extra supports an enlarged entrance for TDCPP, which could facilitate the entry of the coordination complex of Zn 2+ with TDCPP into the pocket and improve TDCPP capacity of OsTIL.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Yanhui Zhang,Fangmin Chen,Jin Feng,Fang Wang,Ling Xiong,Luanfeng Wang,Xinchun Shen,Haizhao Song
Polysaccharides, particularly those with prebiotic functions, have profound effects on human health. This study aimed to elucidate the stability and prebiotic potential of a polysaccharide derived from Momordica charantia L. (MCPS-3) through a comprehensive analysis of its behavior during simulated digestion and fermentation. Our findings indicated that MCPS-3 maintained its structural integrity during oral, gastric, and intestinal digestion. This was evidenced by the consistent reducing sugar content, molecular weight, and monosaccharide composition. This stability confirmed that the glycosidic bonds of MCPS-3 remained intact throughout digestion. Then, MCPS-3 underwent fermentation by gut microbiota, resulting in significant production of short-chain fatty acids (SCFAs) and a notable change in microbiota composition. Specifically, the fermentation of MCPS-3 leads to an increase in beneficial SCFAs-producing genera, while decreasing the presence of harmful bacteria. These changes suggested an improved gut environment, which is conducive to health benefits. The study further demonstrated that the fermentation products of MCPS-3 possessed substantial anti-inflammatory properties. This was indicated by the reduction of pro-inflammatory mediators and the enhancement of anti-inflammatory cytokines in LPS-stimulated RAW 264.7 macrophage cells. These results underscored MCPS-3's promise as a prebiotic candidate with potential applications in gut health promotion and inflammation modulation.
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高影响因子
Acta Biomaterialia
·
2017
·
IF 6.319
Shengjun Mu,Yongjun Liu,Tianqi Wang,Jing Zhang,Dandan Jiang,Xiaoyue Yu,Na Zhang
A novel and intelligent pH-controlled system having an “on-off” switch based on poly( l -histidine) (PLH) and poly(ethylene glycol) (PEG) coated mesoporous silica nanoparticles (MSNs) (MSNs-PLH-PEG) was designed and evaluated for tumor specific drug release. The unsaturated nitrogen-rich polymer, PLH, which can change its solubility at different pH values, was employed for establishing the reversible “on-off” switch. In vitro drug release results demonstrated that MSNs-PLH-PEG has a pH-controlled “on-off” profile with the change of pH value between pH 7.4 and 5.0. Furthermore, in vitro cellular uptake study results showed that the entrapped drug could be efficiently released from MSNs-PLH-PEG under acidic endosome/lysosome. In vitro cell cytotoxicity and in vivo antitumor studies results indicated that sorafenib loaded MSNs-PLH-PEG exhibited good anti-proliferation and tumor growth inhibition effects. Haemolysis assay and histological analysis of MSNs-PLH-PEG showed negligible haemolysis activity and no visible tissue toxicity at the test dose. This study represents a promising and intelligent pH-controlled intelligent system for drug delivery and controlled release. Statement of Significance A novel pH-controlled intelligent and reversible “on-off” switch system based on poly( l -histidine) and poly(ethylene glycol) coated mesoporous silica nanoparticles (MSNs-PLH-PEG) by “graft to” synthesis method was constructed for tumor specific drug release. The unsaturated nitrogen-rich pH-sensitive polymer, PLH, which can change its solubility in different pH values, was employed as the reversible “on-off” switch in MSNs for the first time. The pH-controlled “on-off” switch manner was observed in the drug release results in vitro . In the in vivo antitumor studies, sorafenib loaded MSNs-PLH-PEG could effectively suppressed tumor growth in H22 tumor bearing mice. It is expected that the pH-controlled intelligent “on-off” switch system we designed holds remarkable promise and provides valuable strategy for possible applications in cancer therapy.
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