Molecular Catalysis
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2022
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IF 5.089
Nan Li,Changping Jian,Yaping Song,Li Wang,Ata Ur Rehman,Yanghe Fu,Fumin Zhang,De-Li Chen,Weidong Zhu
Herein, we reported a facile and scalable approach for the synthesis of Fe-based MOF MIL-88A(Fe) via a simple liquid-phase route at atmosphere pressure, and its application as a heterogeneous catalyst for the efficient aerobic oxidation of cyclohexene to value-added 2-cyclohexene-1-ol. Over 130 g of spindle-shaped MIL-88A(Fe) nanocrystals with high crystallinity, monodispersed particle size, and large specific surface area were easily synthesized per batch according to our method. The resultant MIL-88A(Fe) exhibited a high catalytic activity (conversion: 81%) with 70% selectivity for 2-cyclohexene-1-ol in the aerobic oxidation of cyclohexene with O 2 as the sole oxidant under mild reaction conditions (0.5 MPa of O 2 , 353 K for 8 h), outperforming the analogues reported in the literatures. The combined experimental and theoretical approach support the reaction mechanism of the oxidation of cyclohexene via both the free radical reaction pathway and Fe-mediated reaction pathway, resulting in the selective formation of 2-cyclohexene-1-ol.
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高影响因子
PLoS One
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2022
·Vol. 17
·期 10
·e0275428
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IF 3.752
Zhi-Bin Dong,Yu-Jia Wang,Meng-Lin Cheng,Bo-Jun Wang,Hong Lu,Hai-Li Zhu,Ling Liu,Min Xie
Oxaliplatin (OXA) is a third-generation platinum compound with clinical activity in multiple solid tumors. Due to the repetition of chemotherapy cycle, OXA-induced chronic neuropathy presenting as paresthesia and pain. This study explored the neuropathy of chemotherapy pain and investigated the analgesic effect of 2-bromopalmitate (2-BP) on the pain behavior of OXA-induced rats. The chemotherapy pain rat model was established by the five consecutive administration of OXA (intraperitoneal, 4 mg/kg). After the establishment of OXA-induced rats, the pain behavior test, inflammatory signal analysis and mitochondrial function measurement were conducted. OXA-induced rats exhibited mechanical allodynia and spinal inflammatory infiltration. Our fluorescence and western blot analysis revealed spinal astrocytes were activated in OXA rats with up-regulation of astrocytic markers. In addition, NOD-, LRR- and pyrin domain-containing 3 (NLRP3) inflammasome mediated inflammatory signal cascade was also activated. Inflammation was triggered by dysfunctional mitochondria which represented by increase in cyclooxygenase-2 (COX-2) level and manganese superoxide dismutase (Mn-SOD) activity. Intrathecally injection of 2-BP significantly attenuated dynamin-related protein 1 (Drp1) mediated mitochondrial fission, recovered mitochondrial function, suppressed NLRP3 inflammasome cascade, and consequently decreased mechanical pain sensitivity. For cell research, 2-BP treatment significantly reversed tumor necrosis factor-α (TNF-α) induced mitochondria membrane potential deficiency and high reactive oxygen species (ROS) level. These findings indicate 2-BP decreases spinal inflammation and relieves OXA-induced neuropathic pain via reducing Drp1-mediated mitochondrial dysfunction.
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高影响因子
POWDER TECHNOLOGY
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2026
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IF 5.5
Shi-Peng Deng,Xue-Fei Peng,Hong-Lei Yan,Zhan-Ku Li,Jing-Chong Yan,Wei-Dong Zhang,Shi-Biao Ren,Zhi-Cai Wang,Shi-Gang Kang,Heng-Fu Shui,Zhi-Ping Lei
Bio-based 2-MTHF is a green alternative for efficient lignite wax extraction. • 2-MTHF achieved 7.9 wt% yield, a 58% increase over toluene extraction. • Crude wax yield reached 5.3%, approaching China's National Grade II standard. • Low activation energy (9.02 kJ·mol −1 ) confirms efficient matrix disruption. Lignite, which is rich in high-value montan wax, is currently mostly burned directly, resulting in a waste of resources. At the same time, traditional toluene extraction methods are facing increasingly stringent regulations due to their toxicity and environmental risks, which hinders the efficient utilization of resources and the adoption of environmentally preferable production routes. This study proposes the bio-based solvent 2-methyl tetrahydrofuran (2-MTHF) as a greener and more efficient alternative to toluene. 2-MTHF can effectively penetrate the pores of the lignite matrix, disrupting non-covalent interactions (such as hydrogen bonds) between wax molecules and the coal matrix, thereby achieving selective and efficient dissolution. Under mild conditions (140 °C, 60 min, solid-to-liquid ratio 1:10, particle size 0.15–0.25 mm), the 2-MTHF extract rate reached 7.9 wt%, a 58% increase compared to toluene (5.0 wt%) under the same conditions; the defatted montan wax yield was 5.3%, also higher than that of toluene (3.3%) (an increase of approximately 61%), and the crude wax product approaches China's National Grade II standard, with a resin content of 33.3% slightly above the 27% limit, while its acid value and saponification value comply with the Grade II requirements. Kinetics and mass transfer analysis indicated that the process follows a first-order kinetic model, with an apparent activation energy of only 9.02 kJ·mol −1 , and is controlled by intraparticle diffusion, further confirming that 2-MTHF can effectively weaken non-covalent interactions within lignite and promote the selective leaching of wax. Download: Download high-res image (128KB) Download: Download full-size image
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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2018
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IF 4.816
Hong-Jin Tang,Wei Li,Mei Zhou,Li-Ying Peng,Jin-Xin Wang,Jia-Huang Li,Jun Chen
Xanthine oxidase, which catalyzes the oxidative reaction of hypoxanthine and xanthine into uric acid , is a key enzyme to the pathogenesis of hyperuricemia and gout. In this study, for the purpose of discovering novel xanthine oxidase (XO) inhibitors, a series of 2-arylbenzo[ b ]furan derivatives ( 3a - 3d , 4a - 4o and 6a - 6d ) were designed and synthesized. All these compounds were evaluated their xanthine oxidase inhibitory and antioxidant activities by using in vitro enzymatic assay and cellular model. The results showed that a majority of the designed compounds exhibited potent xanthine oxidase inhibitory effects and antioxidant activities, and compound 4a emerged as the most potent xanthine oxidase inhibitor (IC 50 = 4.45 μM). Steady-state kinetic measurements of the inhibitor 4a with the bovine milk xanthine oxidase indicated a mixed type inhibition with 3.52 μM K i and 13.14 μM K is , respectively. The structure-activity relationship analyses have also been presented. Compound 4a exhibited the potent hypouricemic effect in the potassium oxonate-induced hyperuricemic mice model. A molecular docking study of compound 4a was performed to gain an insight into its binding mode with xanthine oxidase. These results highlight the identification of a new class of xanthine oxidase inhibitors that have potential to be more efficacious in treatment of gout.
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高影响因子
JOURNAL OF SOLID STATE CHEMISTRY
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2023
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IF 3.3
Shuang Chen,Yin Zhu,Xiaopeng Wei,Guoyuan Zheng,Qiule Zhao,Shuyi Mo,Jilin Wang,Disheng Yao,Nan Tian,Fei Long
A novel bismuth-based zero-dimensional organic-inorganic hybrid material (C 6 H 5 CH 2 NH 3 ) 2 (CH 3 CH 3 NH 2 ) 3 Bi 2 Br 11 was synthesized by a hydrothermal method . The crystal structure, intermolecular interactions , chemical groups, chemical bond characterization, optical and thermal stability of the sample were systematically investigated by single crystal X-ray diffraction, powder X-ray diffraction, Hirshfeld surface analysis, field scanning electron microscopy, Fourier transform infrared spectrometer, Raman spectra , thermogravimetric analysis , and Ultraviolet–visible diffuse reflectance spectra. The results indicated that the (C 6 H 5 CH 2 NH 3 ) 2 (CH 3 CH 3 NH 2 ) 3 Bi 2 Br 11 crystal displayed a triclinic crystal system with a P-1 space group at room temperature with a = 8.5290(4) Å, b = 14.2484(10) Å, c = 18.9386(10) Å, α = 94.418(5) °, β = 102.260(4) °, γ = 106.595(5) °, V = 2131.9(2) Å 3 , Z = 2, R 1 = 0.0936, w R 2 = 0.1536. The compound displayed typical zero-dimensional consisting of two benzylamine organic [C 6 H 5 CH 2 NH 3 ] + cations, three dimethylamine organic [CH 3 CH 3 NH 2 ] + cations and a corner-sharing dimer unit [Bi 2 Br 11 ] 5– . Infrared and Raman vibrational study indicates the presence of [CH 3 CH 3 NH 2 ] + . The 2D fingerprint plot of Hirshfeld surface analysis shows that H⋯Br/Br⋯H (56.8 %) and H⋯H (31.4 %) are major contributions to the intermolecular contact of (C 6 H 5 CH 2 NH 3 ) 2 (CH 3 CH 3 NH 2 ) 3 Bi 2 Br 11 . The sample presented relatively perfect thermal stability up to 240 °C and a wide band gap of about 2.75 eV. It provides some reference value for exploring organic-inorganic hybrid materials with low toxicity and high thermal stability.
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高影响因子
FOOD AND CHEMICAL TOXICOLOGY
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2023
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IF 4.3
Ningxiang Yu,Zeyi Wu,Yijue Wang,Abel Wend-Soo Zongo,Xiaohua Nie,Yuanchao Lu,Qin Ye,Xianghe Meng
2- tert -butyl-1,4-benzoquinone (TBBQ), a degradation product of lipid antioxidant Tert-Butylhydroquinone (TBHQ), is a new hazardous compound in foods . This study investigated whether co-ingestion of dietary protein and TBBQ can alleviate the toxicity of TBBQ. The results indicated that soy protein isolate, whey protein isolate, and rice protein significantly reduced the residual amount of TBBQ during simulated gastrointestinal digestion. This result was attributed to the excellent elimination capacity of the released amino acids for TBBQ through formation of adducts. Among 20 amino acids, histidine , lysine, glycine, and cysteine showed better elimination capacity for TBBQ; they can eliminate 92.1%, 89.4%, 86.1%, and almost 100%, respectively, in 5 min at pH 8.0. Further study indicated that amino acids with lower ionization constant exhibited greater TBBQ elimination capacity. In addition, incubation of the cells with 50 μM TBBQ for 12 h decreased the cell viability to 28.95 ± 3.25%; while amino acids intervention was involved in the alleviation of TBBQ cytotoxicity via decreasing ROS. Particularly, cysteine showed 100 times more TBBQ detoxifying capacity than other amino acids. This work could provide a theoretical basis for the potential application of amino acids for detoxifying TBBQ in the food industry.
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高影响因子
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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2020
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IF 5.573
Heping Zhu,Shilong Ying,Bingluo Zhou,Xiao Liang,Quan He,Ping Song,Xinyang Hu,Keqiang Shi,Mingteng Xiong,Hongchuan Jin,Yuanjiang Pan
Microtubules play a vital role in cell mitosis. Drugs targeting taxol or vinca binding site of tubulin have been proved an effective way to against cancer. However, drug resistance and cancer recurrence are inevitable, there is an urgent need to search for new microtubule-targeting agents (MTAs). In our study, a series of novel 2-aryl-3-sulfonamido-pyridines ( HoAns ) had been designed, synthesized, and evaluated for their antiproliferative activities in vitro and in vivo . Among them, compound HoAn32 exhibited the most potent activity with IC 50 values ranging from 0.170 to 1.193 μ M in a panel of cancer cell lines. Mechanism studies indicated that compound HoAn32 bound to the colchicine site of β-tubulin, resulting in colony formation inhibition, G2/M phase cell cycle arrest, cell apoptosis as well as increased the generation of ROS in both RKO and SW620 cells. In addition, compound HoAn32 showed potent anti-vascular activity in vitro . Furthermore, compound HoAn32 also exhibited outstanding antitumor activity in SW620 xenograft tumor models without observable toxic effects, which was more potent than that of ABT-751 . In conclusion, our findings suggest that compound HoAn32 may be a promising microtubule destabilizing agent and deserves for further development in cancer therapy.
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JOURNAL OF MEDICINAL CHEMISTRY
·
2022
·
IF 8.039
Na Liu,Yichi Zhang,Yingshou Lei,Rui Wang,Meimiao Zhan,Jianbo Liu,Yuhao An,Yaoqi Zhou,Jian Zhan,Feng Yin,Zigang Li
Coronavirus disease 2019 (COVID-19) pandemic, a global health threat, was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 papain-like cysteine protease (PLpro) was recognized as a promising drug target because of multiple functions in virus maturation and antiviral immune responses. Inhibitor GRL0617 occupied the interferon-stimulated gene 15 (ISG15) C-terminus-binding pocket and showed an effective antiviral inhibition. Here, we described a novel peptide–drug conjugate (PDC), in which GRL0617 was linked to a sulfonium-tethered peptide derived from PLpro-specific substrate LRGG. The EM-C and EC-M PDCs showed a promising in vitro IC50 of 7.40 ± 0.37 and 8.63 ± 0.55 μM, respectively. EC-M could covalently label PLpro active site C111 and display anti-ISGylation activities in cellular assays. The results represent the first attempt to design PDCs composed of stabilized peptide inhibitors and GRL0617 to inhibit PLpro. These novel PDCs provide promising opportunities for antiviral drug design.
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高影响因子
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2021
·
IF 6.514
Dongdong Luo,Zhikun Guo,Xuecui Zhao,Lijuan Wu,Xiaochun Liu,Yingzhi Zhang,Yuhang Zhang,Zirong Deng,Xianjun Qu,Shuxiang Cui,Shengbiao Wan
Sphingosine-1-phosphate receptor 2 (S1PR2) has been identified as a brand-new GPCR target for designing antagonists to reverse 5-FU resistance. We herein report the structural optimization and structure-activity relationship of JTE-013 derivatives as S1PR2 antagonists. Compound 9d was the most potent S1PR2 antagonist (K D = 34.8 nM) among developed compounds. Here, compound 9d could significantly inhibit the expression of dihydropyrimidine dehydrogenase (DPD) to reverse 5-FU-resistance in HCT116 DPD and SW620/5-FU cells. Further mechanism studies demonstrated that compound 9d not only inhibited S1PR2 but also affected the transcription of S1PR2. In addition, compound 9d also showed acceptable selectivity to normal cells (NCM460). Importantly, compound 9d with suitable pharmacokinetic properties could significantly reverse 5-FU-resistance in the HCT116 DPD and SW620/5-FU xenograft models without obvious toxicity, in which the inhibition rates of 5-FU were increased from 23.97% to 65.29% and 27.23% to 60.81%, respectively. Further immunohistochemistry and western blotting analysis also demonstrated that compound 9d significantly decreases the expression of DPD in tumor and liver tissues. These results indicated that compound 9d is a promising lead compound to reverse 5-FU-resistance for colorectal cancer therapy.
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Yang Wang,Xiaolin Nie,Zihao Lv,Yi Hao,Qingqing Wang,Qufu Wei
Achieving rapid hemostasis and highly effective antibacterial holds significant importance in the early-stage treatment of wounds. In this study, a hybrid aerogel patch comprising carbon quantum dots (CQDs) modified 2-dimensional (2D) porphyrinic metal–organic framework (MOF) nanosheets was designed by incorporating gelatin methacrylate (GelMA) and polyacrylamide (PAM) based matrix. On one hand, CQDs were stably doped onto the surface of the 2D MOF nanosheets , thereby enhancing the photodynamic activity through fluorescence resonance energy transfer (FRET) process. After the preparation of hybrid aerogel patch, the patch loaded with CQDs-doped 2D MOF exhibited excellent photodynamic bactericidal activity against Gram-positive Staphylococcus aureus (>99.99 %) and Gram-negative Escherichia coli (>99.99 %). On the other hand, the hybrid patch with highly porous and absorbent structure can rapidly absorb blood to aggregate clotting components and form a hydration barrier covering the wound to enhance hemostasis. Besides, the hemolysis and cytotoxicity assays demonstrated a good biocompatibility of this designed patch. In summary, this 2D MOF-loaded aerogel patch holds a potential to achieve rapid hemostasis and effective anti-infection in the early-stage treatment of traumatic wounds.
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高影响因子
ANALYTICAL CHEMISTRY
·
2022
·
IF 8.008
Fajin Qu,Jiangnan Shu,Shanshan Wang,Mohammad A. Haghighatbin,Hua Cui
It is highly desired to exploit good nanomaterials as nanocarriers for immobilizing chemiluminescence (CL) reagents, catalysts and antibodies to develop signal probes with intensive and stable CL properties for immunoassays. In this work, N-(4-aminobutyl)-N-ethylisoluminol (ABEI) and Co2+ bifunctionalized polymethylacrylic acid nanogels (PMAANGs-ABEI/Co2+) were synthesized via a facile strategy by utilizing carboxyl group-rich PMAANGs as nanocarriers to immobilize ABEI and Co2+. The obtained PMAANGs-ABEI/Co2+ showed extraordinary CL performance. The CL intensity is 2 orders of magnitude higher than that of previously reported ABEI and Cu2+–cysteine complex bifunctionalized gold nanoparticles with high CL efficiency. This was attributed to the excellent catalytic ability of Co2+ and polymethylacrylic acid nanogels, as well as the improved CL catalytic efficiency from a decreased spatial distance between ABEI and the catalyst. The as-prepared nanogels also possess abundant surface reaction sites and good CL stability. On this basis, a sandwich immunoassay for the nucleocapsid protein of SARS-CoV-2 (N protein) was developed by using magnetic bead connected primary antibody as a capture probe and PMAANGs-ABEI/Co2+ connected secondary antibody as a signal probe. The linear range of the proposed method for N protein detection was 3.16–316 ng/mL, and its detection limit was 2.19 ng/mL (S/N = 3). Moreover, the developed immunoassay was performed with a short incubation time of 5 min, which greatly reduced the detection time for N protein. By using corresponding antibodies, the developed strategy might be applied to detect other biomarkers.
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高影响因子
Journal of Environmental Chemical Engineering
·
2023
·
IF 7.7
Chen Yang,Xuefeng Hu,Yao Huang,Baiyu Liu,Junhan Yang
We report a rational and scalable synthetic approach to prepare Fe-decorated carbon nitride materials assisted by carbonized polyamine (C-Fe@PDA-CN). The material exhibited extremely high activity and stability for the degradation of 2-mercaptobenzothiazole (MBT) and other organic pollutants (phenol, BPA , MB , and RhB) under visible light irradiation. Furthermore, escape from CN to C-Fe@PDA provides an electron transfer channel to facilitate carrier separation and accelerate the generation of active species, as confirmed by photoluminescence , photoelectrochemical, and electron paramagnetic resonance (EPR). Fe exists in the material coordinated with the pyrrole nitrogen of polydopamine. This coordination structure is conducive to the generation of singlet oxygen ( 1 O 2 ). It is confirmed by steady-state phosphorescence spectroscopy (PH) that 1 O 2 originates from electron transfer. Superoxide radicals are generated by electron transfer and then oxidized into 1 O 2 by holes. The main intermediates of MBT degradation were identified by the LC-MS method, and a possible photocatalytic mechanism based on quenching experiments and EPR tests was proposed.
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危险品化学品经营许可证（带存储）