EUROPEAN POLYMER JOURNAL
·
2021
·
IF 4.598
Shumin Wang,Xiaoguo Ji,Shumin Chen,Chunyue Zhang,Yibing Wang,Haodong Lin,Liming Zhao
Stanching severe traumatic bleeding requires hemostatic materials that can provide rapid and efficient hemostasis. However, most currently available hemostatic agents exhibit low efficiency and poor biocompatibility. In this study, a novel carboxymethyl chitosan modified with methacrylic anhydride (double-bonded carboxymethyl chitosan)/cysteamine-modified chondroitin sulfate (Me-CMC/CSS) rapid hemostatic dressing was developed using thiol-ene click chemistry. The freeze-dried Me-CMC/CSS dressings absorbed water rapidly and transformed into soft hydrogels that could seal wounds, achieving good hemostasis. The relative blood clotting index of the optimal Me-CMC/CSS dressing was decreased by 53% ( p < 0.001) and 29% compared with a pure Me-CMC dressing and a commercial hemostatic gelatin sponge, respectively. In a rat liver hemorrhage model, the Me-CMC/CSS dressing stopped bleeding rapidly, and the total blood loss was significantly decreased by 92% ( p < 0.0001) compared with the untreated group and was lower than that with gelatin sponge treatment. The Me-CMC/CSS dressing also exhibited a higher ability to adhere to platelets than the gelatin sponge. Furthermore, the Me-CMC/CSS dressing exhibited good hemocompatibility and cytocompatibility. The results indicate that the composite dressings can be potentially applied as rapid hemostatic materials.
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高影响因子
Regenerative Biomaterials
·
2020
·Vol. 7
·期 4
·381-390
·
IF 4.882
Liu Zhu,Ye Weilong,Zheng Jingchuan,Wang Qindong,Ma Guowu,Liu Huiying,Wang Xiumei
Sequential administration and controlled release of different drugs are of vital importance for regulating cellular behaviors and tissue regeneration, which usually demands appropriate carriers like microspheres (MS) to control drugs releases. Electrospray has been proven an effective technique to prepare MS with uniform particle size and high drug-loading rate. In this study, we applied electrospray to simply and hierarchically fabricate sphere-in-sphere composite microspheres, with smaller poly(lactic-co-glycolic acid) MS (∼8–10 μm in diameter) embedded in a larger chitosan MS (∼250–300 μm in diameter). The scanning electron microscopy images revealed highly uniform MS that can be accurately controlled by adjusting the nozzle diameter or voltage. Two kinds of model drugs, bovine serum albumin and chlorhexidine acetate, were encapsulated in the microspheres. The fluorescence-labeled rhodamine-fluoresceine isothiocyanate (Rho-FITC) and ultraviolet (UV) spectrophotometry results suggested that loaded drugs got excellent distribution in microspheres, as well as sustained, slow release in vitro. In addition, far-UV circular dichroism and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) results indicated original secondary structure and molecular weight of drugs after electrospraying. Generally speaking, our research proposed a modified hierarchically electrospraying technique to prepare sphere-in-sphere composite MS with two different drugs loaded, which could be applied in sequential, multi-modality therapy.
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高影响因子
CELLULOSE
·
2022
·Vol. 29
·期 10
·5803-5816
·
IF 6.123
Zhang Qi,Luo Yangyang,Wang Dengke,Yang Zheming,Zheng Jinxia,Xie Mali,Shao Linjun,Du Yijun,Qi Chenze
In this paper, chitosan composite nanofibers with mean diameters of 300–500 nm have been prepared by electrospinning with poly(methacrylic acid) as the crosslinking agent and poly(ethylene oxide) as the cospinning polymer. Afterwards, these composite nanofibers were annealed at temperatures ranging from 110 to 190 °C to improve their solvent resistance. Their morphologies and structures were characterized by scanning electron microscopy, infrared spectroscopy (IR) and positron annihilation life spectroscopy. These composite nanofibers were used to adsorb the Pd 2+ cations in aqueous solutions. The effects of chitosan content, annealing temperature, adsorption temperature, solution pH and initial Pd 2+ concentration were carefully studied. The adsorption result shows that these composite nanofibers had better adsorption performance than the pristine chitosan and commercial activated carbon. Under the optimized adsorption conditions, the maximum adsorption capacity was found to be 366 mg/g. The adsorption kinetic, FT-IR and XPS confirmed the chemical adsorption behavior of Pd 2+ cations on the composite nanofibers. The thermodynamic parameters (ΔG 0 , ΔH 0 and ΔS 0 ) acquired by Van’t Hoff equation indicated that the adsorption process was spontaneous and exothermic in nature. Moreover, selective adsorption study revealed that these composite nanofibers exhibited good adsorption selectivity for Pd 2+ cations from the mixture of metal ions in aqueous solution. At last, the reusability of these novel composite nanofibers was tested for four runs. Overall, this study indicated that the as-prepared nanofiber mat was an efficient adsorbent for the recovery of precious palladium cations from aqueous solutions.
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高影响因子
AAPS PHARMSCITECH
·
2022
·Vol. 23
·期 5
·1-10
·
IF 4.026
Guo Chen,Zhu Xichun,Yuan Haoyang,Liu Haoyu,Zhang Yu,Yin Tian,He Haibing,Gou Jingxin,Tang Xing
In recent years, the oral administration of vinorelbine has gradually replaced intravenous administration in the treatment of several types of tumors. Even though the risk of phlebitis is avoided with oral administration, oral vinorelbine is still not a highly patient-compliant route due to the severe gastrointestinal toxicity. Vinorelbine-loaded liposomes with high encapsulation efficiency and suitable particle size were prepared using the ammonium sulfate gradient method. Chitosan-coated liposomes showed the slowest in vitro release compared to uncoated liposomes and vinorelbine solution. No damage was observed in the intestinal epithelial cells of mice orally administered with coated vinorelbine liposomes due to the low presence of the free drug in the gastrointestinal tract and the LD 50 was increased from 129.83 to 182.25 mg/kg compared to oral vinorelbine solution. In addition, the positive surface potential of chitosan-coating endowed liposomes with mucosal adhesive function, delaying the time to reach the peak plasma concentration of vinorelbine from 1 to 4 h after administration. And bioavailability was increased to 2.1-fold compared to vinorelbine solution. In short, a new strategy to address the severe gastrointestinal side effects of oral vinorelbine has been developed.
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高影响因子
CARBOHYDRATE POLYMERS
·
2020
·
IF 7.182
Juanjuan Fu,Yinglian Zhu,Fansheng Cheng,Shuangling Zhang,Tiantian Xiu,Yue Hu,Shuo Yang
For preparing stable water-in-oil-in-water emulsion, the role of nanoparticles in stabilizing the interface is very important. In this study, chitosan hydrochloride-carboxymethyl chitosan (CHC-CMC) nanoparticles were prepared considering electrostatic interactions; then the emulsion was prepared and the stability characteristics in presence of NaCl (0–200 mmol/L) and 30 d storage were studied. CHC-CMC nanoparticles (261 nm) were obtained when the CHC: CMC ratio was 1:2. CHC-CMC formation was verified by FT-IR when a new peak appeared at 1580 cm −1 ; W 2 contained 2 wt % CHC-CMC and W 1 contained 1 wt % sodium alginate , the creaming index (81.6 %) was higher for the emulsions than Tween 80 (67.4 %) after 30 d. Confocal laser scanning microscopy confirmed the double microstructures, in contrast to the collapse with Tween 80, because the CHC-CMC nanoparticles were densely adsorbing on the oil-water interface. This indicates that CHC-CMC has a stronger ability to stabilize W 1 /O/W 2 emulsion than Tween 80.
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高影响因子
Frontiers in Chemistry
·
2024
·
IF 3.8
Sun Jingxuan,He Lina,An Qi,Ye Xu,Ma Jinjie,Yan Jing,Xie Xiaoqi,Sun Xiangyu,Niu Yumei,Cao Wenxin
Introduction: Facial nerve injury significantly impacts both the physical and psychological] wellbeing of patients. Despite advancements, there are still limitations associated with autografts transplantation. Consequently, there is an urgent need for effective artificial grafts to address these limitations and repair injuries. Recent years have witnessed the recognition of the beneficial effects of chitosan (CS) and graphene in the realm of nerve repair. Dental pulp stem cells (DPSCs) hold great promise due to their high proliferative and multi-directional differentiation capabilities.Methods: In this study, Graphene/CS (G/CST) composite tubes were synthesized and their physical, chemical and biological properties were evaluated, then DPSCs were employed as seed cells and G/CST as a scaffold to investigate their combined effect on promoting facial nerve injury repair.Results and Disscussion: The experimental results indicate that G/CST possesses favorable physical and chemical properties, along with good cyto-compatibility. making it suitable for repairing facial nerve transection injuries. Furthermore, the synergistic application of G/CST and DPSCs significantly enhanced the repair process for a 10 mm facial nerve defect in rabbits, highlighting the efficacy of graphene as a reinforcement material and DPSCs as a functional material in facial nerve injury repair. This approach offers an effective treatment strategy and introduces a novel concept for clinically managing facial nerve injuries.
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PubMed
高影响因子
CARBOHYDRATE RESEARCH
·
2018
·
IF 2.074
Zhiqiang Jiang,Xiaoyan Dong,Yan Sun
Amyloid β-protein (Aβ) aggregation is crucial for the pathogenesis of Alzheimer's disease, and surface charge of nanoparticles (NPs) has been recognized as an important factor influencing Aβ aggregation. Herein, we report a systematic study on the issue with a series of self-assembled chitosan-hyaluronic acid composite (CH) NPs of different surface charges (CH1 to CH7, zeta potentials from +38 to −35 mV). Both the positive and negative CH NPs inhibited Aβ aggregation and the inhibitory effect increased with increasing the surface charges density. Circular dichroism spectroscopy and atomic force microscopy revealed the difference in their working mechanisms. Studies at different pH values further confirmed the importance of electrostatic interactions in Aβ aggregation and presented that the effects of CH NPs changed due to the change of Aβ charge property with pH. This work has thus provided new insight into the surface charge effects on Aβ aggregation.
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高影响因子
CHEMOSPHERE
·
2022
·
IF 8.943
Jibao Deng,Hefei Wang,Haisheng Zhan,Chenxi Wu,Yi Huang,Bing Yang,Ahmed Mosa,Wanting Ling
The capability of laccase to oxidate a broad range of polyphenols and aromatic substrates in vitro offers a new technological option for the remediation of polycyclic aromatic hydrocarbon (PAH) pollution with high cytotoxicity. However, laccase application in the remediation of PAH-contaminated sites mainly suffers from a low oxidation rate and high cost because of the difficulty in its recovery. In this study, laccases were immobilized on magnetic Fe 3 O 4 particles coated with chitosan (Fe 3 O 4 @SiO 2 -chitosan) to improve the operational stability and reusability in the treatment of PAH pollution. The enzyme fixation capacity reached 158 mg g −1 , and 79.1% of free laccase activities were reserved under the optimum immobilized condition of 4% glutaraldehyde, 1.0 mg mL −1 laccase, 2 h covalent bonding time, and 6 h fixation time. The degradation efficiencies of anthracene (ANT) and benzo[a]pyrene (B(a)P) by Fe 3 O 4 @SiO 2 -chitosan immobilized laccase in 48 h were 81.9% and 69.2%, respectively. Furthermore, it is very easy to magnetically recover the immobilized laccase from reaction systems and reuse it in a new batch. The relative activities of immobilized laccase were over 50% for the degradation of ANT and B(a)P in three catalytic runs, reaching the goal of substantially reducing cost in practice. According to the results from quantum calculations and mass spectrum analyses, the degradation products of ANT and B(a)P by laccase were anthraquinone and B(a)P-dione, respectively. The findings from this study provide valuable insight in promoting the application of immobilized laccase technology in the remediation of PAH contamination.
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高影响因子
FOOD HYDROCOLLOIDS
·
2022
·
IF 11.504
Jiahao Yu,Shanlin Xu,Gulden Goksen,Caifu Yi,Ping Shao
Deep eutectic solvents (DES) as plasticizers of chitosan film show great potential for food packaging. This paper introduced some novel antioxidant and antibacterial films based on chitosan and DES consisting of choline chloride (ChCl) and organic acids. The effects of the composition and contents of choline-based DES on structures, mechanical properties, thermal stability, contact angle, optical, antioxidant and antibacterial properties of chitosan films were studied. FTIR analysis showed that choline-based DES did exist in the chitosan film with good polymer matrix compatibility. Most of the films exhibited uniform, flat surfaces and cross sections. The Young's modulus of the films decreased inversely to the level of choline-based DES, and maximal mechanical characteristics were achieved for films plasticized with ChCl and acetylsalicylic acid. The addition of choline-based DES apparently reduced water contact angles, decreased the decomposition temperature and the thermal stability of chitosan films. In terms of antioxidant capacities and ultraviolet (UV) shielding, chitosan films plasticized with choline-based DES containing acetylsalicylic acid and vitamin C had strong UV shielding and antioxidant properties. Chitosan films plasticized with choline-based DES containing acetylsalicylic acid, malonic acid and lactic acid showed excellent antibacterial properties against Escherichia coli and Staphylococcus aureus . In conclusion, the chitosan film with the choline-based DES, especially for ChCl and acetylsalicylic acid showed a good application prospect in food active packaging.
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高影响因子
CARBOHYDRATE POLYMERS
·
2015
·
IF 4.074
Zhengyang Li,Tingting Li,Libao An,Pengfei Fu,Cangjian Gao,Zhiming Zhang
Chitosan/polymethylmethacrylate (PMMA) composite nanofibrous membrane was prepared by electrospinning technique with a single solvent system. Characterization with Fourier transformation infrared spectroscopy (FT-IR) indicated that there was weak interaction (such as hydrogen bonds) between PMMA and chitosan. Scanning electron microscopy (SEM) measurements illustrated that the average diameter of the composite nanofibers decreased as the chitosan content was increased, while the number of nano/micrometer sized beads increased in the membrane. The composite nanofibrous membrane with chitosan:PMMA ratio of 0.3:1.0 exhibited a maximum adsorption capacity (67.0 mg g −1 ) of Cr(VI) in static adsorption, which was nearly three times higher than that of chitosan powder (22.9 mg g −1 ). The adsorption capacity of Cr(VI) via filtration became even higher, where the maximum value was 92.5 mg g −1 at pH 3.0. Notably, most of Cr(VI) has been removed after the first filtration at all pH values (2.0–6.0) investigated in this report. The adsorption capacity of the composite nanofibrous membrane decreased slightly (17.1%) after three filtration cycles even with the solution of pH 2.0, which shall be attributed to the enhanced mechanical strength and acid fastness of the composite membrane. X-ray photoelectron spectroscopy (XPS) analysis indicated that amino groups played an important role in the adsorption of Cr(VI).
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高影响因子
Journal of the Taiwan Institute of Chemical Engineers
·
2016
·
IF 2.848
Wenyu Wang,Qinyan Yue,Baoyu Gao,Ruihua Li
In this study, the tendency of coagulation performances, floc characteristics and membrane resistances under different pH conditions in coagulation–ultrafiltration hybrid process was investigated by different Al species and chitosan (CS). Results indicated that CS as coagulation aid was independent of aluminum species. Coagulation efficiencies of three Al species (Al a , Al b and Al c ) combined with CS were enhanced comparing with Al species used alone and shown similar variation tendencies during the pH range. The values of floc size and strength/recovery factor were relatively high at pH 6, and the maximum fractal dimension was achieved under alkaline conditions generally due to adsorption sweeping. Al a /Al b /Al c combined with CS contributed to larger flocs, higher recovery factors and smaller fractal dimension values than those without CS. The results of ultrafiltration experiments shown that membrane resistances during alkaline ranges were higher than those of acidic conditions, which indicated membrane fouling was more serious in alkaline range. In addition, the total membrane resistance was decreased significantly by CS addition.
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高影响因子
Environmental Technology & Innovation
·
2021
·
IF 5.263
Xiaohui Tang,Yaoyao Huang,Qiang He,Yongjuan Wang,Huaili Zheng,Yadan Hu
With the abuse of tetracycline antibiotics and their high detection rate in the water environment, causing non-negligible environmental hazards and health risks, the treatment of tetracycline wastewater has been paid much attention. Herein, a noval magnetic adsorbent, nitrilotriacetic acid-modified magnetic chitosan microspheres (NDMCMs) was successfully prepared and applied to remove tetracycline antibiotics (TC) from wastewater. The results found that the solution pH and ion strength greatly affected the adsorption capacity of TC by NDMCMs. Additionally, the adsorption capacity of NDMCMs (373.5 mg g −1 ) was four times higher than that of MCMs (92 mg g −1 ) at pH 8.0, attributed to the various amino and carboxyl groups in the grafted chain. The experiment data were better correlated with the Freundlich isotherm model and the pseudo-second-order kinetic model, indicating that the adsorption between TC and adsorbent surfaces occurred as multilayer adsorption, and the chemical interaction played as a rate-limiting step in the adsorption process. The thermodynamic parameter calculation results demonstrated that the adsorption of TC by NDMCMs followed a spontaneous, endothermic, and orderly process. Besides, the regeneration performance of NDMCMs showed that it is fully qualified for practical application of TC adsorption. The adsorption mechanism proposed by the FT-IR spectroscopic analysis of the adsorbent before and after the adsorption of TC was mainly through π - π interaction, cation- π bond, hydrogen bond , and amidation reaction. Based on all experimental results, NDMCMs is an efficient and sustainable magnetic adsorbent, which can be used to remove TC from wastewater.
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高影响因子
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