LIFE SCIENCES
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2020
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IF 3.647
Xiuhuan Chen,Cui Zhang,Yan Guo,Xin Liu,Tianxin Ye,Yuhong Fo,Chuan Qu,Jinjun Liang,Shaobo Shi,Bo Yang
Aim The purpose of the study was to investigate what effects the sigma-1 receptor (S1R) could exert on the cardiac myocyte ion channels in a rodent model of depression and to explore the underlying mechanisms since depression is an independent risk factor for cardiovascular diseases including ventricular arrhythmias (VAs). Materials and methods To establish the depression model in rats, chronic mild unpredictable stress (CMUS) for 28 days was used. The S1R agonist fluvoxamine was injected intraperitoneally from the second week to the last week for 21 days in total, and the effects were evaluated by patch clamp, western blot analysis, and Masson staining. Key findings We demonstrated that depression was improved after treatment with fluvoxamine. In addition, the prolongation of the corrected QT (QTc) interval under CMUS that increased vulnerability to VAs was significantly attenuated by stimulation of S1R due to the decreased amplitude of L-type calcium current (I Ca-L ) and the restoration of reduced transient outward potassium current (I to ) resulting from CMUS induction. The S1R also decelerated I to inactivation and accelerated I to recovery by activating Ca 2+ /calmodulin-dependent kinase II. Moreover, the stimulation of S1R ameliorated the structural remodeling as the substrate for maintenance of VAs. All these effects were abolished by the administration of S1R antagonist BD1047, which verified the roles for S1R. Significance Activation of S1R could decrease the vulnerability to VAs by inhibiting I Ca-L and restoring I to , in addition to ameliorating the CMUS-induced depressive symptoms and structural remodeling.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2020
·Vol. 31
·期 13
·9974-9981
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IF 2.22
Fan Xuemin,Li Peng,Du Juan,Chen Chong,Fu Peng,Hao Jigong,Yue Zhenxing,Li Wei
The (1 − x )[0.935(Bi 0.5 Na 0.5 )TiO 3 –0.065BaTiO 3 ]– x Ba(Zr 0.3 Ti 0.7 )O 3 (BNT–BT– x BZT) ceramics with high-energy storage properties were designed and characterized. All the BNT–BT– x BZT ceramics exhibit a pure perovskite structure. The grain size of ceramics becomes larger as the BZT content increases. Enhanced energy density performances ( W rec = 1.9 J/cm 3 , η = 86%) are achieved for the BNT–BT–0.4BZT ceramics at 210 kV/cm. Specifically, the energy stored in the material can be rapidly released within 0.27 µs. Excellent temperature stability with the variation of W rec less than 7% is realized in a wide temperature range from 20 to 140 °C. Moreover, the energy storage performances have good reliability after 10 5 electric field cycles. The high-energy storage performances indicate that the BNT–BT–0.4BZT ceramics are promising candidates in pulsed-power applications.
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Journal of Advanced Ceramics
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2020
·Vol. 9
·期 3
·292-302
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IF 2.889
Wang Hongxian,Zhao Peiyao,Chen Lingling,Li Longtu,Wang Xiaohui
Multilayer ceramic capacitors (MLCCs) for energy storage applications require a large discharge energy density and high discharge/charge efficiency under high electric fields. Here, 0.87BaTiO 3 -0.13Bi(Zn 2/3 (Nb 0.85 Ta 0.15 ) 1/3 )O 3 (BTBZNT) MLCCs with double active dielectric layers were fabricated, and the effects of inner electrode and sintering method on the energy storage properties of BTBZNT MLCCs were investigated. By using the pure Pt as inner electrode instead of Ag 0.6 Pd 0.4 alloys, an alternating current (AC) breakdown strength ( BDS ) enhancement from 1047 to 1500 kV/cm was achieved. By investigating the leakage current behavior of BTBZNT MLCCs, the Pt inner electrode and two-step sintering method (TSS) were confirmed to enhance the Schottky barrier and minimize the leakage current density. With relatively high permittivity, dielectric sublinearity, and ultra-high BDS , the Pt TSS BTBZNT MLCCs exhibited a surprisingly discharge energy density ( U dis ) of 14.08 J/cm 3 . Moreover, under an operating electric field of 400 kV/cm, the MLCCs also exhibited thermal stability with U dis variation < ±8% over a wide temperature ( t ) range from -50 to 175 °C and cycling reliability with U dis reduction < 0.3% after 3000 charge-discharge cycles. These remarkable performances make Pt TSS BTBZNT MLCCs promising for energy storage applications.
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2020
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IF 16.683
Wangyang Wang,Wei Zhou,Wei Li,Xuewei Xiong,Yuhao Wang,Kang Cheng,Jincan Kang,Qinghong Zhang,Ye Wang
Maximizing the use of palladium without compromises in catalytic activity and stability in the combustion of methane is extremely challenging due to the harsh operation conditions. To achieve this goal, a series of core-shell-structured catalysts with different amounts of palladium nanoparticles confined in hydrophobic silicalite-1 (Pd@S-1) was designed. Unexpectedly, a volcanic trend between catalytic activity and palladium loading was found as the loading increased from 0.3 wt% to 1.6 wt%, among which the 0.6 wt%Pd@S-1 exhibited the highest catalytic activity with a complete combustion temperature of 380 °C. Besides, the 0.6 wt%Pd@S-1 showed an ultrahigh stability in the high temperature applications due to the spatial confinement of palladium inside the rigid zeolite matrix. Moreover, owing to the hydrophobicity of the pure silica zeolite, the Pd@S-1 could selectively hinder the diffusion of water vapor into the palladium sites, leading to the outstanding water-resistance ability.
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CHINESE JOURNAL OF CATALYSIS
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2020
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IF 6.146
Xuemei Li,Junying Tian,Hailong Liu,Congkui Tang,Chungu Xia,Jing Chen,Zhiwei Huang
A highly efficient and green process was developed for the synthesis of useful 5-amino-1-pentanol (5-AP) from biomass-derived dihydropyran by coupling the in situ generation of 5-hydroxypentanal (5-HP, via the ring-opening tautomerization of 2-hydroxytetrahydropyran (2-HTHP)) and its reductive amination over supported Ni catalysts. The catalytic performances of the supported Ni catalysts on different oxides including SiO 2 , TiO 2 , ZrO 2 , γ-Al 2 O 3 , and MgO as well as several commercial hydrogenation catalysts were investigated. The Ni/ZrO 2 catalyst presented the highest 5-AP yield. The characterization results of the oxide-supported Ni catalysts showed that the Ni/ZrO 2 catalyst possessed high reducibility and a high surface acid density, which lead to the enhanced activity and selectivity of the catalyst. The effect of reaction parameters on the catalytic performance of the Ni/ZrO 2 catalyst was studied, and a high 5-AP yield of 90.8% was achieved in the reductive amination of 2-HTHP aqueous solution under mild conditions of 80 °C and 2 MPa H 2 . The stability of the Ni/ZrO 2 catalyst was studied using a continuous flow reactor, and only a slight decrease in the 5-AP yield was observed after a 90-h time-on-stream. Additionally, the reaction pathways for the reductive amination of 2-HTHP to synthesize 5-AP were proposed.
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CHEMICAL ENGINEERING JOURNAL
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2020
·
IF 10.652
Liyu Zheng,Sanyuan Hu,Heping Li,Youwei Yan
The fast development of optoelectronics makes a huge boost to the searching for flexible indium-free transparent conductors. In recent years, metal networks (currently are Au, Ag and Cu) have emerged as promising alternatives, however, facile fabrication of high-performance, chemically stable, and low-cost transparent conductor is still a big challenge. Here, ultra-long W microfibers (with conductivity of 4.3 × 10 4 S/cm) are successfully produced by draw spinning and further assembled into well-regulated patterns. Such a solution-processed patterning effectively eliminates the fiber-to-fiber joint resistance, and thus enables the W network to achieve an ultra-low sheet resistance of 0.2 Ω sq −1 at ~90% transparency, which corresponds to a high figure of merit σ dc /σ opt = 1.7 × 10 4 (up to 10–40 times the value of Cu and Au networks). Moreover, the W network possesses excellent anti-thermal and anti-corrosion properties, which enable it to work in the erosion solution with pH ranging from 1 to 13 with a restrained increase (<3%) in its sheet resistance. With a marvelous combination of high conductivity and transparency, high chemical stability and good mechanical flexibility, the ultrathin W fibers may open a new door to find flexible indium-free transparent conductors for the development of both flexible electronics and energy conversion.
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ACS Catalysis
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2021
·
IF 13.084
Yiwen Yang,Haifeng Qi,Huixiang Li,Zhanwei Xu,Xiumei Liu,Shuyin Yu,Zongchao Conrad Zhang
Efficient hydrolysis of β-1,4-glycosidic bonds of cellulose is a pivotal step in biorefineries of cellulosic biomass. In this work, we discovered that paired PdCl2–CuCl exhibited excellent synergetic catalytic activity over the single PdCl2 or CuCl in the hydrolysis of β-1,4-glycosidic bonds in 1-butyl-3-methylimidazolium chloride ([BMim]Cl) and further investigated the catalytic species in this system. The catalytic activity increased and reached a plateau at a CuCl/PdCl2 ratio of 1 with increasing molar ratio of CuCl/PdCl2 while keeping the Pd concentration constant. A combination of experimental evidence based on in situ far-infrared absorption, X-ray absorption, X-ray photoelectron, and electron paramagnetic resonance spectroscopies and DFT calculations demonstrate the coupling reaction between [PdIICl4]2– and [CuICl3]2– via the Cl bridge to form the heterometallic complex anion [Cl2PdII–Cl–CuICl2]2–. The heterometallic species is stable during the reaction and maintains its catalytic performance in the presence of various oxygenate additives. Using paired PdCl2–CuCl as a catalyst, the activation energy of hydrolytic cleavage of β-1,4-glycosidic bonds of cellobiose is determined as low as 95.8 kJ/mol. PdCl2–CuCl/[BMim]Cl combined with CrCl3 can be reused five times in cellobiose conversion to 5-hydroxymethylfurfural (5-HMF) without an apparent decrease of catalytic activity. The performance of this catalytic system is further verified for efficient cellulose conversion. More than 60% product yield is obtained at 100 °C from the cellulose, affording monosaccharides for efficient production of high value-added chemicals, such as 5-HMF, when CrCl3 is present to catalyze the conversion of glucose to 5-HMF.
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ANALYTICA CHIMICA ACTA
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2021
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IF 6.558
Jing Wen,Lijun Zhou,Ding Jiang,Xueling Shan,Wenchang Wang,Hiroshi Shiigi,Zhidong Chen
Herein, a sensitive and selective electrochemiluminescence (ECL) aptasensor was designed using [email protected] as accelerator towards the perylene derivative (PTC-Cys)/peroxydisulfate (S 2 O 8 2− ) system for kanamycin (KAN) assay. Firstly, the PTC-Cys was prepared by covalently binding l -cysteine to 3,4,9,10-perylenete-tracarboxylic acid, which was acted as the luminophore. Then [email protected] play the part of effective catalyst to accelerate the electrochemical reduction process of S 2 O 8 2− to produce more sulfate radical anions (SO 4 •- ), thus the ECL signal of the compound was noticeably raised by 2.4 times in comparison with that in which only luminophore and S 2 O 8 2− are present, achieving signal amplification of the ECL system. In the presence of KAN, aptamer was pulled down from the sensing interface, achieving a considerable enhancement of ECL intensity in S 2 O 8 2− solution. Upon the optimal condition, our proposed strategy can quantify the concentration of KAN from 1.0 × 10 −13 to 1.0 × 10 −8 M with low limit of detection of 4.2 × 10 −14 M (S/N = 3).Besides, our proposed ECL aptasensor exhibited excellent sensitivity, stability and specificity, and could be successfully applied to detect KAN in practical samples, which proved its potential to detect other antibiotics in food security.
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NEUROCHEMICAL RESEARCH
·
2021
·Vol. 47
·期 2
·264-278
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IF 3.996
Gao Tianyu,Gao Ce,Liu Zhidong,Wang Yun,Jia Xiaoxia,Tian Hao,Lu Qian,Guo Lin
Further understanding the mechanism for microglia activation is necessary for developing novel anti-inflammatory strategies. Our previous study found that the activation of sigma-1 receptor can effectively inhibit the neuroinflammation, independent of the canonical mechanisms, such as NF-κB, JNK and ERK inflammatory pathways. Thus, it is reasonable that an un-identified, non-canonical pathway contributes to the activation of microglia. In the present study, we found that a sigma-1 receptor agonist of 2-morpholin-4-ylethyl 1-phenylcyclohexane-1-carboxylate (PRE-084) suppressed lipopolysaccharide (LPS) elevated nitric oxide (NO) content in BV-2 microglia culture supernatant and LPS-raised mRNA levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), inducible nitric oxide synthase (iNOS) in BV-2 microglia. Moreover, PRE-084 alleviated LPS-increased Ser 9 de-phosphorylation of glycogen synthase kinase-3 beta (GSK-3β), LPS-elevated catalytic activity of calcineurin, and LPS-raised percent and frequency of Ca 2+ oscillatory BV-2 cells. We further found that the inhibitory effect of PRE-084 was reversed by a calcineurin activator of chlorogenic acid and a GSK-3β activator of pyrvinium. Moreover, an IP 3 receptor inhibitor of 2-aminoethoxydiphenyl borate mimicked the anti-inflammatory activity of PRE-084. Thus, we identified a noncanonical pro-neuroinflammary pathway of Ca 2+ oscillation/Calcineurin/GSK-3β and the inhibition of this pathway is necessary for the anti-inflammatory activity of sigma-1 receptor activation.
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ACS Applied Materials & Interfaces
·
2021
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IF 9.229
Fan Zhang,Angelina Angelova,Vasil M. Garamus,Borislav Angelov,Shuyang Tu,Liangliang Kong,Xinlei Zhang,Na Li,Aihua Zou
Targeted therapies of melanoma are of urgent need considering the resistance of this aggressive type of cancer to chemotherapeutics. The voltage-dependent anion channel 1 (VDAC1)–hexokinase-II (HK-II) complex is an emerging target for novel anticancer therapies based on induced mitochondria-mediated apoptosis. The low cell membrane permeability of the anticancer 12-mer peptide N-Ter (RDVFTKGYGFGL) derived from the N-terminal fragment of the VDAC1 protein impedes the intracellular targeting. Here, novel multiblock VDAC1-derived cationic amphiphilic peptides (referred to as Pal-N-Ter-TAT, pFL-N-Ter-TAT, and Pal-pFL-N-Ter-TAT) are designed with a self-assembly propensity and cell-penetrating properties. The created multiblock amphiphilic peptides of partial α-helical conformations form nanoparticles of ellipsoid-like shapes and are characterized by enhanced cellular uptake. The amphiphilic peptides can target mitochondria and dissociate the VDAC1–HK-II complex at the outer mitochondrial membrane, which result in mitochondria-mediated apoptosis. The latter is associated with decrease of the mitochondrial membrane potential, cytochrome c release, and changes of the expression levels of the apoptotic proteins in A375 melanoma cells. Importantly, the mitochondrial VDAC1-derived amphiphilic peptides have a comparable IC50 value for melanoma cells to a small-molecule drug, sorafenib, which has been previously used in clinical trials for melanoma. These results demonstrate the potential of the designed peptide constructs for efficient melanoma inhibition.
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CHEMICAL ENGINEERING JOURNAL
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2021
·
IF 13.273
Pan Liu,Qin-Hao Zhang,Jian-Qing Zhang,Ji-Ming Hu,Fa-He Cao
A method to quickly prepare highly oriented silicalite-1 zeolite films on different substrates at lower temperature was provided in this work. Compared with the traditional hydrothermal synthesis, rubbing a layer of seed pastes on the pretreated substrate surface in advance and using (NH 4 ) 2 SiF 6 as silicon source for subsequent secondary growth process can effectively reduce the synthesis temperature and shorten the contact time between the substrate and the strong alkaline synthesis solution. The thickness of the zeolite films prepared under three optimal conditions is all around 1 μm and the best contact angle value of 142.5° was achieved for the film prepared at 373 K for 4 h, while this values of the film prepared at 363 K for 6 h and 353 K for 10 h were 97.8° and 41.7°, respectively. The results of SECM showed that the detected localized current value of the film prepared at 353 K for 10 h was similar to that on bare steel after immersion in 0.62 M NaCl solution for 24 h (around 0.4 nA). At the same time, the current value measured under the other two preparation conditions was much higher, suggesting that the corrosion resistance of the film prepared under 353 K was unsatisfactory. In addition, EIS results demonstrated that the corrosion resistance of the films prepared at 363 K for 6 h also decreased significantly after 72 h immersion, while the films prepared at 373 K for 4 h still maintained excellent corrosion resistance and no obvious corrosion products were detected even immersion time up to 720 h. This work provides a new strategy for the application of zeolite in the field of material protection.
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ACTA BIOCHIMICA POLONICA
·
2021
·Vol. 68
·期 4
·765-774
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IF 2.149
Shaoyi Li,Yong Li,Bibo Tan,Zhaojie An
Krüppel-like factor 1 (KLF1) is a transcription factor that exhibits promoting effect in cervical cancer, but its correlation with gastric cancer (GC) has not been reported yet. In this study, we explored the role and potential mechanism of KLF1 in GC progression by using a series of experimental methods including RT-qPCR, Western blot, CCK-8 assay, EdU staining, and cell cycle analysis. KLF1 was found to be elevated in GC tissues (n=415) compared with the normal tissues by applying UALCAN to analyze datasets from The Cancer Genome Atlas (TCGA). The upregulation of KLF1 was also validated in GC cell lines. Functional studies proved that RNA interference-mediated silencing of KLF1 inhibited GC cell growth, as evidenced by the decreased cell viability, DNA synthesis, and arrested cell cycle in G1 phase. Moreover, KLF1 knockdown exerted the inhibitory effects on cell migration and invasion as well as the epithelial-mesenchymal transition (EMT) in GC cells. Conversely, overexpression of KLF1 had the opposite effects on GC progression. Furthermore, we proved that the activation of Wnt/β-catenin pathway was markedly inhibited by KLF1 knockdown and promoted by KLF1 overexpression. The blockade of Wnt/β-catenin pathway rescued the effects of KLF1 overexpression. These results suggested that KLF1 promoted the growth, migration, invasion, and EMT process in GC cells, and this promotion was achieved by activating the Wnt/β-catenin pathway. This work will be helpful for searching the potential therapeutic targets for treatment of GC.
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