MATERIALS CHARACTERIZATION
·
2025
·
IF 5.5
Xianshu Dong,Tianshun Dong,Jingkun Li,Yanfei Jiang,Binguo Fu,Guolu Li
To improve the wear resistance of Al 30Si coatings, nano-Y₂O₃-reinforced Al 30Si (Y₂O₃/Al-30Si) coatings were fabricated on 6063 aluminum alloy substrates by atmospheric plasma spraying (APS). The effect of nano-Y 2 O 3 addition on the coating was studied in detail. The results show that nano-Y₂O₃ reduced the porosity of the Al 30Si coatings from 8.2 % to 3.1 %. Nano-Y₂O₃ can provide heterogeneous nucleation sites for primary silicon (β-Si) phases, enabling the Y₂O₃/Al-30Si coating to achieve a 57.4 % reduction in β-Si phase size. Correspondingly, the microhardness, elastic modulus and fracture toughness of the coating increased by 11.0 %, 11.2 % and 48.9 %, respectively. Under the present test conditions, the Y₂O₃/Al-30Si coating exhibited a lower coefficient of friction and a 27.2 % reduction in wear volume. Both the Y₂O₃/Al-30Si and Al 30Si coatings exhibited abrasive, oxidative, and fatigue wear mechanisms.
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DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2025
·
IF 4.6
Xin Liu,Shiyue Niu,Liqian Niu,Xian Wang,Xinxin Liu,Xin Guan,Xinyu Fan,Shuyun Bi
A highly sensitive surface-enhanced Raman spectroscopy (SERS) approach was established for the detection of monosultap using the nanosubstrate of β -CD/Trp/MgO/AgNPs which was MgO-protected silver nanoparticles (AgNPs) assembled tryptophan (Trp) and β -cyclodextrin ( β -CD). Six nanosubstrates including AgNPs, MgO/AgNPs, Trp/AgNPs, β -CD/MgO/AgNPs, Trp/MgO/AgNPs and β -CD/Trp/MgO/AgNPs were compared for their enhancement effect on monosultap. Among them, β -CD/Trp/MgO/AgNPs had the greatest enhancement effect, with an enhancement factor (EF) reaching up to 1.95 × 10 6 . The nanosubstrate of β -CD/Trp/MgO/AgNPs was characterized by various instrumental techniques, such as transmission electron microscopy (TEM), high-angle annular dark-field scanning transmission electron microscopy (HAADF-STEM), zeta potential, X-ray diffraction (XRD), thermogravimetric analysis (TGA), ultraviolet-visible (UV–vis) and Fourier transform infrared (FT-IR). The binding of β -CD/Trp/MgO/AgNPs with monosultap was studied in detail. The optimum experimental conditions were confirmed through single-factor experiments and response surface analysis. The interferences from the coexisting substances (common metal ions, glucose and congeneric drugs) were investigated to evaluate the method selectivity. Under the optimal conditions, the standard curve equation of monosultap was established within the concentration range of 2.00 × 10 −8 –1.00 × 10 −6 mol L −1 , with detection limit (LOD) of 0.970 nmol L −1 (3 σ / S ). The SERS approach was utilized for detecting monosultap in several vegetables and fruits with the recoveries from 96.3 % to 105 %.
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
·
2025
·
IF 2.5
Yu Pan,Rui Li,Huanhuan Ma,Xiaolei Hu,Jun Zhao,Juanjuan Qiao,Xiyao Dou,Yanan Wang,Yanzhi Zhang,Xiuli Wang,Lin Wang
Expression of the critical pyroptosis protein gasdermin E (GSDME) has been reported to be regulated by DNA methylation and negatively correlated with expression of estrogen receptor (ER) in breast cancer tissues, suggesting that estrogen-induced target gene methylation may be involved in the regulation of GSDME expression in breast cancer cells. To test this hypothesis, we treated MCF-7 and T47D ER-positive breast cancer cells with 17-β-estradiol (E 2 ), either alone or in combination with selective ERα antagonist AZD9496, selective ERβ antagonist PHTPP, DNA methyltransferase (DNMT) inhibitor RG108, and selective ER degrader Fulvestrant (Ful). Then, GSDME protein and mRNA expression were examined with western blot and RT-qPCR. Pyroptosis was induced by short-wave ultraviolet (UV-C) and detected with morphological observation, lactate dehydrogenase (LDH) release assay, and propidium iodide-Annexin V-FITC fluorescence staining. The methylation status of the GSDME promoter was tested with methylation-specific PCR. The results demonstrated that 100 nM E 2 significantly decreased GSDME protein and mRNA expression in MCF-7 and T47D cells, and significantly inhibited UV-C-induced pyroptosis. AZD9496 but not PHTPP significantly attenuated the down-regulatory effect of E 2 on GSDME expression. E 2 induced DNA methylation in the GSDME promoter region and up-regulated DNMT1 expression. RG108 strengthened UV-C-induced pyroptosis, and Ful reversed the inhibitory effects of E 2 on UV-C-induced pyroptosis of MCF-7 and T47D cells . Taken together, our study suggests that E 2 down-regulated GSDME expression in ERα-positive breast cancer by promoting GSDME promoter methylation, and inhibited UV-C-induced pyroptosis.
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·
IF 12.6
Shijin Xu,Naidi Yang,Fangning Du,Ziying Zhang,Yin Zhang,Yixuan Zhang,Jiawei Liang,Yihan Zhao,Jiajun Zhang,Ziwei Zhang,Xiaoxuan Han,Zena Chen,Zhiqiang Zhou,Shu Zhang,Lin Li,Ying Lv
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, marked by extensive stromal fibrosis and a profoundly immunosuppressive, immune-excluded tumor microenvironment (TME) that hampers the efficacy of immune checkpoint blockade. Although photodynamic therapy (PDT) can induce immunogenic cell death (ICD) and stimulate anti-tumor immunity, its effectiveness against PDAC is limited by insufficient immune activation and persistent stromal-mediated immunosuppression. To address these challenges, we develop a liposomal nanodrug that co-encapsulates a mitochondrial-targeted photosensitizer (MP) and a TGF-β receptor inhibitor (LY2109761) to synergize PDT with PD-1 checkpoint blockade. MP selectively accumulates in mitochondria and, upon light activation, amplifies mitochondrial reactive oxygen species production, inducing mitochondrial damage. This damage triggers the release of mitochondrial DNA and damage-associated molecular patterns, activating the STING pathway and eliciting potent ICD and anti-tumor immune responses. Simultaneously, liposome-mediated delivery of LY2109761 mitigates stromal desmoplasia and reverses TGF-β-driven immune suppression, enhancing effector T cell infiltration and activity. In murine PDAC models, this dual-action strategy transforms the immune-cold TME into an immune-inflamed phenotype, sensitizing tumors to PD-1 therapy and leading to pronounced tumor regression and prolonged survival. Our findings present a promising nanodrug-based approach to remodel the fibrotic and immunosuppressive TME of PDAC and enhance immunotherapeutic outcomes.
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产品关联
DOI
PubMed
高影响因子
POLYMER ENGINEERING AND SCIENCE
·
2025
·
IF 3.2
Yuling Chen,Yunong Tian,Jiahao Ouyang,Xuan He,Bo Wang,Dandan Li,Yong Ye
To address the challenge of selectively extracting β-sitosterol from Camellia oil—a complex, lipid-rich matrix containing structurally similar sterols—a photo-responsive molecularly imprinted polymer (MIP) was developed using a hybrid functional monomer system. Functional monomers were systematically screened via UV–Vis spectroscopy and density functional theory (DFT) to ensure molecular-level selectivity and optimal cavity matching. The imprinting system combined methacrylic acid (MAA) with either acrylamide (AAm) or 3-aminopropyltriethoxysilane (APTES), introducing synergistic hydrogen bonding and π-π stacking. A photo-responsive azobenzene monomer enabled reversible photo-isomerization under 365/440 nm light, allowing precise spatiotemporal control of β-sitosterol adsorption/release. Co-assembly behavior was validated by 1 H-NMR spectroscopy. The MIPs were characterized by FT-IR, XPS, TGA, SEM, BET, DSC and UV-DRS, while molecular docking elucidated the photo-responsive mechanism. Adsorption performance was evaluated using isothermal, kinetic, and thermodynamic models, alongside imprinting factor analysis. When applied to solid-phase extraction (SPE) from crude Camellia oil, the MIPs exhibited excellent selectivity, reusability, and enrichment efficiency. The maximum adsorption capacity reached 11.02 mg/g, and β-sitosterol purity increased to 78.3% ~ 82.1%. This work offers a green, reusable, and light-controllable platform for selective sterol recovery from edible oil systems.
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DOI
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Qingchun Zhang,Hao Zhu,Rui Wang,Jianfei He,Christos Ritzoulis,Owen Griffith Jones,Weilin Liu,Wei Tang,Jianhua Liu
Effect of prior hydrolysis and subsequent 36 h glycation on the ability of amyloid-like fibrils derived from β-Lactoglobulin (FG 36 Hβ-Lg) to provide physicochemical stability to fish oil emulsions was systematically determined under varying pH, ionic strength, thermal, and storage conditions. In vitro digestion studies coupled with a Caco-2 cell model investigation evaluated the emulsions' cellular uptake, transmembrane transport, and antioxidant properties. GC–MS analysis of the post-digestion micellar phase revealed that emulsification enhanced the apparent permeability of eicosapentaenoic acid (EPA). FG 36 Hβ-Lg conferred superior EPA transport efficiency and the strongest cellular antioxidant effects on emulsions, compared to proteins modified by hydrolysis or glycation alone, or lacking fibrillar structure. Parallel reaction monitoring showed that FG 36 Hβ-Lg emulsions upregulated key regulatory proteins involved in lipid metabolism and inflammation, such as HMGCR and NFKB1. These findings demonstrate that modified β-Lactoglobulin fibrils improved physical and oxidative stability of emulsions and show promise to enhance bioavailability of omega-3 fatty acids.
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DOI
PubMed
高影响因子
MATERIALS & DESIGN
·
2025
·
IF 7.9
Qi Lai,Shaorong Huang,Yu Wu,Hu Bei,Shuilin Chen,Kun Zhang,Yuqin Xu,Xiaoyong Zhang,Guicai Sun,Yulong Ouyang
Photothermal therapy has rapidly gained attention as a promising strategy for tumor treatment, owing to its noninvasive nature, ease of operation, high spatial precision, and minimal risk of developing drug resistance. Despite its advantages, the simple and efficient synthesis of photothermal agents (PTAs) that simultaneously exhibit high photothermal conversion efficiency, excellent water dispersibility, low toxicity, biodegradability, and strong therapeutic performance remains a significant challenge. In this study, we successfully synthesized a benzobisthiazole-based conjugated polymer (DPD-CAN-OH) bearing pendant β-cyclodextrin groups via a click condensation reaction. Doxorubicin was subsequently loaded onto DPD-CAN-OH through the formation of a host–guest inclusion complex, resulting in the DPD-CAN-OH-DOX formulation. Characterization results demonstrated that both DPD-CAN-OH and DPD-CAN-OH-DOX exhibit small particle sizes, high water dispersibility, excellent photothermal conversion efficiency, and favorable biodegradability. Biological assays further confirmed that DPD-CAN-OH is associated with low cytotoxicity and good biocompatibility. Notably, DPD-CAN-OH showed significant potential for osteosarcoma treatment by enhancing reactive oxygen species generation and inducing apoptosis in cancer cells. Importantly, the DPD-CAN-OH-DOX complex exhibited markedly superior antitumor efficacy compared to treatment with doxorubicin or DPD-CAN-OH alone, highlighting the therapeutic benefits of combining chemotherapy with photothermal therapy. Considering the straightforward and efficient synthesis process, along with the excellent physicochemical and biological characteristics of the PTAs developed, we believe this work provides valuable new insights into the design and fabrication of multifunctional PTAs for effective cancer therapy.
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产品关联
DOI
高影响因子
Energy Storage Materials
·
2018
·
IF 0
Lubin Ni,Guang Yang,Qi Wang,Suqin Duan,Chao Shen,Ju Xie,Guosheng Niu,Huan Li,Ming Chen,Guowang Diao
Lithium-sulfur (Li-S) batteries have currently attracted wide attention due to their high energy density of 2600 Wh kg −1 and low costs. However, commercial applications of Li-S batteries still have been hindered by several issues, such as low sulfur utilization, self discharge, low efficiency, and poor cycling stability mainly caused by shuttle effect. β-Cyclodextrins (β-CDs) are well-known supramolecular hosts, capable of including hydrophobic molecules inside their large cavities. Taking advantage of the remarkable molecular recognition properties of β-CDs, they are thus expected to effectively suppress shuttle effect by dynamically forming supramolecular inclusion complexes with the polysulfides . Here, we introduce a new strategy of using β-cyclodextrin polymers (β-CDPs) as supramolecular receptors chemically grafted onto reduced graphene oxide nanosheets (rGO) to construct ternary supramolecular nanostructure of rGO@CDP@S hybrid cathode for Li-S batteries. Interestingly, this proof-of-concept model system has successfully demonstrated reversible capture and release of lithium polysulfides to confine an unfavorable polysulfide shuttle effect via supramolecular host-guest interaction in Li-S batteries. Furthermore, interaction mechanism between β-CD and polysulfide was deeply investigated at the molecular level. More importantly, the {cyclodextrin/polysulfide} supramolecular inclusion complex was first isolated and fully characterized with a wide range of spectroscopic experiments and computational studies. The cyclodextrins-modified graphene-base sulfur cathode rGO@β-CDP@S exhibits remarkably enhanced electrochemical performances in terms of higher specific capacity (1329 mA h g −1 at 0.1 C), rate capability (387 mA h g −1 at 5.0 C), and excellent cycle life (capacity decay rate of 0.040% and 0.053% per cycle after 1000 cycles at 2.0 and 3.0 C), compared to pristine graphene-coated rGO@S composite. Moreover, it enables good cycling performance of high-sulfur-loading cathodes (S mass-loading of 5.3 mg cm −2 ) achieving discharge capacity of 560 mAh g −1 (Areal capacities: 3.0 mA h cm - 2 ) at 0.2 C after 100 cycles. The results open up a rational approach to shed new lights on designing new functional molecular materials as cathodes for Li–S batteries.
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DOI
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2021
·Vol. 32
·期 11
·15046-15058
·
IF 2.478
Zhong Yue,Chen Zhou,Chen Gui,Luo Yang,Zhang Lizhong,Hua Bin,Li Jianhui,Sun Yifei
The development of an efficient synthesis process for carbon-based supercapacitor electrodes is highly appreciated for its practical application. In this work, using β-cyclodextrin (O and C sources), melamine (C and N sources) and zinc chloride (active agent) as affordable precursors, we proposed a cost-efficient route integrating one-pot hydrothermal treatment and in situ carbonization/activation to obtain a N/O co-doped hierarchically porous carbon sheets and employ them as a potential electrode for supercapacitor. The β-cyclodextrin with abundant hydrophobic cavity assists the formation of porous architecture with a large specific surface area (SSA) of 1427 m 2 g −1 . The materials are systematically characterized using various technologies including SEM, XRD, Raman, TEM and XPS measurements. Further, the supercapacitor performances are analyzed using cyclic voltammetry at different scan rates, ac impedance and galvanostatic charge/discharge measurement. A specific capacitance of 240 F g −1 (at 0.5 A g −1 ) and 120 F g −1 (at 0.3 A g −1 ) could be obtained in three-electrode system and symmetric two-electrode full device measurements, respectively. This work points out a new avenue for the fabrication of carbon-based high-performance supercapacitors.
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高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2022
·
IF 6.364
Qiang Zhi,Shan Zhao,Nan-Long Zhang,Bao-Qiang Hou,Bo Wang,Jian-Feng Yang
The directional freezing of β-Si 3 N 4 whiskers suspensions followed by high-temperature sintering was employed for fabricating novel highly porous fibrous Si 3 N 4 three-dimensional (3D) scaffolds. A honeycomb-like structure was achieved, in which the directionally aligned lamellar walls were composed of the oriented fibrous Si 3 N 4 grains and bridged by the transverse grains. Ultrahigh porosities ranging from 97.8% to 90.2% and rather low densities from 0.073 to 0.320 g cm −3 could be obtained by controlling the Si 3 N 4 contents from 1.5 to 7.5 vol%. The longitudinal compressive strength was superior to the transverse and increased obviously from 0.19 to 3.7 MPa as the porosity decreased. The superior compressive strength was due to the excellent resistance to bucking-induced elastic instability for the lamellar fibrous Si 3 N 4 walls. Meanwhile, the dielectric constant and loss were decreased to 1.08 and 6.6 × 10 −4 , respectively. This study provides a strategy for fabricating porous Si 3 N 4 ceramics with ultrahigh porosities and improved strength.
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高影响因子
JOURNAL OF ORGANIC CHEMISTRY
·
2024
·
IF 3.3
Jin Yan,Suijie Zhong,Xu Chen,Yihuan Luo,Hua Cao,Xiang Liu,Limin Zhao
Here, we report controlled and site-selective C–H alkenylation and dialkenylation of indolizines and pyrrolo[1,2-a]quinolines with β-alkoxyvinyl trifluoromethylketones under simple and practical conditions. Moreover, this direct C–H alkenylation strategy can also be extended to imidazo[1,2-a]pyridines. Notably, without a transition metal and external oxidant, efficient dehydrogenative β-alkenylation of tertiary amines with β-alkoxyvinyl trifluoromethylketones is presented.
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DOI
高影响因子
Journal of Materials Research and Technology-JMR&T
·
2019
·
IF 3.327
Yinxin Yang,Lingyun Huang,Quanquan Dai,Long Cui,Shijun Liu,Yanlong Qi,Wei Dong,Jianyun He,Chenxi Bai
In this work, hexagonal boron nitride ( h BN) was modified to introduce hydroxyl groups. The abundant hydroxyl groups in β-cyclodextrin (βCD) provide many reactive sites to form covalent links with epoxy groups in epoxy butadiene rubber (EBR). Therefore, we propose the utilization of biological βCD as a novel interfacial crosslinker, assisting in the dispersion of the hydroxylated h BN ( m BN) via hydrogen bonding, to prepare EBR/βCD/ m BN nanocomposites. Such interfacial interactions not only effectively promote the homogeneous dispersion of m BN in the matrix, but also enhance the mechanical property of nanocomposites. Meanwhile, a high thermal conductivity of 0.187 W/m K was obtained by introducing m BN (4 wt%), reaching 2.83 times of the value for the vulcanized butadiene rubber (BR, 0.066 W/m K). The promising mechanical and thermal conductivity properties of our new materials, and the environmentally friendly curing agent makes them attractive for thermal management application, the tread and sidewall compound of tire.
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DOI
高影响因子
危险品化学品经营许可证（带存储）