DRUG DELIVERY
·
2025
·
IF 8.1
Yilin Xu,Min Wang,Jing Wu,Manshu Zou,Donghai Wu,Jing Gong,Pingjie Wang,Hong Yan,Xinhua Xia
Liver cancer is a common malignancy in the world, and its incidence and mortality rate are increasing year by year. The disease has a short course and a high mortality rate, posing a serious threat to humanity and health. The objective of this study is to create novel liver-targeted nanoparticles as a potential treatment for liver cancer. The aptamer (APS613-1) modified redox-sensitive norcantharidin solid lipid nanoparticles (Apt-PEG2000-ss-NCTD-SLNs) were prepared by emulsified ultrasonic dispersion method and characterized. The tumor targeting, antitumor effect and safety of the nanoparticles were investigated and evaluated in vitro and in vivo. The particle size of Apt-PEG2000-ss-NCTD-SLNs was 87.95 ± 3.32 nm, and the encapsulation efficiency was about 80.74 ± 2.36%, which had good biocompatibility. The results of in vitro experiments showed that, compared with unmodified solid lipid nanoparticles (NCTD-SLNs), Apt-PEG2000-ss-NCTD-SLNs had better targeting for liver tumor cells, and a stronger ability to inhibit cell proliferation and migration, as well as promote cell apoptosis. The in vivo results revealed that Apt-PEG2000-ss-NCTD-SLNs demonstrated good safety and anti-tumor efficacy, and its mechanism was achieved through the inhibition of cell proliferation and induction of apoptosis. The functionalized nanoparticles modified by aptamer APS613-1 can be used for the liver-targeted delivery of antitumor drugs for the treatment of liver cancer, and Apt-PEG2000-ss-NCTD-SLN is a potential drug for the treatment of liver cancer.
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高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Ling Yu,Fengkai Qiu,Yumin Hu,Tingting Liao,Mengqian Zhai,Ronghua Wu,Qianhui He,Huilin Hu,Shuiwei Xia,Junguo Hui,Zufei Wang,Yang Yang,Rongfang Qiu,Minjiang Chen,Weiqian Chen,Jianfei Tu,Jiansong Ji,Chenying Lu
Because of the high incidence and mortality of cancer, there is an urgent need for more effective tumor diagnostic imaging and treatment strategies. Single-molecule therapeutics have emerged as a promising strategy to address the limitations of independent imaging and therapeutic modalities, thereby significantly reducing adverse side effects for patients. For the first time, we successfully synthesized NaGd(MoO4)2 nanoparticles via a homogeneous precipitation method in polyol media, which serve as a single-molecule agent for MRI imaging and metallic immunotherapy. With the addition of iRGD, we obtained iRGD-NaGd(MoO4)2. The iRGD-NaGd(MoO4)2 nanoparticles exhibit excellent tumor-targeting capability and significantly enhance T1-weighted MRI contrast with a longitudinal relaxivity of 4.95 mM–1 s–1. In terms of antitumor immunotherapy, iRGD-NaGd(MoO4)2 not only directly activates the cGAS-STING pathway but also induces ferroptosis in tumor cells, resulting in the generation of aberrant dsDNA and thereby indirectly activating the STING pathway. The dual pathway elicits a tumor-specific immune response, plays a significant role in promoting the maturation of DC cells, activates DC and T cells to secrete high levels of TNF-α, IL-6 and other cytokines, and regulates the polarization of macrophages from M2 phenotype to M1 phenotype. This mechanism significantly suppresses tumor growth. Beyond the metallic immunotherapy induced by Mn2+, Zn2+, and Co2+, this study provides robust validation of MoO42– as an effective cGAS-STING agonist. Moreover, this study achieved the synergy of multiple disciplines including biomaterials, tumor immunotherapy and medical imaging. This not only promotes the innovative integration in various fields, but also provides new treatment strategies and imaging tools for cancer treatment, which has important clinical application prospects.
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高影响因子
ACS Applied Nano Materials
·
2025
·
IF 5.5
Xu Chen,Liqiang Wang,Yonglan Yang,Qiongmei Mai,Qianyu Cai,Yuezhao Zhou,Xufeng Zhu,Yanan Liu,Jie Liu
Mucolytics provide an effective therapeutic strategy for promoting drug penetration into mucus layers in treating acute lung injury (ALI). However, for an ideal therapeutic system, how to further achieve targeted delivery in a mucolytics therapeutic system remains a challenge. Herein, we utilized indocyanine green (ICG) and two cationic pillar arenes (CWP[5] and CWP[6]) to synthesize two types of pH-responsive nanovesicles through host–guest reactions (ICG-CWP[5] and ICG-CWP[6]). And then we connected them with copolymers (Man@Cys) to obtain thiolated nanovesicles (ICG-CWP[5]/[6]MC), which endowed nanovesicles with targeting capability. In vitro and in vivo, ICG-CWP[5]MC and ICG-CWP[6]MC not only demonstrated mucus penetration but also demonstrated targeted delivery of CCR2-siRNA into lung mononuclear macrophages through cell imaging and near-infrared (NIR) imaging. Notably, among those, ICG-CWP[5]MC showed superior delivery efficiency due to smaller size. Then, the therapeutic system with local administration effectively inhibited the inflammatory response of macrophages, with the CCR2-siRNA specifically silencing the chemokine receptor. And it exhibited higher efficiency in treatment of ALI by inhibiting the pulmonary inflammatory injury. Overall, the thiolated nanovesicles provide new drug delivery to the lungs for improving the treatment effect of pneumonia.
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ACS Nano
·
2025
·
IF 16
Yin Zhou,Yutong Chen,Wentao Zhao,Jiafeng Wang,Yi Chen,Haobo Wen,Yiyan He,Ning Li,Hongli Mao,Yuwen Cui,Zhongwei Gu
Intracellular bacterial infections are challenging due to immune evasion and antibiotic resistance, especially within macrophages harboring dormant bacteria. Here, a synergistic antibacterial strategy is presented using the PG3M@GaPP nanoflowers, which integrate immune modulation, iron metabolism disruption, and antibacterial photodynamic therapy (APDT) to eliminate intracellular bacteria. This nanoflower encapsulates a gallium–protoporphyrin IX complex (GaPP) within mannose-functionalized poly-l-lysine dendrimers (PG3M), enabling targeted delivery to macrophages via mannose receptor recognition. PG3M@GaPP promotes macrophage polarization to the anti-inflammatory M2 phenotype, enhancing immune modulation and bacterial uptake. The platform’s positive charge facilitates endosomal escape, releasing GaPP in the acidic intracellular environment, where free iron ions compete with gallium ions to form the iron–protoporphyrin IX complex (FePP). This disrupts the gallium/iron ion balance, enhancing the Trojan horse effect of gallium ions and inducing iron metabolism-dependent bacterial death. Additionally, laser activation of GaPP generates reactive oxygen species (ROS), further amplifying bacterial killing via APDT. In vitro and in vivo experiments show that PG3M@GaPP outperforms both free GaPP and commercial antibiotics in eliminating intracellular bacteria. These nanoflowers offers an alternative, nonantibiotic approach to combat intracellular infections, addressing drug resistance and providing a promising platform for antibacterial therapies.
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高影响因子
Small Methods
·
2025
·
IF 9.1
Zheng Chen,Qiyue Wang,Sirui Cui,Xi Hu,Peihua Lin,Bo Zhang,Daishun Ling,Fangyuan Li
Piezoelectric materials have emerged as versatile tools for ultrasound-triggered cancer therapy, yet their clinical application is constrained by inefficient charge separation and the limited availability of catalytic substrates in the tumor microenvironment. Here, an electronegativity-modulated piezoelectric metal–organic framework (CapMOF@HA) is reported through controlled heteroepitaxial growth of CaO 2 on pMOFs, followed by surface functionalization with hyaluronic acid (HA) for tumor-targeting capability for enhanced piezocatalytic therapy. Of note, the electronegativity-modulated heterogeneous interfaces between CaO 2 and pMOF promote the separation of electron–hole pairs while suppressing recombination through the electronegativity effect, significantly amplifying piezocatalytic reactive oxygen species (ROS) generation (•OH, 1 O 2 , and •O 2 ⁻) under ultrasound stimulation. Furthermore, the controlled decomposition of calcium peroxide provides a continuous supply of H 2 O 2 and O 2 as catalytic substrates, while releasing Ca 2+ to induce calcium overload, triggering mitochondrial dysfunction and glutathione peroxidase 4 inhibition for ferroptosis induction. This strategy integrates enhanced piezoelectric catalysis with ferroptosis induction, overcoming long-standing limitations in piezocatalytic systems to achieve precise and robust tumor ablation. By combining substrate self-sufficiency with multifunctional therapeutic mechanisms, this work establishes tumor piezocatalytic ferroptosis as a transformative platform for next-generation piezoelectric cancer therapy.
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ACS Nano
·
2025
·
IF 16
Yingjie Zhao,Tian Liu,Yi Wang,Lingxiao Li,Xue Lin,Wenjing Wang,Jingzhe Sheng,Mengyu Liu,Dongchun Liu,Zhonggui He,Bingjun Sun,Yuki Takahashi,Jin Sun
Homodimer prodrug nanoassemblies (HPNAs) gain significant attention due to their ultrahigh drug-loading capacity and carrier-free nature but suffer from poor self-assembly stability and rapid clearance from blood circulation. Cell membranes prove as a promising coating material for nanoparticle modification, offering specialized properties such as specific recognition, prolonged circulation time, and immune evasion. Here, we present a cancer cell membrane-modified biomimetic nanoassembly system designed for combined chemo-immunotherapy. We design a paclitaxel dimer-based small-molecule self-assembling prodrug, PTX-STeS-PTX (PSTeSP). The biomimetic nanoassemblies are constructed by using R848/PSTeSP nanoassemblies (RPNAs) to create a nanocore with an outer layer modified by cancer cell membranes (CCM), abbreviated as CCM-coated RPNAs (RP@CCM NAs). The CCM modification improves the stability of RPNAs in blood circulation and increases their accumulation at tumor sites. Additionally, CCM-coated RPNAs exhibit enhanced homologous targeting specificity toward cancer cells, significantly promoting cellular uptake and selectively inducing cytotoxicity in tumor cells. Furthermore, the incorporation of R848 into the PSTeSP-based nanoassemblies enhances the immune complexity at tumor sites, reshapes the tumor immune microenvironment, and inhibits cancer cell metastasis, enabling a combined chemotherapy and immunotherapy approach. This study explores the potential of CCM as a surface modification material to enhance the pharmacokinetic profile and tumor-specific targeting of HPNAs, offering a rational strategy for HPNA-based drug delivery systems in effective cancer treatment.
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ANTIOXIDANTS & REDOX SIGNALING
·
2025
·
IF 6.1
Xian-Dong Li,Yue-Xin Ning,Yi-Feng Pei,Jing-Yuan Niu,Jian Luo,Yi-Na Zhang,Zi-Ai Zhao,Xiao-Wen Hou,Qian-Kun Zhao,Tian-Ce Xu,Hui-Sheng Chen
Aims: Cathodal transcranial direct current stimulation (C-tDCS), a noninvasive physical therapy, has potential neuroprotective effects in acute ischemic stroke. However, the rational timing of its application and the underlying mechanisms remain inadequately understood. This study aims to investigate its neuroprotective effects and the involved mechanisms.Results: Our in vivo results indicated that C-tDCS applied during the reperfusion phase but not during the ischemic phase significantly improved neurological outcomes, reduced infarct volume, and mitigated histopathological damage in middle cerebral artery occlusion/reperfusion rats. C-tDCS during the reperfusion phase suppressed ferroptosis, activated nuclear factor erythroid 2-related factor 2 (Nrf2), and inhibited mitophagy. In vitro, the ferroptosis inducer RSL3 negated the protective effects of cathodal direct current stimulation on HT22 neuronal cells subjected to oxygen-glucose deprivation/reoxygenation injury. Furthermore, the Nrf2 inhibitor ML385 and the mitophagy activator FCCP reversed the inhibitory effects of C-tDCS on ferroptosis, with FCCP also affecting Nrf2 activation by C-tDCS.Innovation and Conclusions: These results demonstrate that C-tDCS during reperfusion attenuates cerebral ischemia-reperfusion injury by coordinating mitophagy inhibition and Nrf2 activation to counteract ferroptosis, which provides new evidence for its potential translational clinical applications. Antioxid. Redox Signal. 00, 000–000.
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Biomaterials Science
·
2025
·
IF 5.7
Zihan Zhu,Yan Zhang,Lianggan Luo,Xuan Shang,Xinli Fan,Wei Bian,Jing Wang,Xinjing Tang
Due to the high morbidity and mortality, cancer has become a global health crisis, posing a great threat to human health. Traditional cancer treatments include surgery, chemotherapy and radiotherapy, but these methods can lead to serious adverse reactions. Therefore, it is of great significance to develop new and effective methods for cancer diagnosis and treatment. In this article, orange fluorescent carbon dots (CDs) were synthesized by the hydrothermal method using biogenic amines. Upon further surface modification with a salivary acid, a novel nanocomplex (CDs-SA-PTX) was prepared by loading the chemotherapeutic drug paclitaxel that could be released under a pH-responsive behavior. In addition, upon irradiation with a near-infrared laser, the temperature of the CDs-SA-PTX nanocomplexes increased to 45.7 °C, indicating a good photothermal effect with a conversion efficiency of 43.8%. In the cellular uptake experiment, CDs-SA-PTX exhibited good capability for nucleolar targeting similar to CDs. The cell viability experiment showed that CDs-SA-PTX together with laser irradiation demonstrated the best breast cancer cell killing ability than other groups. Further in vivo data indicated that CDs-SA-PTX could be efficiently enriched in tumor tissues and could almost completely inhibit tumor growth with laser irradiation. The nanocomplexes provide an ideally versatile platform with the advantages of simple ingredients, easy preparation, active targeting, imaging-guided photothermal therapy and chemotherapy.
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2025
·Vol. 36
·期 18
·1-11
·
IF 2.8
Liu KunLei,Liu Xumin,Dong Qingchen,Song Lijun,Liang Xinhui,Hu Dianfang,Yu Shihui
Flexible transparent conductive films based on copper nanowires (Cu NWs) are used in a variety of optoelectronic devices. However, their use is limited due to poor stability and adhesion. Herein, highly reliable flexible transparent conductive thin films consisting of SrSnO 3 (STO) and Cu NWs are fabricated using a combination of spin-coating and radio frequency magnetron sputtering techniques. The optical and electrical properties can be modified by changing the number of spin-coating cycle of Cu NWs. The STO thin films can effectively improve optical–electric performance of Cu NWs (before coating STO: 22.1 Ω/sq. at 81.5%, after coating STO: 18.7 Ω/sq. at 82.8%). Furthermore, after 20 tape tests and 2000 bending cycles (with a bending radius of 5.0 mm), the resistance of STO/Cu NW composites remains unchanged, demonstrating exceptional mechanical flexibility and adhesion retention. In addition, the composites show higher stability to high-temperature and high-humidity conditions, oxidation, corrosion, and sulfidation compared with that of Cu NW networks, which is due to the effective covering of STO layer. The combination of these characteristics makes the composite thin films an excellent candidate for substrates of novel flexible optoelectronic devices.
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Food Chemistry-X
·
2025
·
IF 8.2
Jing-Liu He,Kai-Xin Jiang,Ting Wei,Jin-Lei Geng,Zi-Fan Zhao,Jing Feng,Jie Li,Hong-Yan Liu,Shang Lin,Ding-Tao Wu
To utilize thinned young kiwifruit for potential industrial applications, this study compared structural properties and in vitro bioactivities of pectic polysaccharides isolated from three thinned young red-fleshed kiwifruit cultivars, including Actinidia chinensis cv. ‘Donghong’, ‘Hongshi’, and ‘Hongyang’. The results demonstrated that these young kiwifruit byproducts were rich in pectic polysaccharides, with extraction yields of 90.7–101.3 mg/g dry weight. Although their bound polyphenols (8.02–8.93 mg GAE/100 mg), esterification degrees (50.45–61.32 %), and molecular weights (7.44 × 10 4 –8.51 × 10 4 Da) varied across cultivars, the glycosidic linkage patterns showed remarkable consistency, dominated by homogalacturonan (12.07–13.84 mol%) and rhamnogalacturonan-I (70.25–75.09 mol%) regions. Notably, all these pectic polysaccharides, particularly those isolated from the ‘Donghong’ cultivar, demonstrated notable antioxidant, antiglycation, prebiotic, and immunoenhancing activities in vitro . These findings indicate that thinned red-fleshed kiwifruit byproducts are rich sources of RG-I enriched pectic polysaccharides, with significant potential as functional food ingredients.
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Materials Today Bio
·
2025
·
IF 10.2
Mingcheng Wang,Huixi Yi,Qibao Zheng,Muhammad Adnan Younis,Liyou Guo,Zhixiong Zhan,Muhammad Rizwan Younis,Chengzhi Jin,Dong-Yang Zhang
The high metastatic rate of breast tumor is the prominent reason of its poor prognosis, while the inflammatory microenvironment of tumor tissues further promoted tumor metastasis. Although photothermal therapy (PTT) displays high antitumor efficacy, the rise of inflammation-induced reactive oxygen species (ROS) during PTT exacerbate tumor metastasis. To prevent breast tumor metastasis and relieve inflammation-induced oxidative stress during PTT, herein, we developed self-assembled nanodrugs (FCP) consisting of carminic acid, iron ion, and polyvinylpyrrolidone, demonstrating photoacoustic imaging-guided PTT and anti-inflammatory activity to restrict the growth of both primary breast tumor and metastatic tumor. The as designed self-assembled spherical FCP nanoparticles (NPs, 41 nm) exhibited good light to heat conversion and broad-spectrum multienzyme (superoxide dismutase, etc.) mimetic activity to scavenge excess ROS and alleviate oxidative stress. Meanwhile, FCP NPs showed a positive correlation between the photothermal heating and ROS scavenging, allowing the continuous consumption of ROS during PTT. Importantly, owing to the intrinsic bimodal photothermal and photoacoustic imaging abilities, FCP NPs effectively guided and monitored the in vivo treatment process, which facilitated to restrict the growth of both primary and metastatic breast tumor in vivo due to coordinated PTT and anti-inflammation as confirmed by TUNEL, ki67, and matrix metalloproteinase-9 stainings. Whereas FCP NPs did not pose any potential damage to the vital organs, presenting good biosafety in vivo . We envision that self-assembled nanodrugs with concurrent anti-inflammatory and photothermal activities may have great clinical prospects in the treatment of metastatic cancers.
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Cell Reports
·
2025
·
IF 6.9
Zhao Cui,Jiameng Li,Caifeng Li,Shiwen Deng,Wei Liu,Tong Lei,Junxian Cao,Ziyi Wang,Xiaoxu Wang,Shuhua Ma,Yinhua Zhu,Hongjun Yang,Peng Chen
α-ketoglutaric acid (AKG), a tricarboxylic acid cycle metabolite central to aerobic metabolism and longevity, retains unresolved anti-aging protein targets. Here, we demonstrate that reduced isocitrate dehydrogenase 1 (IDH1) expression during senescence lowers AKG production, accelerating the aging of mesenchymal stem cells (MSCs). Exogenous AKG or IDH1 overexpression restores AKG levels, enabling 2-oxoglutarate and Fe(II)-dependent oxygenase domain-containing protein 1 (OGFOD1)-catalyzed hydroxylation of ribosomal protein S23 (RPS23) at proline 62. Mechanistically, AKG stabilizes the OGFOD1-RPS23 complex, enhancing translation accuracy to limit misfolded protein accumulation while sustaining synthesis rates, thereby balancing proteostasis. The natural flavonoid scutellarin (Scu), identified as an IDH1 agonist, elevates AKG to delay MSC senescence. In aged mice, Scu improves cognitive function, reduces osteoporosis and skin aging, and suppresses senescence-associated secretory phenotype. Our findings identify the AKG-IDH1-RPS23 axis as a regulator of stem cell senescence and we propose metabolic reprogramming strategies for anti-aging therapies.
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危险品化学品经营许可证（带存储）