Journal of Inorganic and Organometallic Polymers and Materials
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2025
·
IF 4.9
Yang Chen,Cai Peng
Metal-organic frameworks (MOFs), consisting of both organic linkers and metallic ions, are expected to be excellent drug delivery agents for the treatment of cancer. However, the stability of MOF in the gastrointestinal tract remains to be resolved. In this study, we synthesized a MOF, namely Zr-NDC. Next, a thiolated chitosan (TCS) surface-modified Zr-NDC was developed, providing a strong impetus for oral 5-FU delivery. The most favorable interaction sites between 5-FU and Zr-NDC were explored by computer simulation. Then, the physicochemical properties of TCS-MOF, such as particle size, size distribution, and morphology, were evaluated. Through a series of experiments, including in vitro drug release experiments, MTT analysis, and in situ single small intestinal perfusion (SPIP), the results showed that under the protection of TCS-MOF, the release rate (2.3%) of 5-FU in an acidic environment was far lower than in artificial intestinal juice (60%). The coating of TCS on the surface of Zr-NDC has the effect of controlling drug release. TCS coating can enhance the acid resistance limit of MOF and further increase the adhesion and permeability of 5-FU to the intestinal mucosa. It is expected that TCS-MOF@5-FU can serve as a potential drug delivery system for oral 5-FU.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Xiaojing Ma,Jiachen Lv,Jiale Fu,Hongshun Hao,Jingran Bi,Hongman Hou,Gongliang Zhang
In this study, phenethyl isothiocyanate nanoemulsion (PNE) was formulated for creating composite films with pectin and chitosan. Two types of PNE/pectin/chitosan (PNE-PC) films (PNE-PC1, PNE-PC2) were made by introducing PNE into films with different pectin/chitosan (PC) contents. Compared to PC films, PNE-PC films showed greater hydrophilicity and improved elongation at break, with Fourier transform infrared spectroscopy, X-ray and microstructural observations confirming PNE's good compatibility within the film matrices. The PNE-PC2 film exhibiting a cumulative release of 55.3 % of PNE over 72 h and confirmed to inhibit Staphylococcus aureus for up to 48 h. Furthermore, beef covered with PNE-PC2 film showed lower total viable count compared to uncovered and polyethylene-covered groups. The film also stabilized beef pH and maintained total volatile basic nitrogen values within a safe range. It effectively suppressed sulfide production, preventing undesirable odors and extending beef shelf life, demonstrating the potential of PNE-PC films for food packaging applications.
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JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2025
·Vol. 172
·期 4
·047505
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IF 3.3
Moustafa Zahran,Suzan Mohammed,Magdy A.-H. Zahran,Magdi Abdel Azzem
Congo red (CR), a synthetic azo dye, is known for its high toxicity and potential to bioaccumulate in the food chain. Exposure to CR-contaminated water can lead to various health issues, including cancer, underscoring the need for effective quantification and treatment methods. While reliable, traditional chromatographic and spectroscopic techniques are often complex, require toxic solvents, and may not be suitable for rapid or on-site analysis. Herein, we report a replacement tool for quantifying CR in water samples using an electrochemical sensor modified with biosynthesized chitosan-capped silver nanoparticles (AgNPs). AgNP identification was accomplished using ultraviolet-visible spectroscopy and square wave voltammetry (SWV), which showed AgNP characteristic peaks at 438 nm and 0.06 V, respectively. A transmission electron microscope confirmed the spherical shape of AgNPs and their average size (30 nm). The electrocatalytic activity of AgNPs towards CR was also approved using cyclic voltammetry, SWV, and impedance spectroscopy. Thus, the SWVs of different concentrations of CR were used to obtain the calibration curve, showing limits of detection and quantification of 0.017 and 0.056 μM, respectively. Additionally, the interferences and real sample studies showed that the chitosan-capped AgNPs sensor is suitable for quantifying CR in river water samples with high selectivity.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yonghao Chen,Meijie Qu,Chenshen Liu,Shuhui Li,Xincheng Wang,Daixuan Gong,Ping Tang,Yuezhen Bin
Humidity-driven actuators have attracted much attention from researchers due to their fast response and recovery speed, high sensitivity, and large bending deformation. Graphene oxide (GO), with abundant oxygen-containing functional groups and a large specific surface area, has been widely used in the field of flexible humidity-driven actuators. However, pure graphene oxide films have poor mechanical properties and are easily damaged in practical applications, and these limitations can be addressed by integrating GO with other materials. It has been reported that chitosan (CS) and sodium alginate (SA) can be assembled together by ultrasound to prepare CSSA nanofibers with high tensile strength and excellent hygroscopic properties. In this study, a uniform, flexible actuator based on a thin film was developed by combining graphene oxide with CSSA nanofibers. The obtained 32 μm CSSA10-GO1 film (the mass ratio of CSSA and GO is 10:1) exhibits excellent humidity-driven performance, with maximum deflection angle and driving force of 218° and 2.5 N at ΔRH = 45 %, and response and recovery times of 20.5 s and 201.8 s, respectively. In addition, the film has excellent cycle and solubility resistance stability, and the prepared film remains stable even after 50 humidity cycle tests and 7 days of immersion in water. In addition, the composite film was able to grip and lift heavy objects up to 70 times its own weight by simple design. With such excellent properties, the prepared composite film is expected to be used in soft robotics, artificial muscles and other applications.
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Polymers
·
2025
·Vol. 17
·期 10
·1341
·
IF 4.9
Min Zhou,Zhenglin Liu,Dandan Lu,Jiajun Wang,Zili Chen,Yunren Qiu
Due to the similar physicochemical properties of rare earth ions, their separation presents significant challenges. In this study, acidic phosphonic chitosan (aPCS) was prepared by modifying chitosan with phosphite and formaldehyde for improving the water solubility and complexing ability of rare earth ions in acidic aqueous solutions. DFT calculations revealed that its phosphonic groups serve as preferred reaction sites, forming stable bidentate complexes with rare earth cations. The complexation abilities of aPCS and phosphorylated chitosan (PCS) for La(III) were compared at various pHs by complexation–ultrafiltration. The results showed that aPCS achieved a 97% rejection for La(III), while 70% for PCS at pH 5 and P/RE 10. Furthermore, aPCS maintained higher rejection than PCS at pH of 3 to 7. In conclusion, aPCS demonstrates excellent potential for the selective extraction and purification of rare earth ions.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2018
·
IF 3.909
Ruixin Li,Jinxia He,Hongguo Xie,Wenxia Wang,Santosh Kumar Bose,Yeqing Sun,Jianen Hu,Heng Yin
To investigate the effect and mechanism of chitosan nanoparticles (CSNPs) on the germination and seedling growth of wheat ( Triticum aestivum L.), we conducted systematic research on the impact of different concentrations (1–100 μg/mL) of CSNPs and chitosan (CS). The result of energy-dispersive spectroscopy (EDS) and confocal laser scanning microscopy (CLSM) showed that adsorption of CSNPs on the surface of wheat seeds was higher than that of CS. CSNPs had growth promoting effect at a lower concentration (5 μg/mL) compared with CS (50 μg/mL). In addition, the application of 5 μg/mL CSNPs induced the auxin-related gene expression, accelerated indole-3-acetic acid (IAA) biosynthesis and transport, and reduced IAA oxidase activity resulting in the increase of IAA concentration in wheat shoots and roots. The results suggest that CSNPs have positive effect on seed germination and seedling growth of wheat at a lower concentration than CS due to higher adsorption on the surface of wheat seeds.
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Materials Today Communications
·
2022
·
IF 3.662
Weijie Xu,Xin Gao,Huaping Tan,Shengke Li,Tianle Zhou,Jianliang Li,Yong Chen
The purpose of this study is to prepare polysaccharide-based hydrogel dressing integrated with microspheres which has excellent self-healing ability and sustained antibacterial function for wound healing application. The hydrogel is derived from carboxymethyl chitosan (CMCS) and carboxymethyl cellulose (CMC) via the Schiff’s base reaction, without the addition of chemical catalyst. Also, the CMCS microspheres containing an antibacterial drug, e.g., tetracycline hydrochloride (TH), were prepared by an emulsion cross-linking. Parameters were optimized during the preparation experiment to improve various properties of the microspheres/hydrogel composite dressing. This gel dressing has good elasticity, when compressive strain was 0.7 mm/mm, the tangent elastic modulus was up to 1.7 MPa. Furthermore, its drug sustained release performance was significantly better than the drug directly embedded in the hydrogel. TH could sustain release stably within 12 h, without obvious burst release phenomenon. Antibacterial experiments showed that 20 mg/mL microspheres made composite dressing a better performance than control microspheres and hydrogel. Potential of the composite scaffolds was further demonstrated by culture of human adipose-derived stem cells (ASCs) in vitro. Cell culture showed that this composite hydrogel could support survival and proliferation of ASCs. These characteristics provide a potential opportunity to use this composite gel dressing in drug delivery and wound healing applications.
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Journal of Analysis and Testing
·
2021
·Vol. 6
·期 3
·327-334
·
IF 0
Qi Wen-Jing,He Hong-Kun,Tian Xue,Song Yi,Li Xue-Ni,Li Rong,Hu Ping-Ping,Huang Xiao-Mei
We established a fluorescence “turn-on” sensing platform for glutathione (GSH) detection utilizing chitosan-based glutaraldehyde non-conjugated polymers (GCPF) as nanomaterials via fluorescence resonance energy transfer (FRET) principle. Owing to the overlapping property of absorption spectrum of MnO 2 nanosheets with fluorescence spectrum of GCPF, fluorescent intensity of GCPF was quenched in the presence of MnO 2 nanosheets because of FRET principle. When GSH was added, MnO 2 nanosheets were reduced and decomposed into large amounts of Mn 2+ ions owing to reducing property of GSH. Accordingly, the quenched fluorescent intensity was turned on again. Therefore, this platform based on MnO 2 nanosheet has been first applied to fluorescence “turn-on” detection of GSH from 0.5 to 50 μmol/L with sdetection limit of 84 nmol/L. It showed high selectivity in GSH detection towards other ions and biomolecules such as L-lysine, L-threonine, L-valine, L-glutamic acid and DL-aspartic acid. When it was utilized in detecting GSH in serum samples, satisfactory recoveries ranged from 101.5% to 103.2%, indicating the accuracy of this fluorescence “turn-on” platform in bioanalysis.
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JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
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2015
·Vol. 15
·期 9
·6435-6443
·
IF 1.556
He Miao,Lu Liying,Zhang Jinchi,Li Danzhen
Immobilized chitosan-Ag nanoparticles (CTS-Ag NPs) with special surface state have been synthesized successfully through immobilizing Ag NPs on the amino-enriched surface of CTS by reducing Ag (I) in situ. The antimicrobial efficiency and potency of CTS-Ag NPs against Escherichia
coli and Staphylococcus aureus were studied. Our results reveal that surface-immobilized CTS-Ag NPs show better antimicrobial efficacy than several other reported monodisperse colloidal Ag NPs, because the unique surface state of our CTS-Ag NPs leads to both “contact killing”
and “ion mediated killing” functions. Due to the synergetic effect of CTS and Ag NPs, the immobilized CTS-Ag NPs present a broader antimicrobial spectrum and a more effective antifungal activity against Monilia albican. In addition, CTS as an environment friendly dispersant
can help to reduce the cytotoxicity of Ag NPs on higher organisms. The immobilized CTS-Ag NPs are stable and can maintain good disinfection potential after 6 months’ shelf-time.
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JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2015
·Vol. 15
·期 6
·4245-4254
·
IF 1.556
Li Yan,Xu Cong,Qiu Tianbao,Xu Xiaoyan
The Cd(II) ion imprinting electro-spun crosslinked chitosan nanofiber mats were successfully prepared using Cd(II) as template ions and glutaraldehyde (GA) as crosslinker to investigate the adsorption of Cd(II) and Pb(II) ions in aqueous solutions. The Cd(II) ion imprinting electro-spun
crosslinked chitosan nanofiber mats were characterized by the Fourier Transform Infrared Spectrometer (FTIR), Scanning Electron Microscope (SEM), Thermal Gravimetric Analysis (TGA), elemental analysis and solubility tests. The prepared chitosan nanofiber mats exhibited a higher adsorption
capacity for both Cd(II) (364.3 mg/g) and Pb(II) (272.0 mg/g) ions. The dynamic study demonstrated that the adsorption process followed the second-order kinetic equation. Langmuir and Freundlich adsorption models were used to analyze the equilibrium isotherm data. The results showed that the
Langmuir model was best suitable for predicting the adsorption isotherm of the studied system. The as prepared Cd(II) ion imprinting electro-spun crosslinked chitosan nanofiber mats might be used as an effective adsorbent for Cd(II) and Pb(II) removal from heavy metal wastewater.
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PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
·
2023
·
IF 4.7
Xiaomin Zhao,Yunfei Zhang,Li Chen,Zhiqing Ma,Bin Zhang
The practical application of essential oils (EOs) as an alternative for synthetic pesticides in agricultural production is severely limited because of their instability, high volatility, and water insolubility. Nanoencapsulation of EOs is an important strategy to overcome these limitations. In view of this, this study aimed to develop chitosan-thymol nanoparticle (NCS-Thy) with pH-responsive which can be used as an intelligent botanical fungicide to control Botrytis cinerea . The NCS-Thy nanoparticle was prepared by ionic crosslinking method with the loading capacity and encapsulation efficiency of 29.87% and 41.92%, respectively. The synthesized NCS-Thy nanoparticle was further characterized by Fourier transform infrared spectroscopy analysis, transmission electron microscopy observation, and dynamic lights scattering . The results of release kinetics and antifungal activity of NCS-Thy under different pH conditions were determined. The results showed that the NCS-Thy nanoparticle had excellent pH-responsiveness and can release more thymol under acidic conditions formed by B. cinerea , thereby achieving higher antifungal effects. Therefore, compared with unencapsulated thymol, the NCS-Thy nanoparticle had higher antifungal activity against B. cinerea in vitro . In addition, both the protective and curative efficacies of detached leaf test and pot experiment were significantly higher than those of unencapsulated thymol. Among them, the protective efficacy of NCS-Thy in the pot experiment was 78.73%, which was significantly higher than that of unencapsulated thymol with 61.13%. Therefore, the pH-responsive chitosan-thymol nano-preparation had a promising prospect of application in practical management of gray mold as an intelligent botanical fungicide.
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Polymers
·
2018
·Vol. 10
·期 10
·1046
·
IF 2.935
Dong Wang,Wanli Cheng,Yiying Yue,Lihui Xuan,Xiaohui Ni,Guangping Han
Cellulose nanocrystals/chitosan/polyvinyl alcohol (CNC/CS/PVA) composite nanofibrous films were prepared while using an electrospinning technique and successfully thiol-functionalized. Then, the modified films were used for the sorption-desorption of Cu(II) and Pb(II) ions. Subsequently, the adsorption capacity of the films was investigated by changing the CNC loading level, solution pH, and adsorption time. Results showed that the adsorption of metal ions by the films was the best with CNC loading level of 5 wt %, pH of 6, and adsorption time of 4 h. The adsorption behavior of the films was agreed with the Freundlich model. The adsorption equation of metal ions could be described while using a pseudo-second order model. Based on the Langmuir model, the maximum adsorption capacities of Cu(II) and Pb(II) ions were estimated to be 484.06 and 323.49 mg/g, respectively. The Cu(II) and Pb(II) ions adsorption efficiencies of the films after 4 adsorption-desorption cycles were 90.58% and 90.21%, respectively. This study may provide a feasible approach for the application of functional CNC/CS/PVA nanofibrous films in the treatment of water.Keywords:electrospining;chitosan;cellulose nanocrystals;nanofibrous films;metal adsorption
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