PHARMAZIE
·
2018
·Vol. 73
·期 10
·594-597
·
IF 1.016
Wu Bo,Chen Xi,Zhou Ying,Hu Pingjun,Wu Dan,Zheng Guodong,Cai Yi
Background: Andrographolide (Andro) belongs to the main bioactive ingredients of Andrographis paniculata. Many studies have shown that andro has a variety of pharmacological activities such as anti-inflammatory, anti-bacterial, anti-virus, anti-oxidant, immune regulation
and liver protective effects. Moreover andro has been reported to have anticancer activity in multiple types of cancer, including gastric cancer, breast cancer, lung cancer and so on. However, there is no report about the effect of andro on the human NPC cell line C666-1 and the molecular
mechanisms of andro-mediated apoptosis in C666-1 cells remain to be clarified. Methods: Cell proliferation was measured by a CCK8 assay, cell apoptosis rate was evaluated by flow cytometric analysis, and the protein expression of LKB1/AMPK signaling pathways was detected by Western
blotting. Results: Treatment with andro inhibited cell proliferation and induced apoptosis of C666-1 cells. Moreover, andro could activate LKB1-AMPK signaling. We also demonstrated that Ca2+/calmodulin-dependent protein kinase kinaseβ (CaMKKβ) was not involved in
the regulation of andro on AMPK activation in C666-1 Cells. Conclusions: Andro suppressed proliferation and induced apoptosis of C666-1 cells through regulating the LKB1/AMPK/mTOR signal pathway.
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Oxidative Medicine and Cellular Longevity
·
2018
·
IF 4.936
Xinnong Liu,Qingtian Zhu,Min Zhang,Tao Yin,Rong Xu,Weiming Xiao,Jian Wu,Bin Deng,Xuefeng Gao,Weijuan Gong,Guotao Lu,Yanbing Ding
Oxidative stress plays a crucial role in the pathogenesis of acute pancreatitis (AP). Isoliquiritigenin (ISL) is a flavonoid monomer with confirmed antioxidant activity. However, the specific effects of ISL on AP have not been determined. In this study, we aimed to investigate the protective effect of ISL on AP using two mouse models. In the caerulein-induced mild acute pancreatitis (MAP) model, dynamic changes in oxidative stress injury of the pancreatic tissue were observed after AP onset. We found that ISL administration reduced serum amylase and lipase levels and alleviated the histopathological manifestations of pancreatic tissue in a dose-dependent manner. Meanwhile, ISL decreased the oxidative stress injury and increased the protein expression of the Nrf2/HO-1 pathway. In addition, after administering a Nrf2 inhibitor (ML385) or HO-1 inhibitor (zinc protoporphyrin) to block the Nrf2/HO-1 pathway, we failed to observe the protective effects of ISL on AP in mice. Furthermore, we found that ISL mitigated the severity of pancreatic tissue injury and pancreatitis-associated lung injury in a severe acute pancreatitis model induced by L-arginine. Taken together, our data for the first time confirmed the protective effects of ISL on AP in mice via inhibition of oxidative stress and modulation of the Nrf2/HO-1 pathway.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2018
·Vol. 25
·期 27
·27274-27282
·
IF 2.8
Luo Jingyang,Zhang Qin,Wu Lijuan,Cao Jiashun,Feng Qian,Fang Fang,Chen Yinguang
1,4-Dioxane is an emerging pollutant, which widely exists in natural environments and poses potential risks to the living organisms. However, its effect on the denitrification process is still unknown. In this study, the effects of 1,4-dioxane on the denitrification process were therefore investigated by using Paracoccus denitrificans as the model denitrifier. The obtained results showed that the exposure of 1,4-dioxane exhibited remarkable lag or inhibition on the denitrification process, especially with high dose. In the control without 1,4-dioxane exposure, Paracoccus denitrificans showed high denitrification efficiency (98.5%). However, the efficiency decreased to 78.5, 63.9, and 9.3% with 0.50, 0.75, and 1.0% ( v / v ) 1,4-dioxane dose, respectively. The dose-induced inhibition of denitrification by 1,4-dioxane could be partially attributed to the negative effects on proliferation and viability of functional microorganisms by conjugating and disrupting the cell membranes. Furthermore, 1,4-dioxane caused biotoxicity to the intracellular activities of denitrifiers via disturbing carbon source utilization and interfering the key enzymes responsible for glycolysis. The decrease of microbial viability and activity inevitably resulted in the decline of key enzymes (NAR, NIR, NOR, and N 2 OR) closely related with denitrification process, which could be the direct reason for the decrease of denitrification performance.
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CHEMOSPHERE
·
2018
·
IF 4.427
Haiyang Zhang,Peiyan Wang,Hongyan Yu,Kaiyuan Yu,Zheng Cao,Feibo Xu,Xu Yang,Miao Song,Yanfei Li
Aluminum (Al) is a recognized environmental pollutant that causes neuroinflammatory lesions, leading to neurodegenerative diseases. Interleukin-1 (IL-1) signaling pathway is responsible for regulating inflammatory lesions. However, it remains unclear whether IL-1 signaling pathway is involved in neuroinflammatory lesions induced by Al exposure. In the present study, one hundred and twenty Wistar rats were orally exposed to 0, 50, 150 and 450 mg/kg BW/d aluminum trichloride (AlCl 3 ) for 90 days, respectively. We found that AlCl 3 exposure increased hippocampal Al concentration, reduced hippocampus coefficient, impaired cognitive ability, deteriorated microstructure of hippocampal CA1 and CA3 regions, increased reactive oxygen species (ROS) level, activated astrocytes and microglia, increased pro-inflammatory cytokines contents and mRNA expressions, and decreased anti-inflammatory cytokines contents and mRNA expressions in the hippocampus. These results indicated that AlCl 3 induced the hippocampal inflammatory lesion (HIL). Moreover, AlCl 3 exposure increased the mRNA and protein expression of IL-1 signaling pathway core components in the hippocampus, demonstrating that AlCl 3 activated IL-1 signaling pathway. Furthermore, the correlation between interleukin-1β (IL-1β) content and HIL and activation of the IL-1 signaling pathway was analyzed. Results showed that IL-1β content was positively correlated with pro-inflammatory cytokines contents and mRNA expressions and activation of IL-1 signaling pathway, and was negatively correlated with hippocampus coefficient, anti-inflammatory cytokines contents and mRNA expressions, and the number of hippocampal neurons. The above results demonstrate that AlCl 3 -induced HIL is associated with IL-1 signaling pathway, in which IL-1β is a link.
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CHEMICAL ENGINEERING JOURNAL
·
2015
·
IF 4.321
Ziwei Zhang,Fang Wang,Weiben Yang,Zhen Yang,Aimin Li
In this study, a novel macroporous amination resin (named as GMDA) with the matrix of divinylbenzene and glycidyl methacrylate was synthesized and utilized to remove 8-amino-1-naphthol-3,6-disulfonic acid (H-acid) from water. The adsorption behaviors of the synthetic resin were studied systematically and compared with three commercial resins (the hypercrosslinked resin NDA-88, the anion-exchange resin D-301, and the macroporous resin XAD-4) in terms of adsorption capacity, equilibrium time, isotherm adsorption , the effect of existing inorganic ions and regeneration properties. The characteristic methods of BET surface area, pore size distribution, SEM , FTIR , XPS and Zeta potential were investigated to analyze the resins and adsorption process . The GMDA resin has wider pore diameter than the NDA-88 resin to attract H-acid more quickly with higher adsorption amounts; the larger BET surface area of the GMDA resin ensures more binding sites than the D-301 resin in the adsorption process; the functional groups on the surface of the GMDA resin is more effective than the hydrophobic matrix of the resin XAD-4 in the removal of H-acid. Especially, the regeneration and dynamic experiments indicate the anti-fouling performance of GMDA resin is much better than the others. This research not only provides guidance for understanding the adsorption mechanism of H-acid onto the four resins, but also gives theoretical basis for the design of resin structure according to the targeted contaminants.
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RSC Advances
·
2015
·Vol. 5
·期 30
·23981-23989
·
IF 3.84
Wei Xu,Chao Lin,Huan Liu,Hongbo Yu,Kai Tao,Shenghu Zhou
Tungsten substituted mesoporous FDU-12 (W-FDU-12) catalysts were synthesized by a one-pot hydrothermal process using F127 as the structure directing agent. The studies of TEM, SAXS and BET illustrated that the highly ordered mesoporous structure of FDU-12 was maintained in the doped W-FDU-12 samples. XPS studies revealed that a high concentration of W5+ species appeared in doped W-FDU-12 catalysts whereas supported WO3/FDU-12 and WO3/SiO2 catalysts only contained W6+ species. Tandem catalytic conversion of 1-butene and ethene to propene through isomerization of 1-butene to 2-butene and consecutive cross metathesis of 2-butene and ethene in a fixed-bed reactor at different temperatures and atmospheric pressure was used to evaluate the catalytic performance of the W-FDU-12 catalyst, combined with MgO. The catalytic results showed that the doped W-FDU-12 illustrated a superior catalytic performance relative to the supported WO3/FDU-12 and WO3/SiO2 catalysts. The higher metathesis activity of W-FDU-12 catalysts can be ascribed to the good dispersion of W species and the incorporation of W species into the framework of FDU-12, forming a substantial amount of W5+, which was beneficial for the cross metathesis of 2-butene and ethene to propene.
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Soft Matter
·
2015
·Vol. 11
·期 23
·4717-4722
·
IF 4.029
Tianxiang Yin,Jiequn Wu,Shuzhen Wang,Weiguo Shen
The aggregation behaviors of surface active ionic liquid 1-butyl-3-methylimidazolium bis(2-ethylhexyl) sulfosuccinate in aqueous solutions were investigated by conductometry, densimetry, fluorimetry, 1H nuclear magnetic resonance (1H NMR) spectroscopy, dynamic light scattering (DLS), and transmission electron microscopy (TEM), which confirmed two distinguished critical concentrations. The first critical concentration was believed to be the critical aggregation concentration (CAC), where two different types of aggregates were formed, namely, micelles with the size of 10 nm and vesicles with the size of 100 nm. The second critical concentration at two-fold CAC was suggested to be resulting from the insertion of the imidazolium cations into aggregates.
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JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
·
2015
·Vol. 122
·期 1
·349-358
·
IF 2.042
Yu Guo-Min,Wang Li-Sheng,Sun Jian,Shao Xian-Zhao
A phosphorous flame retardant of phosphoric acid, P, P′-1, 4-phenylene P, P, P′, P′-tetraphenyl ester (PAPTE) was synthesized by diphenyl chlorophosphate and hydroquinone. The structural features of PAPTE were investigated with mass spectrometry, infrared spectroscopy, X-ray powder diffraction and nuclear magnetic resonance methods. The thermal behavior of PAPTE was carried out with thermogravimetric (TG) analysis instruments. The kinetic parameters, including the activation energy and pre-exponential factor of the decomposition process for the title compound, were calculated through the Friedman method, the Kissinger–Akahira–Sunose method and the Flynn–Wall–Ozawa method, while the thermal decomposition mechanism was also studied with the invariant kinetic parameters (IKP) method based on a set of TG data obtained at different heating rates. It was shown that the activation energies calculated for the decomposition reaction by different methods were found to be consistent with the conversion functions calculated by means of the IKP method which depend on a set of kinetic methods.
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JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
·
2014
·Vol. 53
·期 6
·737-744
·
IF 3.245
Ying-Ying Zhang,Ren-Jian Wei,Xing-Hong Zhang,Bin-Yang Du,Zhi-Qiang Fan
The alternating copolymerization of CO 2 with the terminated epoxides anchoring long alkyl groups is rarely reported because of their low reactivity and polycarbonate selectivity. This work describes a well-controlled solvent-free copolymerization of CO 2 with 1, 2-epoxydodecane (EDD) with a long electron-donating alkyl group via the catalysis of Zn-Co(III) double metal cyanide complex catalyst. The productivity of the catalyst was up to 2406 g polymer/g Zn, that is, EDD conversion was 99.2%. The alternating degree of CO 2 -EDD copolymers were more than 99% and had high number-average molecular weights ( M n s) of >100 kg mol −1 , while only 1.0 wt % 4-decyl-1,3-dioxolan-2-one (DC) were detected. Moreover, by introducing styrene oxide (SO) with electron-withdrawing phenyl group into EDD-CO 2 copolymerization system, a new random terpolymer with either electron-withdrawing or electron-donating side groups was produced with single glass transition temperatures ( T g s) in a wide range from 3 to 56 °C, which might be potentially used as biodegradable elastomers or plastics. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015 , 53 , 737–744
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BIOORGANIC & MEDICINAL CHEMISTRY
·
2013
·
IF 2.903
Xiu Liu,Ling Zhang,Jin-Guo Tan,Han-Hong Xu
Based on the discovery of thymine as an ecdysteroid agonist, a series of 1,4-disubstituted diacylhydrazine derivatives with a thymine moiety were designed and synthesized. The activities of these compounds against Spodoptera litura (Fabricius) were evaluated by the insect immersion method. Results showed that compound 2h with an N -cyclohexylmethyl substituent exhibits the most potent agonist activity with a median lethal concentration of 23.21 μg/mL. This compound also caused malformation of molting larvae and adults. Compound 2h was further demonstrated as an ecdysteroid agonist by reporter gene assay on the Spodoptera frugiperda cell line (Sf9 cells). A molecular docking study indicated that hydrophobic interactions and the formation of hydrogen bonds between the compounds and the ecdysone receptor play critical roles in promoting the binding affinity of the compound. The structure of compound 2h may serve as a favorable template for the development of new ecdysteroid agonists with a pyrimidinedione moiety.
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Journal of Nanomaterials
·
2014
·
IF 1.611
Shifeng Li,Yanming Shen,Min Xiao,Dongbin Liu,Lihui Fan,Zhigang Zhang
Controlled release formulations have been shown to have potential in overcoming the drawbacks of conventional plant growth regulators formulations. A controlled-release formulation of 1-naphthylacetic acid (NAA) and indole-3-butyric acid (IBA) simultaneous intercalated MgAl-layered double hydroxides (LDHs) was prepared. The synthetic nanohybrid material was characterized by various techniques, and release kinetics was studied. NAA and IBA anions located in the gallery of MgAl-LDHs with bilayer arrangement, and the nanohybrids particles were of typical plate-like shape with the lateral size of 50–100 nm. The results revealed that NAA and IBA have been intercalated into the interlayer spaces of MgAl-LDHs. The release of NAA and IBA fits pseudo-second-order model and is dependent on temperature, pH value, and release medium. The nanohybrids of NAA and IBA simultaneously intercalated in LDHs possessed good controlled release properties.
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HIGH PERFORMANCE POLYMERS
·
2017
·
IF 1.179
Gongyi Liu,Zijun Xia,Shanshan Jin,Xiaoxia Guo,Jianhua Fang
A series of novel cross-linked blend membranes have been successfully prepared from poly(2,2′-(p-oxydiphenylene)-5,5′-bibenzimidazole) (OPBI) and partially quaternized poly(1-vinylimidazole) (QPVI) at varied polymer weight ratios using 1,6-dibromohexane as the cross-linker. The resulting cross-linked blend membranes are ductile and transparent. Cross-linking causes slight increase in tensile strength and significant improvement in immobilization of the QPVI. The effect of the QPVI content on membrane properties such as mechanical properties, thermal stability, ion exchange capacity, water uptake, swelling ratio, and anion conductivity is investigated. The charge–discharge performance of the single cells assembled with the cross-linked blend membranes has also studied and compared with that of the one assembled with Nafion 117. The cross-linked blend membranes exhibit three to four orders lower VO2+ permeability than Nafion 117 leading to much slower self-discharge rate and significantly higher coulombic efficiency of the former. The single cells assembled with the cross-linked blend membranes show higher coulombic efficiency and energy efficiency at low current densities than the one assembled with Nafion 117. Furthermore, the single cell assembled with the cross-linked blend membrane OPBI/QPVI(3:7, weight ratio)-Cross-linked (CL) shows little decay in energy efficiency after 300 charge–discharge cycles test at 80 mA cm−2 indicating good durability of this membrane.
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