BMEMat
·
2024
·
IF 0
He Ren,Zewen Wu,Jingxuan Li,Nan Zhang,Coo Yee Nah,Jiexin Li,Jingyu Zhang,Jonathan F. Lovell,Liyun Zhang,Yumiao Zhang
Rheumatoid arthritis (RA) is a systemic autoimmune disease that leads to the destruction of articular cartilage and bone. RA is characterized by immune cell infiltration and abnormal proliferation of synoviocytes in the joints. Herein, we developed a biomimetic formulation via co-loading the anti-inflammatory agent Celastrol (Cel) along with the stabilizer Vitamin K (VK) in antirheumatic methotrexate (MTX)-conjugated Pluronic F127 (F127) micelles. Micelles were then coated with B cell derived membrane, yielding MTX loaded Cel Micelle (CeViM)-micelle@B, which were investigated for RA treatment. VK, used at levels well within safety margins, was identified as a carrier compound that could stabilize Cel within micelles, increasing the encapsulation efficiency of Cel. In addition, MTX, a front-line RA therapeutic, was chemically grafted to F127 via a responsive linker sensitive to the chemically reducing environments. As such, CeViM-micelle@B released pristine MTX in response to the intracellular reducing environments, which combined with Cel to suppress pro-inflammatory responses. B cell membrane coating enhanced accumulation of CeViM-micelle@B in joints, leading to a 75% decrease of inflammatory cytokine secretion in vitro, and significantly ameliorated cartilage and bone structures in the collagen-induced arthritis murine model. Taken together, this biomimetic nanoparticle holds potential as a next-generation targeted RA treatment.
研究领域:
免疫学
·
药理学
·
纳米医学
·
自身免疫疾病
✓ 已验证
DOI
Landslides
·
2019
·Vol. 16
·期 7
·1313-1324
·
IF 4.252
Yang Wentao,Wang Yunqi,Sun Shao,Wang Yujie,Ma Chao
Detecting slope movement before landslides occur in mountain regions is crucial for disaster reduction. In October 2018, a gigantic landslide occurred on the Jinsha River, causing dammed-lake breach flood 500 km downstream. In this work, we used 25 Sentinel-2 images from November 2015 to August 2018 to explore the capability of this high temporal resolution optical images in detecting slope movement before the Jinsha River landslide. Normalized difference vegetation index (NDVI) was calculated to composite temporal profiles using all Sentinel-2 images. With this NDVI time series, unsupervised K-means classifier was applied to initially classify the study area and find the best thresholds for automatically extracting landslide scars in the image series. These extracted landslide scars were validated using interpreted results from two high spatial resolution images of similar dates in 2015 (user’s accuracy 89.7%, producer’s accuracy 83.6%) and 2018 (user’s accuracy 90.8%, producer’s accuracy 74.9%). After validation, extracted landslide scars of different years were counted and displayed in an RGB composite image to highlight slope movement. In addition, monotonous decrease/increase of NDVI was also observed, indicating continuous expansion of landslide scarps and movement of landslide head along the slope on the landslide surface. This work demonstrated the capability of Sentinel-2 time series images to capture slope movement with short revisit time at low cost. By incorporating other environmental information (such as elevation), this proposed method has the potential to consistently map pre-landslide slope movements over a large region.
研究领域:
遥感地质学
·
环境灾害监测
·
地理信息系统
·
山地灾害防治
·
地球观测
✓ 已验证
DOI
高影响因子
Joule
·
2024
·
IF 38.6
Boya Wang,Wanhai Zhou,Yanyan Zhang,Tengsheng Zhang,Xinran Li,Yutong Feng,Ruizheng Zhao,Wei Li,Ahmed Elzatahry,Yasser Hassan,Dongyuan Zhao,Dongliang Chao
Potassium-sulfur electrochemistry represents a compelling energy storage technology due to its cost-efficient chemicals and unparalleled capacity. However, achieving high sulfur redox utilization (SRU) remains a great challenge during K + storage due to K 2 S n kinetics inertia. Here, for the first time, we unveil an aqueous K + -S electrochemistry, leveraging boosted K 2 S n conversion kinetics in water. A stable two-electron charge transfer process is achieved via tuning K 2 S solubility. Spectroscopic evaluation and molecular dynamics simulations reveal a unique solid-liquid-solid conversion pathway (S ↔ K 2 S 4 ↔ K 2 S), which effectively avoids soluble K 2 S shuttling. Consequently, an unprecedented K + storage capacity of 1,619 mAh g −1 ( ca. 96% SRU) can be achieved with 95% initial Coulombic efficiency, appealing cyclability over 500 times, and a high-energy density of 392 Wh kg S+Zn −1 . These findings signify a paradigm shift and introduce transformative opportunities for the design of safe and high-energy aqueous batteries.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
Small
·
2024
·Vol. 20
·期 44
·2404581
·
IF 13
Pengxiang Zhang,Feng Dang,Xin Zhang,Ce-Wen Nan,Bao-Wen Li
Printing technology enables the integration of chemically exfoliated perovskite nanosheets into high-performance microcapacitors. Theoretically, the capacitance value can be further enhanced by designing and constructing multilayer structures without increasing the device size. Yet, issues such as interlayer penetration in multilayer heterojunctions constructed using inkjet printing technology further limit the realization of this potential. Herein, a series of multilayer configurations, including Ag/(Ca 2 NaNb 4 O 13 /Ag) n and graphene/(Ca 2 NaNb 4 O 13 /graphene) n ( n = 1–3), are successfully inkjet-printed onto diverse rigid and flexible substrates through optimized ink formulations, inkjet printing parameters, thermal treatment conditions, and rational multilayer structural design using high- k perovskite nanosheets, graphene nanosheets and silver. The dielectric performance is optimized by fine-tuning the number of dielectric layers and modifying the electrode/dielectric interface. As a result, the graphene/(Ca 2 NaNb 4 O 13 /graphene) 3 multilayer ceramic capacitors exhibit a remarkable capacitance density of 346 ± 12 nF cm −2 and a high dielectric constant of 193 ± 18. Additionally, these devices demonstrate moderate insulation properties, flexibility, thermal stability, and chemical sensitivity. This work shed light on the potential of multilayer structural design in additive manufacturing of high-performance 2D material-based ceramic capacitors.
研究领域:
材料科学
·
电子工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FUSION SCIENCE AND TECHNOLOGY
·
2026
·
IF 1.2
Hu Wang,Chao Fang,Zhengbao Yu,Jin Liu,Jing Huang,Jing Wei,Weihua Wang,Wei Lu,Xiaowu Yu
The thermal conductivity of epoxy resin decreases sharply to approximately 0.01 W·m−1·K−1 at 4 K, significantly limiting its application in nuclear fusion engineering. To address this limitation, this study prepared epoxy composite reinforced with silver, diamond, or wollastonite at 50 vol % and 70 vol %, and systematically investigated their 4-K thermal conductivity. The results demonstrated that at 70 vol %, the silver epoxy composite achieved a thermal conductivity of 5 W·m−1·K−1, which is more than two orders of magnitude higher than that of the diamond-epoxy composite (0.05 W·m−1·K−1). At 50 vol %, the silver epoxy composite (0.12 W·m−1 ·K−1) exhibited similar thermal conductivity to the wollastonite epoxy composite (0.1 W·m−1·K−1). Increasing the silver filler from 50 to 70 vol % enhanced the thermal conductivity from 0.12 to 5 W·m−1·K−1, representing a 42-fold improvement.Through combined theoretical analysis, microstructural characterization, and finite element analysis, the following conclusions were drawn. The electron conduction–dominated fillers were the preferred choice for the cryogenic thermal conductivity epoxy composite. In the discrete composite, even the electron conduction–dominated filler could not significantly improve the cryogenic thermal conductivity of the epoxy composite; even 50 vol % silver only reached approximately 0.12 W·m−1 ·K−1. The synergistic effect between the filler type and the distribution (electron conduction–dominated filler combined with continuous filler distribution) can substantially enhance the cryogenic thermal conductivity of the epoxy composite. This work provides technical support for the design of high-performance thermal management materials for superconducting magnet cooling systems in fusion reactors.
✓ 已验证
产品关联
DOI
高影响因子
Materials Today Communications
·
2024
·
IF 3.7
Shengtao Liang,Junshan Hu,Ming Xu,Luxiang Xu,Hao Fu
The effect of K + ions doping on YbVO 4 : Er 3+ was studied under the excitation of a 980 nm laser. The intensity of multiple emission peaks increased was found to be enhanced at 527 nm ( 2 H 11/2 → 4 I 15/2 ), 553 nm ( 4 S 3/2 → 4 I 15/2 ), 654 nm ( 4 F 9/2 → 4 I 15/2 ), and 803 nm ( 4 I 9/2 → 4 I 15/2 ), including green, red, and near-infrared spectra. The optimal doping concentration was 0.1 K + ions in YbVO 4 : 0.02Er 3+ . The enhancement of upconversion luminescence is attributed to the presence of defect bands, which facilitate the absorption of excited photons and enable effective energy transfer from abundant electrons to Yb 3+ ( 2 F 5/2 ) and Er 3+ ( 4 I 11/2 ) ions. YbVO 4 : Er 3+ /K + was utilized in a three-mode temperature sensor, employing TCEL modes of 2 H 11/2 / 4 S 3/2 , NTCEL modes of 2 H 11/2 / 4 F 9/2 and 4 S 3/2 / 4 F 9/2 , and single luminescence intensity at I 803 . It exhibited maximum relative sensitivities of 1.36 % (298 K), 0.77 % (398 K), 0.44 % (298 K), and 1.69 % (623 K), respectively, highlighting its potential in high-precision optical temperature sensing applications.
研究领域:
材料科学
·
光学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF POWER SOURCES
·
2024
·
IF 8.1
Shuang Liu,Ying Wang,Zhengxin Zhu,Jingwen Xu,Zuodong Zhang,Kai Zhang,Song Jin,Zehui Xie,Taoli Jiang,Xiaoyang Wang,Zaichun Liu,Jinghao Chen,Qia Peng,Muhammad Sajid,Touqeer Ahmad,Wei Chen
Rechargeable hydrogen gas batteries are gaining significant attention as a highly reliable electrochemical energy storage technology. However, the high costs of both cathode and anode limit their widespread applications. Here, we demonstrate a low-cost H 2 /K + hybrid battery using Fe–Mn-based Prussian white - K 2 · 74 Mn[Fe(CN) 6 ] 0.90 ·0.13H 2 O (KMF) as cathode and non-noble metal high entropy alloy (NNM-HEA) as anode. It demonstrates a high capacity of 146.1 mAh g −1 at 1 A g −1 with excellent rate performance and stability. Even with a ∼7-fold increase in active loading of the KMF cathode, the capacity of the H 2 /K + battery remains as high as 100.5 mAh g −1 . Furthermore, a low-cost H 2 /K + hybrid battery using our newly developed NNM-HEA based hydrogen catalytic anode is successfully fabricated, which shows an extended capacity with a retention of 90% after 1200 cycles. This work will pave the way for designing low-cost electrode materials for high-performance, large-scale energy storage hydrogen gas batteries.
研究领域:
材料科学
·
能源存储技术
✓ 已验证
产品关联
DOI
高影响因子
CARBON
·
2021
·
IF 9.594
Na Yang,Rong Shao,Zhengping Zhang,Meiling Dou,Jin Niu,Feng Wang
Gelatin, a natural macromolecular substance formed by the hydrolysis of collagen, offers the advantages of abundant resources and low cost. It is a good precursor for the synthesis of N, O-doped carbon materials. Although some gelatin-derived carbon materials have been used for electrochemical energy storage , there have been few studies for the mechanism of gelatin carbonization . In addition, the influence of heteroatoms and defects on the K-ion storage performance remains unclear. In this work, in situ and ex situ characterization methods have been used to study the mechanism of gelatin carbonization. The pathways leading to formation of the carbon framework, heteroatom doping and defect generation in gelatin-based carbons during the pyrolysis process have been clearly identified. Moreover, by means of DFT calculations and experimental measurements, it has been confirmed that heteroatoms and defects both play important roles in improving the storage performance of potassium ions. By virtue of its abundance of both heteroatoms and defects, our optimized anode shows better electrochemical performance than graphite anodes. This study not only clarifies our understanding of carbonization mechanism and mechanism of K-ion storage in carbon materials, but also provides pathways for the synthesis and applications of new carbon-based anode materials for alkali-ion batteries.
✓ 已验证
产品关联
DOI
高影响因子
CHEMISTRY OF MATERIALS
·
2024
·
IF 7.2
Huan Pei,Luyong Zhang,Huanhuan Cheng,Shibin Wang,Zhihua Yang,Fangfang Zhang,Shilie Pan
Four hydroxyfluorooxoborates, α-K2[B3O3F4(OH)] (I), β-K2[B3O3F4(OH)] (II), Cs(NH4)3[B3O3F4(OH)]2 (III), and RbCs5[B3O3F4(OH)]3 (IV), with identical fundamental building block (FBB) [B3O3F4(OH)]2–, were obtained successfully and characterized comprehensively. A phase transition between I and II was detected, which led to a space group evolution from centrosymmetric to noncentrosymmetric. The F– and OH– substitution effect was studied based on II and its hydroxyborate derivative K2[B3O3(OH)5], which reveals the corresponding changes in the band gap and the nonlinear optical properties. In addition, the cationic-size effect on the arrangement of the [B3O3F4(OH)]2– FBBs and the birefringent properties were discussed for the title compounds. This study contributes to the advancement of structural chemistry and sheds some light on the structure–property relationship studies of hydroxyfluorooxoborates.
研究领域:
材料化学
·
晶体学
✓ 已验证
产品关联
DOI
高影响因子
CHEMISTRY OF MATERIALS
·
2024
·
IF 7.2
Meng Cao,Jisheng Song,Haonan Ren,Fan Yang,Rong Chen
With the development of integrated circuit miniaturization, the RC delay caused by the interconnect resistance of metal wires and the capacitance of interlayer dielectric materials limits the high integration and miniaturization of electronic devices. As a promising low-k dielectric material, metal–organic frameworks (MOFs) can effectively alleviate this problem. In this work, we report an atomic regulation strategy of ultralow k MIL-53 film, achieved by converting an Al2O3 seed layer deposited via atomic layer deposition (ALD) and subsequently modifying through atomic layer infiltration (ALI). Thanks to the linear relationship between the thickness of the MIL-53 film and the Al2O3 seed layer prepared by ALD, precise nanoscale control of the MIL-53 films was realized. To meet both mechanical and dielectric property requirements, ALI modification is introduced, effectively regulating Young’s modulus and hardness of MIL-53 films from 19.5 and 0.17 GPa to 29.1 and 0.36 GPa, respectively, while the dielectric constant can be tuned from 1.93 to 2.59. The reconciliation of these properties is achieved by regulating the porosity of the MIL-53 framework through the additional Al–O clusters during the ALI. Furthermore, the superhydrophobic properties (140.7°) and the nearly constant dielectric constant after 9 months of aging reflect its potential as a dielectric insulating material. The proposed preparation and modification strategy of MOF films based on atomic regulation has broad potential for application in low-k interconnect integrated circuits.
研究领域:
材料科学
·
电子工程
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 7
·3409-3416
·
IF 3.925
Hao Liu,Yaowei Wang,Fengqi Zhang,Congcong Xu,Xiaoyuan Liao,Yan Jiang,Shuxiang Lu
A series of K-based oxide catalysts supported on aluminium oxide (γ-Al2O3) with different surface areas were synthesized using an impregnation method and investigated by the decomposition of sulfones from oxidized diesel fuels. The synthesized catalysts were characterized by N2 adsorption–desorption isotherms, CO2-TPD and HR-SEM methods to explore the relationship between the structure of the catalysts and sulfone conversion. The results showed that the K element was highly dispersed on the surface of γ-Al2O3. The prepared catalyst was further applied in the decomposition reaction of dibenzothiophene sulfone (DBTS) to evaluate the catalytic performance. The sulfone conversion could achieve 63.9% in 10% K2O/3-Al2O3 within 20-minute reaction time at 260 °C. Moreover, our experimental test showed that the sulfone conversion was linearly correlated with the logarithm of the total basic sites of the K2O/γ-Al2O3 catalyst.
研究领域:
化学工程
·
催化科学
✓ 已验证
DOI
高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2025
·Vol. 109
·期 1
·e70351
·
IF 3.8
Lulu Jiang,Wenqi Lei,Zhiming Zhao,Kejia Chen,Chuangchang Lei,Donglin Han
Ba 3 MoNbO 8.5 is a recently emerging hexagonal perovskite-derivative oxide with high oxide ion conductivity. Mo and Nb-sites were commonly doped with acceptor dopants to regulate the transport properties. In this work, Ba-site was introduced with cation deficiency and doped with K. The tolerance of Ba-deficiency ( x ) in Ba 3‒ x MoNbO 8.5‒ x is within 0.03–0.06, and the solubility of K ( x ) in Ba 3‒ x K x MoNbO 8.5‒ x /2 is higher than 0.3. Although forming Ba-deficiency of x = 0.03 does not influence the conductivity significantly, doping K to x = 0.15 and 0.3 decreases the bulk conductivity obviously. Furthermore, even though these samples can be hydrated, H 2 O/D 2 O isotope effect was not observed, indicating that there is no or negligibly small proton conduction, and hydration even decreases the bulk conductivity. Interestingly, doping K reduces the difference in conductivity between the measurements in the dry and wet atmospheres. By annealing in a wet atmosphere for 90 h, the Ba 2.7 K 0.3 MoNbO 8.35 composition is unstable at 400°C, but shows good chemical stability at 600°C.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）