JOURNAL OF MOLECULAR STRUCTURE
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2016
·
IF 1.78
Dan-dan Yang,Riu Wang,Jin-long Zhu,Qi-yue Cao,Jie Qin,Hai-liang Zhu,Shao-song Qian
Three novel complexes, [Cu( L ) 2 (H 2 O)]( 1 ), [Zn( L ) 2 (H 2 O) 2 ]·CH 3 OH·1.5H 2 O( 2 ), and [Ni( L ) 2 (H 2 O) 1.8 ]·CH 3 OH·1.2H 2 O ( 3 ) (HL = 2-{4-[bis(4-fluorophenyl)methyl]pipera-zin-1-yl} acetic acid), were synthesized and structurally determined by single-crystal X-ray diffraction. Molecular docking study preliminarily revealed that complex 1 had potential Monoamine oxidase B inhibitory activity. All acquired compounds were tested against rat brain MAO-B in vitro. In accordance with the result of calculation, it showed complex 1 (IC 50 = 1.85 ± 0.31 μ M) have good inhibitory activity against MAO-B at the same micromolar concentrations with positive control Iproniazid Phosphate (IP, IC 50 = 7.59 ± 1.17 μ M). These results indicated that complex 1 was a potent MAO-B inhibitor.
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Catalysis Science & Technology
·
2024
·Vol. 14
·期 6
·1568-1578
·
IF 4.4
Qifeng Chen,Peng Zheng,Haodi Liu,Yuanrong Zhang,Shuaitao Li,Hongpian Guo,Yanfen Fang,Xun Hu,Ran Duan
The combination of photocatalytic dehalogenation of halogenated aromatics and C–C coupling synthesis of valuable organics is an interesting method for the elimination of pollutants and synthesis of valuable chemicals. Herein, we present a green method for the photocatalytic dehalogenation of benzyl bromide and selective coupling synthesis of bibenzyl achieved on the dual active sites of single-atom Cu and surface oxygen vacancies (VOS) generated in situ on ultrathin 2D-TiO2(B) nanosheets. The experimental results show that single-atom Cu sites on ultrathin TiO2(B) nanosheets can improve charge transfer and separation efficiency and stabilize VOS formed in situ; the presence of VOS not only improves light absorption capacity but also favors the adsorption of reactant benzyl bromide molecules. More importantly, the dual sites of single-atom Cu and adjacent VOS form a solid frustrated Lewis pair, favor the adsorption of benzyl bromide molecules, activate the C–Br bond, and boost the C–C coupling synthesis of bibenzyl. This work provides a novel insight into photocatalytic C–C coupling through the synergistic effect of single-atom Cu and VOS on ultrathin nanosheet photocatalysts.
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Polymer Chemistry
·
2010
·Vol. 1
·期 8
·1205-1214
·
IF 0
Peng-Fei Gou,Wei-Pu Zhu,Zhi-Quan Shen
Novel well-defined drug-grafted seven-arm amphiphilic star poly(ε-caprolactone-co-carbonate)-b-poly(ethylene glycol)s based on a β-CD core [CDS-P(CL-co-DTC)-D-b-PEG] have been synthesized by the combination of controlled ring-opening polymerization (CROP), esterification coupling reactions and “click” reactions. First, 5,5-dibromomethyl-trimethylene carbonate (DBTC) bearing two bromide pendent groups was synthesized and used to copolymerize with CL to prepare seven-arm star random copolymers [CDS-P(CL-co-DBTC)] in the presence of per-2,3-acetyl-β-cyclodextrin and Sn(Oct)2. Second, esterification coupling reaction between CDS-P(CL-co-DBTC) and carboxyl-terminated mPEG led to amphiphilic seven-arm star copolymers [CDS-P(CL-co-DBTC)-b-PEG]. Subsequently, the bromide pendent groups on CDS-P(CL-co-DBTC)-b-PEG had been converted into azide groups by treating with NaN3. Finally, alkyne functionalized ibuprofen had been grafted onto the hydrophobic block of the star copolymers by copper(I)-catalyzed “click” reaction. 1H NMR, FT-IR and SEC analyses confirmed the well-defined drug grafted star architecture. These copolymers could self-assemble into multi-morphological aggregates in water, which were characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM).
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Polymer Chemistry
·
2024
·Vol. 15
·期 25
·2590-2597
·
IF 4.1
Huixuan Xu,Weigang Sun,Zhonglin Wei,Jungang Cao,Dapeng Liang,Yingjie Lin,Haifeng Duan
Herein, we provide details of the synthesis and characterization of a novel 2-carbon-extended diol derived from isomannide, 2,2′-((3S,3aR,6S,6aR)-hexahydrofuro[3,2-b]furan-3,6-diyl)bis(ethan-1-ol) and the corresponding semi-aromatic copolyester (PIeT) based on it and dimethyl terephthalate. This new polyester (PIeT) has a weight-average molecular weight of about 40 000 g mol−1. The NMR analysis showed that the isohexide unit was retained under applied conditions. DSC and WAXD analyses demonstrated that the polyester is semicrystalline.
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Journal of Environmental Chemical Engineering
·
2021
·
IF 5.909
Jiamin Li,Xiaoli Li,Guang Wu,Jiaqing Guo,Xiaohong Yin,Manman Mu
Visible light driven photocatalytic degradation of organic pollutants , such as bisphenol A (BPA) in wastewater, is considered as a promising strategy to solve the environmental issue . A two-dimensional (2D) porphyrin Co-TCPP MOF decorated 2D B-TiO 2−X nanosheet was successfully prepared through a facile hydrothermal method. The 2D–2D heterostructure could give rise to a built-in electric field to effectively promote the interfacial charge transfer and separation of photogenerated electron and holes. The presence of oxygen vacancy in the as-prepared heterostructure could greatly enhance the visible light harvesting ability to generate more photogenerated carriers. The Co-TCPP MOF@B-TiO 2−X exhibited remarkable photocatalytic performance for the degradation of BPA, whose degradation rate was up to 97% within 120 min irradiation. The degradation efficiency of this composite was 7.3 and 19.3 times higher than those of single Co-TCPP MOF and B-TiO 2−X respectively. The intimate contact between B-TiO 2−X and Co-TCPP MOF reduced interface resistance for charge migration, prolonged photoelectron lifetime and facilitated the charge carriers’ separation. The trapping tests verified that ·O 2 - was the mainly active species of BPA degradation. This strategy not only proves that the combination of B-TiO 2−X and Co-TCPP MOF is a feasible strategy to improve the photocatalytic degradation of BPA, but also provides some new inspirations for the construction of efficient 2D–2D composite photocatalysts.
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JOURNAL OF ARTHROPLASTY
·
2024
·
IF 3.4
Junqi Niu,Fanggang Bi,Qing Tian,Ke Tian
Background Aseptic loosening around the prosthesis is a common cause of failure in total joint arthroplasty. Polyethylene wear particles trigger the release of inflammatory factors by macrophages. Key mediators involved in osteoclastogenesis include interleukin-6, tumor necrosis factor-α, receptor activator of nuclear factor kappa B (RANK), RANK ligand (RANKL), and bone protection hormone (Osteoprotegerin [OPG]). The purpose of our experiment was to see whether melittin can slow down the release of inflammatory mediators through the NF-kB pathway, regulate the RANKL/OPG ratio, reduce osteoclast formation, and delay the onset of arthritis in rats. Methods A total of 20 male Sprague-Dawley rats (10 months, Specific Pathogen Free, 350 g ± 20 g) were randomly divided into 5 groups: sham group, model group, melittin concentration 1 group (0.2 mg/kg), concentration 2 group (0.4 mg/kg), and concentration 3 group (0.6 mg/kg). All rats were implanted with TA2 high-purity titanium rods. A drill was used to create a bone canal along the long axis of the femur in the intercondylar notch. The model group and experimental groups were exposed to polyethylene particles, while the sham group did not receive any particles. Results The melittin group exhibited significantly increased serum levels of serum P, calcium-phosphorus product, OPG, PINP, PINP/CTX-I, and OPG/RANKKL ( P < .05). In the experimental group, micro computed tomography scanning results revealed a decrease in the amount of bone defect around the prosthesis. Immunofluorescence analysis demonstrated a decrease in the expression of IKKα and P65, while the expression of OPG showed an upward trend. Both Hematoxylin-Eosin and Tartrate-Resistant Acid Phosphatase staining revealed less osteoclast and inflammatory cell infiltration in bone resorption pits. Conclusions Our study demonstrates that melittin has the ability to inhibit the NF-kB pathway in a rat model, and reduce the impact of RANKL/OPG, thereby delaying osteoclast activity and alleviating periprosthetic osteolysis.
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高影响因子
MICROCHIMICA ACTA
·
2018
·Vol. 185
·期 3
·1-9
·
IF 5.705
Huang Shan,Feng Mengmeng,Li Jiawen,Liu Yi,Xiao Qi
The authors describe an electrochemical method for the determination of the single-stranded DNA (ssDNA) oligonucleotide with a sequence derived from the genom of hepatitis B virus (HBV). It is making use of circular strand displacement (CSD) and rolling circle amplification (RCA) strategies mediated by a molecular beacon (MB). This ssDNA hybridizes with the loop portion of the MB immobilized on the surface of a gold electrode, while primer DNA also hybridizes with the rest of partial DNA sequences of MB. This triggers the MB-mediated CSD. The RCA is then initiated to produce a long DNA strand with multiple tandem-repeat sequences, and this results in a significant increase of the differential pulse voltammetric response of the electrochemical probe Methylene Blue at a rather low working potential of −0.24 V (vs. Ag/AgCl). Under optimal experimental conditions, the assay displays an ultrahigh sensitivity (with a 2.6 aM detection limit) and excellent selectivity. Response is linear in the 10 to 700 aM DNA concentration range.
Schematic of a voltammetric method for the determination of attomolar levels of target DNA. It is based on molecular beacon mediated circular strand displacement and rolling circle amplification strategies. Under optimal experimental conditions, the assay displays an ultrahigh sensitivity with a 2.6 aM detection limit and excellent selectivity.
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JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2024
·
IF 5.8
Jiuyuan Han,Rengang Shi,Yingjie Ren,Lei Cao,Liang Wang,Tao Zhou,Xueqing Yu,Minmin Mao,Hadi Barzegar Bafrooei,Bing Liu,Zhilun Lu,Ehsan Taheri-Nassaj,Xinghua Zheng,Huixing Lin,Kaixin Song
In this paper, a strategy for preparing MgAl 2- x (Mg 0.5 Ge 0.5 ) x O 4 (0 ≤ x ≤ 0.12) solid solution ceramics through the substitution of (Mg 0.5 Ge 0.5 ) 3+ for Al 3+ in the octahedral lattice of spinel crystal structure A(tetra)B 2 (octa)O 4 via traditional high-temperature solid-state reaction method is presented. The intrinsic and extrinsic factors influencing their microwave dielectric properties , including the inversion degree of A/B lattice sites (lattice occupancy), bond length and bond valence, as well as grain sizes, were investigated using Rietveld refinement of X-ray powder diffraction data and scanning electron microscopy. To verify the applicability for the next-generation 5 G-n257/n258 millimeter wave frequency band, the Q × f values were tested within the frequency range of 12–25 GHz. Notably, MgAl 1.91 (Mg 0.5 Ge 0.5 ) 0.09 O 4 ceramics exhibited a high Q × f value of 105, 384 GHz @11.83 GHz, low ε r of 8.7, and τ f of −66.4 ppm/℃. SrTiO 3 was added to tune the τ f to a near-zero value of +2.6 ppm/℃ with high Q × f value of 51, 152 GHz @11.53 GHz and ε r of 9.91. Finally, a microstrip filter with a center frequency of 3.6 GHz was designed using this composite ceramic, successfully demonstrating its practical application in the low-frequency band of 5 G networks.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2026
·
IF 4.6
Yudi Guo,Jiaming Li,Erqing Zhao
Sc and B doping enlarges the electrolyte lattice and reduces grain boundaries. • The LASBTP003 electrolyte shows an optimal ionic conductivity of 0.882 mS/cm. • PVDF-HFP-LITFSI-SN-10LASBTP003 SCE displays enhanced electrochemical performance. • Li/SCE/ LiFePO 4 full cell shows an excellent long-term cycling stability. NASICON-type Li 1.3 Al 0.3 Ti 1.7 (PO 4 ) 3 (LATP), with excellent air stability, a wide electrochemical window and low cost, is an attractive electrolyte for lithium-ion batteries (LIBs). However, its low electrical conductivity and poor interface contact impede its practical applications. Herein, LATP was doped with Sc and B elements, and the properties of the resultant LATP-based solid electrolytes were thoroughly studied. The structural characterization suggests that doping of Sc and B densifies the electrolyte structure, enlarges the lattice, and reduces grain boundaries. The optimized Li 1.3 Al 0.24 Sc 0.03 B 0.03 Ti 1.7 (PO 4 ) 3 (LASBTP003) achieves a high ionic conductivity of 8.82 × 10 −4 S/cm, equivalent to 4-fold that of pure LATP. The composition of LASBTP003 electrolyte with PVDF-HFP and SN results in PVDF-HFP-LITFSI-SN-LASBTP003 solid composite electrolyte with enhanced ionic conductivity of 8.89 × 10 −5 S/cm, attributed to the reduced PVDF-HFP crystallization and established lithium-ion migration pathways at LASBTP003/PVDF-HFP interface. PVDF-HFP-LITFSI-SN-10LASBTP003 also displays a wide electrochemical window of 4.85 V and a high Li-ion transference number of 0.41. The Li/ PVDF-HFP-LITFSI-SN-10LASBTP003/Li symmetric battery delivers a long cycling of 1800 h under a current density of 0.1 mA/cm 2 . Moreover, LiFePO 4 /PVDF-HFP-LITFSI-SN-10LASBTP003/Li full cell delivers a long-term cycling stability, with a capacity retention of 86.92% after 1000 cycles at 0.5C. Overall, the proposed PVDF-HFP-LITFSI-SN-10LASBTP003 has great potential for LIB applications. Download: Download high-res image (195KB) Download: Download full-size image
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Antioxidants
·
2026
·Vol. 15
·期 5
·649
·
IF 8.2
Jue Yang,Peng Zhao,Lianghong Zhou,Hui Song,Zili Feng,Hongjian Cui,Yanmei Li,Jianfei Qiu,Xiaojiang Hao
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited targeted therapeutic options, underscoring the urgent need for novel treatment strategies. Feilike (FLK), a Traditional Chinese Medicine formula with heat-clearing and detoxifying properties, aligns with key pathological features implicated in breast cancer progression. In addition, several of its components have demonstrated anti-tumor activity, positioning FLK as a potential therapeutic candidate for TNBC. In this study, we employed an integrated approach combining network pharmacology, transcriptomic analysis, and experimental validation to investigate the anti-TNBC effects of FLK. Our results demonstrate that FLK significantly inhibits the proliferation of TNBC cell lines and patient-derived organoids and induces typical pyroptotic features, including cell swelling and increased lactate dehydrogenase (LDH) release. Mechanistically, FLK triggers a mutant p53 signaling cascade involving calcium dysregulation, endoplasmic reticulum stress (ERS) activation, mitochondrial dysfunction, and reactive oxygen species (ROS) accumulation, which collectively activate the P38/JNK–Caspase-3/GSDME pathway to induce pyroptosis. In vivo, FLK markedly suppresses tumor growth in a 4T1 orthotopic mouse model and enhances the anti-tumor efficacy of Cyclophosphamide. Furthermore, Licochalcone B (LCB) is identified as a key bioactive constituent that recapitulates the pyroptosis-inducing effects of FLK. Collectively, our findings uncover a previously unrecognized mutant p53–ERS–ROS–MAPK signaling axis underlying FLK-induced pyroptosis and provide mechanistic insight and experimental evidence supporting the repurposing of FLK as a potential therapeutic strategy for TNBC.
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CERAMICS INTERNATIONAL
·
2022
·
IF 5.532
Yingquan Chen,Rui Li,Yan Zhang,Yanping Long,Na Liu,Haijun Xia,Xiong Luo,Bin Meng
A series of lead-free perovskite-structured high-entropy dielectric ceramics with a composition of (La 0.25 Sr 0.25 Ba 0.25 Na 0.25 )(Ti 0.5 Me 0.5 )O 3 (Me = Sn, Zr, Hf) were designed by doping at both the A and B sites. Specifically, these ceramics were prepared via a solid-state reaction method combined with conventional sintering at 1500 ° C for 10 h. All high-entropy ceramics were consisted of a perovskite-structured single solid solution with an average grain size of 2.78–3.85 μm. Of the three samples, (La 0.25 Sr 0.25 Ba 0.25 Na 0.25 )(Ti 0.5 Sn 0.5 )O 3 exhibited the highest dielectric constant, which remained stable from in 25–312 ° C. All three groups of high-entropy ceramics showed typical relaxor behaviour. The discharge energy density ( W d = 0.31 J/cm 3 ), energy storage efficiency ( η = 90.88%) and breakdown strength ( BDS = 300 kV/cm) of (La 0.25 Sr 0.25 Ba 0.25 Na 0.25 )(Ti 0.5 Sn 0.5 )O 3 were much higher than those of BaTiO 3 ( W d = 0.08 J/cm 3 , η = 46.09%, BDS = 30 kV/cm) and other reported lead-free dielectric ceramics. These results demonstrate that high-entropy (La 0.25 Sr 0.25 Ba 0.25 Na 0.25 )(Ti 0.5 Me 0.5 )O 3 ceramics are promising new candidates for high-performance, lead-free dielectric ceramics.
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Bioengineered
·
2022
·
IF 6.832
Yuanmei Che,Jianglong He,Xiaopeng Li,Daxian Wu,Yi Zhang,Guicai Yuan
microRNAs, as small endogenous RNAs, influence umpteen sophisticated cellular biological functions regarding neurodegenerative and cerebrovascular diseases. Here, we interrogated miR-381-3p’s influence on BV2 activation and neurotoxicity in ischemic and hypoxic environment. Oxygen-glucose deprivation (OGD) was adopted to induce microglial activation and HT-22 neuron damage. Quantitative polymerase chain reaction (qRT-PCR) was taken to check miR-381-3p expression in OGD-elicited BV2 cells and HT-22 neurons. It transpired that miR-381-3p expression was lowered in BV2 cells and HT-22 cells elicited by OGD. miR-381-3p up-regulation remarkably hampered inflammatory mediator expression in BV2 cells induced by OGD and weakened HT22 neuron apoptosis. In vivo, miR-381-3p expression was abated in HI rats’ ischemic lesions, and miR-381-3p up-regulation could ameliorate inflammation and neuron apoptosis in their brain. C-C chemokine receptor type 2 (CCR2) was identified as the downstream target of miR-381-3p, and miR-381-3p suppressed the CCR2/NF-κB pathway to mitigate microglial activation and neurotoxicity. Therefore, we believed that miR-381-3p overexpression exerts anti-inflammation and anti-apoptosis in ischemic brain injury by targeting CCR2
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