Polymers
·
2018
·Vol. 10
·期 10
·1046
·
IF 2.935
Dong Wang,Wanli Cheng,Yiying Yue,Lihui Xuan,Xiaohui Ni,Guangping Han
Cellulose nanocrystals/chitosan/polyvinyl alcohol (CNC/CS/PVA) composite nanofibrous films were prepared while using an electrospinning technique and successfully thiol-functionalized. Then, the modified films were used for the sorption-desorption of Cu(II) and Pb(II) ions. Subsequently, the adsorption capacity of the films was investigated by changing the CNC loading level, solution pH, and adsorption time. Results showed that the adsorption of metal ions by the films was the best with CNC loading level of 5 wt %, pH of 6, and adsorption time of 4 h. The adsorption behavior of the films was agreed with the Freundlich model. The adsorption equation of metal ions could be described while using a pseudo-second order model. Based on the Langmuir model, the maximum adsorption capacities of Cu(II) and Pb(II) ions were estimated to be 484.06 and 323.49 mg/g, respectively. The Cu(II) and Pb(II) ions adsorption efficiencies of the films after 4 adsorption-desorption cycles were 90.58% and 90.21%, respectively. This study may provide a feasible approach for the application of functional CNC/CS/PVA nanofibrous films in the treatment of water.Keywords:electrospining;chitosan;cellulose nanocrystals;nanofibrous films;metal adsorption
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ANALYST
·
2014
·Vol. 139
·期 17
·4216-4222
·
IF 3.906
Chong Sun,Lie Ma,Qiuhui Qian,Soniya Parmar,Wenbo Zhao,Bo Zhao,Jian Shen
Analysts are always interested in finding new functional nanomaterials and devices with good properties for electrochemical sensor applications. In this paper, hyperbranched polyester nanoparticles with carboxylic acid functional groups (HBPE–CA NPs) were synthesized and combined with chitosan wrapped around Au nanoparticles (CS–Au NPs) to prepare a novel and sensitive electrochemical immunosensor by adsorption of carcinoembryonic antibody (anti-CEA) on the (HBPE–CA)/CS–Au NPs modified glass carbon electrode (GCE). Under the optimized conditions, the proposed immunosensor displayed a good amperometric response to carcinoembryonic antigen (CEA). Moreover, based on the antibiofouling properties, the immunosensor could be used for the direct detection of CEA in whole blood, and exhibited a wide detection range (1–107 fg mL−1), and a low detection limit of 0.251 fg mL−1 (signal/noise = 3). Control experiments were also carried out by using ascorbic acid (AA), uric acid (UA), human immunoglobulin G (IgG), BSA and glucose in the absence of CEA. The good stability and repeatability of this immunosensor were also proven. Importantly, the results of the detection of clinical whole blood specimens with the proposed immunosensor showed good consistency with the data determined by enzyme-linked immunosorbent assay (ELISA) in serum samples. Furthermore, the developed immunosensor could provide a promising immunoassay strategy for clinical applications, since the values we measured in whole blood directly are likely closer to the real values.
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Materials Science & Engineering C-Materials for Biological Applications
·
2016
·
IF 3.42
Huinan Chen,Xiaodong Xing,Huaping Tan,Yang Jia,Tianle Zhou,Yong Chen,Zhonghua Ling,Xiaohong Hu
An antibacterial and biodegradable composite hydrogel dressing integrated with microspheres is developed for drug delivery and wound healing. The mechanism of gelation is attributed to the Schiff-base reaction between aldehyde and amino groups of oxidized alginate (OAlg) and carboxymethyl chitosan (CMCS). To enhance antibacterial and mechanical properties, tetracycline hydrochloride (TH) loaded gelatin microspheres (GMs) were fabricated by an emulsion cross-linking method, followed by integrating into the OAlg-CMCS hydrogel to produce a composite gel dressing. In vitro gelation time, swelling, degradation, compressive modulus and rheological properties of the gel dressing were investigated as the function of microsphere ratios. With increasing ratios of microspheres from 10 to 40 mg/mL, the composite dressing manifested shorter gelation time and lower swelling ratios, as well as higher mechanical strength. Comparing to other formulations, the gel dressing with 30 mg/mL microspheres showed more suitable stabilities and mechanical properties for wound healing. Also, in vitro drug release results showed that the loaded TH could be sustained release from the composite gel dressing by contrast with pure hydrogels and microspheres. Furthermore, powerful bacteria growth inhibition effects against Escherichia coli and Staphylococcus aureus suggested that the composite gel dressing, especially the one with 30 mg/mL GMs containing TH, has a promising future in treatment of bacterial infection.
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KEY ENGINEERING MATERIALS
·
2020
·
IF 0
Ming Chun Li,Mei Hua Xin
In this study, a new type of surfactant, N, N-dialkyl-3, 6-O-sulfopropyl chitosan (SPDACS) was prepared with two kinds of chitosan (Mw 10 and 50 kDa) and three kinds of alkyl groups (octyl, decyl and lauryl) respectively. The substitution degree of alkyl chain was around 1.50, and the substitution degree of sulfopropyl was around 1.70. The relationship of structure and surfactivity of chitosan-based surfactants were studied with six different structures of SPDACS.The results showed that the length of alkyl side chain and the molecular weight of chitosan main chain of SPDACS had distinct effect on the surface tension (γ) and the critical micelle concentration (CMC). CMC and γ could be reduced as the length of alkyl and the molecular weight of chitosan increased. For the products with 50 kDa of chitosan, the CMC decreased from 0.014 to 0.006 mg/mL, and γ down to 23.59 from 28.76 mN/m as the length of alkyl increased from 8C to 12C. The similar patterns happened for the products with 10 kDa of chitosan. The mean size of the blank micelles decreased with the growth of the length of alkyl, and the molecular weight of chitosan had little effect on the particle size. The zeta potential of all micelles were above -35mV which meant the micelles had good stability in the solution.The product of 5-SPDLCS (50 kDa, lauryl) with the best surfactivity were selected for the study of PTX solubilization. The optimal ratio of 5-SPDLCS/PTX was determined to be 1/1.1. The results showed the encapsulation effificiency (EE) and loading effificiency (LE) were 92.2 % and 50.36 % respectively. The solubility of PTX in water reached to 6.08 mg/mL. The solubility of PTX was 60,000 times higher than that of PTX (< 0.0001mg/mL) in pure water.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Haishan Wu,Jingbo He,Haoran Cheng,Liu Yang,Hyun Jin Park,Jinglei Li
Chitosan-based nanoparticles (CNPs) are widely used in drug delivery, cosmetics formulation and food applications. To accelerate the manufacturing of CNPs, the present study develops a workflow to prepare CNPs in a continuous model. Based on machine learning, the workflow precisely predicts size and polymer dispersity index (PDI) value of CNPs, which impacts on the colloidal stability and applications. Multi-inlet vortex mixer (MIVM) device was fabricated by 3D printing as the reactor. Peristaltic pump was applied to deliver the reaction streams into the MIVM device and produce CNPs by flash nanoprecipitation (FNP) in a continuous way. The developed MIVM device produces CNPs in a controlled manner at a higher output which is promising for upscale applications. Twelve machine learning algorithms were employed to investigate the potential relationship between the reaction independent variables and hydrodynamic characteristics of CNPs. Random Forest, Decision Tree, Extra Tree and Bagging algorithms performed better than other algorithms with the average prediction accuracy around 90 %. The current study demonstrated that supervised machine learning guided FNP using the developed MIVM device is an effective strategy for accurate and intelligent production of CNPs and other similar nanoparticles.
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JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2020
·Vol. 20
·期 3
·1660-1669
·
IF 1.134
Deng Yu-Ying,Xiao Xin-Feng,Wang Dan,Han Bo,Gao Yu,Xue Jian-Liang
Cu-BTC was synthesised by hydrothermal method in this study to adsorb and remove the toxic heavy metal hexavalent chromium Cr(VI) in water. The EDTA-chitosan/Cu-BTC was prepared by the surface modification of Cu-BTC with EDTA-modified chitosan. The initial concentration effects of adsorbed
chromium solution, adsorbent dosage, adsorption time, adsorption temperature and pH of chromium solution on adsorption capacity were estimated using the single-factor optimisation experiment. Results show that the adsorption capacity of the modified composite was higher than that of Cu-BTC.
Cu-BTC and EDTA-chitosan/Cu-BTC exhibited significant adsorption of Cr(VI) under acidic conditions in water and basically independent of temperature. Their adsorption processes conformed with the pseudo-second-order model. The Langmuir adsorption isotherm model obtained the adsorption isotherm,
which indicated that the adsorption process was single molecule adsorption. Isotherm fitting obtained the maximum adsorption amounts of Cr(VI) for Cu-BTC and EDTA-chitosan/Cu-BTC at 27.32 and 46.51 mg·g-1, respectively. Factor and principal component analyses show that the
main factors affecting the adsorption of Cr(VI) in the EDTA-chitosan/Cu-BTC composites are pH, initial concentration and adsorption time. Therefore, EDTA-chitosan-modified Cu-BTC was a more feasible metal-organic framework material than Cu-BTC because of better adsorption performance, which
can be used for adsorption removal of Cr(VI) in water.
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POLYMER SCIENCE SERIES A
·
2021
·Vol. 63
·期 6
·757-768
·
IF 1.206
Huang Qiao,Yu Haojie,Wang Li,Shen Di,Chen Xiang,Wang Nan
Abstract The glucose-responsive insulin release system was proved to be an effective way to deliver insulin. Here, dendritic mesoporous silica and phenylboronic acid were used to prepare a simple insulin delivery system, and its glucose-responsive properties were studied. Briefly, dendritic mesoporous silica was prepared by the biphase stratification approach. 3-Fluoro-4-carboxyphenylboronic acid was grafted on the hydroxypropyl chitosan to obtain phenylboronic acid-modified hydroxypropyl chitosan. In a weakly acidic environment, insulin was loaded on the dendritic mesoporous silica. The loading capacity and encapsulation efficiency could reach 32.1 and 94.6%, respectively. After that, modified hydroxypropyl chitosan was coated on the insulin-loaded dendritic mesoporous silica to obtain an insulin release system. Then sodium alginate was coated on insulin release system followed by calcium ion crosslinking to obtain another insulin release system. The results demonstrated that both systems had excellent performance in sustained insulin release. Glucose-responsive behavior was observed in the case of the former insulin release system.
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JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2015
·Vol. 15
·期 6
·4245-4254
·
IF 1.556
Li Yan,Xu Cong,Qiu Tianbao,Xu Xiaoyan
The Cd(II) ion imprinting electro-spun crosslinked chitosan nanofiber mats were successfully prepared using Cd(II) as template ions and glutaraldehyde (GA) as crosslinker to investigate the adsorption of Cd(II) and Pb(II) ions in aqueous solutions. The Cd(II) ion imprinting electro-spun
crosslinked chitosan nanofiber mats were characterized by the Fourier Transform Infrared Spectrometer (FTIR), Scanning Electron Microscope (SEM), Thermal Gravimetric Analysis (TGA), elemental analysis and solubility tests. The prepared chitosan nanofiber mats exhibited a higher adsorption
capacity for both Cd(II) (364.3 mg/g) and Pb(II) (272.0 mg/g) ions. The dynamic study demonstrated that the adsorption process followed the second-order kinetic equation. Langmuir and Freundlich adsorption models were used to analyze the equilibrium isotherm data. The results showed that the
Langmuir model was best suitable for predicting the adsorption isotherm of the studied system. The as prepared Cd(II) ion imprinting electro-spun crosslinked chitosan nanofiber mats might be used as an effective adsorbent for Cd(II) and Pb(II) removal from heavy metal wastewater.
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JOURNAL OF BIOMATERIALS APPLICATIONS
·
2017
·
IF 2.31
Mazhar Ali Raja,Muhammad Arif,Chao Feng,Shah Zeenat,Chen-Guang Liu
A novel pH-responsive polymer based on amphiphilic N-acetyl histidine and arginine-grafted chitosan was synthesized using N-acetyl histidine as hydrophobic segment and arginine as hydrophilic segment by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide-mediated coupling reactions as anticancer drug delivery system for doxorubicin. The structure of the synthesized polymer was confirmed by Fourier transform infrared and 1H nuclear magnetic resonance analysis. Due to self-association behavior, N-acetyl histidine and arginine-grafted chitosan structured nanoparticles with in size range of 204 nm. N-acetyl histidine and arginine-grafted chitosan with different substitution degree of N-acetyl histidine were initially prepared and characterized. The critical micelle concentration decreased with increasing substitution degree of N-acetyl histidine. Furthermore, N-acetyl histidine and arginine-grafted chitosan nanoparticles exhibited an acidic pH-triggered aggregation and disassembling nature. The doxorubicin-encapsulated nanoparticles based on synthesized conjugate (N-acetyl histidine and arginine-grafted chitosan/doxorubicin nanoparticles) showed a sustained drug release pattern, which could be hastened under acidic pH conditions but delayed with increasing substitution degree of N-acetyl histidine. Anticancer effects demonstrated that N-acetyl histidine and arginine-grafted chitosan/doxorubicin nanoparticles could suppress both sensitive and resistant human breast tumor cell line (MCF-7) efficiently in a dose- and time-dependent pattern. Confocal microscopy results evidenced increased cellular uptake and enhanced retention of the synthesized nanoparticles in drug-resistant cells demonstrating better efficacy of nanoparticles over native doxorubicin. These results suggest that N-acetyl histidine and arginine-grafted chitosan/doxorubicin nanoparticles might be promising carriers for delivery of hydrophobic drug doxorubicin against drug-resistant tumors.
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JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2019
·Vol. 19
·期 12
·7993-8003
·
IF 1.093
Liu Shan-Shan,Ge He-Yi,Cheng Shi-Lin,Zou Yu,Zhang Kai-Li,Chu Cai-Xia,Gu Nian-Liang
In this work, a novel magnetic biomass adsorbent was synthesized by a simple method. The adsorbent prepared from chitosan, graphene oxide and CoFe2O4 with a ‘skin-like’ morphology had a strong adsorption capacity for methylene blue adsorption and was
easily separated from the liquid. The synthesized samples were characterized by scanning electron microscope, energy dispersive spectroscopy, fourier transform infrared spectroscopy and X-ray diffractomer. The adsorption capacity of the adsorbent was evaluated. The various factors affecting
the adsorption performance were explored. Meanwhile, the adsorption process was simulated by five kinetic models and four isotherm models. The adsorption process was well described by the Pseudo-second-order kinetic model and the Freundlich isotherm model. ΔG < 0, ΔH
< 0 and ΔS < 0 indicate that the adsorption process was a spontaneous, exothermic and randomness decrease process. The adsorbents loaded with methylene blue could be desorbed by soaking in dilute hydrochloric acid. The adsorption–desorption cycle experimental results
showed that the adsorbent had good reusability performance.
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POLYMER SCIENCE SERIES B
·
2020
·Vol. 62
·期 3
·196-205
·
IF 0.976
Jinyu Sun,Yuan Yizhong,Tian Xiaohui
Abstract A new type of cross-linked copolymer granule was synthesized via emulsion polymerization and was characterized by FTIR spectroscopy. The O -carboxymethyl-chitosan was used as emulsifier for the copolymerization of methyl methacrylate and diacetone acrylamide. The resulting copolymer latex showed good compatibility with natural rubber. Morphology and surface roughness of modified natural rubber were measured by SEM and AFM. The tensile strength of natural rubber film reaches the maximum when the amount of additive was about 4%. Glass transition temperature and aging resistance were elevated. Protein spillage dropped in ca. 5 times, which could meet the minimum of the allergy protein.
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PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
·
2023
·
IF 4.7
Xiaomin Zhao,Yunfei Zhang,Li Chen,Zhiqing Ma,Bin Zhang
The practical application of essential oils (EOs) as an alternative for synthetic pesticides in agricultural production is severely limited because of their instability, high volatility, and water insolubility. Nanoencapsulation of EOs is an important strategy to overcome these limitations. In view of this, this study aimed to develop chitosan-thymol nanoparticle (NCS-Thy) with pH-responsive which can be used as an intelligent botanical fungicide to control Botrytis cinerea . The NCS-Thy nanoparticle was prepared by ionic crosslinking method with the loading capacity and encapsulation efficiency of 29.87% and 41.92%, respectively. The synthesized NCS-Thy nanoparticle was further characterized by Fourier transform infrared spectroscopy analysis, transmission electron microscopy observation, and dynamic lights scattering . The results of release kinetics and antifungal activity of NCS-Thy under different pH conditions were determined. The results showed that the NCS-Thy nanoparticle had excellent pH-responsiveness and can release more thymol under acidic conditions formed by B. cinerea , thereby achieving higher antifungal effects. Therefore, compared with unencapsulated thymol, the NCS-Thy nanoparticle had higher antifungal activity against B. cinerea in vitro . In addition, both the protective and curative efficacies of detached leaf test and pot experiment were significantly higher than those of unencapsulated thymol. Among them, the protective efficacy of NCS-Thy in the pot experiment was 78.73%, which was significantly higher than that of unencapsulated thymol with 61.13%. Therefore, the pH-responsive chitosan-thymol nano-preparation had a promising prospect of application in practical management of gray mold as an intelligent botanical fungicide.
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