Journal of Food Measurement and Characterization
·
2026
·
IF 3.6
Arshad Atif,Si Tingchen,Dai Yanxi,Sun Yue,Li Xueling,Gao Kun,Liang Jin
The aim of this study was to investigate the effect of golden ear mushroom (GEM) powder and large-leaf yellow tea (LYT) powder on physico-mechanical, rheological properties of dough, nutritional content, cooking quality, color, texture, antioxidant capacity, and sensory attributes of dried noodles. Mixolab results showed that the addition of GEM powder increased dough water absorption, while LYT powder improved dough strength and promoted starch gelatinization. Fortified doughs exhibited higher elastic (G՛) and viscous modulus (G՛՛) with lower loss tangent values. Nutritional analysis showed increased insoluble dietary fiber (1.52 to 1.83 g/100 g) and fat content (1.43 to 2.42 g/100 g), accompanied by a slight decrease in protein content (10.07 to 8.88 g/100 g) in fortified noodles. Antioxidant activity (DPPH and ABTS scavenging) was significantly enhanced ( p < 0.05) compared with the control group. Cooking quality was affected, with increased water absorption and cooking loss (6.22%-11.48%) in fortified noodles, but xanthan gum addition effectively reduced cooking loss to 7.88% and improved texture by increasing hardness (8689.43 g) and chewiness (6368.98 g). Color analysis showed reduced lightness (L*) and increased redness (a*) and yellowness (b*) in fortified noodles. GEM and LYT powder reduced sensory qualities of noodles, while xanthan gum improved texture and acceptability. This study provided a valuable theoretical basis for the industrial application of GEM powder and LYT powder and the development of high-quality dried noodles.
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Journal of Materials Chemistry A
·
2026
·
IF 9.2
Junchao Duan,Wanyin Xu,Tianhe Gao,Xiaolian Li,YaXuan Sun,Wenkang Miao,Dongling Jia,Heguang Liu,Qianqian Li
Cobalt is an interesting candidate to catalytically convert CO2 gas to value-added chemicals through a thermal hydrogenation reaction. However, its catalytic activity and long-term stability are strongly hindered by its dispersion and phase state. In this work, we deeply investigate the dispersion and reduction behavior of a Co3O4 nano-sized catalyst and precisely optimize its catalytic properties in CO2 hydrogenation by modulating the dispersion and metal–support interactions. Finally, it achieves a stable CO2 conversion of 28% with CH4 selectivity above 85% during a 30 hour longevity test. The improvement is attributed to the strengthened metal–support interaction between Co3O4 nanoparticles (NPs) and the g-C3N4 carrier, which stabilizes the active metallic Co species and significantly boosts catalytic activity and durability. This study provides valuable insights into the structural requisites for optimizing CO2 hydrogenation catalysts and offers a feasible strategy for designing efficient non-noble metal catalysts for CO2 utilization.
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Vaccines
·
2026
·Vol. 14
·期 3
·276
·
IF 3.5
Bin Wang,Kehui Wang,Zhiyao Xu,Weihua Liu,Xianhuang Li,Linhao Li,Renhui Zhou,Xingyue Du,Jin Jin,Yaqing Xu,Rihui Qin,Xiong Liu,Dayang Zou,Wei Liu
Background:The global spread of monkeypox virus (MPXV) highlights an urgent need for thermostable and easily administrable vaccines. Current orthopoxvirus vaccines are limited by cold-chain dependence and inconvenient injection-based delivery.Objectives:This study aimed to develop a dissolvable microneedle (DMN) vaccine against monkeypox based on a replication-deficient orthopoxvirus platform, through systematic formulation screening, stabilization mechanism exploration, and rigorous in vivo immunogenicity evaluation.Methods:A film-based approach was adopted for efficient, high-throughput formulation screening and thermostability assessment. NTV was mixed with excipients and dried into solid films. Stability was monitored via RT-qPCR after storage at 4 °C to 40 °C. The lead formulation was physically characterized, then used to fabricate MVA-BN-loaded DMN patches, which were further evaluated for in vivo immunogenicity via immunization inBALB/cmice.Results:The optimal formulation F2 (containing dextran, L-threonine, and BSA/HSA) showed a potency loss of only ~1 log10after 2 months at 25 °C, and <1 log10loss after 1 week at 37 °C. SEM revealed a porous virus-entrapment morphology, and FTIR indicated enhanced hydrogen bonding between the virus and the dextran matrix. The formulation was successfully manufactured into DMNs that dissolved within 5 min. In mice, these DMNs elicited robust MPXV-specific IgG and neutralizing antibody responses, with immunogenicity comparable to that induced by conventional intramuscular injection.Conclusions:This study successfully established a thermostable formulation and dissolvable microneedle delivery platform for replication-deficient orthopoxvirus vaccines against monkeypox. The optimized DMN vaccine induced robust MPXV-specific immune responses in mice with immunogenicity comparable to intramuscular injection, addressing the core limitations of current vaccines and providing a promising solution for monkeypox prevention.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2026
·
IF 4.1
Li Yijiang,Chen Shaoxing,Huang Leijuan,Lin Biying,Cai Zhixiong,Xie Yuanfu
Alkaline phosphatase (ALP) is an important clinical biomarker, and rapid activity quantification is needed in routine diagnostics. Here, we report a CoOOH nanosheet–based colorimetric assay for ALP that uses a H₂O₂-free TMB chromogenic module. CoOOH nanosheets catalyze the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) to produce the blue oxidized product, while ALP hydrolyzes ascorbic acid 2-phosphate (AAP) to generate ascorbic acid (AA), which reduces/decomposes CoOOH and suppresses the TMB signal, resulting in a distinct blue-to-colorless readout. Under optimized conditions, the absorbance response is linear with ALP activity from 0.01 to 25 mU mL −1 with a detection limit of 0.01 mU mL −1 . The assay shows good robustness against common matrix components (e.g., urea, glucose, proteins, and major inorganic ions), whereas thiol-containing reductants can attenuate the signal at elevated levels. Serum recovery tests gave recoveries of 94.30–97.50% with RSDs of 1.9–4.9%, confirming reliability in complex matrices. This method provides a simple, cost-effective, and sensitive approach for ALP activity measurement. In addition, the CoOOH–TMB pair serves as a general H 2 O 2 -free TMB signal module, suggesting potential adaptability to microplate-based ALP-linked immunoassay/ELISA formats. Graphical
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JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2026
·
IF 3.1
Zhang Yili,Deng Jingyu,Yang Zitong,Qi Wenkai,Dai Xinyi,Zhang Yuxia
In the study, we present a molten salt-assisted hard-templating strategy for synthesising cobalt and nitrogen-doped carbon nanoflowers (Co/N-CNFs) as high-performance electrocatalysts for highly sensitive and selective electrochemical dopamine detection. The hierarchical surface roughness and excellent conductivity of Co/N-CNFs, combined with their uniformly dispersed Co sites, facilitate exceptional electrocatalytic performance toward dopamine oxidation. Electrochemical measurements demonstrated that the Co/N-CNFs composite exhibited outstanding performance for dopamine sensing, featuring a broad linear response range from 1 to 1000 µM and an exceptionally low detection limit of 0.13 µM. Moreover, the sensor exhibited remarkable stability, excellent anti-interference capability, and high accuracy in actual sample analysis. The work presents an innovative design strategy for Co/N-doped carbon catalytic systems, enabling the detection of dopamine in spiked human serum samples.
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Nature Communications
·
2026
·
IF 18.1
Wang Xue,Zhong Yuan,Li Tingting,Xu Lingzhang,Xu Wenwu,Yang Yingguo,Fan Chunru,Dong Weinan,Luo Guizhong,Jiang Feng,Zhang Fujun,Lu Min,Zhang Yu,Wu Zhennan,Bai Xue
Metal nanoclusters (NCs) are attracting increasing attention for their molecule-like photoluminescence (PL) properties, while achieving emission tuning remains a challenge. Here, we report the solvation-triggered isomerization of surface terminations and modulation of electron transfer dynamics in the 6-mercaptopurine-9-β-D-ribofuranoside (6-MPR)-protected gold NCs, to attain a controllable emission spanning widely from 495 nm sky-blue to 800 nm near-infrared light. Specifically, the isomerization of 6-MPR gives Au(I)-thione isomer terminals (i.e., R 1 domain) and Au(I)-thiol isomer terminals (i.e., R 2 domain), confers the gold NCs with two prominent emission bands at 590 nm (i.e., PL I from the electron transfer emission state) and 770 nm (i.e., PL II from the triplet state), respectively. The further solvation of gold NCs is rationally designed by mapping out fourteen different organic solvents into four categories referring to their inherent properties of viscosity, polarity, coordination ability, and the strength of proton-giving capacity. This allows for rational conversion between R 1 and R 2 domains, and is concurrent with modulation of the proton-coupled electron transfer dynamics and thus customizable emission tuning.
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Phytopathology Research
·
2026
·Vol. 8
·期 1
·31
·
IF 4.3
Weng Xuexiang,Li Yuting,Wen Yiqi,Chen Yiru,Zhu Zifeng,Yu Liyuan,Liu Xia,Sun Ping,Ruan Yongming
Pathogenic fungi such as Botrytis cinerea ( B. cinerea ) present a major challenge to sustainable agriculture. In this study, we report the design and synthesis of a novel thiol-functionalized dendritic mesoporous silica-based nano-fungicide (Ag@DMSNs-SH), featuring ultrasmall silver nanoparticles (AgNPs) uniformly generated and immobilized in situ within the thiolated silica framework. This innovative synthesis strategy ensures homogeneous AgNPs dispersion, enhanced stability, and a sustained silver release profile. Ag@DMSNs-SH demonstrated superior, dose-dependent antifungal activity against B. cinerea compared to free AgNPs. At 1.5 mg/mL, it achieved 78.63% mycelial growth inhibition over six days, significantly outperforming free AgNPs (15.57% inhibition, P < 0.05). Mechanistic studies revealed that Ag@DMSNs-SH disrupts the fungal cell membrane, causing cytoplasmic leakage. In detached strawberry leaf assays, Ag@DMSNs-SH demonstrated a high curative efficacy, suppressing disease by 92.27% at the minimum inhibitory concentration (MIC), compared to 36.64% for free AgNPs. Its high antifungal performance was further confirmed in potted plant and field trials, where Ag@DMSNs-SH reduced disease incidence from 92.78% to 26.11% and from 83.30% to 19.79%, respectively. These results establish Ag@DMSNs-SH as a new generation of sustained-release nano-fungicide with strong potential for the management of fungal diseases in high-value crops.
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DRUG METABOLISM AND DISPOSITION
·
2026
·
IF 3.6
Qianqian Zhang,Jingyi Hu,Yangbo Liu,Dongzhao Xie,Linyue Bai,Zhuang Hu,Yanjun Tang,Siqi Feng
The therapeutic efficacy of 5-fluorouracil (5-FU), a cornerstone of gastric cancer chemotherapy, is predominantly limited by its catabolic inactivation in tumors. Dihydropyrimidine dehydrogenase (DPD) is the rate-limiting enzyme responsible for 5-FU inactivation, and its tumor-specific overexpression constitutes a primary mechanism of 5-FU resistance. Here, we report a novel strategy to increase the sensitivity of 5-FU by targeting the post-translational regulation of DPD. We demonstrate that the NEDD8-activating enzyme (NAE) inhibitor MLN4924 significantly enhancesthe antitumor activity of 5-FU in both cellular and animal models of gastric cancer without augmenting systemic toxicity. Mechanistically, MLN4924 treatment inhibits the neddylation of DPD, which is dependent on the NAE1/UBC12 axis. This inhibition triggers the ubiquitination and subsequent proteasomal degradation of DPD, thereby reducing intracellular 5-FU catabolism and augmenting its cytotoxic effects. Our findings identify neddylation as a previously unrecognized regulatory mechanism governing DPD protein stability and activity. This work identifies the neddylation-DPD axis as a novel therapeutic target and provides a strong rationale for combining NAE inhibition with 5-FU-based chemotherapy in gastric cancer.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Mei Dai,Liangkai Wu,Juncong Zou,Dexin Wang,Xiang Li,Shaohua Wu,Xinxing Zhou,Chunping Yang,Shanying He
Liquid-phase advanced oxidation processes (AOPs) offer a promising approach for enhanced VOC removal. However, hampered by low gas-liquid mass transfer efficiency and insufficient reactive oxygen species production, the efficient elimination of hydrophobic VOCs remains a challenge. This study evaluated the enhancement of aromatic hydrocarbon elimination from gas streams by adding H 2 O 2 or peroxymonosulfate (PMS) to ozone micro-nano bubbling (O 3 /MNB) technology. Results indicated that MNB increased the O 3 mass transfer coefficient (K L a) to 0.17 min −1 , 4.9 times that of conventional macrobubbling. Under an inlet load of (16 ± 0.8) g·m −3 ·h −1 and empty bed contact time (EBCT) of 45 s, adding H 2 O 2 or PMS markedly increased VOC removal. The O 3 /MNB/H 2 O 2 system achieved removal efficiencies of 86%, 83%, and 86% for benzene, toluene, and xylene, corresponding to elimination capacities of (13.76 ± 0.69), (13.28 ± 0.66), and (13.76 ± 0.62) g·m −3 ·h −1 , respectively. In the O 3 /MNB/PMS system, the removal efficiencies for these compounds were 91%, 80%, and 83%, with elimination capacities of (14.56 ± 0.73), (12.80 ± 0.64), and (13.28 ± 0.23) g·m −3 ·h −1 , respectively. Electron paramagnetic resonance (EPR), quenching tests, and probe experiments revealed that O 3 /MNB/H 2 O 2 system primarily utilized hydroxyl radicals (•OH) and singlet oxygen ( 1 O 2 ), whereas O 3 /MNB/PMS system employed •OH and sulfate radicals (SO 4 •- ). System optimization demonstrated that the O 3 /MNB/H 2 O 2 system showed optimal performance for moderate-to-low concentration waste streams under controlled pH, while the O 3 /MNB/PMS system exhibited superior adaptability for complex, high-concentration exhausts across broad pH ranges. This work provides a theoretical basis for industrial hydrophobic VOC treatment and insights into advanced low-temperature control technologies.
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2026
·
IF 19.7
Dezhi Chen,Longfei Liu,Zhaolin Dou,Fanhao Kong,Xinshu Ji,Hongru Zhou,Min Wang
We report a Pd 1 -MnO 2 that enables efficient bio polyols/sugars electrooxidation under acidic conditions. • The catalyst achieves a fourfold activity that MnO 2 , a 91.1% Faradaic efficiency, and a 288 h stability for formic acid production. • A lattice oxygen assisted deprotonation mechanism is proposed to accelerate C–H/O–H bond activation and C–C bond cleavage in acidic media. Replacing the energy-intensive oxygen evolution reaction (OER) with the oxidation of biomass-derived polyols and sugars has been widely demonstrated in alkaline media, yet it remains fundamentally challenging in acidic environments due to the intrinsic difficulty of activating C–H/O–H bonds. Herein, we report an atomically dispersed palladium doped manganese dioxide (Pd 1 –MnO 2 ) catalyst that effectively overcomes these limitations. This catalyst exhibits over 4-fold enhancement in catalytic activity compared with pristine γ-MnO 2 , achieving a Faradaic efficiency of 91.1% and sustaining a formic acid production rate of 650 μmol cm −2 h −1 over 288 h during glycerol oxidation. Mechanistic investigations reveal a lattice oxygen assisted deprotonation mechanism, wherein single-atom Pd activates adjacent lattice oxygen to accelerate C–H/O–H bonds activation and subsequently promote hydrated C–C bond cleavage, thereby enabling the highly selective oxidation of diverse bio-polyols and sugars to formic acid. Furthermore, by integrating Pd 1 –MnO 2 into a PEM electrolyzer, we demonstrate a practical strategy for upgrading the mixed soluble sugars from hydrolysis of raw biomass to formic acid, and techno-economic analysis corroborates the economic advantages of this approach. Collectively, this work provides molecular-level design principles for developing oxygen-mediated electrocatalysts capable of operating efficiently in acidic environments. Download: Download high-res image (222KB) Download: Download full-size image
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2026
·
IF 19.7
Die Yuan,Kai Li,Xuebin Lu,Chaoqin Zhao,Guijian Zhang,Ping Ning,Dongdong Zhang,Xin Sun,Shuangyou Bao,Chi Wang
A dual-channel electron-donation pathway enables reductant-free Fe 2+ /Co 2+ regeneration. • Pollutants and S 2- synergistically drive reversible M(III)/M(II) redox cycling. • Co 9 S 8 /FeS/PMS achieves rapid and complete levofloxacin degradation within 10 min. A magnetic Co 9 S 8 /FeS composite derived from cobalt slag was developed for reductant-free PMS activation through a novel dual-channel electron-donation pathway involving S 2- species and levofloxacin (LEV). The catalytic performance and mechanism were investigated through degradation kinetics, reactive-species identification, X-ray absorption fine spectroscopy (XAFS), X-ray photoelectron spectroscopy (XPS) analyses, density functional theory (DFT) and life cycle assessment. The Co 9 S 8 /FeS/PMS system completely degraded LEV within 10 min (k = 0.4498 min −1 ), maintained efficient removal over pH 3.0–11.0 and after five cycles (>95%), with 1 O 2 as the dominant reactive species. DFT calculations, together with XAFS/XPS analyses, revealed that S 2− and LEV serve as dual electron donors to facilitate Fe 3+ /Co 3+ reduction, achieving nearly complete Fe/Co redox cycling and sustained PMS activation. Compared with conventional single-electron-donor Fenton-like systems, this strategy eliminates the need for external reductants and substantially reduces environmental impacts, offering a sustainable route for converting cobalt slag into recyclable catalysts for antibiotic wastewater treatment. Download: Download high-res image (176KB) Download: Download full-size image
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ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2026
·Vol. 60
·期 30
·21320-21331
·
IF 12.2
Ma Likun,Sun Peng-Fei,Deng Yuling,Zhu Zhiyang,Liang Huaxing,Yang Yi,Lu Xinglin
Achieving stringent boron compliance in seawater desalination
has
long depended on energy-intensive multipass reverse osmosis (RO) with
alkaline dosing, creating a trade-off between energy consumption and
water quality. This work breaks this bottleneck by developing a hybrid
single-pass multistage (HSPM) system with selectivity-optimized loose
RO membranes. Tailoring commercial RO membranes into high-flux variants
via a 5 h controlled chlorination achieves an optimal balance, whereas
an extended 20-h modification causes an impractical 24.1-fold increase
in boron passage. Mechanistic analysis reveals that the 4-fold increase
in apparent activation energy ( E a ) for
B(OH) 4 – transport at pH 11 fails to fully
offset the intrinsic loss of steric selectivity under neutral conditions.
To overcome this material-level limitation, a multidimensional performance
map identifies the operational sweet spot of the HSPM system, enabling
membranes with moderate boron rejection and high water permeance to
meet the 1.0 mg L –1 threshold via multistage blending
and energy recovery. Coupling the 5 h chlorinated membrane with an
optimized 3-stage configuration theoretically yields a ∼42.5%
energy saving versus conventional two-pass RO. This research establishes
a novel paradigm for application-specific membrane selection and process
synergy, offering a scalable, low-carbon blueprint for desalination
and water reuse.
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