Journal of Materials Chemistry C
·
2024
·
IF 5.7
Jiahao Pan,Yuchen Zhang,Zhentao Pang,Yu Deng,Zhenda Lu
This work presents a high-content platform for investigating the critical interplay between the nanoparticle cluster size, structure, and plasmon-enhanced fluorescence at a single particle level. The platform enables the controlled assembly of pre-synthesized, bio-conjugatable Ag@Au nanocubes into clusters with varying sizes and configurations, ultimately arranged in an array pattern. Notably, the platform statistically reveals that Ag@Au nanocubes achieve over two orders of magnitude greater fluorescence enhancement compared to Au nanoparticles alone. Moreover, it identifies a crucial size regime for maximizing fluorescence enhancement. Clusters containing 1–4 nanocubes exhibit a direct correlation between the fluorescence intensity and the number of particles, as well as cluster configuration. Compact clusters display a significantly stronger fluorescence response compared to loosely packed configurations. This high-content platform offers a powerful approach for the rapid, simultaneous characterization of multiple nanoparticles, paving the way for efficient, large-scale fluorescence-based detection.
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DOI
高影响因子
MICROCHIMICA ACTA
·
2022
·Vol. 189
·期 9
·1-11
·
IF 6.408
Zhai Hongguo,Wang Yue,Yin Jiaqi,Zhang Yuhao,Guo Qi,Sun Xia,Guo Yemin,Yang Qingqing,Li Falan,Zhang Yanyan
MXene@Au as the base and Au@SiO 2 as signal amplification factor were used for constructing an ultrasensitive “on–off” electrochemiluminescence (ECL) biosensor for the detection of Pb 2+ in water. The use of MXene@Au composite provided a good interface environment for the loading of tris(2,2-bipyridyl)ruthenium(II) (Ru(bpy) 3 2+ ) on the electrode. Based on resonance energy transfer, the Au (core) SiO 2 (shell) (Au@SiO 2 ) nanoparticles stimulate electron transport and promote tripropylamine (TPrA) oxidation. The luminescence effect of Au@SiO 2 was five times that of AuNPs and SiO 2 nanomaterials alone, and the ECL intensity was greatly improved. In addition, Pb 2+ activated the aptamer to exert its endonuclease activity, which realized the signal cycle amplification in the process of Pb 2+ detection. When Pb 2+ was added, the ECL signal weakened, and the Pb 2+ concentration was detected according to the decreased ECL intensity. Under optimized experimental conditions, this aptamer sensor for Pb 2+ has a wide detection range (0.1 to 1 × 10 6 ng L −1 ) and a low detection limit (0.059 ng L −1 ). The relative standard deviation (RSD) of the sensor is 0.39–0.99%, and the recovery of spiked standard is between 90.00 and 125.70%. The sensor shows good selectivity and high sensitivity in actual water sample analysis. This signal amplification strategy possibly provides a new method for the detection of other heavy metal ions and small molecules. Graphical abstract
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Min Zhang,Baolong Li,Yu Du,Gaojian Zhou,Yanyan Tang,Yanfen Shi,BiYu Zhang,Zhou Xu,Qingli Huang
The preparation and construction of novel nanostructures as targeting theranostic is of great significance for diagnosis and treatment of tumor. Herein, a novel PANI/ [email protected] @MnO 2 (PPAuMns) yolk-shell enzymatic theranostic agent was fabricated firstly via in situ deposition of Au nanoparticles (Au NPs) and reduction of KMnO 4 on the surface of PANI/PPy nanocomposites. In addition to high biocompatible and biodegraded performance, PPAuMns possessed amazing tumor microenvironment (TME)-responsive O 2 generation capacity, magnetic resonance imaging (MRI) property, enzymatic activity and excellent photothermal conversion effect. Chemotherapeutics doxorubicin and folic acid (FA) were further loaded and decorated on it for targeted tumor therapy. Experiments in vitro and in vivo indicated that DOX-loaded [email protected] demonstrated excellent synergistic anti-tumor effect combining chemotherapy (CT), chemo-dynamic therapy (CDT) and photothermal therapy (PTT). This work offers a paradigm to design and construct tumor diagnosis and therapy platforms employing TME-responsive synergistic strategy of photothermal ablation, chemo-dynamic and chemotherapy.
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2015
·
IF 4.097
Shenguang Ge,Yan Zhang,Lina Zhang,Linlin Liang,Haiyun Liu,Mei Yan,Jiadong Huang,Jinghua Yu
A trimetallic dendritic Au@PdPt nanparticles (Au@PdPt NPs) with intrinsic peroxidase-like catalytic activity were fabricated by a facile method. Au@PdPt NPs catalyzed the reduction of H 2 O 2 with the help of the electron mediator (thionine), which produced the electrochemical signals dramatically amplified. A sandwiched sensor was designed and implemented in the paper chip device for the determination of K-562 cells. The surface of dendritic Au@PtPd NPs was linked with folic acid by click chemistry. Folic acid was attached to the folate receptor (FR) of cell surface with high affinity. So, K-562 cells could be assayed based on folic acid-functionalized Au@PtPd NPs. On the other hand, folic acid-functionalized Au-paper working electrode on origami electrochemical device was fabricated, which could be used to capture K-562 cells. The twice utilization of folic acid for the capture of K-562 cells as well as the attachment of dendritic Au@PtPd NPs nanoprobe, which enhanced the selectivity of sensor for the determination of cells. The proposed biosensor exhibited excellent analytical performance toward the cytosensing of K562 cells with a wide detection linear range from 1.0 × 10 2 to 2.0 × 10 7 cells mL −1 and a detection limit of 31 cells mL −1 . Further, the proposed electrochemical sensor was applied to monitor cells. Au@PtPd NPs nonenzymatic catalysts could be used as signal-amplifying nanoprobes for ultrasensitive electrochemical sensing.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Junkang Guo,Xiaohu Fan,Jiayuan Wang,Shenghui Yu,Minwang Laipan,Xinhao Ren,Chao Zhang,Lei Zhang,Yongtao Li
The design and synthesis of efficient adsorbents for recovery of precious metal from secondary resources are of great environmental and economic significance. In present study, an efficient and redox-active adsorbent (UiO-66-BTU) was fabricated by modifying Zr-MOF (Zirconium-based Metal Organic Framework) with bisthiourea for gold recovery in aqueous solution. It is indicated that Au(III) adsorbing onto UiO-66-BTU is an irreversible, favorable chemisorption process conformed to D-R model and pseudo-second-order model. The UiO-66-BTU showed significant adsorption ability (680.20 mg/g at pH 2.0) and high selectivity towards Au(III) in presence of various mixed ions in actual wastewater, which were mainly attributed to the Lewis soft–soft interaction, ion-exchange/electrostatic interactions, and redox reaction between Au(III) and S-containing functional groups. Notably, we demonstrated that the reduction of Au(III) to metallic gold as a dominant recovery mechanism involving the in situ confined nucleation, fusion and growth of AuNPs to branched Au precipitation, with Au(0) accounted for approximately 80% for the recycling products. Furthermore, the UiO-66-BTU membrane achieved similar high adsorption capacity and the membrane surface remains active to efficiently recovered metallic particles with an excellent repeatability at eight cycles of adsorption. The reduced Au particles formed isolated clusters with bigger size and regular hexagonal shape. Consequently, UiO-66-BTU has great potential for gold recycling in industrial practice.
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高影响因子
Journal of Materials Chemistry A
·
2019
·Vol. 7
·期 36
·20945-20951
·
IF 10.733
Xue Zhao,Chen Yao,Hao Chen,Yunfan Fu,Changjun Xiang,Suhang He,Xiaohai Zhou,Haibo Zhang
Ammonia has been obtained from the Haber–Bosch process for decades, which requires an unendurably high temperature and high pressure. Alternatively, electrochemical conversion of N2 to NH3 turns out to be a promising method with much lower energy consumption and accessible reaction conditions. In this work, a novel nano-gold catalyst supported on a boron organic polymer (Au/M-BOP) was prepared and achieved both excellent ammonia yield and faradaic efficiency at low potential (r(NH3): 45.54 μg h−1 cm−2 or 75.89 μg h−1 mgcat.−1 FE: 10.35%), results that are close to the top of the pyramid compared to published literature results. Moreover, the catalyst is conveniently accessible through a pre-immobilized in situ reduction, and can maintain its electrocatalytic activity for multiple uses, which could have potential implications in the industrialization of the electrocatalytic production of ammonia.
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高影响因子
Nanomaterials
·
2018
·Vol. 8
·期 5
·353
·
IF 3.504
Yue Chen,Yuanyuan Zhang,Qiangwei Kou,Yang Liu,Donglai Han,Dandan Wang,Yantao Sun,Yongjun Zhang,Yaxin Wang,Ziyang Lu,Lei Chen,Jinghai Yang,Scott Guozhong Xing
In this work, we report the enhanced catalytic reduction of 4-nitrophenol driven by Fe3O4-Au magnetic nanocomposite interface engineering. A facile solvothermal method is employed for Fe3O4hollow microspheres and Fe3O4-Au magnetic nanocomposite synthesis via a seed deposition process. Complementary structural, chemical composition and valence state studies validate that the as-obtained samples are formed in a pure magnetite phase. A series of characterizations including conventional scanning/transmission electron microscopy (SEM/TEM), Mössbauer spectroscopy, magnetic testing and elemental mapping is conducted to unveil the structural and physical characteristics of the developed Fe3O4-Au magnetic nanocomposites. By adjusting the quantity of Au seeds coating on the polyethyleneimine-dithiocarbamates (PEI-DTC)-modified surfaces of Fe3O4hollow microspheres, the correlation between the amount of Au seeds and the catalytic ability of Fe3O4-Au magnetic nanocomposites for 4-nitrophenol (4-NP) is investigated systematically. Importantly, bearing remarkable recyclable features, our developed Fe3O4-Au magnetic nanocomposites can be readily separated with a magnet. Such Fe3O4-Au magnetic nanocomposites shine the light on highly efficient catalysts for 4-NP reduction at the mass production level.Keywords:Fe3O4hollow microspheres;Fe3O4-Au magnetic nanocomposites;catalytic reduction;4-nitrophenol
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Ningyi Chen,Bingcai Pan
Toxic metal-organic complexes are ubiquitous in contaminated waters but more challenging than free ion counterparts for water decontamination. Currently, almost all the available analytical methods, including Au nanoparticles-mediated colorimetric assay, cannot discriminate metal-organic complexes from the total metal content, which greatly impedes the development of specific decontamination strategies for metal-organic complexes. In this study, we found that nitrilotriacetic acid (NTA) functionalized AuNPs could be used to determine various Cr(III) complexes (Cr(III)-lactate, Cr(III)-malonate, Cr(III)-oxalate, Cr(III)-tartrate, Cr(III)-citrate and Cr(III)-EDTA) in water. Mechanism study indicated that at acidic pHs (pH = 1.6), the protonation of organic ligands resulted in partial dissociation of Cr(III) from the corresponding complexes to expose its accessible orbitals for re-coordination with NTA. Such re-coordination induces the aggregation of the dispersed NTA-AuNPs and thereafter causes considerable changes both in color and UV–Vis spectrum of the solution. The nanosensor is highly selective to Cr(III)-organic complexes with detection limits of 0.029 μM for Cr(III)-lactate, 0.043 μM for Cr(III)-malonate, 0.35 μM for Cr(III)-oxalate, 0.079 μM for Cr(III)-tartrate, 2.58 μM for Cr(III)-citrate and 0.90 μM for Cr(III)-EDTA, respectively. The feasibility of the proposed colorimetric assay has been verified by using the authentic natural and industrial water samples. We believe this study will be of fundamental significance to push forward the application of Au NPs colorimetric assay in authentic waters contaminated by toxic metals.
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高影响因子
Analytical Methods
·
2019
·Vol. 11
·期 23
·2960-2968
·
IF 2.378
Le Peng,Jun Zhou,Zhaoheng Liang,Yaping Zhang,Lucia Petti,Tao Jiang,Chenjie Gu,Danting Yang,Pasqule Mormile
Based on surface-enhanced Raman scattering (SERS) technology, Au@Ag@4MBA@5′-NH2-ssDNA probes and a Ag/TiO2@3′-NH2-ssDNA substrate were prepared and constructed into a sandwich structure to develop a high sensitivity bioassay of miRNA-21. The Au@Ag@4MBA@5′-NH2-ssDNA probes were prepared by immobilizing 5′-NH2-ssDNA onto the surfaces of 4MBA-labelled Au@Ag core–shell nanoparticles, and the Ag/TiO2@3′-NH2-ssDNA substrate was prepared by immobilizing 3′-NH2-ssDNA on the surface of Ag/TiO2 nanowires SERS-active substrates. The experimental results showed that the SERS-based sandwich bioassay of miRNA-21 presented a low limit of detection of 0.75 fM and a broad dynamic range from 1.0 fM to 1.0 nM. Also, the test data for the SERS-based sandwich bioassay were not only consistent with that of the real-time fluorescence quantitative polynucleotide chain reaction (RT-qPCR) method but also displayed higher detection sensitivity. It was shown that the SERS-based sandwich bioassay of miRNA-21 has importance for use in potential applications involving diagnosing clinical cancer patients.
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高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2022
·
IF 4.831
Cuiping Wang,Huan Zhang,Chunrong Wang
In this study, we developed an innovative approach that combines solid phase microextraction (SPME) with surface-enhanced Raman spectroscopy (SERS) to detect pesticide ferbam rapidly. An Au nano-glass capillary was fabricated by coating template-freely synthesized three-dimensional network Au nanostructures (3D-NW AuNSs) on the roughened surface of glass capillary and used for SPME and SERS respectively. Significant Raman signals were obtained by the SPME-SERS method, followed by detection of ferbam in water and orange juice samples with only 1 min SPME process. Results showed that Au nano-glass capillaries could achieve the detection of ferbam with limit of detection of 0.05 μg/L, and coefficient of determination ( R 2 ) of 0.9913. The recovery of predicted results was in the range of 88.46–103.29% and the relative standard deviation (RSD) was 3.5–8.2%. This study demonstrated potential capability of the SPME-SERS method for rapid (within 1 min) and sensitive detection of organic compounds in complex matrices. The SERS-active Au nano-glass capillary is easy to carry and operate, and is expected to play a role in the detection of trace pollutants.
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高影响因子
Molecular Catalysis
·
2018
·
IF 0
Xia Chen,Xu Ye,Wen-Yu Liang,Qing Zhou,Giang Vo-Thanh,Ye Liu
The unique amphiphilic Zwitterionic P,O-hybrid ligand ( L1 ) containing phosphino-fragment and −SO 3 − group was synthesized and firstly applied in Au-catalyzed hydration of alkynes. Without the aid of any auxiliary additive such as acid or silver salt, L1 -based Au-catalyst exhibited excellent activity towards hydration of alkynes to yield ketones with 100% selectivity according to Markovnikov’s rule. On the other hand, L1 -based Au-catalyst could be recycled for 4 runs in room temperature ionic liquid of [Bmim]PF 6 without obvious activity loss, and also exhibited wide generality to the hydration of different alkynes.
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DOI
ANALYST
·
2015
·Vol. 140
·期 5
·1672-1677
·
IF 4.107
Wei Wang,Na Zhao,Xiaoxiao Li,Jun Wan,Xiliang Luo
A novel controlled-release biosensor for isothermal amplified detection of ATP using Au nanocages (AuNCs) capped with a DNA molecular gate is reported for the first time, and has been successfully tested in intracellular ATP detection. Two kinds of SH-modified short strand DNAs S1 and S2 were assembled on the surface of the AuNCs by means of Au–thiolate bonding. The hybridization of a long-strand DNA S3 with the two immobilized SH-DNAs leads to the formation of molecular gates. The molecular gates were designed to inhibit the release of the fluorescent molecules such as Rhodamine-B (RhB), which were filled in the hollow interiors of AuNCs. The primer S4 was employed to play the role of a recognition moiety. The specificity recognition reaction between ATP and ATP aptamer gave rise to the primer S4 released from a double-stranded hybrid formed with the ATP aptamer. The released S4 will initiate the autonomous replication–scission–displacement process with the assistance of DNA polymerase and nicking endonuclease. As a result, the DNA synthesis and the DNA cycle achieved the opening of the DNA-based molecular gates and the significant amplification of the release of the guest molecules from AuNCs. In order to realize the cyclic enzymatic amplification of the release of the guest molecules from AuNCs, the long-strand S3 is ingeniously designed in such a way that it contains a Nb.Bpu10I nicking endonuclease recognition sequence and a sequence complementary to the primer S4. The fabricated system was demonstrated to be an efficient biosensor for target molecule detection qualitatively and quantitatively.
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