JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Wan Menghui,Gao Minjie,Luo Wen,Jin Lin,Zhao Yanbao,Sun Lei
Conventional pesticides generally suffer from low actual utilization efficiency due to their large particle sizes, weak leaf adhesion and rain erosion. Developing functional nanomaterials with high foliar affinity and rain-fastness remains a major challenge for enhancing pesticide utilization efficiency. Herein, we developed novel jellyfish-like nanocarriers for pesticide delivery. Firstly, jellyfish-like mesoporous polydopamine (J-mPDA) were prepared via an interface anisotropic self-assembly strategy. The unique jellyfish-like structure may enlarge the contact area and the topological interaction between the leaf surface and the nanocarrier. The synthesized J-mPDA carriers presented radial mesopores with a cross-sectional size of about 290 nm and an imidacloprid (IMI) loading efficiency of 22.4%. After loading IMI, tannic acid-copper ions (TA/Cu) networks were utilized to cap the loaded-pesticide pores (IMI@J-mPDA@TA/Cu). The obtained IMI@J-mPDA@TA/Cu exhibited pH/near-infrared dual responsiveness release properties. The IMI@J-mPDA@TA/Cu significantly improved the adhesion and retention efficiency of the foliar surface. Furthermore, the obtained nanoparticles displayed good biosafety and no significant inhibitory effect on bacteria and seed germination. In addition, IMI@J-mPDA@TA/Cu possessed an improved 6-fold anti-UV photostability compared with IMI, and high control efficacy against Plutella xylostella . As a result, this work provides a novel option to address adhesion inefficiencies and reduce pesticide runoff, making it a promising for efficient pesticide delivery. Graphical
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JOURNAL OF MEDICINAL CHEMISTRY
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2020
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IF 6.205
Ji Liu,Xin Liu,Jianqiang Qian,Chi Meng,Peng Zhu,Jiaying Hang,Yaling Wang,Biao Xiong,Xiaodong Qiu,Weizhong Zhu,Yumin Yang,Yanan Zhang,Yong Ling
Two novel theranostic agents HJTA and HJTB have been designed and synthesized by covalently linking a β-carboline derivative, with antitumor activities and pH-responsive fluorescence, with a 2-exomethylenecyclohexanone moiety, which can be activated by the tumor-targeting glutathione (GSH)/glutathione S-transferase π (GSTπ). These agents showed pH- and GSH-dual-responsive fluorescence in tumor cells but not in normal cells. Importantly, HJTA selectively illuminated tumor tissue for up to 7 h and generated precise visualization of orthotopic colonic tumors through the blood circulation system in intraoperative mice. Furthermore, HJTA exhibited potent and selective antiproliferative activities and colonic tumor inhibition in mice. Finally, HJTA induced great cancer cell apoptosis and autophagy by regulating the expression of apoptotic and autophagic proteins. Therefore, this pH/GSH-dual-responsive fluorescent probe with cancer-targeting therapeutic activity provides a novel tool for precise diagnosis and tumor treatment, therefore broadening the impact of multifunctional agents as theranostic precision medicines.
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高影响因子
CARBON
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2022
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IF 11.307
Xin Wang,Lei Zhao,Jinshuang Hu,Hua Wei,Xiaoyang Liu,Enshou Li,Shenghong Yang
Heteroatom doping except oxygen is the main method to improve the performance of carbon quantum dots (CQDs), the application is also limited by unpredictable biological negative effects and environmental risks from heteroatoms (N/P/S, etc.). To maximize the role of oxygen while avoiding the negative effects of other heteroatoms, herein, we rationally designed and synthesized a new type of carbon-oxygen quantum dots (COQDs) with high fluorescent performance aim to realize pH sensing and reactive oxygen species (ROS) scavenging. The toxicity test results from four levels of bacterias, Hela cells , Daphnia Magna, and zebrafish indicate that the designed COQDs possess high biocompatibility and low environmental risk. Based on the opposing response of COQDs and Rhodamine 6G (Rh 6G) fluorescent signal to pH changes in the range of 6.0–9.0, a COQDs-Rh 6G complex was constructed by combining Rh 6G for ratiometric pH sensing, and a scanning colorimetric analysis model was further developed for the rapid pH judgment of commercially available waters. The proposed COQDs and pH sensing system were also successfully applied for bioimaging and intracellular pH analysis, respectively. More importantly, the designed COQDs also exhibit excellent ROS scavenging ability, which can be used as an effective antioxidant with good biocompatibility .
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MICROCHEMICAL JOURNAL
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2023
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IF 4.8
Jiamin Liang,Zhongrui Wang,Yanan Zhao,Yue Gao,Huan Xing,Yuxin Song,Guang Yang,Juan Hou
Herein, fluorescent carboxymethyl cellulose polymer dots (B-PDs) were synthesized by a straightforward route under mild conditions using ethylenediamine-modified carboxymethyl cellulose (CMC-NH 2 ) and phenylboronic acid as precursors. The B-PDs exhibit a uniform nanoscale size distribution, good water solubility, photostability and excellent fluorescence emission with a high fluorescence quantum yield of 21.6 %. The B-PDs display a reversible fluorescence response with blue emission in acidic solution and green emission in alkaline solution. Moreover, the B-PDs can be designed as an excellent fluorescent sensor for glucose detection. After the addition of glucose, the FL intensity at λ ex = 388 nm can be enhanced due to the assembly of glucose on the B-PDs based on the reversible reaction between boronic acid and cis -diols through the aggregation-induced enhancement effect (AIE). Two good linear relationships can be obtained between (F-F 0 )/F 0 and the glucose amount ranging from 0 ∼ 0.005 M (R 2 = 0.9971) and 0.01 ∼ 1.2 M (R 2 = 0.9984), and the detection limit (LOD) was calculated to be 52 μM (3σ/slope). Meanwhile, the proposed probe was successfully utilized to analyze glucose in human urine samples (recovery: 97.9–104.1 %, RSD: 2.64–4.23 %) by the standard addition method, indicating good feasibility as a practical platform for sensing.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Yue Hu,Lu Zhang,Lin-feng Wei,Fei-yan Lu,Le-huai Wang,Qiao Ding,Ming-shun Chen,Zong-cai Tu
Urolithin A (UroA) is gut metabolites of ellagitannins possessing a vast range of biological activities, but its poor water solubility and low bioavailability hinder its potential applications. This study utilized the pH dependent dissolution characteristics of UroA and employed a simple pH-driven method to load UroA into liposomes. The characterization and stability of obtained liposomes under different conditions were evaluated, and their oral bioavailability was tested by pharmacokinetics , and compared with UroA liposomes prepared using traditional thin film dispersion (TFM-ULs). Results indicated that liposomes could effectively encapsulate UroA. The UroA liposomes prepared by the pH-driven method (PDM-ULs) showed lower particle size, polydispersity index , zeta potential , and higher encapsulation efficiency than TFM-ULs. Interestingly, better thermal stability , storage stability, in vitro digestion stability, and higher bioaccessibility were also found on PDM-ULs. Moreover, pharmacokinetic experiments in rats demonstrated that PDM-ULs could significantly improve the bioavailability of UroA, with an absorption efficiency 1.91 times that of TFM-ULs. Therefore, our findings suggest that liposomes prepared by pH-driven methods have great potential in improving the stability and bioavailability of UroA.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2023
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IF 8.6
Junwei Chen,Qianwen Yu,Mingxia Wang,Dan Liu,Linfang Dong,Zhenyu Cui,Benqiao He,Jianxin Li,Feng Yan
The treatment of various oily wastewaters generated in human production and life has been a huge challenge in recent years. Responsive materials for controlled wettability surface have a great potential for oil-water separation. Inspired by the superior pH-responsive of poly (2-( N, N′ -dimethylamino) ethyl methacrylate) (PDMAEMA), a pH-responsive self-cleaning PVDF ultrafiltration membrane containing both carboxyl and tertiary amine groups were prepared by a simple grafting and co-blending method. The membrane fabrication process consisted of introducing 3-Dimethylaminopropylamine (DMPA) into the SMA side chain, resulting in the creation of the amphiphilic polymer DMPA@SMA. This polymer was then mixed with PVDF to produce DMPA@SMA/PVDF membranes. The optimized DMPA@SMA/PVDF membranes showed excellent superhydrophilicity/underwater superhydrophobicity, with a water contact angle of 0° and an underwater oil contact angle higher than 150° for crude oil. These endowed the as prepared membrane with a high pure water flux of 852 L·m −2 ·h −1 and anti-crude-oil-adhesion property. The separation efficiency exceeded 98% for various surfactant-stabilized oil-in-water emulsions, whether it’s positively charged emulsion or negatively charged emulsion. More interestingly, the carboxyl and tertiary amine groups presented the membrane with pH responsivity, and the membrane surface can be triggered by acid or alkali with self-cleaning performance. Strategy proposed in the present work offers a convenient and effective way to prepare membranes treating oil-in-water emulsions with either negative or positive charges.
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CHEMICAL ENGINEERING JOURNAL
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2023
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IF 15.1
Li Sun,Chaoqun Hou,Nuo Wei,Yifei Tan,Qianwei Liang,Jianguo Feng
Environmentally responsive pesticide nanocarriers can respond to the metabolites of pathogenic fungi as well as the soil microenvironment to achieve intelligent release of pesticides. In this work, a smart pH and cellulase dual environmentally responsive pesticide delivery system (Tebu@ZnMOFs@CMC) was constructed by combining carboxymethyl cellulose (CMC) and Zn-based metal–organic frameworks (ZnMOFs), which are loaded with tebuconazole (Tebu). Physicochemical characterization indicates the successful preparation of Tebu@ZnMOFs@CMC nanoparticles. The Tebu loading capacity was approximately 18.26%. Release simulations showed a higher cumulative release of Tebu under acidic and cellulase-promoted conditions. The surface coverage of carboxymethyl cellulose could effectively improve its spread on wheat and rice leaves. Compared with tebuconazole suspension concentrate (Tebu@SC) and tebuconazole technical, Tebu@ZnMOFs@CMC nanoparticles showed higher antifungal activity. It also had lower acute toxicity to zebrafish, Daphnia magna and earthworms, and no significant effect on wheat and rice. Thus, the dual environmentally responsive Tebu@ZnMOFs@CMC nanoparticles have great potential for achieving on-demand and targeted pesticide delivery.
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JOURNAL OF APPLIED POLYMER SCIENCE
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2023
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IF 3
Zhao Wang,Jiajian Shi,Mengyao Gu,Xiaojuan Zhang,Ruilong Sheng
Developing facile, green, and efficient synthetic methodology for preparing surface-functionalized nanogels has attracted tremendous attention in the field of polymer chemistry and biomaterials engineering. Herein, a series of “clickable” P(MAA-PMA) nanogels with reactive alkyne groups were conveniently prepared by “one-pot” reflux-precipitation polymerization (RPP), their particle sizes and zeta potentials are solid content-dependent. Using P(MAA-PMA)-1 nanogels as the model, the physicochemical properties including particle size, surface potential, morphology, solution stability, and pH/redox responsiveness were characterized in detail. Moreover, the pH/redox dual-responsive drug release feature/kinetics and parameters were analyzed using Korsmeyer–Peppas model and Gallagher–Corrigan model. Then the surface of nanogels was facilely modified with various thiol-containing functional ligands via thiol-yne photo click reaction. As targeted drug carriers, doxorubicin (DOX)-loaded folic acid (FA)-functionalized nanogels (FA@Nanogels/DOX) demonstrated higher tumor cell proliferation inhibition effect in B16F10 cancer cells than that in CHO-K1 normal cells, while the non-FA-functionalized counterparts (Nanogels/DOX) do not show similar effect. This work provides a versatile “one-pot RPP-photo Click functionalization” strategy to construct surface-functionalized pH/redox dual responsive nanogels for efficient and targeted drug delivery.
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JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
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2023
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IF 3.4
Xueqiang Sun,Fuxin Li,Lingyan Yuan,Zhitong Bing,Xun Li,Kehu Yang
Resveratrol (Res) is known for its potential in treating various types of cancers, with a particular advantage of causing minimal toxic side effects. However, its clinical application is constrained by challenges such as poor bioavailability, low water solubility, and chemical instability in neutral and alkaline environments. In light of these limitations, we have developed a pH-responsive drug delivery nanoplatform, Res@ZIF-8/TA NPs, which exhibits good biocompatibility and shows promise for in vitro cancer therapy. Benefiting from the mild reaction conditions provided by zeolitic imidazolate frameworks (ZIFs), a “one-pot method” was used for drug synthesis and loading, resulting in a satisfactory loading capacity. Notably, Res@ZIF-8/TA NPs respond to acidic environments, leading to an improved drug release profile with a controlled release effect. Our cell-based experiments indicated that tannic acid (TA) modification enhances the biocompatibility of ZIFs. 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di- phenytetrazoliumromide (MTT assay), Hoechst 33342/PI staining, cell scratch assay, Transwell and Reverse Transcription quantitative PCR (RT-qPCR) assays further demonstrated that Res@ZIF-8/TA NPs inhibited colon cancer cell migration and invasion, and promoted apoptosis of colon cancer cells, suggesting a therapeutic potential and demonstrating anti-cancer properties. In conclusion, the Res@ZIF-8/TA NPs pH-responsive drug delivery systems we developed may offer a promising avenue for cancer therapy. By addressing some of the challenges associated with Res-based treatments, this system could contribute to advancements in cancer therapeutics.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Yuting Zhang,Xin Gao,Xiaoning Tang,Lincai Peng,Heng Zhang,Shumei Zhang,Qiuyue Hu,Jiaqi Li
Cellulose hydrogels have gained attention in the field of wound healing due to their biodegradability, biocompatibility, and the capacity to sustain a humid environment that promotes healing. Conventional cellulose hydrogels were usually lacked responsiveness to changing wound conditions, and limited capacity for controlled release of active substances. The composite hydrogels with Berberine (BBR) loading were prepared from bamboo parenchymal cellulose and in situ crosslinking carboxylated-β-cyclodextrin (BPCH-B) via dissolution. The inclusion of BBR enhanced the antibacterial properties of cellulose hydrogel while maintaining biocompatibility and drug delivery capabilities. The dual-responsive dressing was demonstrated to modulate drug release kinetics in accordance with the pH and temperature conditions prevailing within the wound site. Specifically, study exhibited a significant increase in drug release (over 70 %) under alkaline pH (7.6) and temperature (40 °C) conditions. Full-thickness wound healing experiments indicated that BPCH-B had better healing ability, and the wound healing area of BPCH-B treated was 80 % within 12 days, while the control group was only 50 %. This strategy for generating functional wound healing can be further control release of drug compounds for treatment of wounds, enabling development of practical wound care materials.
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ACS Applied Energy Materials
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2023
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IF 6.4
Xiaoxiao Cheng,Yun Tong
Structural engineering of the molybdenum disulfide (MoS2) retains its importance for the application of the hydrogen evolution reaction (HER) in a full pH range. However, the catalytic performance of reported MoS2-based materials, especially in neutral conditions, is unsatisfactory. Herein, an effective synergy between CoP, Ni2P, and MoS2 nanosheets is established via a simple strategy, which constructs a self-supporting (CoP/Ni2P/MoS2–CC) electrode endowed with abundant catalytic active sites, optimal electronic structure, and improved charge transfer capability. The optimized CoP/Ni2P/MoS2–CC sample shows low overpotentials of 335, 119, and 211 mV at 100 mA cm–2 in neutral, alkaline, and acidic electrolytes with small Tafel slopes of 63, 62, and 82 mV dec–1, respectively. Remarkably, the catalytic performance in neutral medium is superior to that of most of the reported MoS2-based hybrid electrocatalysts. Our work proves a facile and feasible strategy to promote the pH-universal catalytic activities of MoS2-based heterogeneous structures for hydrogen production.
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International Journal of Polymeric Materials and Polymeric Biomaterials
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2023
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IF 3.2
Wenqin Xu,Xing Li,Xianmei Wu,Guanghua Pan,Nanchun Chen,Xiuli Wang,Qinglin Xie
pH-responsive hydrogel antibacterial microspheres were prepared by complex coacervation method and used as drug carriers to load the antibiotic substitute potassium diformate (KDF). The results showed that the three-dimensional network structure of the composite hydrogel was formed among the polysaccharide components, and Zeolite A loaded with KDF was uniformly dispersed in it. The results of drug release behavior and kinetics in vitro showed that the drug release rate was higher and the release mechanism followed the Ritger-Peppas model, which indicated that the antibacterial microspheres had a good pH response. In vitro, the carrier showed broad-spectrum antibacterial activity, good biocompatibility, and degradability.
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