JOURNAL OF POLYMERS AND THE ENVIRONMENT
·
2022
·Vol. 30
·期 11
·4863-4876
·
IF 4.705
Fan Yajun,Shen Dianling,Yan Yu,Hu Xiaopeng,Guo Yaping,Zhong Yujun,Li Zhiyang,Xie Lianwu
To achieve efficient adsorption and recycling of Cu 2+ in wastewater, using Cu 2+ as template ion, glutaraldehyde as crosslinker, three sodium alginate hydrogel beads including SA, SAC, and SAB beads were prepared by imprinting sol–gel method using sodium alginate (SA) with carboxymethyl cellulose (CMC) and β -cyclodextrin ( β -CD) as different precursors, respectively. Scanning electron microscopy and Fourier transform infrared spectroscopy were used to characterize and analyze morphology and composition change of the hydrogel beads, respectively. When the mass ratio of SA to CMC or SA to β -CD reach 1:1, the SAC beads or SAB beads are nearly homogeneous sphere. Then the effects of pH, adsorption time, initial concentration of Cu 2+ , adsorbent dosage, and coexisting ions on the adsorption efficiency of three hydrogel beads were investigated. The results indicated that adding carboxymethyl cellulose and β -cyclodextrin into skeleton of beads increased the toughness of the beads and improved the adsorption capacity of Cu 2+ . Compared to the saturated adsorption capacity 510 mg/g of Cu 2+ on SA, the saturated adsorption capacity of Cu 2+ on SAB and SAC reached 817 mg/g and 822 mg/g, respectively. And their adsorption efficiency for Cu 2+ are over 95% at 25 °C with pH of 7, contact time within 350 min, adsorbent dosage of 4 mg/50 mL, and initial concentration of 5 mg/L. Thus, SAC and SAB beads could be used as adsorption material for detecting and removing Cu 2+ from wastewater.
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Theranostics
·
2019
·
IF 8.063
Xu-Qi Kang,Gao-Feng Shu,Sai-Ping Jiang,Xiao-Lin Xu,Jing Qi,Fei-Yang Jin,Di Liu,Yong-Hong Xiao,Xiao-Yang Lu,Yong-Zhong Du
The prevalence of antibiotic resistance and lack of alternative drugs have posed an increasing threat to public health. Here, we prepared β-Ga 2 O 3 :Cr 3+ nanoparticles modified with ICAM1-antibody-conjugated TPGS (I-TPGS/Ga 2 O 3 ) as a novel antibiotic carrier for the treatment of drug-resistant infections. Methods : I-TPGS/Ga 2 O 3 were firstly characterized by measuring particle size, morphology, crystal structure, drug loading capacity, and in vitro drug release behaviors. The in vitro antibacterial activities of I-TPGS/Ga 2 O 3 /TIG were evaluated using standard and drug-resistant bacteria. The internalization of I-TPGS/Ga 2 O 3 was observed by fluorescence confocal imaging, and the expression levels of the efflux pump genes of TRKP were analyzed by real-time RT-PCR. In vitro cellular uptake and in vivo biodistribution study were performed to investigate the targeting specificity of I-TPGS/Ga 2 O 3 using HUEVC and acute pneumonia mice, respectively. The in vivo anti-infective efficacy and biosafety of I-TPGS/Ga 2 O 3 /TIG were finally evaluated using acute pneumonia mice. Results : It was found that TPGS could down-regulate the over-expression of the efflux pump genes, thus decreasing the efflux pump activity of bacteria. I-TPGS/Ga 2 O 3 with small particle size and uniform distribution facilitated their internalization in bacteria, and the TPGS modification resulted in a significant reduction in the efflux of loaded antibiotics. These properties rendered the encapsulated tigecycline to exert a stronger antibacterial activity both in vitro and in vivo . Additionally, targeted delivery of I-TPGS/Ga 2 O 3 mediated by ICAM1 antibodies contributed to a safe and effective therapy. Conclusion : It is of great value to apply I-TPGS/Ga 2 O 3 as a novel and effective antibiotic delivery system for the treatment of drug-resistant infections.
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高影响因子
PHYTOMEDICINE
·
2025
·
IF 8.3
Rui Hao,Tian Li,Beibei Zhou,Jiaxin Shao,Weibo Zhao,Beibei Jiao,Xia Sun,Jian Zhang
Background : Bushen Huoxue Formula (BSHXF), a traditional Chinese medicine, effectively treats premature ovarian insufficiency (POI) by modulating of lipid metabolism. Purpose : This study aimed to investigate the underlying mechanism through which BSHXF improves POI by regulating lipid metabolism. Methods Network pharmacology identified potential pathways associated with BSHXF in POI. A POI rat model was induced using subcutaneous corticosterone injections and treated with BSHXF to assess its efficacy. The impact of BSHXF on lipid metabolism, autophagy, and the LRP6/β-catenin signaling pathway was evaluated in these rats. Additionally, palmitic acid (PA)-induced granulosa cells (KGN cells) were used in vitro . A LRP6 inhibitor (Salinomycin sodium salt, Sal) was applied to these cells, followed by a series of molecular biology experiments to elucidate the specific regulatory role of BSHXF on lipid metabolism. Results : Network pharmacology analysis indicated that the Wnt/β-catenin signaling pathway is a potential target of BSHXF in POI. In vivo , BSHXF alleviated POI-like symptoms in rats, reduced lipid accumulation, suppressed excessive autophagy, and activated the LRP6/β-catenin signaling pathway. In vitro , Sal inhibited the ability of BSHXF-containing serum to activate LRP6/β-catenin signaling, reduce lipid accumulation, and counteract excessive autophagy in PA-induced KGN cells. This was accompanied by increased expression of LRP6 and β-catenin, enhanced lipogenesis, elevated lipid droplet formation, decreased lipid catabolism, and oxidation, and enhanced autophagic flux. Cycloheximide chase and Western blot analyses further confirmed that BSHXF stabilizes LRP6 by inhibiting its ubiquitin-proteasomal degradation. Conclusions : BSHXF activates LRP6/β-catenin signaling pathway by inhibiting the ubiquitination degradation of LRP6, thereby improving POI. This study reveals that BSHXF may improve POI by modulating LRP6 stability, thereby affecting lipid metabolism.
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高影响因子
Materials Today Bio
·
2025
·
IF 10.2
Gang Li,Pengqi Zhu,Caifang Gao,Ye Cai,Ru Feng,Jinghua Sun,Ruiping Zhang
Vitiligo is a depigmenting autoimmune disease driven by oxidative stress and immune-mediated melanocyte destruction. Current therapies are limited by poor drug permeability, systemic side effects, and insufficient efficacy. Herein, we developed a novel carbomer-based hydroxypropyl-β-cyclodextrin-encapsulated crisaborole/curcumin hydrogel (Cri/Cur@CD-Gel) for combinational transdermal intervention of vitiligo via dual antioxidant and anti-inflammatory pathways. Hydroxypropyl-β-cyclodextrin (HP-β-CD) inclusion complexation overcame the inherent hydrophobicity of crisaborole (Cri) and curcumin (Cur), significantly enhancing their aqueous solubility, stability, and transdermal permeability. Leveraging its skin-adhesive properties, the carbomer hydrogel matrix enhanced drug retention and enabled sustained release at lesion sites, thereby improving drug bioavailability. In vitro , Cri/Cur@CD, leveraging the solubilizing power of HP-β-CD, restored melanocyte viability under oxidative stress, scavenged ROS, normalized mitochondrial membrane potential, and elevated cAMP levels to enhance melanogenesis and tyrosinase activity. In vivo , Cri/Cur@CD-Gel achieved significant repigmentation in monobenzone-induced vitiligo mice, markedly reducing epidermal ROS, CD8+ T-cell infiltration, and inflammatory cytokines (TNF-α, IL-1β, and IL-6). This study demonstrates that the combination of HP-β-CD-based encapsulation and carbomer hydrogel delivery serves as a potential topical administration platform for co-delivering hydrophobic crisaborole and curcumin, and establishes a promising strategy to alleviate vitiligo, that concurrently addresses oxidative damage, inflammatory responses, and melanocyte regeneration.
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PubMed
高影响因子
Frontiers in Pharmacology
·
2025
·
IF 4.8
Xiaoli Deng,Chunjie Hu,Lin Li,Guixian Yang,Chikun Li,Wanxun Zhang,Guangyu Cheng
Background Lung cancer is a leading cause of cancer-related deaths, with cisplatin being a cornerstone of treatment. However, resistance to cisplatin presents a significant challenge. β-elemene, a natural compound, has demonstrated potential to reverse cisplatin resistance. LncRNA LINC00511 has been implicated in cisplatin resistance through its role in activating the PI3K/AKT/mTOR pathway, which supports tumor survival and proliferation. Purpose This study aims to investigate the mechanism by which β-elemene overcomes cisplatin resistance in lung cancer by regulating LINC00511. Methods Human lung adenocarcinoma cells (A549 and A549/DDP) were treated with β-elemene and cisplatin. Cell proliferation and apoptosis were assessed using CCK-8, EdU staining, and flow cytometry. LINC00511 expression was measured by qRT-PCR, and protein levels of PI3K, AKT, and mTOR were evaluated via Western blot. A xenograft model was used to confirm in vivo effects. Results β-elemene significantly enhanced cisplatin-induced apoptosis in A549/DDP cells, reduced LINC00511 expression, and inhibited the PI3K/AKT/mTOR pathway. LINC00511 knockdown further potentiated these effects, both in vitro and in vivo . Xenograft models confirmed the enhanced anti-tumor effects of the combination treatment. Conclusion β-elemene overcomes cisplatin resistance in lung cancer by downregulating LINC00511 and inhibiting the PI3K/AKT/mTOR pathway. These findings propose a promising therapeutic strategy for treating cisplatin-resistant lung cancer.
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Applied Food Research
·
2025
·
IF 6.2
Wang-Wei Zhang,Rui-Xi Zhang,Xiu-Xiu Zhang,Zhi-Jing Ni,Kiran Thakur,Jian-Guo Zhang,Zhao-Jun Wei
This study successfully developed a ternary ZCP-PCPP nanocomposite using zein (ZN), chitosan (CS), and the polyphenols extracted from Polygonatum cyrtonema Hua (PCPP) to stabilize Pickering emulsions. The optimal ZN-CS was 2:1, which resulted in the ZCP-PCPP nanocomposite with the strongest encapsulation ability for PCPP, uniform particle size, and strong structural stability. Infrared spectroscopy, fluorescence spectroscopy, and X-ray diffraction confirmed that ZN, CS, and PCPP interacted mainly through hydrogen bonding and hydrophobic forces. Stability analyses demonstrated that ZCP-PCPP markedly enhanced the physical stability and oxidative resistance of the emulsions. Furthermore, ZCP-PCPP nanoparticles at 3–5% (w/v) effectively protected β-carotene against thermal and ultraviolet degradation. These findings highlight that combining natural polymers with bioactive polyphenols provides an efficient strategy for producing stable Pickering emulsions with strong antioxidant protection potential.
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JOURNAL OF ENVIRONMENTAL MANAGEMENT
·
2025
·
IF 8.4
Chenyang Wang,Weichi Liu,Zhen Tian,Lincai Wang,Dongmei Jiang,Qian Liu,Ruyan Li
Enhancing photoinduced charge carrier separation is critical for photocatalysis. This study grafted the primary hydroxyl groups on the primary face of β-Cyclodextrin (β-CD) exhibiting low steric hindrance and high nucleophilicity on the surface of Silver phosphate (Ag 3 PO 4 ) to construct a composite photocatalyst, APCD, with bifunctional channel for electron transfer and pollutant delivery. Theoretical calculations and experimental characterizations revealed that the composite structure facilitates electron redistribution and induced an interfacial electric field. While the hydrophobic cavity of β-CD attracted interfacial electrons, promoting cyclic electron transport and enhancing charge carrier separation efficiency. Furthermore, the hydroxyl-rich outer surface of β-CD endowed APCD with high hydrophilicity, while its hydrophobic cavity selectively recognized organic pollutants via a host-guest interaction mechanism, accelerating pollutant enrichment. APCD-3 achieved 99.36 % degradation of Rhodamine B (RhB) within 40 min, exhibiting a reaction kinetics rate 11.86 times higher than that of pure Ag 3 PO 4 , along with excellent recyclability. Based on band structure and photocatalytic mechanism analyses, APCD-3 was confirmed to universally degrade dyes, antibiotics, and produce H 2 O 2 . In this study, a novel material with bifunctional channel for electron transfer and pollutant transport was ingeniously constructed via utilize the unique structure of β-CD, which provides a new approach for the development of composite photocatalysts with high carrier separation efficiency.
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JOURNAL OF FOOD COMPOSITION AND ANALYSIS
·
2021
·
IF 4.556
Yingying Han,Jinhua Du,Zhaolin Song
In this study, twenty-three commercial yeasts were inoculated into hawthorn ( Crataegus pinnatifida , Bunge (Rosaceae)) extracted juice to explore their fermentation characteristics, β-glucosidase activity, ethyl carbamate production, volatile compounds of resulted wines, along with the relationship of β-glucosidase activity on ethyl carbamate and volatile compounds. β-Glucosidases were yeast and culture medium dependence. However, their activities in wines were merely 9.50 %–30.7 % of that in YM (yeast extract, malt extract) medium. Ethyl carbamate, which was also yeast dependence, was correlated with β-glucosidase (0.426*) whereas less affected by physicochemical indices of hawthron wines. Volatile compounds were not correlated with β-glucosidase activity whereas related to the physicochemical indices. α-Terpineol, which was originally existed in the juice, was increased by the fermentation, while (-) linalool oxide, rose oxide, linalool, terpinen-4-ol, citronellol and nerolidol were newly produced during fermentation. FC9 was the most optimal yeast for hawthorn wine making because of its excellent ethanol production, higher β-glucosidase activity, moderate amounts of volatile compounds, best sensory score and lower EC (5.48 μg/L).
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高影响因子
POLYMER
·
2021
·
IF 4.43
Hongchao Yan,Qian Jiang,Jing Wang,Shuang Cao,Yuan Qiu,Hong Wang,Yonggui Liao,Xiaolin Xie
It has been attracted broad interest to construct stimulus responsive supramolecular hydrogels as smart materials over the past few decades; however, the design of multi-stimuli responsive hydrogels remains a formidable challenge. Herein, a multi-stimuli responsive supramolecular hydrogel has been designed on the basis of methoxy-azobenzene-grafted poly (acrylic acid) (PAA-mAzo) and β-CD dimer, which involves the host-guest and electrostatic interactions. Besides the common thermo-responsive behavior, the hydrogel also exhibits reversible sol-gel transition under green and blue light irradiations because of the disassociation and association of host–guest interaction between mAzo and β-CD. In addition, the hydrogel turns into precipitate at low pH due to the decrease of solubility of PAA in aqueous solution. The electrostatic interaction between the negatively charged carboxylic acid groups and hydrated protons at high pH makes the recovery of hydrogel. At last, the release of rhodamine B loaded in the triple-stimuli responsive hydrogel can be accelerated by green light irradiation and low pH, which demonstrates the potential applications in biomedical materials .
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JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
·
2019
·Vol. 95
·期 3
·862-874
·
IF 2.659
Fei Rao,Gangqiang Zhu,Miaomiao Wang,Siyaka Mj Zubairu,Jianhong Peng,Jianzhi Gao,Mirabbos Hojamberdiev
BACKGROUND Photocatalysis is one of the effective ways to solve the problem of water and gas pollution. An excellent photocatalyst should have the following advantages: efficient photocatalytic activity for gas and water pollutants, recyclable and stable characteristics, non-toxic and low-cost. Constructing heterojunctions and introducing oxygen vacancies (OVs) are two effective measures to achieve these targets. RESULTS It is found that the 1.0% Pd/PdO/β-Bi 2 O 3 exhibits the best photocatalytic activity with an efficiency of 97.4% for Bisphenol A (BPA) degradation and 47.6% for nitric oxide (NO) removal within 30 min. The 1.0% Pd/PdO/β-Bi 2 O 3 composite shows 23.3% efficiency in the photodegradation of BPA under 595 nm monochromatic light irradiation, while β-Bi 2 O 3 tends to be invalid. Moreover, the OVs promote the removal of NO without irradiation. CONCLUSION In this work, a novel ternary Pd/PdO/β-Bi 2 O 3 material as high-performance photocatalyst for the BPA degradation and NO removal was synthesized. The presence of OVs promotes the activation of the oxygen molecule, thereby facilitating the photocatalytic process. The p - n junction of PdO/β-Bi 2 O 3 and the Schottky barrier of Pd/β-Bi 2 O 3 significantly limit the recombination of photoinduced electron–hole pairs in the composite. Furthermore, an artifact in the electron spin resonance (ESR) spectrum obtained by spin trapping with 5,5-dimethyl-1-pyrroline N -oxide (DMPO) as adducts confirms that both hydroxyl radical (•OH) and superoxide radical (•O 2 − ) species are involved in the photocatalytic process. The present work offers a new perspective for developing the composite photocatalysts with high efficiency through loading of metal nanoparticles and creating an heterojunction. © 2019 Society of Chemical Industry
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SENSORS AND ACTUATORS B-CHEMICAL
·
2025
·
IF 7.7
Jiahui Li,Yuanyuan Zhang,Zhengshun Wen,Jiangbing Shuai,Xiaofeng Zhang,Jinru Zhou,Aiqian Ye,Linglin Fu
The delayed reporting of milk allergen residue detection results is a significant factor contributing to substantial losses for food production enterprises. Cumbersome operational procedures and high testing costs often lead to the abandonment of tests, resulting in frequent allergic reactions among milk-sensitive populations. Therefore, there is an urgent need for a novel, rapid, and low-cost detection method to mitigate enterprise losses and protect allergic individuals. This study investigates the formation mechanism of convection PCR, driven by Fast Taq polymerase in standard PCR tubes, and develops a fluorescence detection device for convection PCR. Through molecular docking and experimental validation of the trimmed β-LG aptamers, we elucidate their potential multi-site binding mechanism. Utilizing this mechanism, we designed a dual-strand hybridization magnetic bead detection system (dsA-SA-B), employing easily synthesized and amplified aptamer complementary strands as an indicator signal; Signal amplification was achieved within 15 min, while the entire detection process was completed in less than 50 min. This detection method allows for the rational selection of aptamer sequences based on actual testing needs, enabling the detection of hydrolyzed milk powder. The method demonstrated a linear detection range for β-LG from 5 to 100 μg/mL, with a detection limit as low as 0.25 μg/mL, effectively identifying hydrolyzed milk powder. This approach transforms protein detection into nucleic acid detection, and lays a solid foundation for multiplex PCR detection of eight major food allergens, facilitating the widespread detection of milk allergens and ultimately contributing to improved food safety and public health.
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高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Yuechen Zhu,Yuhao Wu,Xinliu Tan,Liu Jiang,Yonghua Xiong
Nanozymes have emerged as promising alternatives to natural enzymes due to their facile synthesis, cost-effectiveness, and exceptional storage stability. However, the catalytic performance—particularly for those derived from metal-organic frameworks (MOFs)—remains suboptimal because of their low substrate affinity. In this study, we developed a β-cyclodextrin-doped iridium-incorporated porphyrin-MOF nanozyme (CD-PCN-224-Ir). The incorporated iridium components serve as highly active catalytic centers, offering robust peroxidase-like activity. Simultaneously, the doped β-cyclodextrin creates localized hydrophobic microenvironments that facilitate the enrichment of hydrophobic substrates such as tetramethylbenzidine. Consequently, the specific activity of CD-PCN-224-Ir (424 U/mg) increases by 2.6-fold compared to its undoped counterpart (161 U/mg). Leveraging the improved catalytic performance, we constructed a CD-PCN-224-Ir nanozyme-based enzyme-linked immunosorbent assay for the ultrasensitive detection of aflatoxin B 1 , achieving a detection limit of 12.6 pg/mL and a half-maximal inhibitory concentration of 60.9 pg/mL. This work not only offers an effective strategy for enhancing MOF nanozyme activity through biomimetic microenvironment modulation but also demonstrates its significant potential in food safety monitoring.
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危险品化学品经营许可证（带存储）