JOURNAL OF ORGANIC CHEMISTRY
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2023
·
IF 3.6
Yuan Li,Jiamei Shen,Yawei Shen,Yanfeng Li,Kai Luo,Lei Wu
A novel and efficient tandem SN2 nucleophilic substitution/Dieckmann condensation reaction of α-iodomethyl phosphine oxide with methyl thiosalicylate derivatives has been developed by using NaOH as a base, which enables the expeditious synthesis of 2-phosphonyl-3-hydroxybenzo[b]thiophene derivatives in moderate to high yields under simple conditions. This research provides not only a convenient method for the functionalization of benzo[b]thiophenes at the 2-position and 3-position but also new organophosphorus molecules. Furthermore, several new phosphonyl-substituted benzo[b]thiophenes were obtained from the resultant 2-phosphonyl-3-hydroxybenzo[b]thiophenes.
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ANALYTICA CHIMICA ACTA
·
2023
·
IF 6.2
Wen Yin,Ji Hu,Fang Chen,Li Zhu,Yingxin Ma,Nuo Wang,Hongping Wei,Hang Yang,Shan-Ho Chou,Jin He
Background COVID-19 (coronavirus disease 2019) pandemic has had enormous social and economic impacts so far. The nucleocapsid protein (N protein) is highly conserved and is a key antigenic marker for the diagnosis of early SARS-CoV-2 infection. Results In this study, the N protein was first captured by an aptamer (Aptamer 58) coupled to magnetic beads (MBs), which in turn were bound to another DNA sequence containing the aptamer (Aptamer 48-Initiator). After adding 5′-biotinylated hairpin DNA Amplifier 1 and Amplifier 2 with cohesive ends for complementary hybridization, the Initiator in the Aptamer 48-Initiator began to trigger the hybridization chain reaction (HCR), generating multiple biotin-labeled DNA concatamers. When incubated with synthetic streptavidin-invertase-Ca 3 (PO 4 ) 2 hybrid nanoflower (SICa), DNA concatamers could specifically bind to SICa through biotin-streptavidin interaction with high affinity. After adding sucrose, invertase in SICa hydrolyzed sucrose to glucose, whose concentration could be directly read with a portable glucometer, and its concentration was positively correlated with the amount of captured N protein. The method is highly sensitive with a detection limit as low as 1 pg/mL. Significance We believe this study provided a practical solution for the early detection of SARS-CoV-2 infection, and offered a new method for detecting other viruses through different target proteins.
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Analytical Methods
·
2017
·Vol. 9
·期 19
·2812-2820
·
IF 1.9
Yanyi Fu,Qinglin Sheng,Jianbin Zheng
Au nanoparticles supported on nickel hydroxide nanowires with multiple cavities (Au/m-Ni(OH)2) were synthesized and used for the enhanced electrochemical sensing of dopamine (DA). m-Ni(OH)2 nanowires were first fabricated based on an anion exchange strategy and then chosen as supports for Au nanoparticles without an additional stabilizer and surfactant. The morphology and composition of the nanocomposites were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD) and energy-dispersive X-ray spectroscopy (EDS). TEM observations revealed that Au nanoparticles were uniformly embedded in the cavities of m-Ni(OH)2 nanowires, with a high dispersion and a narrow size of 2 nm. Electrochemical investigations indicated that the as-prepared sensor exhibited fascinating performance towards the oxidation of DA. The linear range for DA detection was 0.45 μM to 1.78 mM with a low detection limit of 0.09 μM (S/N = 3). Additionally, the DA sensor possessed an excellent selectivity in the presence of potentially interfering substances such as ascorbic acid (AA), uric acid (UA) and glucose (Glu). Therefore, it is expected that Au/m-Ni(OH)2 nanocomposites could be used as electroactive materials for developing DA sensors.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2021
·Vol. 32
·期 5
·6239-6248
·
IF 2.478
Fan Wenli,He Youyi,Long Lizhen,Gao Yalei,Liu Fuchi,Liu Jun
To research and develop the potential red emission phosphors for warm white-light-emitting diodes (WLED), we systematically investigated double alkaline rare-earth molybdates KGd 1− x Eu x (MoO 4 ) 2 (0.05 ≤ x ≤ 1) phosphors. The crystal structure, morphology, chemical composition, and photoluminescence properties of the phosphors with different Eu 3+ doping concentrations were investigated in detail. The results indicate that Eu 3+ doping concentration can affect the crystal structure and morphology of KGd 1− x Eu x (MoO 4 ) 2 phosphors. The luminescence performance reveals that KGd 1− x Eu x (MoO 4 ) 2 phosphor could emit intense red emission under multiplexed excitations at 362, 382, 394, 465, and 535 nm, which are matched well with the commercial UV, blue and green LED chips. An abnormal quenching behavior was observed in the KGd 1− x Eu x (MoO 4 ) 2 phosphors. And the quenching behavior at the excitation of Eu 3+ –O 2− Charge-Transfer band and Eu 3+ ions 4 f –4 f transitions is quite different. Finally, we fabricated a WLED lamp by coating the InGaN blue chip with a mixture of YAG: Ce 3+ yellow phosphors and KEu(MoO 4 ) 2 red phosphors. The obtained WLED lamps showed warm white light with a lower CCT value (~ 5142 K) than that fabricated without the red phosphors (CCT = 5892 K). These results proved that the KGd 1− x Eu x (MoO 4 ) 2 could be a very promising red-emitting phosphor for WLED.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2021
·
IF 5.816
Chi Zhang,Zhuohong Xie,Yi Liang,Dingding Meng,Zheng Wang,Xin He,Weiye Qiu,Mei Chen,Ping Liang,Zhonghua Zhang
Ni(OH) 2 has been long studied as an effective oxygen evolution electrocatalyst . Nevertheless, its catalytic activity can still be further enhanced by microstructural modification and Fe-doping. In this study, with the assistance of adsorbent ferrihydrite (FH), we obtain Fe-doped β-Ni(OH) 2 nanoplates with Fe 2 O 3 nanoparticles decorated on the surface via a facile hydrothermal process. The Fe-doping, decorated Fe 2 O 3 nanoparticles , and special microstructure endow β-Ni(OH) 2 nanoplates with an improved oxygen evolution activity in alkaline solutions. For the sample with optimal FH amount, the overpotential to motivate a current density of 10 mA cm −2 is 280 mV, with a low Tafel slope of ~64.17 mV dec −1 . During the 10 h i-t test at 1.50 V vs. RHE , the current density has an attenuation of only 23.7%. The study opens a facile avenue to modify Ni(OH) 2 -based OER catalyst from perspectives of both microstructures and compositions .
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DALTON TRANSACTIONS
·
2021
·Vol. 50
·期 16
·5617-5623
·
IF 4.39
Dandan Wang,Xinyuan Zhang,Fei Liang,Zhanggui Hu,Yicheng Wu
Birefringent crystals can modulate and detect the polarization of light, and have been widely used in the field of optoelectronic devices. The combination of a d10 transition metal cation and π-conjugated (H2C3N3O3)− group is a feasible approach for the synthesis of new crystal structures possessing large birefringence and short cutoff edges. Herein, a new hydroisocyanurate birefringent material Zn(H2C3N3O3)2·3H2O (ZHCY) was synthesized by a mild hydrothermal method. ZHCY featured a 2D layered ribbon structure constituted by coplanar π-conjugated (H2C3N3O3)− hydroisocyanurates, and displayed a wide band gap (5.24 eV) and a large birefringence (Δnexp ∼ 0.323, Δncal = 0.283 at 800 nm). Theoretical calculations revealed that its optical properties mainly originated from the π-conjugate coplanar (H2C3N3O3)− groups, which contribute to the enhancement of birefringence.
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TRANSACTIONS OF NONFERROUS METALS SOCIETY OF CHINA
·
2021
·
IF 2.917
Ai-min LIU,Meng-xia GUO,Zhong-ning SHI,Yu-bao LIU,Feng-guo LIU,Xian-wei HU,You-jian YANG,Wen-ju TAO,Zhao-wen WANG
Zinc chloride (ZnCl 2 ) was dissolved in the 1,3-dimethyl-2-imidazolinone (DMI) solvent, and the metallic zinc coatings were obtained by electrodeposition in room-temperature ambient air. The conductivity ( σ ), viscosity ( η ), and density ( ρ ) of the DMI−ZnCl 2 solvated ionic liquid at various temperatures ( T ) were measured and fitted. Furthermore, cyclic voltammetry was used to study the electrochemical behavior of Zn(II) in the DMI−ZnCl 2 solvated ionic liquid, indicating that the reduction of Zn(II) on the tungsten electrode was a one-step two-electron transfer irreversible process. XRD and SEM−EDS analysis of the cathode product confirmed that the deposited coating was metallic zinc. Finally, the effects of deposition potential, temperature and duration on the morphology of zinc coatings were investigated. The results showed that a dense and uniform zinc coating was obtained by potentiostatic electro- deposition at −2 V (vs Pt) and 353 K for 1 h.
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NEW JOURNAL OF CHEMISTRY
·
2021
·Vol. 45
·期 9
·4236-4245
·
IF 3.591
Jia Zhang,Jian Yang,Junying Tian,Hailong Liu,Xuemei Li,Weiguo Fang,Xun Hu,Chungu Xia,Jing Chen,Zhiwei Huang
The synthesis of useful amines from bio-based carbonyl compounds is highly desired owing to their mild reaction conditions and green sustainability. The reductive amination of bio-furfural-derived 2-hydroxytetrahydropyran (2-HTHP) to high-value-added 5-Amino-1-pentanol (5-AP) was carried out over efficient Ni–Al2O3 catalysts prepared by a co-precipitation method. Among the Ni–Al2O3 catalysts with different Ni loadings (0–100 wt%) tested, the 50Ni–Al2O3 catalyst exhibited the highest 5-AP yield of 91.3% under mild conditions of 60 °C and 2 MPa H2. This catalyst also presented good stability during a 150 h time-on-stream without appreciable deactivation. Characterization results showed that the 50Ni–Al2O3 catalyst exhibited small Ni0 nanoparticles (5.5 nm), a high reduction degree (up to 95%), and a large amount of strong Lewis acid sites. The cooperative catalysis of the strong Lewis acid sites and highly dispersed metallic Ni sites is suggested to play an important role in achieving high efficiency in 2-HTHP reductive amination.
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Microfluidics and Nanofluidics
·
2021
·Vol. 25
·期 2
·1-13
·
IF 2.529
Ge Xue-hui,Du Yu-han,Huang Xiaolian,Mo Liangji,Wang Hongxing,Qiu Ting
In this paper, the peppermint oil/HP-β-CD (2-hydroxypropyl-β-cyclodextrin)/chitosan composite microcapsules were prepared. The release ability of these microcapsules was improved for peppermint oil through the combination of molecular encapsulation by HP-β-CD and physical encapsulation by chitosan shell. First, stable peppermint oil/HP-β-CD pre-emulsion was prepared by stirring, based on which the optimal conditions were determined for producing the pre-emulsions with the highest encapsulation efficiency. Then, the pre-emulsion was moved into the flow-focusing microfluidic device as the inner phase and was cut into droplets by chitosan aqueous solution as the middle phase and the octanol as the outer phase to obtain templated emulsions. They were collected using a Petri dish with n-octane coagulation bath containing glutaraldehyde and 2 wt% span80 to be cured into microcapsules. The crosslinking time and the ratio of HP-β-CD in the templated emulsions were adjusted to investigate their impact on the microcapsule structures and correspondingly the capability of the microcapsules to retain peppermint. It was found out that the extended crosslinking time and the addition of HP-β-CD can improve the capability of the composite microcapsules to retain peppermint oil. It provides a straightforward method to produce composite microcapsules. Besides, the microcapsules with improved retaining ability were obtained by combing molecular and physical encapsulation, thus laying a foundation for the exquisite, efficient and polylaminate protection of the volatile perfume or other physically or chemically active components.
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MATERIALS & DESIGN
·
2021
·
IF 7.991
Xuesong Zhang,Yuguang Li,Changxiang Li,Fan Yang,Zhengming Jiang,Liyan Xue,Zhiheng Shao,Zhigang Zhao,Meiying Xie,Shuwen Yu
In this study, a new type of (La 0.2 Ce 0.2 Gd 0.2 Er 0.2 Tm 0.2 ) 2 (WO 4 ) 3 single-phase high-entropy ceramic (HEC) powder was designed, prepared by solid-phase synthesis, and evenly mixed into an epoxy resin (EP) matrix to test the thermal neutron and γ-ray shielding performance. In terms of γ-ray shielding, (La 0.2 Ce 0.2 Gd 0.2 Er 0.2 Tm 0.2 ) 2 (WO 4 ) 3 showed a higher lead equivalent value than EP at 65 keV, indicating a clear shielding effect in the feeble absorbing area of lead-based and bismuth-based materials; moreover, (La 0.2 Ce 0.2 Gd 0.2 Er 0.2 Tm 0.2 ) 2 (WO 4 ) 3 showed good γ-ray shielding performance in both low-energy and medium-energy regions. In terms of thermal neutron shielding, the composite with the highest HEC content (EP/W3) had a nearly 100% shielding efficiency, while that of EP was approximately 50%, indicating that this material has favorable thermal neutron and γ-ray shielding performance. Moreover, the thermal conductivity of the resulting composite material was lower than 0.3 W·m −1 ·K −1 , the tensile strength was higher than 10 MPa, and the density was lower than 1.5 g·cm −3 . All these results suggest that (La 0.2 Ce 0.2 Gd 0.2 Er 0.2 Tm 0.2 ) 2 (WO 4 ) 3 is a candidate radiation shielding material.
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Experimental and Therapeutic Medicine
·
2021
·Vol. 22
·期 6
·1-8
·
IF 2.447
Chun Lei,Yafeng Hou,Jiong Chen
Bone marrow stromal cell antigen 2 (BST2) has been reported to act as an oncogene in the tumorigenesis of numerous types of cancer. Bioinformatics analysis has predicted the binding interaction between BST2 and specificity protein 1 (SP1) and the involvement of SP1 in pancreatic cancer. Therefore, the present study set out to verify this interaction and determine how it may affect pancreatic cancer progression. Normal human pancreatic duct epithelial cells (HPDE6‑C7) and pancreatic cancer cell lines (SW1990, BxPC3, PANC1 and PSN‑1) were selected for western blotting and reverse transcription‑quantitative PCR detection of BST2 expression. Colony formation, Cell Counting Kit‑8 and wound healing assays were performed to detect the proliferative and migratory abilities of PANC1 cells following transfection with small interfering RNA against BST2. The expression of proliferation and migration markers were assayed using western blotting. Chromatin immunoprecipitation and luciferase reporter assays were employed to verify the bioinformatics prediction of BST2‑SP1 binding. PANC1 cell proliferation and migration were analyzed following BST2 knockdown and SP1 overexpression. In comparison with HPDE6‑C7 cells, all four pancreatic cancer cell lines were found to exhibit increased BST2 expression levels to varying degrees, with the highest levels observed in PANC1 cells. BST2 knockdown inhibited PANC1 cell colony formation, proliferation and migration. Additionally, SP1 was shown to bind to the BST2 promoter and could promote PANC1 cell proliferation and migration when overexpressed. However, BST2 knockdown rescued SP1 overexpression‑induced PANC1 cell colony formation, proliferation and migration. In conclusion, activation of BST2 by the transcription factor SP1 was shown to accelerate pancreatic cancer cell proliferation and migration, suggesting that BST2 and SP1 may be plausible therapeutic targets in targeted therapy for pancreatic cancer.
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Foods
·
2021
·Vol. 10
·期 10
·2357
·
IF 4.35
Fei Li,Solju Pak,Jing Zhao,Yunlu Wei,Yuyu Zhang,Quanhong Li
A neutral pumpkin polysaccharide (NPPc) was extracted fromCucurbia moschataand its structural characterization is performed. Moreover, uptake behaviors of an NPPC were investigated at the cellular level. The results showed that NPPc, an average molecular weight (Mw) of 9.023 kDa, was linear (1→4)-α-D-Glcpresidues in the backbone, which branched point atO-6 position of (1→4,6)-α-D-Glcp. The side chain contained (1→6)-α-D-Glcpand terminal glucose. The cellular uptake kinetics results showed that the uptake of fluorescent-labeled NPPc was in time- and dose-dependent manners in Caco-2 cells. For subcellular localization of NPPc, it was accumulated in endoplasmic reticulum and mitochondrion. This study illustrates the characteristics on the uptake of NPPc and provides a rational basis for the exploration of polysaccharides absorption in intestinal epithelium.Keywords:Cucurbia moschata;polysaccharide;structural characterization;uptake characteristic
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