EUROPEAN POLYMER JOURNAL
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2021
·
IF 4.598
Yao Fan,Qiaohui Lu,Wencheng Liang,Youchang Wang,Yan Zhou,Meidong Lang
In this work, polyvinyl alcohol (PVA) with antimicrobial properties (QPVD), which were modified by 2-(Dimethylamino)ethyl methacrylate (DMAEMA) and 1-bromobutane. QPVD/chitosan (CS) composite sponge dressing (QPVDC) were prepared using freeze-drying process and cross-linked with glutaraldehyde vapor. Interestingly, compared with CS wound dressing, water absorption and flexibility of QPVDC wound dressing could be significantly improved with QPVD introduced. Among them, the water absorption of QPVDC sponge was up to 2300% and the elongation at break increased by 40–113%. In addition, QPVDC sponges with more quaternary ammonium could improve higher antibacterial activity, and the highest antibacterial activity of QPVDC sponges was close to 100% against E. coli and S. aureus . The results of hemolysis and cytotoxicity in vitro indicated that QPVDC wound dressing had excellent hemocompatibility and cytocompatibility. In summary, QPVDC wound dressing could protect from bacterial infection and accelerate wound healing. Thus, QPVDC had high potential application value for wound dressing.
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DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Xueyan Li,Suya Li,Chong Peng,Yuanfei Wang,Yun Li,Shuyi Yang,E. Tao
To avoid the environmental detriment caused by Cr(VI) waste, this study constructs a dual cross-linking network structure using sodium alginate (SA) and polyvinyl alcohol (PVA). Chitosan (CS) is further introduced through electrostatic attraction and hydrogen bonding and SA/PVA/CS (SPC) composite with porous structure is successfully prepared for the removal of Cr(VI) from wastewater. Batch adsorption experiments show that SPC has excellent adsorption capacity and practical usability with a broad pH applicability range. Under optimal adsorption conditions (pH = 2, t = 150 min, T = 35 °C, m/ V = 2 g/L, C 0 = 10 mg/L), the Cr(VI) removal rate of SPC achieves 89.2 %. Adsorption kinetics and isotherm models indicate that the adsorption process is primarily multi-layer and chemical adsorption. Additionally, FT-IR and XPS reveal that the adsorption mechanism of SPC for Cr(VI) involves a synergy of electrostatic attraction, reduction, ion exchange and complexation. Density functional theory (DFT) simulations also confirm the dominant role of CS in the Cr(VI) adsorption. In summary, SPC shows great potential for Cr(VI) wastewater treatment.
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2019
·
IF 6.361
Jun-Shuai Zhang,Wei-De Zhang
Developing earth-abundant H 2 -production heterogeneous photocatalysts with robust activity and stability has attracted great interests. Herein, a low-cost photocatalyst was prepared by binding nickel complex covalently from primary amines of chitosan (NiL) onto photosensitive carbon nitride nanosheets (CN) through electrostatic interaction. Introduction of NiL results in more efficient utilization of solar energy, photogenerated electrons’ direct transfer and lower overpotential for water reduction. The optimized NiL3-CN photocatalyst shows the highest H 2 evolution rate of 346 μmol g −1 h −1 under visible light irradiation and exhibits high stability during test. This work presents great potentials for sustainable conversion of solar energy, and sheds positive light on the development of heterogeneous photocatalysts via anchoring H 2 -evolving molecule catalysts confined by inexpensive macromolecules onto a semiconductor photosensitizer through a facile and valid method.
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高影响因子
CARBOHYDRATE POLYMERS
·
2017
·
IF 4.811
Rui Wang,Xin Song,Tao Xiang,Qiang Liu,Baihai Su,Weifeng Zhao,Changsheng Zhao
A straightforward mussel-inspired approach was proposed to construct chitosan-polyurethane coatings and load Ag nanoparticles (AgNPs) to endow polyethersulfone (PES) membranes with dual-antibacterial and antifouling properties. The macromolecule O -carboxymethyl chitosan (CMC) was directly reacted with catechol in the absence of carbodiimide chemistry to form the coating and load AgNPs via in situ reduction; while lysine (Lys) was used as a representative small molecule for comparison. Then, PEG-based polyurethane (PU) was used for constructing Lys-Ag-PU and CMC-Ag-PU composite coatings, which substantially improved the protein antifouling property of the membranes. Furthermore, the CMC-Ag-PU coating exhibited superior broad-spectrum antibacterial property towards E. coli and S. aureus than Lys-Ag-PU coating. Meanwhile, the CMC-Ag-PU coating showed sustained antifouling property against bacteria and could reload AgNPs to be regenerated as antibacterial and antifouling coating. This approach is believed to have potential to fabricate reusable antifouling and antibacterial coatings on materials surfaces for aquatic industries.
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高影响因子
CARBOHYDRATE POLYMERS
·
2016
·
IF 4.219
Yurui Xu,Sajid Asghar,Liu Yang,Hongying Li,Zhilin Wang,Qineng Ping,Yanyu Xiao
Curcuminoid (Cur) loaded polysaccharide nanoformulations with blood-brain barrier (BBB) penetration and brain targeting properties, based on hyaluronic acid (HA) and chitosan hydrochloride (CSH) (Lf-Cur-PSNPs) were developed as a novel delivery system for malignant glioma. Formulations were investigated for physicochemical characteristics, cytotoxicity, uptake, and BBB penetration. The results showed that Lf M -Cur-PSNPs (concentration of Lf was 0.5 mg/mL) were preferentially taken up by brain capillary endothelial cells than Cur-PSNPs at any time. After crossing the BBB, Lf M -Cur-PSNPs remained largely intact and were more effective in targeting glioma cells (C6). In vivo imaging studies in mice exposed Lf M -PSNPs could effectively permeate BBB and preferentially accumulate in the brain (2.39 times greater than PSNPs). Moreover, PSNPs were detected in brain up to 72 h. This data indicates that Lf-Cur-PSNPs could effectively target and accumulate within the gliomas after enhanced permeation through BBB, thus should be further explored for their potential in CNS maliganancies.
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高影响因子
JOURNAL OF MATERIALS CHEMISTRY
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2012
·Vol. 22
·期 11
·4861-4873
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IF 5.968
Sisi Cui,Haiyan Chen,Hongyan Zhu,Junmei Tian,Xuemei Chi,Zhiyu Qian,Samuel Achilefu,Yueqing Gu
Upconversion nanoparticles (UCNPs) have attracted much attention as potential photosensitizer carriers for photodynamic therapy (PDT) in deep tissues. In this study, hydrophilic UCNPs were prepared by coating amphiphilic chitosan (N-succinyl-N′-octyl chitosan, SOC) on the surface of hydrophobic oleic acid-capped NaYF4 UCNPs (OA-UCNPs). Water-insoluble photosensitizer zinc(II) phthalocyanine (ZnPc) was loaded into the SOC-coated UCNPs (SOC-UCNPs) via hydrophobic interactions to form a novel drug delivery system for in vivo deep tissue PDT triggered by near-infrared (NIR) light. The ZnPc-loaded SOC-UCNPs exhibited good dispersibility, excellent optical properties and good photostability. Under NIR light irradiation, the measurement of singlet oxygen production indicated that ZnPc effectively generated singlet oxygen induced by the emission from the UCNPs. Cell viability assays showed the low cytotoxicity of the UCNPs after surface modification. In vitro and in vivo therapeutic investigation evidenced the prominent PDT effects of ZnPc-loaded SOC-UCNPs upon NIR light irradiation. Furthermore, NIR imaging of ICG derivative-loaded SOC-UCNPs after intra-tumoral injection indicated the high retention of SOC-UCNPs only in the tumor site. Histological examination confirmed the negligible toxicity of ZnPc-loaded SOC-UCNPs on other organs. All the results demonstrate the promising potential of using SOC-UCNPs as new photosensitizer carriers for PDT of cancer and other diseases in deep tissues.
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高影响因子
JOURNAL OF POLYMERS AND THE ENVIRONMENT
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2021
·Vol. 30
·期 3
·855-866
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IF 3.667
Wang Zhihui,Wang Yanfei,Yao Chen
In this study, Polyethyleneimine modified magnetic chitosan (MCS-PEI) was synthesized by grafting polyethyleneimine onto chitosan and adding magnetic Fe 3 O 4 with sodium polyphosphate as crosslinking agent. The structure of the prepared material was characterized by FT-IR, SEM, EDS, XRD and XPS, which showed MCS-PEI was successfully synthesized. After a series of single factor experiments, the adsorption data fitted well with the Langmuir model ( R 2 = 0.99), being the maximum adsorption capacity equal 181.8 mg g −1 . The pseudo-second-order model ( R 2 = 0.997) and Dubinin-Radushkevich model ( R 2 = 0.9598) indicated that the adsorption process was chemical adsorption. And thermodynamic studies showed that the adsorption was spontaneous and exothermic. The adsorption rate decreased by no more than 4% after the four adsorption–desorption experiments. This work illustrates that MCS-PEI is an environmental friendly, efficient and low-cost adsorbent.
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高影响因子
Journal of Materials Chemistry B
·
2021
·Vol. 10
·期 4
·598-606
·
IF 6.331
Shuai Wu,Xiaoyang Cheng,Xiaomu Xu,Jiacheng Wu,Zhiqiang Huang,Zhenzhao Guo,Ping He,Changren Zhou,Hong Li
In this work, the role of chitosan (CS) in improving the properties of bioactive glass (BG) paste for wound healing was studied. Based on in vitro evaluation, it was found that the addition of CS neutralizes the pH value from 11.0 to 7.5, which did not lead to decreasing the bioactivity of BG paste in vitro. The rheological properties showed that the composite paste had higher bio-adhesion and better affinity with the skin surface than either CS or the BG paste. The antibacterial property evaluation showed that the composite paste had stronger antibacterial activity than either CS or BG paste and promoted the proliferation of HUVECs (human umbilical vein endothelial cells) and HaCat (human immortalized keratinocyte cells). Comparatively, the effect of promoting the proliferation of HUVECs is more significant than that of HaCat. The burn-wound model of rat was developed for evaluating in vivo activity, and the addition of CS effectively promoted wound healing without obvious inflammation according to the IL-1β and IL-6 staining. This novel paste is expected to provide a promising alternative for wound healing.
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高影响因子
JOURNAL OF CHROMATOGRAPHY A
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2021
·
IF 4.759
Canhong Zhu,Jiani Wu,Xueting Jin,Yinghua Yan,Chuan-Fan Ding,Keqi Tang,Di Zhang
Chemical modification of biological materials is indispensable for enrichment of phosphorylated peptides. In this work, we synthesized a biomimetic honeycombed affinity chromatography (IMAC) adsorbent by preparing Crosslinked Chitosan, chelating aminomethyl phosphate decorated with Ti (IV) cation. The as-prepared CTSM@AMPA-Ti 4+ composites with stable structure, low steric hindrance, and high Ti 4+ loading amount were used as a promising adsorbent for enrichment of phosphopeptides. CTSM@AMPA-Ti 4+ showed extremely high sensitivity (0.4 fmol) and selectivity at a low composition molar ratio of β-casein/BSA (1:1000). What's more, it can keep its performance in the case that used to capture phosphorylated peptides from standard protein ten times or soaking in the acid/base solution for a long time. In addition, CTSM@AMPA-Ti 4+ successfully captured 35 phosphorylated peptides from human saliva. This study offers a way about diversiform functionalization of CTSM in phosphoproteome analysis and disease research.
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高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2023
·Vol. 140
·期 20
·e53857
·
IF 3
Hong Song,Chaofan Liu,Daxiang Gui,Ye Sha,Qingping Song,Puyou Jia,Jiangang Gao,Ying Lin
The development of sustainable and functional epoxy resins from renewable biomass is gaining increasing attention. Herein, renewable and mechanically strong epoxy resins from chitosan and tung oil that possess proton conduction properties are developed. Firstly, tung oil-based epoxy monomers and chitosan based chain transfer agent were prepared. Then, a “grafting from” reversible addition-fragmentation chain transfer (RAFT) polymerization was carried out on chitosan using epoxy monomers toward elastic graft copolymer, which combined rigid backbone and flexible side chains in one macromolecule. After being cured with citric acid (catalyst-free), a biomass-based epoxy resins with dual network structure can be obtained. The thermal and mechanical properties of these epoxy resins could be tuned through controlling the content of cross-linkers. Moreover, the chitosan bearing abundant amino groups not only enhanced strength of the epoxy resins, but also endowed them with proton conductivity. Overall, the epoxy resins exhibited high tensile strength and comparable proton conduction, which provides a new paradigm to design green functional materials for potential applications.
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高影响因子
JOURNAL OF POLYMERS AND THE ENVIRONMENT
·
2022
·Vol. 30
·期 7
·2943-2954
·
IF 4.705
Lu Yanran,Zhang Wen,Wang Mei,Zhang Hua,Li Jiahui,Luo Wenhao
The adsorption is widely used to remove dyes from wastewater because of its low cost, simple preparation, and environmental friendliness. However, the existing adsorbents suffer from difficult recycling, inconvenient use, and a low regeneration rate. In this study, polyacrylonitrile (PAN) and graphene oxide (GO) was mixed for electrospinning GO/PAN nanofiber membrane and then chitosan (CS) was grafted to obtain CS-GO/PAN nanofiber membrane. CS-GO/PAN membranes were characterized with FE-SEM, EDX, FT-IR and, WCA. The effects of membrane types, dosage, solution pH on the removal of dye sunset yellow (SY) were systematically investigated. The results showed that more than 80% of SY were removed within 15 min at pH 2 using 100 mg CS-GO/PAN membrane. Adsorption kinetic data were fitted well with the pseudo-second-order model and adsorption achieved equilibrium within 240 min. The isotherm study followed the Langmuir model with the actual maximum adsorption capacity of 211.54 mg/g. After 5 adsorption–desorption cycles, the adsorption efficiency and the desorption efficiency of CS-GO/PAN were over 90% and 93%, respectively. Moreover, the membrane recovered easily from the water while its integrity was still maintained. The CS-GO/PAN membrane demonstrates the virtue of high adsorption capacity, easy operation, and good reusability, which could be considered as a promising material for adsorbing dyes in wastewater.
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高影响因子
Biomaterials Science
·
2021
·Vol. 9
·期 16
·5533-5541
·
IF 6.843
Xiaodong Jing,Yanzhen Sun,Yang Liu,Xiaoli Ma,Hao Hu
Timely and effective wound treatment is of great significance in acute bleeding caused by accidents and chronic wounds such as diabetic foot ulcers, venous leg ulcers, pressure sores. A hydrogel as wound dressing can provide a suitable microenvironment for wound healing and prevent bacteria and dust from reaching the wound. The loading of therapeutic factors in the hydrogel has been proved to accelerate wound healing. Polydeoxyribonucleotide (PDRN), as a series of nucleic acid fragments extracted from salmon, has the functions of improving angiogenesis, promoting cell activity, increasing collagen synthesis, and developing the anti-inflammatory response. These effects have positive implications for wound healing. But naked PDRN is difficult to take up by cells. Inspired by gene vectors, we prepared a PDRN-loaded CaCO3 nanoparticle (PCNP) to improve the delivery efficiency of PDRN. PCNPs were encapsulated in an alginate/chitosan-based hydrogel (Gel@PCNPs). The prepared hydrogel has plasticity and is suitable for various irregular wounds. The released gene carrier, PCNP, can be effectively taken up by skin fibroblasts. Under the action of PDRN, the wound healing rate has been confirmed to be significantly accelerated. We believe that this polysaccharide-based hydrogel loaded with PDRN vectors is a promising wound dressing.
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高影响因子
危险品化学品经营许可证（带存储）