INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Huayang Tang,Yian Chen,Dexun Fan,Fengguang Zhao,Shuangyan Han
D-allulose, a low-calorie rare sugar catalyzed by D-allulose 3-epimerase (DAE), is highly sought after for its potential health benefits. However, poor reusability and stability of DAE limited its popularization in industrial applications. Although metal-organic frameworks (MOFs) offer a promising enzyme platform for enzyme immobilization, developing customized strategies for MOF immobilization of enzymes remains challenging. In this study, we introduce a designable strategy involving the construction of bimetal-organic frameworks (ZnCo-MOF) based on metal ions compatibility. The DAE@MOFs materials were prepared and characterized, and the immobilization of DAE and the enzymatic characteristics of the MOF-immobilized DAE were subsequently evaluated. Remarkably, DAE@ZnCo-MOF exhibited superior recyclability which could maintain 95 % relative activity after 8 consecutive cycles. The storage stability is significantly improved compared to the free form, with a relative activity of 116 % remaining after 30 days. Molecular docking was also employed to investigate the interaction between DAE and the components of MOFs synthesis. The results demonstrate that the DAE@ZnCo-MOF exhibited enhanced catalytic efficiency and increased stability. This study introduces a viable and adaptable MOF-based immobilization strategy for enzymes, which holds the potential to expand the implementation of enzyme biocatalysts in a multitude of disciplines.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2025
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IF 6.3
Keyi Gu,Yongmin Duan,Shugang Li,Ying Tian,Juan Du,Junjie Zhang
In recent years, inorganic perovskite quantum dots (PQDs) have garnered significant attention, but the photoluminescence (PL) properties and stability of red-emitting PQDs need to be further enhanced. In this work, the precipitation of CsPb(Br/I) 3 quantum dots into borosilicate glass was effectively enabled by the high-temperature melt-quenching method. With the B 2 O 3 /SiO 2 ratio increased, the glass network structure gradually loosened, which enhanced the precipitation of PQDs. Simultaneously, the PL intensity of CsPb(Br/I) 3 PQDs glass increased, with a near twentyfold rise in the photoluminescence quantum yield (PLQY). The variable temperature test of PQDs glass shows that PQDs glass has good thermal stability. Finally, a red-emitting LED and a WLED were prepared by using the prepared red-emitting CsPb(Br/I) 3 PQDs glass. This paper serves as a reference for incorporating red-emitting CsPb(Br/I) 3 PQDs glass into WLED development.
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PeerJ
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2017
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IF 2.177
Hang Lu,Zhiqiang Lu,Xue Li,Gentao Li,Yilin Qiao,Robert P. Borris,Youcai Zhang
Background Herb-drug interactions (HDIs) resulting from concomitant use of herbal products with clinical drugs may cause adverse reactions. Organic anion transporter 1 (OAT1) and 3 (OAT3) are highly expressed in the kidney and play a key role in the renal elimination of substrate drugs. So far, little is known about the herbal extracts that could modulate OAT1 and OAT3 activities. Methods HEK293 cells stably expressing human OAT1 (HEK-OAT1) and OAT3 (HEK-OAT3) were established and characterized. One hundred seventy-two extracts from 37 medicinal and economic plants were prepared. An initial concentration of 5 µg/ml for each extract was used to evaluate their effects on 6-carboxylfluorescein (6-CF) uptake in HEK-OAT1 and HEK-OAT3 cells. Concentration-dependent inhibition studies were conducted for those extracts with more than 50% inhibition to OAT1 and OAT3. The extract of Juncus effusus , a well-known traditional Chinese medicine, was assessed for its effect on the in vivo pharmacokinetic parameters of furosemide, a diuretic drug which is a known substrate of both OAT1 and OAT3. Results More than 30% of the plant extracts at the concentration of 5 µg/ml showed strong inhibitory effect on the 6-CF uptake mediated by OAT1 (61 extracts) and OAT3 (55 extracts). Among them, three extracts for OAT1 and fourteen extracts for OAT3 were identified as strong inhibitors with IC 50 values being <5 µg/ml. Juncus effusus showed a strong inhibition to OAT3 in vitro , and markedly altered the in vivo pharmacokinetic parameters of furosemide in rats. Conclusion The present study identified the potential interactions of medicinal and economic plants with human OAT1 and OAT3, which is helpful to predict and to avoid potential OAT1- and OAT3-mediated HDIs.
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FOOD HYDROCOLLOIDS
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2025
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IF 12.4
Qingbo Jiao,Gerui Ren,Nan Lv,Hao Li,Tianrong Wang,Min Huang,Ruibo Wu,Zexing Cao,Hujun Xie
Enhancing protein-protein interactions (PPIs) has been intensively studied, and the use of molecular glues is a cutting-edge technology. Although the number of molecular glues approved by the Food and Drug Administration is limited, (−)-Epigallocatechin-3-gallate (EGCG) has shown potential as a molecular glue. This study aimed to investigate how EGCG regulated the mechanism of PPIs using zein and β-lactoglobulin (β-LG) as model proteins. The molecular dynamics simulations revealed that EGCG enhanced hydrogen bonding and hydrophobic interactions in Zein-β-LG complexes, thereby improving their stability and compactness. The Δ G values for the formation of the complexes were all higher than −20 kcal/mol, suggesting strong protein interactions and spontaneous binding process. To validate the theoretical calculations, experimental verification was also conducted. The turbidity, particle size, and ζ-potential results demonstrated that EGCG enhanced the aggregation and stability of Zein-β-LG complexes. Fluorescence experiments indicated that the Δ G values at 298K were −27.57 kJ‧mol −1 at pH 5.5, −26.26 kJ‧mol −1 at pH 7.0, and −25.58 kJ‧mol −1 at pH 2.5, and the corresponding binding sites were 1.036, 1.018, and 1.118, respectively. Thermodynamic parameters suggested that hydrogen bonding and hydrophobic interactions were the main driving forces involved in the complexation of EGCG and Zein-β-LG. EGCG binding significantly altered the secondary structures and surface properties of the complexes. These insights emphasized the potential of EGCG in modulating protein interactions, with significant implications for protein-based material and delivery system in the food and pharmaceutical industries.
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OPTICAL MATERIALS
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2024
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IF 3.8
Renjie Jiang,Jie Chen,Mingqin Li,Yanna Tian,Shiji Shen,Xuan Yang,Yanru Tang,Yan Sun,Hui Lin,Shengming Zhou
Ce: YAG- Al 2 O 3 composite ceramics are regarded as highly promising materials for laser illumination application due to their high luminous efficacy and thermal stability. Nevertheless, the Ce: YAG ceramics exhibit limited color rendering index (CRI) for indoor lighting due to their low red emission component. In this study, we synthesized high-performance Ce, Mn-doped (Y, Tb) 3 Al 5 O 12 –Al 2 O 3 composite ceramic phosphors via a vacuum solid-state sintering method. It was observed that the introduction of Mn 2+ ions created a second luminescence center with an emission peak centered at 580 nm. As the Mn 2+ concentration increased, the emission peak redshifted from 580 nm to 591 nm, leading to a significant enhancement in the color rendering index of the ceramics. The cross-energy transfer between Tb 3+ and Mn 2+ , Ce 3+ ions augmented the absorption and conversion of blue light by the ceramics, thereby reducing the correlated color temperature greatly. Based on these findings, ceramics with a Ce 3+ concentration of 3 at% and a Mn 2+ concentration of 4 at% exhibited the highest CRI values (81.3 and 75.6) under both laser excitation and LED excitation, establishing them as strong candidates for achieving high color rendering in white LED/LD illumination applications.
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CERAMICS INTERNATIONAL
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2025
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IF 5.6
Chang Liu,Yuhao Kong,Jianhong Zhang,Chongguang Lyu,Huifang Ma
Dielectric capacitors with high power density, cost-effectiveness, and harsh environmental working abilities have gained considerable research attention. Dielectric materials are key components of dielectric capacitors and directly influence their operational performance. Among others, high-entropy perovskites are emerging as attractive candidates for energy storage materials owing to their exceptional performance driven by the high-entropy effect. Here, a high-entropy (1- x )(Bi 0.4 Na 0.2 K 0.2 Ba 0.2 )TiO 3 - x Bi(Zn 2/3 Ta 1/3 )O 3 system for energy storage devices was designed. A systematic study was conducted to investigate the ferroelectric and dielectric properties of BNKBT-BZT high-entropy ceramics (HECs). The resultant sample exhibits strong relaxor properties and exceptional energy storage properties, with a high recoverable energy storage density ( W rec ) of 4.11 J/cm³ and an energy storage efficiency ( η ) of 84 % under an electric field of 260 kV/cm. More interestingly, the BNKBT-15BZT HECs also display outstanding thermal and frequency stability. These findings suggest that the resultant BNKBT-15BZT HECs are highly promising for applications in dielectric energy storage within low-to-moderate electric field ranges.
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JOURNAL OF MOLECULAR LIQUIDS
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2024
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IF 5.3
Run Li,Xiandong Hao,Bo Wang,Ning Zhao,Zhiyong Xu,Wenbo Zhao
In the present work, a novel non-aqueous 3-aminopropanol/polyethylene glycol 200 (3AP/PEG200) absorbent for efficient carbon dioxide (CO 2 ) capture was designed using environment-benign and non-toxic polyethylene glycol 200 (PEG200) as an alternative to water. The mechanism, physical, thermodynamic, and kinetic properties of absorption process was investigated through a combination of experimental and multi-scale computational simulation approaches including molecular dynamics (MD) simulation and quantum chemical (QC) calculations. It was found that the addition of PEG200 not only enhanced the thermal stability of the absorbent, but also did not significantly increase the viscosity. In addition, kinetic studies revealed that the absorption process conforms to a pseudo-first-order equation, with the activation energy ( E a ) value of 20.40 kJ/mol, significantly lower than that of the benchmark 30 % monoethanolamine (MEA) aqueous solution used in industrial CO 2 capture. Furthermore, the enthalpy change ( ΔH ) and entropy change ( ΔS ) values were found to be more negative than those of other liquid absorption systems, indicating that the 3AP/PEG200 absorbent is favorable for CO 2 absorption even at low partial pressures. Most importantly, the absorption system exhibited good regeneration capability, as demonstrated by five absorption–desorption cycle experiments. In conclusion, the non-aqueous 3AP/PEG200 absorbent exhibits low viscosity, high thermal stability, enhanced absorption capacity, and excellent cyclic performance, positioning it as a promising candidate for CO 2 absorption in industrial applications.
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JOURNAL OF ETHNOPHARMACOLOGY
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2024
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IF 4.8
Rong Ma,Yuge Zhou,Weifan Huang,Xiaoni Kong
Ethnopharmacological relevance Epimedium Tourn. ex L. is a traditional Chinese medicine used for thousands of years in China to treat forgetfulness. Icariin is a principal component of the genus Epimedium . Aim of the study The metabolic mechanism of icariin treating forgetfulness is explored. Materials and methods A D-galactose-induced senescent mouse model was employed. The cognitive performance of mice was assessed in the fear conditioning test. Hippocampal pathology was assessed in the immunohistochemistry assay. Plasma metabolome was analyzed using GC-MS method, and the differential metabolites were further identified by UPLC-MS/MS or GC-MS method. The liver function, including ALT and AST, was assessed by enzyme reaction. Icariin was administered intraperitoneally at 50 and 100 mg/kg. Mice were administered five consecutive days per week for 8 weeks. Results Icariin treatment improved hippocampus-related fear memory but not amygdala-related memory, whereas Pexidartinib (PLX3397), a microglial scavenger, did not. Icariin treatment maintained the TMEM119-positive microglial population and decreased the accumulation of the senescent biomarker p16 in the dorsal hippocampus in senescent mouse brains, whereas PLX3397 did not. Notably, p16 in the CA2 subregion significantly decreased in icariin-treated mice than the other hippocampal subregions. The senescent mice exhibited the circulating metabolic characteristics of mild ketoacidosis, active tricarboxylic acid (TCA) cycle, lactic acidosis, hyperglycemia, active detoxification, active cis-oleic acid metabolism, and inhibitory GABA shut. R-3-hydroxybutyric acid primarily produced in the liver was selectively and robustly decreased by icariin treatment, which was not observed with PLX3397. The TCA cycle was rescued in senescent mice by icariin treatment. Icariin also protected liver function (plasma ALT) in D-gal-induced senescent mice. Conclusions Icariin may protect mouse hippocampal cognition from D-gal-induced senescence by protecting microglial homeostasis, and facilitating the utilization of R-3-hydroxybutyric acid is one of the underpins.
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ACS Applied Electronic Materials
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2024
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IF 4.3
Ang Li,Zhiqing Wang,Zhen Peng,Jing Zhou,Wen Chen
The facile ionic transport in all-inorganic CsPbX3 is crucial for the switching behavior and reliability of ion migration-based memristors. This work presents a method of halide ion doping to reduce the bromine vacancies on the surface of CsPbBr3 quantum dots (QDs) and enhance the migration barriers of bromine ions. This improves the performance of memristors and achieves a more stable resistive switching process. The switching voltages (VSET/VRESET) for the CsPb(Br0.93I0.07)3 QD-based device are 0.92 V/–3.01 V. The VSET/VRESET dispersion range has narrowed from ±0.12 V/±0.16 V for the CsPbBr3 QD-based device to a more consistent ±0.07 V/±0.11 V, resulting in a notable improvement in switching voltage uniformity. The stability of the device over 100 cycles has been optimized, and the HRS resistance varies from 550 × (100 ± 17%) Ω to 69550 × (100 ± 4.1%) Ω, with the ON/OFF ratio increasing significantly to 103. Consequently, this approach can effectively modulate memristive behaviors, indirectly suppressing the random generation of conductive channels. This is enlightening in constructing memristors with high stability and storage capacity.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2024
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IF 5.4
Ting Feng,Jiani Shi,Jiaojiao Xia,Xuemei Ren,Onyinye Idowu Adesanya,Hongbo Suo,Bin Zou
In this study, the critical importance of designing an appropriate immobilized carrier and method for free lipase to ensure exceptional biological catalytic activity and stability was emphasized. Covalent organic frameworks (COF-1) were synthesized as a novel porous carrier with an azine structure (-C N-N C-) through the condensation of hydrazine hydrate and benzene-1,3,5-tricarbaldehyde at room temperature. Simultaneously, Rhizomucor miehei lipase (RML) was immobilized within the COF-1 carrier using an in-situ aqueous phase method. Characterization of the carrier and RML@COF-1 and evaluation of the lipase properties of RML and RML@COF-1 through p -Nitrophenyl palmitate hydrolysis were conducted. Additionally, application in the synthesis of 1, 3-dioleoyl-2-palmitoylglycerol (OPO) was explored. The results showed that RML@COF-1 exhibited a high enzymatic loading of 285.4 mg/g. Under 60℃ conditions, the activity of RML@COF-1 was 2.31 times higher than that of free RML, and RML@COF-1 retained 77.25% of its original activity after 10 cycles of repeated use, indicating its excellent thermal stability and repeatability. Under the optimal conditions (10%, 1:8 PPP/OA, 45℃, 5 h), the yield of OPO reached 47.35%, showcasing the promising application prospects of the novel immobilized enzyme synthesized via in-situ aqueous phase synthesis for OPO preparation.
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FOOD CONTROL
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2025
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IF 6.3
Yaoyao Zhang,Zhaohan Feng,Shangde Sun
The 3-monochloropropane-1, 2-diol esters (3-MCPDEs) and glycidyl esters (GEs), which are recognized as contaminants often produced during the deodorization process of refined edible oils, have garnered widespread attention and research interest in recent years due to their potential health risks to humans. Although there have been studies on the formation mechanisms of 3-MCPDEs and GEs, further clarification is still needed in the intrinsic synergistic effects of precursors. Herein, the synergistic effects of acylglycerols, including monoacylglycerols (MAGs), diacylglycerols (DAGs), and triacylglycerols (TAGs) on the formation of 3-MCPDEs and GEs were innovatively investigated through simulated deodorization experiments in model soybean oil systems. Additionally, the effects of simulated deodorization conditions, including temperatures, heating duration, chloride contents, and acylglycerol compositions on the production of 3-MCPDEs and GEs, were also investigated. The results indicated that under the simulated deodorization process and in the presence of chloride ions, the formation of 3-MCPDEs and GEs was facilitated by the synergistic interaction among MAGs, DAGs and TAGs. It is noteworthy that MAGs were more susceptible to forming 3-MCPDEs in the presence of chloride ions, whereas GEs predominantly resulted from the cyclization reaction of DAGs. Concurrently, when the MAGs content was less than 1%, or the presence of DAGs was less than 4% in the model system, the formation of both 3-MCPDEs and GEs was found to be below the EU regulatory limits, thus offering a solid theoretical basis for the control of 3-MCPDEs and GEs in refined oils.
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ELECTROCHIMICA ACTA
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2024
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IF 5.5
Shaoxiong Liu,Jing Dai,Xuexue Li,Jianjun Xia,Mingyang Xie,Zhifeng Huang,Li Liu
Mn 0.5 Ti 2 (PO 4 ) 3 with a NASICON structural is used as an anode material in potassium-ion batteries due to its abundance of vacancies that can hold potassium ions . This characteristic not only contributes to its excellent stability but also results in a high specific capacity. However, the poor electrical conductivity of the polyanionic type structure limits the material's ability to fully utilize its capacity. In this paper, the conductivity and electrochemical stability of the Mn 0.5 Ti 2 (PO 4 ) 3 anode material are enhanced through composite formation with an F-doped carbon layer. The introduction of F into the carbon matrix creates a large number of vacancy defects and F active sites. The vacancies enhance the transport of potassium ions on the Mn 0.5 Ti 2 (PO 4 ) 3 material's surface, while the active sites exhibit strong electronegativity , improving the absorption of potassium ions. Therefore, the diffusion impedance of potassium ions is significantly reduced, leading to an increased diffusion rate of potassium ions. Attributing to the improved reaction kinetics, the Mn 0.5 Ti 2 (PO 4 ) 3 @F-doped carbon composite demonstrates a high specific capacity of 86 mA h g −1 at 10,000 mA g −1 when used as the anode for potassium-ion batteries. Even more, the specific capacity remains a capacity of 136 mA g −1 after 3000 cycles at 1000 mA h g −1 . This study enhances our comprehension of material design by investigating the alteration of carbon matrix to promote the electrochemical characteristics of materials.
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危险品化学品经营许可证（带存储）