JOURNAL OF CONTROLLED RELEASE
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2026
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IF 12.4
Fan Rong,Zhouyu Lu,Yuxuan Wang,Yujia Lu,Guanyi Li,Yiyang Shao,Yanwen Zhang,Zixin Wang,Bin Hao,Yunsheng Yuan,Yaxue Zhao,Haijie Han,Yin Wang
APN-activated self-immolative nanoantibiotic was developed. • H 2 S/Cip co-delivery enabled synergistic anti-inflammatory/antibacterial effects. • The corneal repair from bacterial keratitis was significantly accelerated. Pseudomonas aeruginosa (PA)-induced bacterial keratitis represents one of the most severe corneal infections usually accompanied by prominent inflammatory infiltration. Clinical fluoroquinolone-based therapies yield unfavorable therapeutic outcomes due to the insufficient ocular bioavailability and compromised anti-inflammatory efficacy. In the present work, we report a molecularly engineering strategy to conjugate ciprofloxacin (Cip) with a self-immolative carbonyl sulfide (COS)/hydrogen sulfide (H 2 S) donating motif. The resulting prodrug (termed ASCip) could spontaneously self-assemble into nanosheets in aqueous solution, thereby improving ocular surface retention and drug bioavailability. Importantly, ASCip could be specifically activated by aminopeptidase N (APN), which is overexpressed at the inflammatory sites, enabling the controlled and simultaneous release of Cip and H 2 S, to realize antibacterial and anti-inflammatory effects. In vitro evaluations of this carrier-free nanoantibiotic revealed potent antibacterial activity against PA upon APN activation, favorable biocompatibility, and significant anti-inflammatory effects via modulating the inflammatory mediators and promoting macrophage polarization towards the anti-inflammatory M2 phenotype. In a murine model of PA-infected keratitis, the nanoantibiotic efficiently eradicated pathogens, attenuated ocular inflammation, and remarkably accelerated corneal repair, providing a promising strategy to improve the efficacy of fluoroquinolone-based therapies against bacterial keratitis. More importantly, the strategy developed provides a versatile way to co-deliver COS/H 2 S with other functional motifs. The Cip prodrug ASCip could self-assemble into well-defined nanoantibiotics to enhance ocular retention. Upon APN activation, a spontaneous self-immolative reaction could be triggered to co-deliver H 2 S and Cip simultaneously, enabling synergistic anti-inflammatory and antibacterial effects that promote corneal repair in bacterial keratitis. Download: Download high-res image (114KB) Download: Download full-size image
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高影响因子
Journal of Energy Storage
·
2026
·
IF 10.7
Haikuo Lei,Jiaxue Wan,Yuxuan Zhu,Yanli Ruan
W doping regulates the Co spin configuration and optimizes its electronic structure • The Co-NC-p-W catalyst exhibits superior ORR, OER, and HER performance • Achieves 352.8 mW cm −2 peak power density and > 1700 h cycling in a zinc-air battery • Spin-state modulation accelerates multi-reaction electrocatalytic kinetics • Offers a promising strategy for durable multifunctional electrocatalysts Regulating the electronic spin state of transition metal centers has emerged as an effective strategy to optimize the catalytic activity of multifunctional electrocatalysts. In this work, we report a spin-state-engineered catalyst, Co-NC- p -W, in which the spin configuration of cobalt (Co) sites was modulated by tungsten (W) doping, thereby enhancing the catalyst's intrinsic activity toward multiple electrochemical reactions. A remarkable performance was demonstrated for the oxygen reduction reaction (ORR) and an overpotential of 216 mV at 10 mA cm −2 for the oxygen evolution reaction (OER). In addition, the catalyst displays appreciable hydrogen evolution reaction (HER) activity, requiring an overpotential of 210 mV at 10 mA cm −2 , demonstrating its additional electrocatalytic functionality. The Co-NC- p -W catalyst employed in a rechargeable zinc-air battery delivered a high peak power density of 352.8 mW cm −2 and an exceptional cycling stability exceeding 1700 h. This work highlights the critical role of spin-state modulation in designing efficient multifunctional electrocatalysts for advanced energy conversion and storage applications. Download: Download high-res image (200KB) Download: Download full-size image
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CERAMICS INTERNATIONAL
·
2026
·
IF 6
Xinyu Meng,Huiyu Lu,Jiarui Qi,Bosen Zhang,Jie Huo,Shuangming Wang,Jing Cao,Qianqian Song,Xiao Dong
The valence electron configuration largely determines the performance of functional materials, in which different electron spin and orbital occupancy would induce diverse phenomena. Herein, the study of 3d electronic configuration dominant gas sensing selectivity is presented. Utilizing ultrafast Joule heating, transition metal spinels XCr 2 O 4 (X = Co, Ni, Zn) have been synthesized and consistently exhibit sensing selectivity toward xylene gas. The e g empty orbitals of Cr 3+ 3 d 3 (t 2g 3 e g 0 ) tend to overlap with the π orbitals of xylene molecules, achieving stable xylene adsorption and electron transfer and thus presenting remarkable xylene gas sensing selectivity. The valence electron configurations of 3 d 7 , 3 d 8 and 3 d 10 for Co 2+ , Ni 2+ and Zn 2+ result in a progressively lower response to xylene gas. This valence electron configuration perspective is experimentally supported by gas sensing selectivity of XFe 2 O 4 (X = Co, Ni, Zn) toward acetone molecules, in which the electronic orbital configuration of Cr 3+ 3 d 3 of B sites is replaced by Fe 3+ 3 d 5 . Theoretically, density functional theory (DFT) calculations based on adsorption energy and charge density difference confirm the strong adsorption of xylene at Cr 3+ sites and efficient electron transfer from xylene to Cr sites. Download: Download high-res image (422KB) Download: Download full-size image
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Yufang Li,Lizheng Yang,Dongying Hu
Developed a novel iron and nitrogen co-doped biochar composite cathode from jackfruit peel. • This HBC@FeN-C shows hierarchical pores structure. The Fe 3 O 4 nanoparticles provide abundant Fe(III) active sites. • OH is one of the key active species in efficient heterogeneous electro-Fenton degradation. Biochar materials have emerged as promising platforms for heterogeneous electro-Fenton catalysis, yet increase of their catalytic active sites to improve degradation rate remains challenging. Herein, hierarchical porous biochar was functionalized by iron and nitrogen co-doping. Iron was loaded on the surface of carbon matrix in the form of Fe 3 O 4 nanoparticles to provide catalytic active sites, while nitrogen doping may regulate the electronic structure of carbon matrix. Thanks to the combined effect of mass transfer process promoted by hierarchical pore structure and iron and nitrogen synergetic catalysis, the optimized iron and nitrogen co-doped biochar composite cathode showed significantly enhanced catalytic activity in the electro-Fenton degradation of phenol. It achieved 95.4% phenol degradation rate within 180 min under conditions of 0.10 M sodium sulfate electrolyte (current density of 40 mA/cm², pH = 7, catalyst loading of 6.0 mg, 200 mg/L phenol). The corresponding chemical oxygen demand and total organic carbon removal efficiencies reached 62.7% and 75.3%, respectively. It also exhibited good stability, as verified by cycling tests. Electron paramagnetic resonance analysis confirmed that hydroxyl radical radicals are one of the key reactive species involved in phenol degradation. This study demonstrates that iron and nitrogen co-doped hierarchical biochar composite cathode is an effective strategy for treating high-concentration wastewater. Download: Download high-res image (415KB) Download: Download full-size image
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Advanced Healthcare Materials
·
2026
·
IF 11
Shangyan Shan,Chengyu Liu,Lina Ding,Weishu Zeng,Haoran Cui,Jia Liu,Meiqi Li,Xu Ding,Biao Dong,Liang Cheng,Manlin Qi,Lin Wang
Inflammatory diseases are characterized by overactivated immune responses and a disrupted metabolic equilibrium, particularly in dendritic cells (DCs), where mitochondrial reactive oxygen species (mtROS) burst and metabolic reprogramming drives pathological maturation. While modulating immunometabolism is a promising therapeutic avenue, achieving subcellular-targeted delivery of bioactive molecules remains a formidable challenge. Here, we report a mitochondria-targeted nanozyme designed to concurrently scavenge mtROS and reprogram DC metabolism for effective anti-inflammatory therapy in periodontitis. This system is constructed based on Prussian blue nanoparticles (PB NPs) loaded with manganese carbonyl, a high oxidative stress-responsive carbon monoxide (CO) donor, and further modified with triphenylphosphine for mitochondrial targeting. This nanozyme efficiently accumulates in the mitochondria of activated DCs, where it efficiently scavenges mtROS and concurrently delivers controlled CO release, synergistically modulating DC function. Metabolomics analysis reveals that CO suppresses DC maturation by reprogramming cellular metabolism, including inhibiting the tricarboxylic acid cycle, modulating glycolysis, and disrupting fatty acid synthesis. Consequently, the synergistic action of PB NPs and CO effectively reverses the pro-inflammatory phenotype of DCs, reshapes the immune microenvironment, and ultimately alleviates periodontal inflammation in vivo. This work presents a promising strategy for curing inflammatory diseases by targeting metabolic reprogramming at the subcellular level.
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高影响因子
LANGMUIR
·
2026
·
IF 4.4
Honglin Li,Yingqi Duan,Qingwen Feng,Linjiao Wei,Jingbin Zeng,Ziyue Chen,Qingtong Zhang,Yanpeng Chen,Zifeng Yan
Ag–Cu tandem catalysis provides an effective strategy to enhance C2+ selectivity in the electrochemical CO2 reduction reaction (CO2RR) by integrating CO generation and utilization for C–C coupling. Here, we report a series of Ag@Cu2O, Ag@CuO, and Ag@CuO-BDC core–shell catalysts designed to regulate the CO generation, Cu-oxidation states, and surface structures. The Ag@Cu2O catalysts exhibit pronounced tandem effects, suppressing CH4 formation while enhancing the C–C coupling on the Cu sites. Notably, Ag@Cu2O-30 achieves a high C2H4/CH4 Faradaic efficiency ratio of 6.5 at −1.8 V (vs RHE) with an increased C2H4 partial current density of 12.3 mA cm–2. Oxidation to Ag@CuO further modifies the Cu species distribution, facilitating CO and CO2 diffusion while reducing H2 formation. Moreover, constructing Cu-BDC-MOF followed by electrochemical reconstruction generates additional oxygen vacancies and stabilizes Cu+ species, enhancing C2H4 selectivity and stability but with increased CH4 formation and reduced current density. This study highlights Ag–Cu tandem catalysis and structural regulation of Cu as effective strategies for achieving selective reduction of CO2 toward C2H4.
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PubMed
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2026
·
IF 5.2
Siyuan Chen,Lihao Gu,Chenglong Ye,Xinyi Zhao,Xingxing Zhang,Jianming Xu,Dan Luo,Xi Wang,Jia Luo,Jun Deng,Wei Liu
Hyperpigmentation remains a significant dermatological challenge. Although 4-butylresorcinol (4-BR), undecylenoyl phenylalanine (UPA), and stearyl glycyrrhetinate (SG) exhibit complementary mechanisms targeting these pathways, their therapeutic potential is limited by poor solubility, instability, and insufficient skin permeation. To overcome these barriers, a nanostructured emulsion system co-encapsulating 4-BR, UPA, and SG (BUS-NEs) was developed via high-pressure homogenization. The optimized BUS-NEs displayed a mean particle size of 55.01 nm, encapsulation efficiencies exceeding 90%, good stability, and a sustained release profile. Compared with Free-BUS, BUS-NEs significantly improved cellular uptake and skin permeation while maintaining excellent biocompatibility. Mechanistic studies revealed that BUS-NEs exerted superior anti-melanogenic effects by potently inhibiting intracellular tyrosinase activity, reducing melanin production, and downregulating key genes in the α-MSH-stimulated signaling pathway. Furthermore, BUS-NEs displayed robust antioxidant and anti-inflammatory activities, effectively scavenging ROS and suppressing the secretion of pro-inflammatory cytokines. These multifunctional benefits were validated in advanced models: BUS-NEs significantly reduced melanin deposition and improved skin brightness in UVB-irradiated 3D reconstructed human skin, and demonstrated pronouncedc depigmentation and antioxidant protection in vivo using zebrafish models. In conclusion, the BUS-NEs platform successfully overcomes the delivery limitations of 4-BR, UPA, and SG, enabling their complementary, multi-target action for effective hyperpigmentation management, representing a promising nanotechnological strategy for advanced dermocosmetic applications. Download: Download high-res image (304KB) Download: Download full-size image
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产品关联
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高影响因子
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
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2026
·
IF 4.4
Nan Zheng,Xinyue Liu,Meng Lan,Xiaoli Dong,Yubo Zhang
Co-TiO 2-x with abundant OVs made via one-step hydrothermal. • Optimal sample: high NH 3 yield, good stability & selectivity. • Co & OVs enhance N 2 adsorption/activation for sustainable NH 3 . Photocatalytic nitrogen fixation represents a promising green technology for ammonia synthesis, but its efficiency is largely limited by the adsorption and activation of N 2 molecules on catalyst surfaces. In this study, cobalt-doped brown TiO 2-x with abundant oxygen vacancies was successfully synthesized via a simple one-step hydrothermal method. The brown TiO 2-x exhibits excellent light absorption capacity and abundant oxygen vacancies. Cobalt doping further promotes the separation of photogenerated charge carriers and the photocatalytic reduction ability of brown TiO 2-x , while also inducing the generation of additional oxygen vacancies (OVs). These OVs serve as active sites, effectively improving the adsorption and activation of N 2 , and subsequently reducing it to ammonia. Experimental results demonstrate that the photocatalytic nitrogen fixation performance of the Co doped TiO 2-x is significantly improved. The as-fabricated 7%Co-doped TiO 2-x sample achieves an ammonia production rate of 257.58 μmol·g −1 ·h −1 . In addition, it also exhibits good stability and NH 3 selectivity. This work highlights the promise of coupled doping and defect engineering for creating high-efficiency photocatalysts for sustainable ammonia production. Download: Download high-res image (365KB) Download: Download full-size image
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高影响因子
Nanoscale
·
2026
·
IF 5.2
Wenshuo Zhao,Yanzhe Zhang,Yong-Li Wang,Tong Wu,Yingying Zhang,Jingjing Sun,Xiangrong Liu,YONGJIE ZHAO
Fe-Mn based layered transition metal oxides are compelling candidates for sodium-ion cathodes owing to their high specific capacity and cost-effectiveness. However, their practical application is hampered by inherent challenges including the Jahn-Teller effect, lattice oxygen loss, transition metal dissolution. In this study, Al/Ti co-doped Na0.67Fe0.4Mn0.4Al0.1Ti0.1O2 (FM-AT) cathode is proposed and prepared. The introduction of Al/Ti, creating strong Al-O and Ti-O bonds, effectively stabilizes the lattice oxygen and elevates the reversibility of anionic redox reactions. Furthermore, the stability of the transition metal layer is effectively enhanced, suppressing transition metal dissolution and the P2-OP4 phase transition associated with TMO2 layer slippage at deep charge states. The FM-AT demonstrates excellent cycling stability, with a capacity of 137.1 mAh g-1 under 20 mA g-1 and a capacity retention of 85.5% after 50 cycles (55.7% for the pristine FM cathode). Even after 200 cycles under 200 mA g-1, a capacity retention of 72.1% is achieved (versus 20.9% for the FM). This work offers a novel method for enhancing the structural stability of iron-manganese based electrode and designing cost-effective, high-performance sodium ion cathodes.
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PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
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2026
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IF 7.9
Baihong Yang,Bowen Ran,Cheng Wang,Xiaodong He,Liqun Xu,En-Tang Kang
The development of effective antibacterial surface coatings is essential for reducing the risk of implant-associated infections. Polymers with different charge characteristics, including nonionic, cationic and anionic polymers, have been widely explored for antibacterial/antifouling surface modification. However, a systematic comparison of their interactions with polydopamine (PDA) during coating formation remains limited. In this work, a series of composite coatings were fabricated via a one-step co -deposition process involving dopamine and polymers with different charge properties. The coating formation behavior, interfacial adhesion, stability, surface morphology, and antibacterial performance were systematically investigated. The results demonstrate that co -deposition with cationic polymers, particularly polyquaternary-2 (PQ), and polyhexamethylene biguanide hydrochloride (PHMB), significantly enhances the adhesion and stability of PDA coatings. Among the evaluated systems, the PDA-PQ coating exhibited pronounced antibacterial activity through contact-mediated and photothermal mechanisms while maintaining good cytocompatibility, as confirmed by both in vitro and in vivo assessments. This study elucidates the role of polymer charge in governing PDA-based coating formation and performance, providing valuable insights for the rational design of PDA-based antibacterial coatings for medical device surfaces.
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高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2026
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IF 4.5
Falong Shan,Jingru Dou,Yinghou Li,Yaqi Xu,Guanghui Chen,Pan Zhang,Fei Gao,Jipeng Dong
To address the challenge that Cu + active species in developed Cu + -based adsorbents tend to oxidize to Cu 2+ in humid air, thereby losing their adsorption performance for carbon monoxide, in this study, methyltrimethoxysilane (MTMS) was employed as a hydrophobic modifier to modify the Cu + -based CO adsorbent. The hydrophobically modified Cu + -based CO adsorbent effectively shields the Cu + active species from water, thereby significantly inhibiting their oxidative deactivation. The successful grafting of MTMS onto the ultra-stable Y-type zeolite (USY) support was confirmed, thus markedly enhancing the hydrophobicity of the resulting Cu + -based CO adsorbent. The optimized adsorbent, CuCl(4)@USY-MTMS(24%), exhibits a high CO adsorption capacity of 2.61 mmol/g, coupled with high adsorption selectivity for CO/CO 2 and CO/N 2 . Moreover, the MTMS-modified hydrophobic CuCl(4)@USY-MTMS(24%) adsorbent exhibits significantly enhanced oxidation resistance compared to its unmodified counterpart, after aging in 70% relative humidity air for 24 h, it retains 79% of the CO adsorption capacity of pristine adsorbent, far exceeding the 47% retention of the unmodified version. This remarkable performance confirms that the hydrophobically modified adsorbent achieves stable CO separation.
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高影响因子
Nanomaterials
·
2026
·Vol. 16
·期 8
·474
·
IF 4.8
Chang Chen,Yaohui Xu,Qin Wang,Zhao Ding
CeO2is widely studied in catalysis owing to its Ce4+/Ce3+redox couple and oxygen storage capacity (OSC), but its low-temperature redox activity remains a challenge. To address this, this study investigates the effects of saturated In3+doping (1 mol.%) on the structural, redox, and catalytic properties of nano-octahedral CeO2. Structural and chemical analyses reveal that In3+doping induces lattice contraction from 5.4171 to 5.4129 Å, increases oxygen vacancy concentration from 29.7% to 39.8%, and raises surface Ce3+fraction from 27.6% to 30.0%. Consequently, H2-TPR measurements show that the surface reduction peak temperature decreases from 548 to 406 °C and the onset reduction temperature shifts from 309 °C to 183 °C. Quantitative OSC analysis further demonstrates that the low-temperature OSC increases from 13.17 to 20.57 mmol O2/mol and the high-temperature OSC from 53.36 to 59.38 mmol O2/mol upon doping. As a result of these enhancements, CO-TPSR tests reveal improved low-temperature CO oxidation performance, with the CO2light-off temperature decreasing from 99 to 72 °C and the rapid oxidation temperature from 153 to 96 °C. Notably, H2O and H2signals are detected during CO-TPSR, and FTIR analysis confirms the enrichment of surface hydroxyl groups in the doped sample, offering new mechanistic insights into the involvement of surface species in the reaction pathway. Overall, saturated In3+doping effectively enhances the oxygen vacancy concentration, surface reducibility, and CO oxidation activity of nano-octahedral CeO2.
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高影响因子
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