JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2020
·
IF 4.192
Hui He,Meixiao Cheng,Yuting Liang,Hongxiang Zhu,Yupei Sun,Die Dong,Shuangfei Wang
Novel nanosized biomass-based pH-responsive cellulose nanofibers (CNF-PEI) with excellent biocompatibility were tailored by grafting polyethylenimine (PEI) onto carboxylated cellulose nanofibers (CNF-COOH); the active site (−COOH, 0.96 mmol/g) was anchored on cellulose nanofibers (CNFs) to introduce PEI with a high density (10.57 mmol/g) of amino groups. The as-prepared CNF-PEI not only maintained the good properties of CNFs but also possessed excellent biocompatibility and pH-responsive properties, offering interesting possibilities for pH-induced sustained drug release and medical dressing. The CNF-PEI showed rapid wettability conversion from hydrophilic, underwater superoleophobic (WCA = 20.7°, OCA = 159.3°) to hydrophobic, superoleophilic (WCA = 129.6°, OCA = 29.7°) in response to pH change from acidic conditions to alkaline conditions. The antibacterial activity of CNF-PEI toward Escherichia coli and Listeria monocytogenes was 100% and 94.6% under acidic conditions, respectively. Furthermore, the pH-responsive mechanism of CNF-PEI was revealed by XPS, 13C NMR, 1H NMR, and AFM analyses.
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NANOTECHNOLOGY
·
2020
·Vol. 31
·期 19
·195103
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IF 3.551
Junlong Liang,Xiaokang Jin,Biling Chen,Jinhua Hu,Qianwei Huang,Junmin Wan,Zhiwen Hu,Bing Wang
The integration of chemotherapy drugs and photosensitizers to form versatile nanoplatforms for achieving chemo-photodynamic synergetic therapy has shown great superiority in tumor theranostic applications. We constructed pH-responsive nanoparticles (DOX/PB NPs) encapsulating the chemotherapeutic drug doxorubicin (DOX) into the cores of PLGA NPs coated with bovine serum albumin (BSA) via a water-in-oil (W/O/W) emulsion method. A simple and efficient chemo-photodynamic synergetic nanoplatform (DOX/PB@Ce6 NPs) was obtained by the adsorption of photosensitizer chlorin e6 (Ce6) onto the surface of the DOX/PB NPs. With optimal size, pH-responsive drug release behavior and excellent singlet oxygen production, the DOX/PB@Ce6 NPs have the potential to enhance anti-tumor efficiency. The cellular uptake, cytotoxicity, chemo-photodynamic synergetic effect and biocompatibility of the NPs were evaluated based on HeLa cells via in vitro experiments. The in vitro chemo-photodynamic synergetic experiments indicated that the DOX/PB@Ce6 NPs had remarkable cancer cell killing efficiency under laser irradiation. Notably, by hemolysis assay, all the NPs displayed excellent blood compatibility and were expected to be applicable for intravenous injection. In summary, the designed DOX/PB@Ce6 NPs multifunctional theranostic nanoplatform had excellent reactive oxygen species generation and would be a potential therapeutic platform for chemo-photodynamic synergetic therapy.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2020
·
IF 3.807
Gengxin Hu,Nanxi Li,Yuwei Zhang,Hong Li
The electrochemical oxidative quinone-functionalization of tryptophan (Trp) residues, and the proton-coupled electron transfer properties between quinonized Trp (Trp=O) and its re-reduced species (Trp-OH) are investigated for potentiometric pH sensors. The Trp=O/Trp-OH couples are assembled on a graphite electrode using multiple cyclic voltammetry, and exhibit a pair of well-defined redox peaks at redox potential of 0.090 V (vs. SCE) at pH 7.0 and 298 K. The proton-coupled electron transfer properties of Trp=O/Trp-OH couples are dependent on electrode substrate material, incubation temperature and pH values, and Trp residue sources including amino acid, peptide and protein. The Trp=O/Trp-OH-based surface-confined exothermic electrode reaction rates show a decrease with increasing incubation temperature from 283 to 323 K at pH 5.0. Both of redox peak potential and open-circuit potential under optimum conditions have a good linear pH dependence between 1.0 and 12.0 with sensitivity of more than 52 mV pH −1 and relative standard derivation of 1.5%. The proposed potentiometric pH sensor has significant advantages of low cost, good stability and reproducibility, and strong anti-interference ability. The present study shows a new approach to endow Trp, Trp-containing peptides and non-conjugated proteins with analogous proton-coupled electron transfer performance to prosthetic groups of quinoproteins for monitoring pH changes in milk samples.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2020
·
IF 5.162
Bahaaldin Rashidzadeh,Ebrahim Shokri,Gholam Reza Mahdavinia,Reza Moradi,Sarvin Mohamadi-Aghdam,Shadi Abdi
This work reports the synthesis of novel antibacterial magnetic-/pH-sensitive hydrogel beads based on ionotropic-gelation of alginate biopolymer . Using pomegranate peels extract, green-Ag nanoparticles were synthesized inside a mixture of alginate and Fe 3 O 4 , via in situ method. The alginate beads were investigated by VSM, TEM , XRD, and FE-SEM techniques. The introducing Ag and Fe 3 O 4 nanoparticles in hydrogel beads caused a reduction in the swelling capacity of hydrogel beads. Besides, a pH-dependent swelling behavior was observed for hydrogel beads with a maximum swelling capacity at pH = 7.4. Diclofenac sodium (DS) as a model drug was loaded in hydrogel beads and its release showed a pH-dependent behavior. Drug release studies exhibited significant behaviors on the subject of physiological simulated pHs with a high release rate at pH = 7.4. The alginate beads have shown a prolonged and successive controlled drug release nearly 83% at pH = 7.4 and time 200 min. In addition to the pH, the release of DS from magnetic beads was affected by the external-magnetic-fields. Also, the Ag-incorporated alginate beads showed strong antibacterial activity against S. aureus and E. coli . These results indicated that the hydrogel beads have potentially applicable in drug delivery systems.
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LANGMUIR
·
2020
·
IF 3.557
Wenwen Liu,Junjie Li,Zhihui Qin,Mengmeng Yao,Xinlu Tian,Zhiming Zhang,Li Zhang,Qin Guo,Linhua Zhang,Dunwan Zhu,Fanglian Yao
Circulation stability in vivo and stimuli-responsiveness under a tumor microenvironment of the polymeric prodrug micellar drug delivery systems are very critical to improve the tumor therapeutic efficiency. In this study, a series of polyamidoamine (PAMAM)-graft-poly(2-(diethylamino) ethyl methacrylate) (PDEAEMA)-block-poly(betaine sulfonate) (PSBMA) (PDS) unimolecular micelles were prepared via atom transfer radical polymerization. PAMAM served as a hydrophobic core to load the drug, the PDMAEMA segment was a middle layer to provide both thermo- and pH-sensitivity, whereas the PSMBA shell layer was used to improve the stability of the unimolecular micelles. The PDS exhibited a spherical structure with the size of 10–20 nm at pH 7.4. PDS micelles had excellent stability to resist the large volume liquid dilution. Moreover, it exhibited excellent stability in a complex biological microenvironment because of a superhigh antiprotein adhesion capacity of the PSBMA shell layer compared with PAMAM micelles. Drug release studies confirmed that the DOX can remain in the PDS micelles at pH 7.4 and 37 °C, whereas it can rapidly be released when the pH decreases to 5.0 and/or the temperature increases to 40 °C. In vitro studies suggested that the PDS drug delivery system can effectivity induce apoptosis and inhibit the proliferation of cancer cells. In vivo studies suggested that the PDS micelles prolonged the circulation time, decreased the side effects, and increased the antitumor efficacy. Therefore, the prepared PDS micelles are a potential anticancer drug delivery carrier for cancer therapy.
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Materials
·
2020
·Vol. 13
·期 6
·1279
·
IF 3.057
Yanqin Xu,Liyue Xiao,Yating Chang,Yuan Cao,Changguo Chen,Dan Wang
In order to achieve a controlled release drug delivery system (DDS) for cancer therapy, a pH and redox dual-responsive mesoporous silica nanoparticles (MSN)-sulfur (S)-S- chitosan (CS) DDS was prepared via an amide reaction of dithiodipropionic acid with amino groups on the surface of MSN and amino groups on the surface of CS. Using salicylic acid (SA) as a model drug, SA@MSN-S-S-CS was prepared by an impregnation method. Subsequently, the stability, swelling properties and drug release properties of the DDS were studied by x-ray diffraction, scanning electron microscopy, Fourier transform infrared microspectroscopy, size and zeta potential as well as Brunauer–Emmett–Teller surface area. Pore size and volume of the composites decreased after drug loading but maintained a stable structure. The calculated drug loading rate and encapsulation efficiency were 8.17% and 55.64%, respectively. The in vitro drug release rate was 21.54% in response to glutathione, and the release rate showed a marked increase as the pH decreased. Overall, double response functions of MSN-S-S-CS had unique advantages in controlled drug delivery, and may be a new clinical application of DDS in cancer therapy.Keywords:mesoporous silica nanoparticles;double response;drug delivery;drug release
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Journal of Environmental Chemical Engineering
·
2020
·
IF 4.3
Lilan Huang,Leitao Zhang,Deyuan Li,Qingping Xin,Rui Jiao,Xiaoyang Hou,Yuzhong Zhang,Hong Li
Delicate design of hierarchical and porous nanoarchitectures has become a highly effective strategy to develop novel bimetallic catalyst with improved stability and catalytic performance. Herein, a core-shell hierarchical 4A zeolite/Fe@Cu Fenton-like catalyst with 4A zeolite/Fe as core components and two-dimensional Cu hydroxide nanosheets assemblies as shell structure was fabricated through a simple and scalable approach and used for phenol degradation. The results indicated that 4A zeolite/Fe@Cu bimetallic catalyst had higher catalytic activity and utilization efficiency of H 2 O 2 than that of 4A zeolite/Fe and 4A zeolite@Cu monometallic catalysts at near neutral pH. In the presence of H 2 O 2 , the 4A zeolite/Fe@Cu bimetallic catalyst could remove 95.3 % phenol after 4 h at pH 5, which was much higher than that of monometallic catalyst under the same condition. The enhanced activity of 4A zeolite/Fe@Cu was ascribed to the synergistic effect between the 4A zeolite/Fe (core) and two-dimensional Cu hydroxide nanosheets (shell). More importantly, the copper hydroxide nanosheets with open network structure on the surface of 4A zeolite/Fe@Cu improved the stability of the Fe(III) at acidic conditions, and avoided reduced catalytic efficiency of Fe(III) caused by embedding effect. This strategy provided guidance to the design of high-performance bimetallic Fenton-like catalysts.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2020
·
IF 7.1
Kun Zhou,Zhida Zhao,Pengbo Yu,Zheyao Wang
This paper presents a method of achieving high sensitivity for silicon nanowire (SiNW) field-effect transistor (FET) pH sensor by operating the FETs in both capacitive amplification mode and differential amplification mode. The capacitive amplification is implemented by employing an inversed double-gate configuration that uses the electrode immersed in a solution well etched from the backside of the sensor chip as the top gate and the SiNW metal gate as the back gate. This enables the threshold voltages of the FETs to be amplified through the ratio of the top gate capacitance to the back gate capacitance. The differential amplification is achieved by a readout circuit chip that is vertically integrated with the sensor chip using flip-chip bonding. This allows the back gate to be controlled independently by the circuits, such that the differential amplification that is originally applicable to single-gate FETs can be applied to double-gate FETs. By operating the dual amplifications simultaneously, a sensitivity of 720.7 mV/pH has been achieved in the pH range of 4−10. Small deviations between the SiNW pH sensor and a commercial pH meter in measuring phosphate buffer saline, bovine serum, and tap water demonstrate the capability of the SiNW pH sensor in measuring practical samples.
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RSC Advances
·
2020
·Vol. 10
·期 40
·23532-23542
·
IF 3.119
He Guo,Xiaomeng Cheng,Hongping Li,Jun Li,Jinjin Wei,Chongyang Feng
A new nanoprobe, the luminescent diblock copolymer PNIPAM(MAh-4)-b-P4VP (PN4P), with pH- and thermo-responsive deprotonation-driven emission decay (DDED) and aggregation-induced emission (AIE) features was designed and synthesized. The nanoprobe PN4P can form micellar structures in water with reversible dual-responsive fluorescence (FL) behavior within a wide pH range of 2–11. The critical solution temperature was found at about 32, 30 and 27 °C as the pH switched from 2, 7 to 11. The critical pH value of the probe was about 4.0, and the micelles showed a core–shell inversion in response to pH and thermal stimuli, accompanied by a desirable emission tunability. P4VP as the micellar shell at pH = 2 was more easily dehydrated with the increase in temperature as compared to PNIPAM as the micellar shell at pH > 4. The strongest dehydration of the P4VP shell would make PN4P the most strongly aggregated and the most AIE-active, which supports the 2.10-fold most distinguished thermal-responsive emission enhancement at pH = 2. Moreover, a dramatic acidochromic redshift of the emission band from 450 (pH > 4) to 490 nm (pH = 2) was observed, and the maximum emission at pH = 2 was enhanced by about 2.07-fold as compared with that at pH = 7. Therefore, the probe displays the desired dual responses and good reversibility. AIE and DDED are the two major mechanisms responsible for the dual-responsive emission change, with AIE playing a more important role than DDED. This work offers a promising approach to interpreting temperature (range from 28 to 40 °C) and pH changes (range from 2 to 7) in water.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2020
·
IF 4.192
Yu Xu,Xiang Li,Wei Gong,Hai-Bo Huang,Bei-Wei Zhu,Jiang-Ning Hu
The aim of this study is to construct a pH- and reduction-responsive nanodrug delivery system to effectively deliver a ginsenoside (Rh2) and enhance its cytotoxicity against human hepatocarcinoma cells (HepG2). Here, pullulan polysaccharide was grafted by urocanic acid and α-lipoic acid (α-LA) to obtain a copolymer, α-LA-conjugated N-urocanyl pullulan (LA-URPA), which was expected to have pH and redox dual response. Then, the copolymer LA-URPA was used to encapsulate ginsenoside Rh2 to form Rh2 nanoparticles (Rh2 NPs). The results showed that Rh2 NPs exhibited an average size of 119.87 nm with a uniform spherical morphology. Of note, Rh2 NPs showed a high encapsulation efficiency of 86.00%. Moreover, Rh2 NPs possessed excellent pH/reduction dual-responsive drug release under acidic conditions (pH 5.5) and glutathione (GSH) stimulation with a low drug leakage of 14.8% within 96 h. Furthermore, Rh2 NPs with pH/reduction dual response had higher cytotoxicity than Rh2 after incubation with HepG2 cells for 72 h, indicating that Rh2 NPs had a longer circulation time. After the treatment with Rh2 NPs, the excessive increase of reactive oxygen species and the decrease of superoxide dismutase, glutathione (GSH), and mitochondrial membrane potential suggested that the mitochondrial pathway mediated by oxidative stress played a role in this Rh2 NP-induced apoptosis. In conclusion, this study provides a new strategy for improving the application of ginsenoside Rh2 in the food and pharmaceutical fields.
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CERAMICS INTERNATIONAL
·
2020
·
IF 3.83
Jinyue Zhang,Mingshi Jin,Yong Il Park,Longyi Jin,Bo Quan
Manganese silicate nanoparticles have recently attracted great attention due to the effectiveness of T 1 -weighted magnetic resonance imaging (MRI) contrast agents (CAs) in the mildly acidic and high glutathione (GSH) conditions of the tumor microenvironment. Herein, ultra-small hollow manganese silicate (UHMS) nanoparticles were prepared via a facile, economical, and eco-friendly method based on a hydrothermal process using small silica nanoparticles as both the silicon source and templates. The nanoparticles showed remarkable biocompatibility and dispersion stability after modification with polyethylene glycol (PEG). Owing to their ultra-high longitudinal relaxation rate (r 1 ) at low pH values and high GSH levels, the [email protected] nanoparticles have performed an excellent pH/GSH-responsive T 1 -weighted MRI. Meanwhile, the nanoparticles showed insignificant cytotoxicity in vitro and in vivo. Therefore, the [email protected] nanoparticles show promise as T 1 -MRI CAs in the tumor microenvironment and may be used to assist in clinical cancer diagnosis.
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Environmental Science-Nano
·
2019
·Vol. 6
·期 12
·3699-3711
·
IF 7.704
Wenjing Ma,Mengjie Zhang,Yuansheng Li,Mengmeng Kang,Chaobo Huang,Guodong Fu
One of the most pervasive environmental issues is water contaminated with various oils. Developing an efficient and novel functional membrane for oil/water separation is urgently needed. Herein, a flexible, durable and magnetic pH-responsive F3O4/MA–TiO2/PI electrospun nanofibrous membrane (ENM) was fabricated via an electrospinning and green dip-coating route. Combining the rough hierarchical structure and pH-responsive wettability, the as-prepared hybrid membrane can controllably separate a range of not only heavy oil/water but also light oil/water mixtures by only adjusting the pH of the aqueous medium. Both separations exhibit a large flux and outstanding efficiency for the tested oil/water mixtures even after 20 reuse cycles due to the hierarchical structure and flexibility of the membrane. In addition, the flexibility and magnetism of the membrane make it easily removed with a magnet after the separation of the oil/water mixtures. More importantly, the as-prepared membrane not only has excellent stability towards high temperature, corrosive organic solvent/salt solution immersion, and UV irradiation but also shows great resistance to mechanical abrasion and ultrasonic treatment, and the preparation method is facile, environmentally friendly, and cost-effective. Thus, such a membrane may offer exciting opportunities in the application of oily wastewater treatment and on-demand oil/water separation.
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