JOURNAL OF ETHNOPHARMACOLOGY
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2024
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IF 4.8
Rong Ma,Yuge Zhou,Weifan Huang,Xiaoni Kong
Ethnopharmacological relevance Epimedium Tourn. ex L. is a traditional Chinese medicine used for thousands of years in China to treat forgetfulness. Icariin is a principal component of the genus Epimedium . Aim of the study The metabolic mechanism of icariin treating forgetfulness is explored. Materials and methods A D-galactose-induced senescent mouse model was employed. The cognitive performance of mice was assessed in the fear conditioning test. Hippocampal pathology was assessed in the immunohistochemistry assay. Plasma metabolome was analyzed using GC-MS method, and the differential metabolites were further identified by UPLC-MS/MS or GC-MS method. The liver function, including ALT and AST, was assessed by enzyme reaction. Icariin was administered intraperitoneally at 50 and 100 mg/kg. Mice were administered five consecutive days per week for 8 weeks. Results Icariin treatment improved hippocampus-related fear memory but not amygdala-related memory, whereas Pexidartinib (PLX3397), a microglial scavenger, did not. Icariin treatment maintained the TMEM119-positive microglial population and decreased the accumulation of the senescent biomarker p16 in the dorsal hippocampus in senescent mouse brains, whereas PLX3397 did not. Notably, p16 in the CA2 subregion significantly decreased in icariin-treated mice than the other hippocampal subregions. The senescent mice exhibited the circulating metabolic characteristics of mild ketoacidosis, active tricarboxylic acid (TCA) cycle, lactic acidosis, hyperglycemia, active detoxification, active cis-oleic acid metabolism, and inhibitory GABA shut. R-3-hydroxybutyric acid primarily produced in the liver was selectively and robustly decreased by icariin treatment, which was not observed with PLX3397. The TCA cycle was rescued in senescent mice by icariin treatment. Icariin also protected liver function (plasma ALT) in D-gal-induced senescent mice. Conclusions Icariin may protect mouse hippocampal cognition from D-gal-induced senescence by protecting microglial homeostasis, and facilitating the utilization of R-3-hydroxybutyric acid is one of the underpins.
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ACS Applied Electronic Materials
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2024
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IF 4.3
Ang Li,Zhiqing Wang,Zhen Peng,Jing Zhou,Wen Chen
The facile ionic transport in all-inorganic CsPbX3 is crucial for the switching behavior and reliability of ion migration-based memristors. This work presents a method of halide ion doping to reduce the bromine vacancies on the surface of CsPbBr3 quantum dots (QDs) and enhance the migration barriers of bromine ions. This improves the performance of memristors and achieves a more stable resistive switching process. The switching voltages (VSET/VRESET) for the CsPb(Br0.93I0.07)3 QD-based device are 0.92 V/–3.01 V. The VSET/VRESET dispersion range has narrowed from ±0.12 V/±0.16 V for the CsPbBr3 QD-based device to a more consistent ±0.07 V/±0.11 V, resulting in a notable improvement in switching voltage uniformity. The stability of the device over 100 cycles has been optimized, and the HRS resistance varies from 550 × (100 ± 17%) Ω to 69550 × (100 ± 4.1%) Ω, with the ON/OFF ratio increasing significantly to 103. Consequently, this approach can effectively modulate memristive behaviors, indirectly suppressing the random generation of conductive channels. This is enlightening in constructing memristors with high stability and storage capacity.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2024
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IF 5.4
Ting Feng,Jiani Shi,Jiaojiao Xia,Xuemei Ren,Onyinye Idowu Adesanya,Hongbo Suo,Bin Zou
In this study, the critical importance of designing an appropriate immobilized carrier and method for free lipase to ensure exceptional biological catalytic activity and stability was emphasized. Covalent organic frameworks (COF-1) were synthesized as a novel porous carrier with an azine structure (-C N-N C-) through the condensation of hydrazine hydrate and benzene-1,3,5-tricarbaldehyde at room temperature. Simultaneously, Rhizomucor miehei lipase (RML) was immobilized within the COF-1 carrier using an in-situ aqueous phase method. Characterization of the carrier and RML@COF-1 and evaluation of the lipase properties of RML and RML@COF-1 through p -Nitrophenyl palmitate hydrolysis were conducted. Additionally, application in the synthesis of 1, 3-dioleoyl-2-palmitoylglycerol (OPO) was explored. The results showed that RML@COF-1 exhibited a high enzymatic loading of 285.4 mg/g. Under 60℃ conditions, the activity of RML@COF-1 was 2.31 times higher than that of free RML, and RML@COF-1 retained 77.25% of its original activity after 10 cycles of repeated use, indicating its excellent thermal stability and repeatability. Under the optimal conditions (10%, 1:8 PPP/OA, 45℃, 5 h), the yield of OPO reached 47.35%, showcasing the promising application prospects of the novel immobilized enzyme synthesized via in-situ aqueous phase synthesis for OPO preparation.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Huayang Tang,Yian Chen,Dexun Fan,Fengguang Zhao,Shuangyan Han
D-allulose, a low-calorie rare sugar catalyzed by D-allulose 3-epimerase (DAE), is highly sought after for its potential health benefits. However, poor reusability and stability of DAE limited its popularization in industrial applications. Although metal-organic frameworks (MOFs) offer a promising enzyme platform for enzyme immobilization, developing customized strategies for MOF immobilization of enzymes remains challenging. In this study, we introduce a designable strategy involving the construction of bimetal-organic frameworks (ZnCo-MOF) based on metal ions compatibility. The DAE@MOFs materials were prepared and characterized, and the immobilization of DAE and the enzymatic characteristics of the MOF-immobilized DAE were subsequently evaluated. Remarkably, DAE@ZnCo-MOF exhibited superior recyclability which could maintain 95 % relative activity after 8 consecutive cycles. The storage stability is significantly improved compared to the free form, with a relative activity of 116 % remaining after 30 days. Molecular docking was also employed to investigate the interaction between DAE and the components of MOFs synthesis. The results demonstrate that the DAE@ZnCo-MOF exhibited enhanced catalytic efficiency and increased stability. This study introduces a viable and adaptable MOF-based immobilization strategy for enzymes, which holds the potential to expand the implementation of enzyme biocatalysts in a multitude of disciplines.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2025
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IF 6.3
Keyi Gu,Yongmin Duan,Shugang Li,Ying Tian,Juan Du,Junjie Zhang
In recent years, inorganic perovskite quantum dots (PQDs) have garnered significant attention, but the photoluminescence (PL) properties and stability of red-emitting PQDs need to be further enhanced. In this work, the precipitation of CsPb(Br/I) 3 quantum dots into borosilicate glass was effectively enabled by the high-temperature melt-quenching method. With the B 2 O 3 /SiO 2 ratio increased, the glass network structure gradually loosened, which enhanced the precipitation of PQDs. Simultaneously, the PL intensity of CsPb(Br/I) 3 PQDs glass increased, with a near twentyfold rise in the photoluminescence quantum yield (PLQY). The variable temperature test of PQDs glass shows that PQDs glass has good thermal stability. Finally, a red-emitting LED and a WLED were prepared by using the prepared red-emitting CsPb(Br/I) 3 PQDs glass. This paper serves as a reference for incorporating red-emitting CsPb(Br/I) 3 PQDs glass into WLED development.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2024
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IF 5.7
Yaqiong Liu,Fang Wu,Ming Zhang,Yutong Jin,Xinlei Yuan,Yanling Hao,Lishui Chen,Bing Fang
Human milk oligosaccharides could prevent pathogenic bacterial infections in neonates; however, direct in vivo anti-infection evidence was still lacking. Here, we systematically evaluated the effects of 2′-fucosyllactose (2′-FL) and 3′-sialyllactose (3′-SL) on the structural development and functional maturation in neonates and their defense against enteroaggregative Escherichia coli infection. It was found that supplementation with 2′-FL and 3′-SL improved the resistance of weaned mice to enteroaggregative E. coli. The mechanism related to the promotion of 2′-FL and 3′-SL in the maturation of intestinal mucosal immunity by promoting stem cell differentiation, mucus layer integrity, and tight junction formation. 2′-FL and 3′-SL significantly increased the ratio of Th1 and Treg cells in the lamina propria, contents of short-chain fatty acids, as well as the serum content of IgA. This study lays a theoretical basis for the application of 2′-FL and 3′-SL in infant formula, as well as the development of intestinal health products.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
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IF 9.4
Ye Cao,Yijin Wang,Junli Nie,Chengjie Gao,Wei Cao,Weiwei Wang,He Xi,Wenhao Chen,Peng Zhong,Xiaohua Ma
Recently, the solar-driven interfacial evaporation desalination has attracted more and more attentions due to the advantages of low cost, zero energy consumption, and high water purification rate, etc. One of the bottlenecks of this emerging technique lies in a lack of simple and low-cost ways to construct three-dimensional (3D) hierarchical microstructures for photothermal membranes. To this end, a two-step strategy is carried out by combining surface functionalization with substrate engineering. Firstly, a silane coupling agent 3-aminopropyltriethoxysilane (APTES) is grafted onto an ideal photothermal material of Ti 3 C 2 T x MXene , to improve the nanochannel sizes and hydrophilicity, which are attributed to enlarged interspaces of MXene and introduced hydrophilic group e.g., –NH 2 and –OH, respectively. Secondly, a low-cost and robust nonwoven fiber (NWF) substrate, which has a 3D micron-sized mesh structure with interlaced fiber stacks, is employed as the skeleton to load enough APTES-grafted MXene by a simple soaking method. Benefited from above design, the Ti 3 C 2 T x -APTES/NWF composite membrane with a 3D hierarchical structure shows enhanced light scattering and utilization, water transport and vapor escape. A remarkable evaporation rate of 1.457 kg m −2 h −1 and an evaporation efficiency of 91.48 % are attained for a large-area (5 × 5 cm 2 ) evaporator, and the evaporation rate is further increased to 1.672 kg m −2 h −1 for a small-area (2 × 2 cm 2 ) device. The rejection rates of salt ions and heavy metal ions are higher than 99 % and 99.99 %, respectively, and the removal rates of organic dye molecules are nearly to 100 %. Besides, the composite photothermal membrane exhibits great stabilities in harsh conditions such as high salinities, long cycling, large light intensities, strong acid/alkali environments, and mechanical bending. Most importantly, the photothermal membrane shows a considerable cost-effectiveness of 89.4 g h −1 /$. Hence, this study might promote the commercialization of solar-driven interfacial evaporation desalination by collaboratively considering surface modification and substrate engineering for MXene.
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SENSORS AND ACTUATORS B-CHEMICAL
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2015
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IF 4.097
Suozhu Wu,Tiyun Han,Junjie Guo,Yuansheng Cheng
Here we develop a novel approach for electrochemical detection of fluoride by poly(3-aminophenylboronic acid)-reduced graphene oxide (PAPBA-RGO) nanocomposite modified electrode. In this approach, the proposed electrode was fabricated by a two-step procedure, including direct electrodeposition of graphene oxide and electrochemical polymerization of 3-aminophenylboronic acid. Electrochemical detection of fluoride by PAPBA-RGO nanocomposite modified electrode was performed based on the variation of reduction peak current of ferricyanide, which was induced by the binding between boronic acid groups of PAPBA and fluoride. The obtained results displayed that reduction peak current of ferricyanide decreased with increasing concentration of fluoride, and two good linear relationships between the reduction peak current and the logarithm of fluoride concentration were obtained in the concentration range of 1 × 10 −10 to 1 × 10 −5 M and of 1 × 10 −5 to 1 × 10 −1 M, respectively. The limit of detection of the proposed approach was 9 × 10 −11 M. The interference of other competing ions including Cl − , Br − , I − , NO 3 − , ClO 4 − , Ac − or SO 4 2− was negligible. Furthermore, the PAPBA-RGO nanocomposite modified electrode was employed for detection of fluoride in water samples.
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INORGANIC CHEMISTRY
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2024
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IF 4.3
Tingting Tang,Fangqing Ye,Huang Hua,Chaoyang Li,Jian Shen
With the rapid development of 5G communication technology, microwave dielectric ceramics with high dielectric constants are very conducive to the miniaturization of passive devices. Here, Ba3Ti4–x(Ni1/3Nb2/3)xNb4O21 (BTN ∼ NN, 0.03 ≤ x ≤ 0.15) ceramics with hexagonal phases are synthesized via the solid-phase route. The composite (Ni1/3Nb2/3)4+ ion substitution strategy can substantially improve the microwave dielectric properties of the Ba3Ti4Nb4O21 (BTN) ceramic. The εr and Q × f values depend on the ionicity (Nb–O bonds) and lattice energies (Nb(1)–O3 and Nb(1)–O2(1) bonds). The microwave dielectric properties of the BTN ∼ NN (x = 0.09) ceramic sintered at 1250 °C are εr = 60.3, Q × f = 22073 GHz, and τf = 78.1 ppm/°C. A miniaturized all-ceramic radome (@400 mm × 400 mm × 8 mm) for 5G beam-splitting function is designed and demonstrated using this ceramic. Compared to other radomes designed for other work utilizing low εr, the size of this radome has been reduced by 3/7. The reflection coefficients of the beam splitting function are all 0.73, and the phase shifts are all 360°. This work contributes to the development of miniaturized passive devices from a materials point of view.
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INDUSTRIAL CROPS AND PRODUCTS
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2024
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IF 5.6
Ling Liu,Hong Peng,Ying Shen,Limin Shen,Guiming Fu,Yin Wan,Zhaodi Xu
In-depth understanding the influence of ionic liquid structure on the selective dissolution of the main biopolymers from plant cell walls is necessary for designing ionic liquids that could efficiently pretreat and fractionate lignocellulosic biomass. The current study aimed to investigate the effect of electronegativity of anions of 1-butyl-3-methylimidazolium halide based ionic liquids BmimCl, BmimBr, and BmimI on dissolving bamboo slices. The surface of pretreated bamboo slices and the regenerated carbohydrate-rich fractions were characterized carefully. The results revealed that the ability to damage bamboo cell walls and dissolve bamboo slices followed the order of BmimCl>BmimBr>BmimI, which was consistent with the electronegativity of halogen anions (Cl - >Br - >I - ). The dissolving selectivity for lignin from bamboo cell walls was in the order of BmimBr>BmimI>BmimCl. The ionic liquids performed a greater dissolving selectivity for lignin than carbohydrates (cellulose and hemicellulose). The permeating rate of ionic liquid molecules into bamboo cell walls increased with the enhancement of electronegativity of halogen anions. The regenerated carbohydrate-rich fractions were rich in hemicellulose and cellulose with an amount of lignin. Both temperature and time had also great effect on the dissolution of bamboo slices. On the whole, the electronegativity of halogen anions had a profound impact on the deconstruction of bamboo cell walls and dissolution of bamboo. This study provided important theoretical assistance for designing ionic liquids that could more efficiently pretreat and fractionate lignocellulosic biomass.
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ACS Applied Materials & Interfaces
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2024
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IF 8.3
Xudong Wang,Jiepeng Chen,Yun Huang,Jiapin Liu,Lei Fu,Li Liu,Wenping Zeng,Jie Xiao,Xiaoyan Zhang,Xing Li,Mingshan Wang,Yuanhua Lin,Haijun Cao
Na4MnV(PO4)3 (NMVP) has gained attention for its high redox potential, good cycling stability, and competitive price but suffers from poor intrinsic electronic conductivity and Jahn–Teller effect from Mn3+. In this work, cation/anion doping strategy was used for Aspergillus niger-bioderived carbon-coated NMVP (NMVP/AN) to improve the structural stability and electrochemical performance, where Al3+ doping inhibited the dissolution of Mn and enhanced the Mn3+/Mn2+ redox pair activity; besides, F– doping not only weakens the Na2–O bond but also endows the hierarchical and porous structure of NMVP/AN, which led to a more rapid and fluid transfer of Na+. The elaborately designed Na3.9Mn0.9Al0.1V(PO4)3/AN (NMAVP/AN) exhibits 105.9 mA h g–1 at 0.5 C, and the as-prepared Na3.1MnV(PO3.7F0.3)3/AN (NMVPF/AN) delivers 104.1 mA h g–1 at 5 C. Further demonstration of the hard carbon//NMAVP/AN full cell manifests the good potential of Al3+-doped NMVP/AN for practical applications (100.6 mA h g–1 at 1 C). These findings open up the possibility of unlocking the high-performance Na superionic conductor (NASICON).
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INORGANIC CHEMISTRY
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2024
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IF 4.3
Ziyan Lv,Rukang Li
A new noncentrosymmetric crystal Na12(NbO)3(PO4)7 was successfully synthesized in the niobium phosphate system. Its structure characterizes isolated and highly distorted NbO6 octahedra joining with isolated PO4 groups to form a unit of a (Nb6P6O12) hexagonal star by sharing O atoms. In (Nb6P6O12) hexagonal stars, all Nb and P atoms are in a hexagonal star-like arrangement and all Na atoms are also in a hexagonal star-like arrangement, except for Na(3) and Na(10) atoms. Notably, it exhibits a strong phase-matched second harmonic response: 3 × KDP, which is rare in known niobium phosphate systems. Meanwhile, it also has a wide optically transparent window (0.29–4.44 μm) and a high laser-induced damage threshold (3.5 GW/cm2). More importantly, Na12(NbO)3(PO4)7 is a congruent melting compound that has the potential to be grown into large-sized single crystals by the Czochralski method. These excellent properties make it a promising candidate as a mid-infrared nonlinear optical crystal.
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