Asia-Pacific Journal of Chemical Engineering
·
2025
·
IF 1.6
Shuai Yan,Xin Pu,Zhiyong Qi,Xiaoran Zhang,Xiaoyu Zhou,Xin Han,Lei Ye,Xinglong Qin,Jichang Liu
m -Cresol and p -cresol cannot be effectively separated using conventional distillation because of their proximate boiling temperatures. This study investigated the adsorption separation of cresol using the short b -axis ZSM-5 synthesized via a urea-assisted method. In contrast to the ellipsoidal HZSM-5, which was approximately 1 μm in length, the thickness of the sheet-like HZSM-5 decreased to 36 nm, resulting in an increase in total cresol adsorption capacity from 76 to 122 mg/g. Applying the CLD method, an increase in the TEOS:HZSM-5 ratio from 0 to 0.83 resulted in the increase in p -cresol adsorption capacity from 69 to 106 mg/g, while m -cresol adsorption capacity dropped from 53 to 12 mg/g. The adsorption selectivity significantly rose from 1.3 to 9.7. The adsorption kinetics and isotherms demonstrated that the process was exothermic for p -cresol and endothermic for m -cresol.
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DOI
高影响因子
Photodiagnosis and Photodynamic Therapy
·
2020
·
IF 2.894
Tongtong Zhang,Jianwei Bao,Mengmeng Zhang,Yuanyuan Ge,Jianming Wei,Yu Li,Weixia Wang,Miao Li,Yiguang Jin
Lung cancer is a severe disease with high mortality. Chemotherapy is one major treatment for lung cancer. However, systemic chemotherapeutics usually distribute throughout the body without specific lung distribution so that serious side effects are unavoidable. Photodynamic therapy (PDT) is occasionally used for lung cancer treatment but photosensitizers are also systemically administered and the bronchoscopic intervention under anesthesia may hurt lung tissues. Here, we combined inhaled chemotherapeutics and photosensitizers for chemo-photodynamic therapy (CPDT) of primary lung cancer of rats with external laser light irradiation. Gefitinib PLGA nanoparticles (GNPs) were prepared. The anti-cancer effects of GNPs and/or a common photosensitizer 5-aminolevulinic acid (5-ALA) were explored on A549 cells (adenocarcinomic human alveolar basal epithelial cells) and primary lung cancer rats after intratracheal administration. External light irradiation was applied due to its higher safety compared to internal light irradiation that may result in injuries after a laser optic fiber was intubated into the lung. The remarkable synergistic effect of CPDT was confirmed although the single therapies were also effective, where the high anti-lung cancer effects were shown and some typical lung cancer markers, including CD31, VEGF, NF-κB p65 and Bcl-2, significantly decreased. Moreover, the treatments attenuated inflammation with the downregulation of TNF-α. The combination of pulmonary drug delivery and chemo-photodynamic therapy is a promising strategy for treatment of lung cancer.
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PubMed
高影响因子
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
·
2026
·
IF 2.5
Gu Wenhui,Wu Lingyu,Yang Zhiguo,Cheng Zhongbin,Liu Wenwen,Huang Yi-You,Liu Dan,An Faliang,Li Jian,Zhou Qian,Li Baoli,Luo Hai-Bin
Wendlandia uvariifolia subsp. chinensis (Merr.) Cowan is a traditional medicinal plant used by the Li ethnic group in Hainan Province, China, for the treatment of herpes zoster. However, its pharmacological properties remain unclear. This study aimed to evaluate its phosphodiesterase type 5 inhibitory activity, identify the active components, and explore its therapeutic potential for erectile dysfunction. Through high-throughput screening of 1200 traditional Chinese herbal medicines, this plant was identified as a potential phosphodiesterase type 5 inhibitor. Bioactivity-guided fractionation and gas chromatography–mass spectrometry analysis identified the petroleum ether fraction as the most active fraction, while phytol, one of its identified constituents, inhibited phosphodiesterase type 5 in vitro with an IC₅₀ value of 2.5 ± 0.1 μmol/L. In H₂O₂-injured endothelial cells, petroleum ether fraction significantly restored nitric oxide production. In a paroxetine-induced erectile dysfunction rat model, the fraction improved sexual behavior parameters, restored NO/cGMP signaling, and alleviated pathological remodeling and fibrosis in the corpus cavernosum. In a diabetes mellitus-associated erectile dysfunction rat model, the fraction also improved corpus cavernosum architecture, increased smooth muscle content, and reduced fibrosis, although the increase in the intracavernous pressure/mean arterial pressure ratio did not reach statistical significance. Overall, the results suggest the preclinical anti-erectile dysfunction potential of petroleum ether fraction and support its further mechanistic, pharmacokinetic, safety, and translational evaluation.
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高影响因子
Materials Today Communications
·
2022
·
IF 3.662
Qiao Zhao,Dongqin Xiao,Yuwei Li,Xinghan Chen,Kun Hu,Xuwei Luo,Fei Yang,Zelong Yang,Kang Liu,Gang Feng,Jinhui Liu,Daxiong Feng,Ke Duan
Osteonecrosis of the femoral head (ONFH) is a common disease with limited options of treatment. In this study, we prepared self-setting nano-sized hydroxyapatite carriers incorporating microspheres for controlled release of growth differentiation factor-5 (GDF-5) and/or alendronate (ALN). GDF-5 release enhanced the proliferation of rabbit bone mesenchymal stem cells (BMSCs), and ALN release inhibited the proliferation of macrophages. A rabbit ONFH model was created by liquid nitrogen infusion, and the carriers were implanted into the channel-shaped defects and harvested at 12 weeks. Imaging examination and histological analyses found that all carriers increased new bone formation in the defects, with the group simultaneously incorporating GDF-5 and ALN yielding the greatest improvement. The synergistic release of ALN and GDF-5 from the carrier may offer a promising option for the treatment of ONFH after surgical decompression.
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高影响因子
INTERNATIONAL MICROBIOLOGY
·
2022
·Vol. 26
·期 1
·59-68
·
IF 3.097
Yang Hua,Zhao Dengqi,Wang Shuping,Yang Lijun,Huang Jianying,Zhang Zibin,Li Shijun
An increasing number of infections caused by multidrug-resistant (MDR) Staphylococcus aureus （ S. aureus ） and Escherichia coli （ E. coli ） have severely affected human society. Thus, it is essential to develop an alternative type of antibacterial agents that has a different bacterial resistance mechanism from that of traditional antibiotics. After the synthesis and structural characterization of a cationic pillar[5]arene with pyridinium groups (PP5), the antibacterial and antibiofilm activities as well as its microbial resistance were systematically investigated. In-depth evaluation of biological studies revealed that PP5 was an active antibacterial agent, with surprising antibiofilm formation ability against E. coli and S. aureus. From the results of differential scanning calorimetry and transmission electron microscopy, it was concluded that the microbicidal activity of PP5 was due to the physical disruption of the pathogen’s membrane and the subsequent leakage of cytoplasmic components, which could greatly reduce the rapid generation of resistance. It was presented that the easily available PP5 has high activity to inhibit Gram-positive and Gram-negative bacteria and/or their biofilms with low cytotoxicity. This pillar[5]arene derivative can be used as a good candidate for controlling drug-resistant pathogenic bacterial infections and treating MDR bacteria.
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DOI
PubMed
高影响因子
CHINESE JOURNAL OF CATALYSIS
·
2018
·
IF 3.525
Wenjin Xu,Guangxu Zhang,Hanwei Chen,Guomeng Zhang,Yang Han,Yichuan Chang,Peng Gong
Two series of Mn/beta and Mn/ZSM-5 catalysts were prepared to study the influence of how different Mn precursors, introduced to the respective parent zeolites by wet impregnation, affected the selective catalytic reduction (SCR) of NO by NH 3 across a low reaction temperature window of 50–350 °C. In this study, the catalysts were characterized using N 2 adsorption/desorption, X-ray diffraction, X-ray fluorescence, H 2 temperature-programmed reduction, NH 3 temperature-programmed desorption and X-ray photoelectron spectroscopy. As the manganese chloride precursor only partially decomposed this primarily resulted in the formation of MnCl 2 in addition to the presence of low levels of crystalline Mn 3 O 4 , which resulted in poor catalytic performance. However, the manganese nitrate precursor formed crystalline MnO 2 as the major phase in addition to a minor presence of unconverted Mn-nitrate. Furthermore, manganese acetate resulted principally in a mixture of amorphous Mn 2 O 3 and MnO 2 , and crystalline Mn 3 O 4 . From all the catalysts screened, the test performance data showed Mn/beta-Ac to exhibit the highest NO conversion (97.5%) at 240 °C, which remained >90% across a temperature window of 220–350 °C. The excellent catalytic performance was ascribed to the enrichment of highly dispersed MnO x (Mn 2 O 3 and MnO 2 ) species that act as the active phase in the NH 3 -SCR process. Furthermore, together with a suitable amount of weakly acidic centers, higher concentration of surface manganese and a greater presence of surface labile oxygen groups, SCR performance was collectively enhanced at low temperature.
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高影响因子
Catalysis Science & Technology
·
2016
·Vol. 6
·期 8
·2647-2652
·
IF 5.287
Hualei Hu,Jinghui Lyu,Jiayao Rui,Jie Cen,Qunfeng Zhang,Qingtao Wang,Wenwen Han,Xiaonian Li
Ethylbenzene is the major side product in benzene alkylation with methanol and it is difficult to be suppressed over hierarchical porous ZSM-5. Moreover, the separation of ethylbenzene from xylene still remains a great challenge. Our research indicated that ethylbenzene formation could be highly suppressed by changing the Si/Al ratio of the catalyst. Hierarchical porous ZSM-5 catalysts with different Si/Al ratios were prepared via reducing the amount of Al in the solvent evaporation assisted dry gel conversion method. In this method, tetra-n-propylammonium hydroxide was used as the direct agent to create micropores, and hexadecyltrimethoxysilane was added to create additional porosities by forming organic assemblies which occupied a certain space between zeolitic walls. The catalyst with a Si/Al ratio of 1800 could achieve high benzene conversion (59.5%) and high xylene selectivity (39.0%) as well as excellent suppression of ethylbenzene formation (<0.1%).
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Tianhui Jiao,Waqas Ahmad,Jiaji Zhu,Md Mehedi Hassan,Jingjing Wang,Yawen Rong,Zhiming Guo,Huanhuan Li,Zhen Ding,Changxin Lv,Quansheng Chen
The current study examines aflatoxin B1 (AFB1) as the indicator of the total aflatoxins in wheat with a 5-aminotetramethylrhodamine (NH 2 -Rh)-decorated gold–silver core–shell nanoparticles (Au@Ag CSNPs) sensor based surface enhanced Raman scattering (SERS) strategy, using Hg(II) as the media. The principle of the work was based on the selective interaction of Hg(Ⅱ) media with AFB1 via carbonyl oxygen atoms to inhibit the aggregation of NH 2 -Rh-Au@Ag CSNPs sensor. Due to the nanogap effect induced by sensors aggregation, the quenching in SERS intensity was an indication for AFB1 selective quantification. Under the optimized experimental conditions, a detection limit of 0.03 ng·mL −1 was obtained with a correlation coefficient R 2 = 0.9895 within the dynamic range of 0.1–5.0 ng·mL −1 . This quantification of AFB1 was further coupled with solid-phase extraction in real wheat, hazelnut, and peanut oil samples. The strategy was validated by standard HPLC-FLD approach and was in a good agreement. The proposed detective system offers a promising platform for the rapid determination of traces AFB1 residue in foodstuff with high selectivity and economical efficiency.
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高影响因子
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2021
·Vol. 23
·期 35
·19729-19739
·
IF 3.676
Shijie Wang,Yihang Chen,Yu Jia,Guizhuan Xu,Chun Chang,Qianhui Guo,Hongge Tao,Caihong Zou,Kai Li
The fundamental understanding of glucose conversion to 5-ethoxymethylfurfural (EMF) and ethyl levulinate (EL) (value-added chemicals from biomass) in ethanol solution catalyzed by a Brønsted acid is limited at present. Consequently, here, the reaction pathways and mechanism of glucose conversion to EMF and EL catalyzed by a Brønsted acid were studied, using an experimental method and quantum chemical calculations at the B3LYP/6-31G(D) and B2PLYPD3/Def2TZVP level under a polarized continuum model (PCM-SMD). By further verification through GC/MS tests, the mechanism and reaction pathways of glucose conversion in ethanol solution catalyzed by a Brønsted acid were revealed, showing that glucose is catalyzed by proton and ethanol, and ethanol plays a bridging role in the process of proton transfer. There are three main reaction pathways: through glucose and ethyl glucoside (G/EG), through fructose, 5-hydroxymethylfurfural (HMF), levulinic acid (LA), and EL (G/F/H/L/EL), and through fructose, HMF, EMF, and EL (G/F/H/E/EL). The G/F/H/E/EL pathway with an energy barrier of 20.8 kcal mol−1 is considered as the thermodynamic and kinetics primary way, in which the reaction rate of this is highly related to the proton transfer in the isomerization of glucose to fructose. The intermediate HMF was formed from O5 via a ring-opening reaction and by the dehydration of fructose, and was further converted to the main product of EMF by etherification or by LA through hydrolysis. EMF and LA are both unstable, and can partially be transformed to EL. This study is beneficial for the insights aiding the understanding of the process and products controlling biomass conversion in ethanol solution.
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PubMed
高影响因子
ACS Catalysis
·
2022
·
IF 13.7
Yichao Jin,Sarina Sarina,Hongwei Liu,Wayde Martens,Eric R. Waclawik,Erandi Peiris,Jianfeng Jia,Jing Shang,Liangzhi Kou,Cheng Guo,Huai-Yong Zhu
Production of 2,5-furandicarboxylic acid (FDCA, a platform chemical for the chemical industry in the future) by the selective aerobic oxidation of 5-hydroxymethyl-furfural is a crucial component to enable the FDCA production from sugars. The challenge is to achieve a high FDCA yield at low temperatures. Here, we report a catalyst composed of alloyed nanoparticles (containing 1.5 wt % Ag and 1.5 wt % Pd) supported on CeO2 nanofibers, which achieved an excellent FDCA yield (93%) at 20 °C. Interesting observations include yield deterioration at higher reaction temperatures; water is the source of the oxygen atom(s) added to the oxidized intermediates and product, while O2 molecules adsorbed onto the catalyst scavenge electrons, yielding OH• radicals from OH– ions in the reaction system to drive the oxidation. At 20 °C, we avoid side reactions, but there is no external energy provided for overcoming the activation barriers. The barriers for activating the alcohol groups are significant. We find that the appropriate chemisorption on the catalyst is critical for a high FDCA yield. By tuning the Ag/Pd ratio, we attained the most catalytically active sites, bimetallic surface sites, at the boundaries between Ag and Pd clusters. The chemisorption at these sites is strong enough to cause the selective oxidation of both the aldehyde and alcohol groups in HMF at 20 °C, avoiding side reactions at high temperatures. The knowledge acquired from this study is expected to have implications for other catalytic systems where competitive reactions proceed.
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高影响因子
Molecular Catalysis
·
2017
·
IF 0
Shuang Chu,Li’na Yang,Xingcui Guo,Linlin Dong,Xiufang Chen,Yaru Li,Xindong Mu
The catalytic behavior of a series of MFI catalysts with different Si/Al ratio (25–300) in the direct aqueous-phase hydrolysis of α-cellulose was studied. The effects ultrasonic pretreatment time, ZnCl 2 content, zeolite pore structure and acid-basic properties on catalyst activity and products distribution were systematically investigated. The results indicated that HZSM-5 with lower Si/Al ratio was beneficial for production of glucose and LA from α-cellulose. Ultrasonic pretreatment could decrease the degree of crystallinity and polymerization of α-cellulose, enhance the accessibility of acid sites and ZnCl 2 to the loosened amorphous regions of α-cellulose in water, and improve the hydrolysis efficiency of α-cellulose. The desilicated ZSM-5 (HZSM-5-DS(0.2)) showed much higher catalytic activities as compared to commercial ZSM-5 and α-cellulose conversion reached 76.5% over HZSM-5-DS(0.2) at 200 °C. Catalytic conversion of α-cellulose consisted of at least three important parallel reactions under the present hydrothermal conditions and a plausible pathway was proposed. Effective control of these reactions would be helpful to further maximize the target product yield during the catalytic conversion of α-cellulose.
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Food Science & Nutrition
·
2024
·
IF 3.5
Jialing Lin,Chuanhui Zeng,Xueli Li,Qin Tang,Jing Liao,Yan Jiang,Xianchun Zeng
Heterocyclic amines (HAs) are a group of mutagenic and carcinogenic compounds produced from the processing of high-protein foods, which include 2-amino-3-methylimidazo[4, 5-f]quinoline (IQ) showing the strongest carcinogenic effect. Camels are able to digest HAs in foods, which provide rich microbial resources for the study. Thus, camel rumen and intestinal microbiota were used to degrade IQ, and the dominant microorganisms and their degradation characteristics were investigated. After three generations of culture with IQ as the sole carbon source, the highest abundance in rumen and intestinal microbes was found in the Proteobacteria phylum. The strains of third generation of the rumen contents were mainly attributed to the genera Brevundimonas and Pseudomonas , and the dominant genera in intestine were Ochrobactrum , Bacillus , and Pseudomonas . Microorganisms were further isolated and purified from the third generation cultures. These 27 strains from the rumen (L1–L27) and 23 strains from the intestine (C1–C23) were obtained. Among them, four strains with the most effective degrading abilities were as follows: L6 (28.55% of IQ degrading rate) and C1 (25.19%) belonged to the genus Ochrobactrum , L15 (23.41%) belonged to the genus Pseudomonas , and C16 (20.89%) were of the genus Bacillus . This study suggested the application of abundant microbial resources from camels' digestive tract to biodegrade foodborne toxins.
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高影响因子
危险品化学品经营许可证（带存储）