TALANTA
·
2020
·
IF 5.339
Yayan Tong,Qingxiang Zhou,Yi Sun,Xueying Sheng,Boyao Zhou,Jingyi Zhao,Jinghan Guo
Polyamidoamine dendrimer decorated Fe 3 O 4 magnetic nanoparticles was synthesized and grafted with 4-mercaptobenzoic acid (4-MBA). The resulting material was utilized to develop an effective magnetic solid phase extraction method in combination with high performance liquid chromatography for trace determination of polycyclic aromatic hydrocarbons including phenanthrene (PHE), anthracene (ANT), fluoranthene (FLT), pyrene (PYR) and benzo(a)pyrene (BaP). The MNPs@G3.0@4-MBA exhibited to be an efficient extracting medium due to the existence of terminal benzene ring groups, the internal pores, and strong hydrophobic interactions and π-π interactions. The experiments demonstrated that the proposed method possessed excellent linearity in the concentration range of 0.1–300 μg L −1 with correlation coefficients (R) larger than 0.997, and the limits of detection (LODs, S/N = 3) according to the ratio of signal to noise equal to three of PHE, ANT, FLT, PYR and BaP were 0.014 μg L −1 , 0.032 μg L −1 , 0.055 μg L −1 , 0.027 μg L −1 and 0.039 μg L −1 , respectively. The proposed method was applied to real water samples and the spiked recoveries were over the range of 92–99%. The results showed that the method earned good repeatability and high sensitivity, and the as-prepared materials were stable and reusable, which displayed that the proposed method would have a wonderful application prospect.
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高影响因子
CRYSTENGCOMM
·
2020
·Vol. 22
·期 27
·4591-4601
·
IF 3.117
XiuBo Xie,Cui Ni,Hongying Yu,Wei Du,Xueqin Sun,Dongbai Sun
Core@shell-structured Co@C nanoparticles (NPs) were designed in this work. The shell thickness of carbon at 2.0, 3.2, 3.6, 4.0, and 4.7 nm was tuned by changing the weight ratio (Co : glucose = 2 : 1, 1 : 1, 1 : 2, 1 : 4, 1 : 10) of glucose in the reaction process. The influences of the carbon-shell thickness on the electromagnetic parameters and catalytic activity of the nanocrystalline Co were studied. Among the five samples, the Co@C-21 NPs (carbon-shell thickness of 2.0 nm) mixed with paraffin wax (PW) showed the best reflection loss (RL) of −42.5 dB at 16.1 GHz, while the Co@C-11-PW composite (carbon shell thickness of 3.2 nm) exhibited the best absorption bandwidth for RL < −10 dB of 9.6 GHz (8.4–18.0 GHz) with a matching thickness of 2.6 mm. The natural/exchange resonances, interfacial polarization, and uniformly dispersed Co NPs led to a high microwave absorption performance of the Co@C absorber with good impedance matching. Moreover, as a catalyst for the model removal reaction of 4-nitrophenol (4-NP), the Co@C-110 NPs with a shell thickness of 4.7 nm showed the best kinetic rate constant of 0.31 min−1, 4.3 times higher than that of the Co@C-21 NPs. The Co@C NPs are a potential microwave absorber and effective catalyst for the reduction of 4-NP.
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MEDIATORS OF INFLAMMATION
·
2021
·
IF 4.711
Qiang Zheng,Hang Zhao,Dong Jia,Xu Han,Zhenning Liu,Min Zhao
Paraquat (PQ) can cause multiorgan failure including acute kidney injury (AKI). Our prior study showed that Toll-interacting protein (TOLLIP) protected against PQ-induced acute lung injury. However, the role of TOLLIP in PQ-induced AKI remains undefined. This study was aimed at understanding the role and mechanism of TOLLIP in AKI. Six-eight-week-old male Wistar rats were intraperitoneally injected with 25 mg/kg PQ to induce AKI for 24 h in vivo. HK-2 cells were treated with 300 μM PQ for 24 h to induce cellular injury in vitro or 300 μM PQ and 5 μM nuclear factor-κB (NF-κB) inhibitor BAY11-7082 for 24 h. Rats were infected with adenovirus carrying TOLLIP shRNA via tail vein injection and HK-2 cells with adenovirus carrying TOLLIP shRNA or TOLLIP 48 h before PQ exposure. Results showed that TOLLIP and Toll-like receptor 2/4 (TLR2/4) expressions were boosted in the kidney after PQ intoxication. The toxic effect of PQ on the kidney and HK-2 cells was exacerbated by TOLLIP knockdown, as evidenced by aggravated glomerulus and tubule injury, inflammatory infiltration, and cell apoptosis in the kidney and increased loss of cell viability and apoptotic cells in HK-2 cells. TOLLIP knockdown also enhanced PQ-induced NLR family pyrin domain-containing 3 (NLRP3) inflammasome activation in vivo and in vitro and TLR2/4-NF-κB signaling in vitro, reflected by increased contents of proinflammatory cytokines and expressions of NLRP3 inflammasome-related proteins in the kidney and HK-2 cells and expressions of TLR2, TLR4, and nuclear NF-κB p65 in HK-2 cells. However, TOLLIP overexpression inhibited PQ-induced loss of cell viability, cell apoptosis, NLRP3 inflammasome activation, and TLR2/4-NF-κB signaling in vitro. Additionally, BAY11-7082 abolished TOLLIP knockdown-induced NLRP3 inflammasome activation in vitro, indicating that TOLLIP protected against NLRP3 inflammasome activation in PQ-induced AKI through inhibiting TLR2/4-NF-κB signaling. This study highlights the importance of TOLLIP in AKI after PQ intoxication.
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高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2021
·
IF 5.645
Xiang Zhou,Haojie Ye,Xiuhui Gao,Yumei Feng,Wubin Shao,Puying Qi,Zhibing Wu,Liwei Liu,Peiyi Wang,Song Yang
Natural products (NPs) are inexhaustible wellsprings for new agrochemicals discovery. To excavate novel natural products-based antibacterial leads or candidates potentially targeting FtsZ (filamentous temperature-sensitive protein Z) which is widely regarded as a promising antibacterial target for novel drug discovery, herein, a rapid and efficient screening platform was initially established to disclose the potential FtsZ inhibitors from a variety of commercial natural products. Screening results revealed that 4'-demethylepipodophyllotoxin (DMEP) from renewable Dysosma versipellis ( D. versipellis ) species could distinctly decrease the Xoo FtsZ’ GTPase activity and afforded a ponderable bacteriostatic effect (EC 50 = 38.7 mg L -1 ) against Xanthomonas oryzae pv. oryzae ( Xoo ). Further explorations found that DMEP could disorganize the assembly dynamics of Xoo FtsZ, and thereby yielding long and filamentous Xoo cells from the transmission electron microscopic and fluorescence microscopic imaging. Molecular docking study showed that DMEP displayed strong interactions with Asp38 and Arg205 residues of Xoo FtsZ, indicating that a natural potential FtsZ inhibitor was discovered gradually. The following bioassay result against rice bacterial blight in vivo presented good curative activity (50.0% at 200 mg L −1 ) and protective activity (46.8% at 200 mg L −1 ). Given that natural DMEP has many sites for structural modification, therefore, it can concurrently serve as a novel lead compound for exploring highly bioactive FtsZ inhibitors based on the molecular skeleton of DMEP.
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Journal of Materials Chemistry C
·
2019
·Vol. 7
·期 48
·15162-15165
·
IF 6.641
Zhi Fang,Bingping Yang,Chunli Hu,Jianggao Mao
A new nonlinear optical material, Ba11[Al(PO4)4](P2O7)(PO4)3, was rationally synthesized via the hybridization of three types of anionic groups, namely [AlO4]5−, [PO4]3− and [P2O7]4−, via a spontaneous nucleation method. Ba11[Al(PO4)4](P2O7)(PO4)3 was characterized with high thermal stability, deep ultraviolet transparency and moderate second-order optical nonlinearity, which were favourable for practical applications.
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Journal of Materials Chemistry A
·
2019
·Vol. 8
·期 1
·69-76
·
IF 10.733
Xueshi Jiang,Lulu Sun,Wen Wang,Fei Qin,Cong Xie,Lin Hu,Yinhua Zhou
In this study, we report 10 cm2 nonfullerene solar cells with power conversion efficiency of 10.24%. The demonstration of the large-area cells is based on the HxMoO3-assisted growth of two silver electrodes, namely, the ultrathin-transparent electrode (on the top) and opaque electrode (at the bottom). The device structure has the configuration glass/HxMoO3/opaque Ag (70 nm)/active layer/HxMoO3/ultrathin Ag (8 nm)/MoO3. The chemically reactive HxMoO3 could react with silver oxide during the growth of the initial few nanometers of silver, as inferred from X-ray spectroscopy measurements. The reaction increases the nucleus sites that assist the continuous and uniform growth of the silver films. The percolation threshold thickness of conductive ultrathin Ag films on HxMoO3 can be as low as 4 nm. The root-mean-square surface roughness of opaque silver (70 nm) grown on the HxMoO3 surface is as low as 1.06 nm. HxMoO3 facilitates the growth of uniform, continuous and smooth silver films that enable the efficient large-area nonfullerene organic solar cells.
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高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2019
·Vol. 220
·期 9
·1900022
·
IF 2.622
Wenxiu Zhang,Xianhong Zhang,Yuhong Ma,Dong Chen,Wantai Yang
With UV–vis absorption in the range of 270–435 nm, 4-( N , N -diphenylamino)benzaldehyde (DPAB) takes efficient photoreduction quench with 4-cynao-4-(phenylcarbonothioylthio)pentanoic acid (CTP). The polymerization rates of methyl methacrylate (MMA) are 0.019, 0.056, and 0.102 h −1 at 33, 40, and 50 °C, respectively, in the presence of DPAB and CTP under visible-light irradiation. Dark reaction produces no PMMA at 50 °C for 120 h. The living feature is demonstrated by linearly increasing M n with the monomer conversions and narrow polydispersity index (PDI), chain extension, and block polymerizations with benzyl methacrylate (BnMA) and poly(ethylene glycol) monomethyl ether methacrylate (PEGMA). With PMMA-CTP ( M n = 6800, PDI = 1.17), chain extension gives PMMA with M n = 15 900 and PDI = 1.15. With PMMA-CTP ( M n = 6000, PDI = 1.21) as macro-RAFT, PMMA- b -PBnMA of M n = 12 600 (PDI = 1.44) and M n = 18 500 (PDI = 1.31) are prepared. These results support that there is a positive synergistic effect between polymerization temperature and visible-light irradiation on the photo-RAFT without losing the living features.
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高影响因子
ELECTROCHIMICA ACTA
·
2019
·
IF 5.383
Yuanyuan Dong,Min Zhou,Lei Zhang
3D multiporous Co, N co-doped MoO 2 /MoC (3D Co,N-MoO 2 /MoC) nanorods hybrids were successfully synthesized via carburizing core-shell ZIF-67-cladded MoO 3 nanorods precursor at high temperature. As-fabricated Co,N-MoO 2 /MoC nanorods coated glassy carbon electrodes (GCE) was demonstrated to possess superior electrocatalytic activity for the electro-oxidation of acetaminophen (AC) and 4-aminophenol (4-AP). Such excellent electrochemical performance was largely attributed to the synergistic effect of the unique multiporous structure, the optimal component and abundant active sites of the nanorods. The corresponding electrode reaction mechanisms were studied in detail in this article. Under optimal conditions, the linear detection ranges were 0.05–200.0 μmol/L for AC and 0.05–140.0 μmol/L for 4-AP, respectively, with the low detection limits of 0.013 μmol/L and 0.012 μmol/L. Furthermore, the 3D Co,N-MoO 2 /MoC/GCE revealed excellent sensitivity, good reproducibility, stability and anti-interference ability. The developed electrode was evaluated towards the detecting AC and 4-AP in biological fluids, environment water and pharmaceutical formulations with satisfactory recovery, which had a broad application prospect.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Xue Bai,Jiangdong Dai,Yue Ma,Weibai Bian,Jianming Pan
It is highly desirable to develop an efficient adsorbent with large capacity, high selectivity and fast kinetics to recovery virtually inexhaustible lithium ion (Li + ) resources from salt lake brine. In this work, 2-(allyloxy) methylol-12-crown-4 ether (2AM12C4) functionalized polymer brushes (PVBC-g-PCE) from macroporous polymeric high internal-phase emulsion (PolyHIPE) using UV-initiated surface polymerization are synthesized for selectively recovery of Li + . PVBC-g-PCE possesses the advantages of strong physical strength, high density of accessible binding sites, and the size of highly permeatable voids and interconnecting pores is about 8.0–18 µm and 3.3–4.8 µm, respectively, which is a favorable adsorbent for specific capture Li + . PVBC-g-PCE has a maximum capacity at pH 6.0, and the pH-dependent adsorption amount suggests the grafted polymer brushes of 2AM12C4 is the driving force to enhance binding performance. PVBC-g-PCE has a fast adsorption equilibrium within 45 min, and the kinetic results are well-described by the pseudo-second-order model, indicating the specific host-guest interaction between functionalized 2AM12C4 and Li + is the main adsorption mechanism. Moreover, the maximum monolayer binding amount of PVBC-g-PCE is 4.43 mg g −1 , and the strong affinity in the presence of four kinds of interfering ions (i.e. Na + , K + , Mg 2+ , and Ca 2+ ) is also observed, which can also be proved by the high relative selectivity separation coefficient ( α r ) between 3.16 and 7.98. It is expected that this PVBC-g-PCE with abundant easy-to-access specific recognition sites can be applied as a promising adsorbent for effective separation of Li + .
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MOLECULES
·
2019
·Vol. 24
·期 20
·3806
·
IF 3.06
Qiao Zhang,Yi Zhang,Shi-Kang Zhou,Kan Wang,Min Zhang,Pei-Dong Chen,Wei-Feng Yao,Yu-Ping Tang,Jian-Hua Wu,Li Zhang
The dried roots ofEuphorbia kansuiS.L.Liou ex S.B.Ho have long been used to treat edema in China. However, the severe toxicity caused byEuphorbia kansui(EK) has seriously restricted its clinical application. Although EK was processed with vinegar to reduce its toxicity, the detailed mechanisms of attenuation in toxicity of EK stir-fried with vinegar (VEK) have not been well delineated. Diterpenoids are the main toxic ingredients of EK, and changes in these after processing may be the underlying mechanism of toxicity attenuation of VEK. 3-O-(2′E,4′Z-decadienoyl)-20-O-acetylingenol (3-O-EZ) is one of the diterpenoids derived from EK, and the content of 3-O-EZ was significantly reduced after processing. This study aims to explore the underlying mechanisms of toxicity reduction of VEK based on the change of 3-O-EZ after processing with vinegar. Based on the chemical structure of 3-O-EZ and the method of processing with vinegar, simulation experiments were carried out to confirm the presence of the product both in EK and VEK and to enrich the product. Then, the difference of peak area of 3-O-EZ and its hydrolysate in EK and VEK were detected by ultra-high-performance liquid chromatography (UPLC). Furthermore, the toxicity effect of 3-O-EZ and its hydrolysate, as well as the underlying mechanism, on zebrafish embryos were investigated. The findings showed that the diterpenoids (3-O-EZ) in EK can convert into less toxic ingenol in VEK after processing with vinegar; meanwhile, the content of ingenol in VEK was higher than that of EK. More interestingly, the ingenol exhibited less toxicity (acute toxicity, developmental toxicity and organic toxicity) than that of 3-O-EZ, and 3-O-EZ could increase malondialdehyde (MDA) content and reduce glutathione (GSH) content; cause embryo oxidative damage by inhibition of the succinate dehydrogenase (SDH) and superoxide dismutase (SOD) activity; and induce inflammation and apoptosis by elevation of IL-2 and IL-8 contents and activation of the caspase-3 and caspase-9 activity. Thus, this study contributes to our understanding of the mechanism of attenuation in toxicity of VEK, and provides the possibility of safe and rational use of EK in clinics.Keywords:Euphorbia kansui;diterpenoids;vinegar processing;zebrafish toxicity
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高影响因子
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
·
2018
·Vol. 53
·期 8
·1992-2005
·
IF 2.383
Huifan Liu,Fan Gong,Fashan Wei,Furao Lai,Xiaoyuan Zhang,Hui Wu
Summary Four types of carbohydrates, including Dendrobium officinale polysaccharide, Dendrobium aphyllum polysaccharide and β-glucans from yeast and barley, were examined, and their structures were found to mainly contain 1,4-linked-β- d -Glc p . Artificially simulated gastrointestinal digestion was conducted to characterise the changes of molecular weight, reducing sugars and released free monosaccharides by high-performance liquid chromatography, kits and the newly developed gas chromatography (GC)-mass spectrometry (MS)/MS analysis, which indicated that high molecular weight and complex spatial structures contributed to delayed monosaccharide release following exposure to digestive solution. The spatial structures of carbohydrates were changed during gastric digestion, but their primary structures were destroyed during intestinal digestion. Additionally, for the developed 7890A/7000 GC-TQ/MS-MS, the new analytical method was successfully used to analyse very low concentrations of monosaccharides in the simulated gastrointestinal digestive system.
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高影响因子
Materials Research Express
·
2018
·Vol. 6
·期 1
·015002
·
IF 1.151
Weidan Chang,Shili Liu,Aori Qileng,Weipeng Liu,Yingju Liu
A facile, green and in situ synthesis for the immobilization of monodispersed Au nanoparticles (Au NPs) on eggshell membrane (ESM) using the Lagerstroemia speciosa leaves extract (LSE) was reported. The stable fibrous-network structure of the ESM offered great surface area and abundant functional groups to provide an ideal support, while the leaves extract of Lagerstroemia speciosa can act as stabilizing and reducing reagents for Au NPs without capping reagents or heating. The morphology and surface chemical information were characterized via transmission electronic microscopy (TEM), field emission scanning electron microscopy (FESEM), Fourier transform infrared spectroscopy (FTIR), x-ray photoelectron spectroscopy (XPS), x-ray diffraction analysis (XRD) and thermogravimetric analysis (TGA). The catalyst exhibited excellent performance for the reduction of 4-nitrophenol (4-NP), showing that ESM@LSE@Au from a 0.6 mM Au precursor exhibited the best catalytic activity with the reaction rate constant of 29.70 s−1 · g−1 and a conversion of over 99.84% in 6 min. Moreover, the catalyst can be efficiently recycled by mild centrifugation with a remained conversion over 92.40% after 10 cycles, suggesting the potential for the reduction of nitroaromatic compounds.
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危险品化学品经营许可证（带存储）