CHEMICAL RESEARCH IN TOXICOLOGY
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2026
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IF 4.1
Hang Yin,Xiaoyu Wang,Zhe Wang,Zhen Wang,Xin Lv,Lili Jiang,Jun Cao,Yong Liu
Anaplastic lymphoma kinase (ALK) inhibitors have shown remarkable efficacy in targeted therapy for non-small cell lung cancer (NSCLC). However, it is worth noting that they may cause clinical drug–drug interactions (DDIs) by inhibiting the activities of drug-metabolizing enzymes, thereby leading to unnecessary side effects. This study sought primarily to characterize the inhibition effects of four well-known ALK inhibitors, crizotinib, ceritinib, alectinib, and brigatinib, on human UDP-glucuronosyltransferases (UGTs) in vitro and to assess their potential DDI risks in vivo. Initial studies demonstrated that all tested ALK inhibitors exhibited a varying extent of inhibition profile on UGTs at starting test concentrations (100 or 60 μM). Subsequent kinetic experiments indicated that alectinib was a selective potent inhibitor for UGT1A4 in a competitive manner with a Ki,u value of 0.07 μM. Ceritinib exhibited a potent noncompetitive inhibition against UGT1A1 and UGT1A7 with Ki,u values of 1.28 and 3.08 μM, respectively, and a competitive inhibition against UGT2B7 with Ki,u of 1.16 μM. Crizotinib and brigatinib demonstrated potent inhibition against UGT2B7 and UGT1A8, respectively. In vitro–in vivo extrapolation (IVIVE) suggested that all four ALK inhibitors have potential for DDIs due to their inhibitory effects on UGTs. Among them, the DDI risks of alectinib and brigatinib were much higher than the FDA standard, which may have an impact on the safety of clinical drug use.
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ACS Sustainable Chemistry & Engineering
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2026
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IF 7.6
Dengke Li,Hongyu Jia,Fengbing Liang,Dexin Feng
Efficient and sustainable synthesis of value-added compounds based on biobased materials is consistent with the principles of green chemistry. Biobased chemicals are primarily synthesized from glucose and related feedstocks via two main routes: enzymatic catalysis for one-step synthesis and whole-cell catalysis for multistep synthesis, with the latter being more cost-effective than the former. However, due to the diversity of intracellular conversion pathways, whole-cell synthesis often exhibits a low atom economy for specific reactions. For example, in the key step of quinoline synthesis involving the construction of a nitrogen-containing six-membered ring, the conversion rate in the fermentation broth is less than 15%. To address this issue, we have developed a biochemical fusion preparation process that combines whole-cell synthesis of 2-aminophenol with the chemical catalytic technology. This approach enables the one-pot construction of C–N, C–C, and C═C bonds in situ within the fermentation broth, using 2-aminophenol and biobased acrolein as substrates, thereby efficiently synthesizing the nitrogen-containing six-membered ring and obtaining the target product, 8-hydroxyquinoline (8-HQ). The metal–organic framework catalyst was rationally designed with a Zr metal center for C–N bond formation and sulfonic acid group for C–C and C═C bond formation, while the pore size was optimized for efficient transformation at low substrate concentrations. This precise engineering strategy culminated in the performance of HI-UiO-66-SO3H-3.3, which delivers an 80.7% yield of 8-HQ within 3 h in aqueous solution. The synthesis efficiency of biochemical fusion catalysis is 6.36 times higher than that of conventional biological catalysis, achieving 200 mg·L–1·h–1. The recycling of water and catalyst exhibits clear advantages in terms of green chemistry metrics. In summary, this study achieved the synthesis of biobased 8-HQ in the biochemical fusion catalytic system, which provided the theoretical and experimental support for in situ green derivatization of biobased platform compounds.
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ACS Nano
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2026
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IF 17.3
Shuai Wu,Zhi Yang,Linyu Chen,Lihui Cao,Yonghao Qiu,Huashuo Ma,Qing-Fang Guan,Yahui Cai,Qiliang Fu,Shu-Hong Yu
Wood is a typically hierarchical porous material with an anisotropic structure and properties. For example, the anisotropic optical performance of wood is often governed by its anisotropic structure. So far, the challenge remains in integrating anisotropic wood, yet with an isotropic light-scattering performance. Moreover, wood-based porous scaffolds have not been fully exploited in their investigation of structural and molecular confinement associated with optical properties. Herein, a luminescence-enhanced wood hydrogel is developed by combining with the three-dimensional N-isopropylacrylamide (NIPAM) polymer network and the surface-carboxylated CdSe/ZnS quantum dots (QDs). Wood nanotechnology is applied to the nanostructural control of the wood-based hydrogel, which results in the isotropic optical performance and mechanical enhancement of the luminescent wood hydrogel. This associates with the mesoporous structure of the cellulose scaffold reinforced with the NIPAM hydrogel polymers, where the surface carboxyl groups of QDs are polarized and confined in the cellulose/NIPAM network. The luminescent property of the functional hydrogel can be tailored by altering the temperature around the critical solution temperature of the NIPAM polymers. The domain confinement effect of a wood-based hydrogel on QDs in terms of molecules and structures is investigated. Furthermore, the functional hydrogel demonstrates a great potential for the smart window application with optical regulation, energy savings, and UV-shielding characteristics. We envision that this functional wood-based hydrogel could be applied in the fields of biological imaging, flexible optics, smart sensors, and anticounterfeiting tags.
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ACS Nano
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2026
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IF 17.3
Xiaorong Dou,Huiyao Zhao,Jiahao Li,Shaodong Duan,Jianbo Wu,Jie Mao,Zhi-Min Dang
Dielectric elastomer actuators are ideal drivers for next-generation soft robots due to their large electroactive deformations. However, conventional dielectric elastomers suffer from insufficient breakdown strength and high mechanical loss, which limits their ability to meet the demanding requirements of advanced robotics for high energy and power densities. Herein, we propose a versatile strategy for incorporating organic molecular semiconductors into the dielectric elastomer network. This design simultaneously achieves high breakdown strength (82 V μm–1), desirable modulus, elasticity, and large electro-actuation strain (174%). Consequently, the optimized elastomer delivers a high energy density (169 J kg–1) and an ultrahigh power density (3000 W kg–1), surpassing natural muscle by 8-fold and outperforming all reported dielectric elastomers. A demonstrated light-emitting, fast-moving soft robot further highlights the material’s multifunctional application potential.
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ACS Applied Materials & Interfaces
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2026
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IF 7.8
Xilin Zhang,Pengjun Duan,Hong Yu,Chunyuan Xu,Jiaju Xu,Zhongren Shi,Hao Liu,Chunliu Zhao,Han Gao,Benli Yu,Siqi Li
Self-assembled nanoparticles (NPs) demonstrate significant promise in various fields, such as display, substance detection, and sensing applications. Their structural tunability, high specific surface area, and pronounced interfacial effects make them suitable for fabricating high-performance sensors. However, the fabrication, performance optimization, and system integration of self-assembly remain challenging. To address these challenges, this study synthesized and employed alkylthiol-group-modified hydrophobic zeolitic imidazolate framework-8 (ZIF-8) NPs, which were combined with a gas–liquid interfacial self-assembly strategy to prepare freestanding ZIF-8 self-assembled films. To demonstrate its function, we integrated this film with a U-shaped tapered optical fiber (U-TOF) for evanescent field coupling, creating a novel all-fiber volatile organic compound (VOC) sensing platform. This novel fabrication process circumvents the repetitive growth steps of the existing in situ methods by leveraging the low-loss cross-substrate transfer of gas–liquid self-assembled films. U-TOF sensor fabrication was achieved in under 10 s by utilizing the Langmuir–Blodgett method. Fabricated by this rapid and facile method, the U-TOF sensor ultimately achieved highly sensitive detection of trace ethanol, offering new insights into the efficient preparation of gas-sensitive optical fiber sensors.
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ACS Applied Polymer Materials
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2026
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IF 5.2
Zhenyang Yin,Yitong Jiang,Fengyu Meng,Xiaoming Qi,Jiangsheng Chen,Hongbo Dai,Chen Qian,Yaqin Fu
Flexible polyurethane foam (FPUF) suffers from high flammability and environmental concerns, necessitating sustainable fire protection strategies. This work highlights a nacre-inspired, halogen-free flame-retardant coating with a hierarchical multicomponent “brick–mortar” architecture. Ammonium polyphosphate (APP) and sodium montmorillonite (MMT) act as rigid multiscale “bricks”, while Schiff base-modified chitosan (DCS) cross-linked with gelatin (GEL) forms the adhesive “mortar”, constructing a hydrogen-bonded, organic–inorganic hybrid network with robust interfacial compatibility on FPUF. The resulting FPUF/3A@M-D/G composite demonstrates remarkable fire safety, achieving a limiting oxygen index (LOI) of 32.6% and a UL-94 V-0 rating. Cone calorimetry shows significant reductions in pHRR1 (−46.1%) and pHRR2 (−67.7%), and THR (−16.8%), along with prolonged ignition time (from 4 to 6 s) and increased char yield (from 8.2 to 26.3 wt %). Meanwhile, the coating improves compressive strength (from 7.96 to 9.32 kPa) without compromising elasticity. Mechanistic analyses (SEM, FTIR, Raman, XPS, and Py-GC/MS) reveal a dual flame-retardant action of condensed-phase char reinforcement and gas-phase radical inhibition. This scalable bioinspired strategy provides a halogen-free pathway to simultaneously improve flame retardancy and mechanical robustness of FPUF for applications in transportation, furniture, and energy systems.
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ACS Applied Nano Materials
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2026
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IF 5.8
Song Wang,Hongyan Li,Xiaohu Zhao,Jiaxin Rui,Zhaogang Teng,Lihong Qi,Kai Pan
One-dimensional (1D) CsPbI3 nanowires (NWs) are promising for nanoscale optoelectronic applications due to their strong quantum confinement and anisotropic charge-transport characteristics, yet their practical use is severely limited by high defect density and poor structural stability. Here, we report an intrinsic stabilization strategy for CsPbI3 NWs via controlled Y3+ doping. CsPbI3 nanocrystals with different Y3+ contents were synthesized by a hot-injection method and subsequently transformed into 1D NWs through a solvent-induced phase conversion process. Structural characterizations demonstrate that Y3+ ions substitutionally occupy Pb2+ sites, inducing slight lattice contraction without generating secondary phases. Importantly, Y3+ incorporation markedly suppresses nonradiative defect states and enhances optical performance. The CsPbI3 NWs with an optimal Y3+ doping level of 20% exhibit the highest photoluminescence (PL) intensity and a 3-fold increase in average exciton lifetime, from ∼35 ns for pristine NWs to ∼110 ns after doping. Temperature-dependent PL analysis reveals an increased exciton binding energy from 413.6 to 491.2 meV and an enhanced longitudinal optical phonon energy from 465.2 to 614.6 meV, indicating strengthened exciton confinement and improved thermal stability. Moreover, the 20% Y3+-doped CsPbI3 NWs retain approximately 90% of their initial PL intensity after 28 days of ambient exposure, whereas pristine NWs undergo rapid degradation. These results demonstrate that Y3+ doping enables effective lattice-level defect regulation and intrinsic stabilization of CsPbI3 NWs, providing a robust and quantitative design strategy for high-performance and long-lifetime perovskite optoelectronic devices.
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ACS Sustainable Chemistry & Engineering
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2026
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IF 7.6
Xin Li,Haoyu Chai,Zhifan Yang,Yucai He,Cuiluan Ma
2,5-Furandimethanol (BHMF) is an important biobased chemical, which can be widely used in the production of fuels, drugs, and polymers. However, BHMF production mainly relies on chemical methods for reduction of 5-hydroxymethylfurfural (HMF), which suffer from low selectivity and environmental concerns. In this study, alcohol dehydrogenase AdhP from Escherichia coli was screened and engineered at residue W84 to generate the 84A mutant, exhibiting a 1.3-fold increase in the catalytic reduction rate compared with the wild-type AdhP at pH 7.0 and 35 °C. Coupling W84A with glucose dehydrogenase (GDH) created the recombinant E. coli AD84 whole-cell catalyst, which might efficiently transform high-titer HMF (1 M) into BHMF (118 g/L) in a yield of 93.3% under 30 °C and pH 7.0 in 6 h. Furthermore, a chemoenzymatic one-pot approach was developed to transform waste bread into BHMF, achieving the valorization of food waste through tandem catalysis with a deep eutectic solvent (DES) chemocatalyst and whole-cell biocatalyst. In a deep eutectic solvent (Betaine:Malic acid:Glycerol)-H2O (10:90, wt/wt) system, waste bread (20.0 g/L) was transformed to 5-HMF at 190 °C for 15 min, with a yield of 26%. Subsequently, E. coli AD84 cells catalyzed the bioreduction of waste bread-derived HMF into BHMF, acquiring a yield of 97% (0.26 g of BHMF/g of bread waste). This work constructed a robust reductase biocatalyst for efficiently transforming high titer of HMF and waste bread-derived HMF into BHMF, providing a sustainable approach for food waste valorization.
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FOOD CHEMISTRY
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2026
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IF 10.4
Jiachen Zhao,Huilin Hu,Chao Wang,Yingting Li,Xueyu Jiang,Ming Zhang,Fangkai Han,Ning Yang,Xiaodan Liu,Jiahua Wang,Yingli Wang,Shuo Duan,Huang Dai,Fuwei Pi
Capsaicin, the primary bioactive compound responsible for the pungency in chilli peppers, poses potential health risks at excessive levels. This study introduced a novel approach for capsaicin detection in food products using a reduced graphene oxide and multi-walled carbon nanotubes (rGO/MWCNTs)-based conductive ink integrated electrodes (IDE) produced via inkjet printing. A hybrid ink was synthesized by dispersing rGO and MWCNTs in polyethylene glycol 400, with the mass ratio of 1:2 to facilitate electron transfer. The rGO/MWCNTs-printed IDE sensor provided a dynamic range of 0.1 μM to 100 μM and a detection limit as low as 0.035 μM. The sensor exhibited good repeatability and selectivity, and maintained 97.5% of its initial response over 28 days. Practical applicability was validated in red, green, millet chilli pepper extracts and hotpot seasoning, yielding recoveries of 92.71–108.48%. The printed rGO/MWCNTs IDE platform enables sensitive capsaicin analysis and is suitable for food quality control
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JOURNAL OF HAZARDOUS MATERIALS
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2026
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IF 10.6
Ruoxi Nie,Somia Yassin Hussain Abdalkarim,Bunan Wu,Haibin Ji,Chaopei Chen,Haicheng Huang,Hou-Yong Yu
Petroleum-based plastics are a significant source of global environmental pollution due to their non-biodegradability. Polylactic acid (PLA), a bio-based and biodegradable polymer, appears to be a promising alternative. However, PLA’s slow degradation rate and formation of persistent residues limit its practical application in agriculture. PLA breakdown can be accelerated by designing stable catalysts, such as through immobilization strategies. Enzyme supports can microregulate the surrounding microenvironment, thereby enhancing enzyme–substrate interactions. Herein, we first design an enzyme–cellulose nanocrystal interface to regulate the microenvironment for the degradation of polylactic acid (PLA) films. By grafting Proteinase K (ProK) onto carboxylated cellulose nanocrystals (HSCNC) and incorporating the resulting Pro-HSCNC into PLA matrix, a composite (PCPro) was developed that demonstrates enhanced crystallinity and mechanical strength while preserving ProK enzymatic activity. The Pro-HSCNC not only introduces multiple degradation sites effectively but also enhances water retention and microbial growth, thereby actively managing the local environment to enable faster, controlled degradation. As a result, PCPro reaches up to 29.5% degradation in soil within 120 days while also supporting plant growth, surpassing most PLA composites in degradation performance. Life cycle assessment (LCA) of PCPro shows a significantly lower environmental impact compared to conventional PLA. This work introduces a new approach for designing enzyme-active bio-polyester-based materials with programmable degradation behaviors through enzyme–cellulose interfacial interaction.
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MICROCHEMICAL JOURNAL
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2026
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IF 5.2
Luping Feng,Yujie Fan,Haoran Li,Jing Liu,Jun Xu,Fangrong Zhou,Qingzhe Wang,Jianghong Wang,Enjun Chen,Xinfeng Li,Lixiang Zhang,Hua Wang
An efficient hybrid nanozyme was synthesized through in-situ growing two-dimensional (2D) MoS 2 nanosheets (NSs) onto three-dimensional (3D) Co 1-x S nanocubes (NCs) by one-pot hydrothermal method. This novel heterostructure was found to exhibit much enhanced peroxidase-mimetic catalytic activities compared to pristine Co 1-x S NCs and MoS 2 NSs, due to the accelerated charge transfer facilitated by the 3D/2D interfacial coupling. The core mechanism underlying this enhancement involves synergistic interaction between Co 1-x S and MoS 2 , which promotes electron transfer and increases the generation of reactive oxygen species ( • OH radicals), thereby improving catalytic efficiency. Importantly, the catalytic activity of the Co 1-x S/MoS 2 hybrid nanozyme can be selectively inhibited by sulfide ions (S 2− ) due to competitive utilization of • OH radicals and reduction of oxidized TMB substrate by S 2− . As a result, an efficient catalysis-based colorimetric detection method was developed for S 2− analysis in environmental water samples. Profiting by the cooperative effect between two components as well as the accelerated electron transfer of as-prepared hybrid nanozyme, the developed colorimetric detection method can achieve a wider linear range (0.10–50 μM), a low limit of detection (LOD, 0.021 μM), and excellent recovery rates (98.3%–104.0%) in real water samples, highlighting its potential for practical applications in water safety assessment. This study provides a novel strategy for designing high-performance nanozymes with 3D/2D heterostructures for environmental sensing applications.
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HYDROMETALLURGY
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2026
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IF 6.3
Bingxu Chen,Chunliu Li,Huaijiang Wang,Ruishu Wang,Yingfeng Cuan,Haojie Meng,Bingwu Chu
High strength, temperature resistance, and corrosion resistance are vital for energy storage technologies, which has led to increased demand for vanadium and molybdenum in the high-tech sector, particularly in aerospace, electronics, and defense. The presence of heteropolyacid ions such as MoV 9 O 28 5− and HMoV 9 O 28 4− has a detrimental effect on the separation of vanadium and molybdenum, with severe adverse consequences for the purity of the products derived from these elements. This study proposes a novel method for the gradient separation of vanadium and molybdenum from acidic solutions. First, phase reconstruction of MoV 9 O 28 5− and HMoV 9 O 28 4− is achieved through the synergistic effects of H 2 O 2 , H + , and NH 4 + . Vanadium and molybdenum are precipitated as a mixed precipitate of (NH 4 ) 2 V 6 O 16 and H₂MoO₅. Second, the reduction reaction of H 2 MoO 5 in acetic acid solution is employed for the selective dissolution of molybdenum, and the molybdenum content in the ammonium polyvanadate is reduced to below 0.006%. Finally, the molybdenum in acetic acid is converted to a MoO 3 product with a purity of 99.9% via evaporative crystallization and roasting. This environmentally friendly process efficiently separates vanadium and molybdenum in acidic media using a phase reconstruction method. The proposed method is also applicable to systems containing nickel, aluminum, and other impurities.
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