ACS Biomaterials Science & Engineering
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2022
·
IF 5.395
Wenyi Xia,Tao Yan,Lianlei Wen,Shijie Zhu,Wang Yin,Miao Zhu,Meidong Lang,Chunsheng Wang,Changfa Guo
Despite the fact that heart transplantation (HTx) is a relatively mature procedure, heart ischemic and reperfusion (I/R) injury during HTx remains a challenge. Even after a successful operation, the heart will be at risk of primary graft failure and mortality during the first year. In this study, temperature-sensitive polymer poly(N-n-propylacrylamide-co-N-tert-butyl acrylamide) (PNNTBA) was coated on diallyl trisulfide (DATS)-loaded mesoporous silica nanoparticles (DATS-MSN) to synthesize hypothermia-triggered hydrogen sulfide (H2S) releasing particles (HT-MSN). Because the PNNTBA shell dissolves in phosphate-buffered saline at 4 °C, the loaded DATS could continuously release H2S within 6 h when activated by glutathione (GSH). Furthermore, after co-culturing biocompatible HT-MSN with cardiomyocytes, H2S released from HT-MSN at 4 °C was found to protect cardiomyocytes from ischemic and reperfusion (I/R) injury. In detail, the rate of cell apoptosis and lactate dehydrogenase activity was decreased, as manifested by increased BCL-2 expression and decreased BAX expression. More importantly, in an isolated heart preservation experiment, HT-MSN demonstrated potent protection against cardiac I/R injury and reduced expression of inflammatory factors TNF-α and IL-1β. This study provided a new method for the controlled release of H2S by the donor and myocardial protection from I/R injury.
研究领域:
药理学
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纳米技术
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心脏病学
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生物医学工程
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Journal of Cleaner Production
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2026
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IF 10.7
Haojie Mu,Lei Hu,Ying Sun,Yongping Liu
The recycling of spent lithium iron phosphate batteries (LFPs) has enormous market potential and great significance for environmental protection and sustainable development. Notably, lithium extraction slag (LES) recovery is a critical link in the full-process recycling of spent LFPs, while existing technologies are often limited by low impurity separation efficiency, poor environmental compatibility, or high costs. Herein, this study innovatively integrated solvent extraction with LES recovery and proposed a method for efficient impurity separation and preparation of high-purity 2D flaky regenerated iron phosphate (R-FePO 4 ). Three extractant systems were evaluated for purifying LES leachate, and TBP-kerosene was identified as the optimal extractant composition with corresponding optimal operating conditions determined. Fe and P could be co-extracted, and under conditions of 80% TBP volume fraction ( φ TBP = 80%), 60 s extraction time, and initial phase ratio R = 3, their single-stage extraction efficiencies reached approximately 99.20% and 38.50%, respectively, with excellent impurity separation performance. After cascaded extraction, the maximum extraction efficiencies of Fe and P reached 100% and 82.60%, respectively. McCabe-Thiele diagrams for Fe and P were constructed to determine the theoretical number of stripping stages. After three-stage countercurrent stripping, the maximum mass concentrations of Fe and P in the stripping solution reached 29.20 and 17.23 g L −1 , respectively, while contents of impurities (Al, Ni, Co, Mn, Cu, Ti) remained extremely low. HCl and R-FePO 4 were recovered from the stripping solution via evaporation and chemical precipitation, respectively. XRD, FT-IR, SEM, and EDS characterizations verified that the product was 2D flaky FePO 4 . Chemical titration and ICP-OES analysis showed the Fe/P molar ratio of R-FePO 4 was 0.969, and its impurity content met requirements of multiple standards simultaneously. Collectively, these results confirm the successful recovery of high-purity 2D flaky R-FePO 4 from LES via this method, with the comprehensive recovery rates of Fe and P reaching nearly 100%. Cyclic performance tests of the extractant demonstrate its excellent regenerative performance. The economic and environmental performance of the proposed process was evaluated, revealing its enormous industrial application potential. Eventually, a novel technical process is provided for the LES recycling industry to achieve maximum resource utilization.
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APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
·
2026
·Vol. 132
·期 9
·968
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IF 3
Shahbaz Muhammad Ali Hamza,Nasir Hamid,Afzal Amir Muhammad,Imran Muhammad,Chine Zied,Mumtaz Sohail,Kumar Abhinav,Kamran Muhammad Arshad
Developing multifunctional electrode materials that integrate high energy storage capacity with catalytic activity is essential for next-generation energy systems. Herein, a hierarchically engineered NiSnSe₂@r-GO@Ni-MOF composite was synthesized by the use of a two-step hydrothermal process, combining the high conductivity of r-GO, the porous framework of Ni-MOF, and the redox activity of NiSnSe₂. Structural and morphological investigations (SEM, XRD, Raman, XPS, and BET–BJH) confirmed the formation of a well-integrated mesoporous architecture with a large available electroactive sites and effective electron–ion transport. Electrochemical evaluation exhibited a high specific capacity of 1297.8 C g⁻¹. The assembled asymmetric device (NiSnSe₂@r-GO@Ni-MOF//AC) achieved an energy density of 44.8 Wh kg⁻¹ and a power density of 1120 W kg⁻¹, with 90% capacity retention over 7,000 cycles. Additionally, the composite exhibited excellent HER response and delivered a low overpotential of 49 mV and a Tafel slope of 52 mV dec⁻¹. The boosted bifunctional enactment is accredited to strong interfacial coupling and stabilizes the electrode structure, which highlights a scalable strategy for designing efficient multifunctional heterostructure to overcome the energy crisis in the present era.
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RSC Advances
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2023
·Vol. 13
·期 17
·11728-11732
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IF 3.9
Yanqiang Tong,Weihua Zou,Delin Sun,Zhangheng Wang
Thermochromic wood is an important research direction for wood modification in recent years, and a red poplar-based thermochromic composite (R-PTC) had been prepared in our previous study by compositing a mixture of phase change reagents (tetradecyl ester: C28H56O2 and methyl red: C15H15N3O2) and full poplar wood. In order to improve the heating storage ability of R-PTC and encapsulating phase change reagents to prevent leakage, a new R-PTC composite (PS-R-PTC) was prepared by encapsulated R-PTC with polyethylene glycol 400 (PEG400)–SiO2 in this work. Compared to the original R-PTC samples, the cell walls of PS-R-PTC were not significantly changed by the SiO2 film and we also found that PS-R-PTC with PEG400 (90%)–silica solutions (10%) mixture had better heat storage performance and PS-R-PTC (90%) has better enthalpy change value (R-PTC: 43.01 J g−1; PS-R-PTC (90%): 71.82 J g−1). The PS-R-PTC can show the function of thermal energy storage, which is used in wooden buildings and can be a feasible insulating material for reducing thermal energy losses and hence reducing energy usage. In PS-R-PTC, SiO2 combines with the –OH of the R-PTC and the –OH of PEG400 (HO(CH2CH2O)nH), and these –OH lose hydrogen ions too.
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MATERIALS & DESIGN
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2023
·
IF 8.4
Chao-ping He,Wen-juan Quan,Ya-ling Zeng,Hong-yan Zhou,Pei-dong You,Zhen-xian Li,Ya-mei Li,Li-mei Lin,Bin Liu,Duan-fang Liao,Qin-hui Tuo
Reducing lipid uptake of macrophages and stimulating cholesterol efflux are two necessary steps for atherosclerotic plaque regression. In this study, a compound of curcumin nicotinate (CN) was synthesized from nicotinic acid which can raise raising high-density lipoprotein (HDL) and curcumin which can lower lipid. However, the shortcomings of CN, such as poor water solubility and low bioavailability, limit its clinical application. In this article, a CN loaded biomimetic nanosystem was constructed by using Prussian blue nanoparticles (PB NPs) to improve its solubility, thereby changing its administration route. In addition, hyaluronic acid (HA) modification on the biomimetic PB NPs was adopted to prolong circulation time and improve the accumulation of drugs in the plaque region. Mechanism studies have shown that the constructed nanosystem could exert anti-AS effects through the pathway of Proprotein Convertase Subtilisin/Kexin Type 9(PCSK9) /Low-density lipoprotein receptor (LDL-R), ATP Binding Cassette Transporter A1(ABCA1) /Caveolin-1 /Liver X Receptor (LXR). These findings indicated that the designed nano-platform is expected to be used for prevention and targeted therapy of atherosclerosis.
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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2022
·
IF 7.088
Lei Pang,Jin Li,Zheng Liu,Yin-Sheng Quan,He Huan Sui,Yi Jia,Fener Chen,Jung Joon Lee,Peng Liu,Zhe-Shan Quan,Qing-Kun Shen,Hong-Yan Guo
An extensive study was performed to discover a series of novel 20( R )-panaxadiol derivatives with various substituents at the 3-OH position as nontoxic, brain-permeable, multi-target leads for treating Alzheimer's disease . In vitro analysis revealed that a compound bearing benzyl-substituted carbamate , which we denoted compound 14a , exhibited the most potent neuroprotective activity, with an EC 50 of 13.17 μM. The neuroprotective effect of compound 14a was slightly more potent than that of donepezil and much more potent than that of 20( R )-panaxadiol. Compound 14a at 7.5–120 μM exhibited low toxicity in various cell lines. In addition, compound 14a exhibited a wide range of biological activities , including inhibiting apoptosis ; inducing tau hyperphosphorylation ; affecting beta-amyloid (Aβ), β-secretase, reactive oxygen species , tumor necrosis factor-α, cyclooxygenase-2, and interleukin-1β production; and promoting Aβ 25-35 disaggregation. The effective permeability of compound 14a across the blood-brain barrier was 26.13 × 10 −6 cm/s, indicating that it can provide adequate exposure in the central nervous system. Further, compound 14a improved learning, memory, and novel object recognition in mice, and in vivo toxicity experiments confirmed a good therapeutic safety range. Thus, compound 14a is a promising multifunctional lead for treating Alzheimer's disease and offers new avenues for natural product-derived anti-Alzheimer's disease drugs.
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高影响因子
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
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2022
·Vol. 70
·期 2
·697-706
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IF 2.724
Shijin Wu,Bijiao Wang,Hongde Yan
Asymmetric reduction of ( R )-carvone and ketoisophorone by an engineered ene-reductase from Galdieria sulphuraria (GsOYE) combined with glucose dehydrogenase for NADPH regeneration were studied. A semi-rational protein engineering was used to enhance the activity and selectivity of GsOYE. Upon the sequence alignment and molecular docking results, two amino acid residues at positions 66 and 270 were selected as saturation mutation sites. Finally, a single substitution variant of GsOYE-N270A with complete conversion (100%) and diastereoselectivity (de p >99%) for reduction of ( R )-carvone and a double substitution variant GsOYE-Y66P/N270H with improved stereoselectivity for reduction of ketoisophorone were obtained.
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Asian Journal of Pharmaceutical Sciences
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2022
·
IF 9.273
Mengfang Wu,Tian Xia,Yaran Li,Tianfa Wang,Shijia Yang,Jinchao Yu,Qiaoyan Liang,Teng Shen,Min Yu,Bing Zhao
Cardiovascular disease is the leading cause of global mortality, with anticoagulant therapy being the main prevention and treatment strategy. Recombinant hirudin (r-hirudin) is a direct thrombin inhibitor that can potentially prevent thrombosis via subcutaneous (SC) and intravenous (IV) administration, but there is a risk of haemorrhage via SC and IV. Thus, microneedle (MN) provides painless and sanitary alternatives to syringes and oral administration. However, the current technological process for the micro mould is complicated and expensive. The micro mould obtained via three-dimensional (3D) printing is expected to save time and cost, as well as provide a diverse range of MNs. Therefore, we explored a method for MNs array model production based on 3D printing and translate it to micro mould that can be used for fabrication of dissolving MNs patch. The results show that r-hirudin-loaded and hyaluronic acid (HA)-based MNs can achieve transdermal drug delivery and exhibit significant potential in the prevention of thromboembolic disease without bleeding in animal models. These results indicate that based on 3D printing technology, MNs combined with r-hirudin are expected to achieve diverse customizable MNs and thus realize personalized transdermal anticoagulant delivery for minimally invasive and long-term treatment of thrombotic disease.
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Arabian Journal of Chemistry
·
2023
·
IF 6
Peipei Zhou,Ying Kuang,Lihua Zuo,Shuhong Liang,Zhuolun Li,Lei Chen,Jingxue Li,Jun Zhang,Chenhan He,Xiaobao Wang,Yaojuan Chu,Jianying Pei,Zhi Sun,Shuzhang Du
Background Danshen Ligustrazine Injection (DSLI), composed of the extract of Salvia miltiorrhiza Bunge and Conioselinum anthriscoides 'Chuanxiong', is commonly used in the clinical treatment of ischemic stroke, which is the most common type of cerebrovascular disease, affected by multiple factors. The brain-gut axis is a new type of influencing factor for ischemic stroke, however, there is a lack of systematic research on the relationship between microbiota and host metabolic phenotype. This study aimed to investigate the host metabolic phenotype-microbiome interface in ischemic stroke and the immunomodulatory effects of DSLI. Methods In the study, liquid chromatography-mass spectrometry was used to primarily analyze the quality markers (Q-markers) and the polyphenols of DSLI. Based on 16S rRNA gene sequencing and metabolomics, the variations of microbial composition in different groups were characterized. In addition, a network diagram was constructed to reveal the interrelationship between DSLI-regulated gut microbiota changes and DSLI-regulated brain metabolites in MCAO/R rats. The expression of the aryl hydrocarbon receptor (AhR) in the colon and brain by immunofluorescence and suppressors of cytokine signaling 2 (SOCS2) by western blot were further detected. Results Diminished metabolic diversity and alterations in the tryptophan metabolism pathway were a feature of IS in the study. The results revealed that Clostri_UCG-014 was positively correlated with indoleacrylic acid, indole-3-methylacetate, and Ruminococcaceae was strongly related with L-tryptophan, 3-methylindole, and indole. The results of immunofluorescence showed that the expression of AhR in the colon and brain tissues of rats in the model group was greatly reduced compared with that in the sham-operated group, and was heavily activated with the treatment of DSLI. The levels of aryl hydrocarbon nuclear receptor ARNT2 and SOCS2 were down-regulated in the brains of Model rats, whereas increased by DSLI, further confirming that the brain-gut microbiota-Trp metabolism exists in the pathological changes of stroke and the intervention mechanism of DSLI. Conclusions The present study findings suggest Clostri_UCG-014, Ruminococcaceae, and Firmicute_RF39 play an important role in improving the regulation of immune function in stroke through tryptophan metabolites by acting on the AhR-SOCS2 axis.
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BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT
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2019
·
IF 1.097
Yu Wang,Huanhuan Shao,Suiyi Zhu,Kejian Tian,Qing Qiu,Hongliang Huo
In this study, we investigated environmental oestrogen 17β-estradiol (E2) degradation by a mixed culture of Rhodococcus equi DSSKP-R-001(RS) and Comamonas testosteroni QYY20150409(CT). The results demonstrated that the two strains exhibited synergistic E2 degradation activity, showing that multispecies bacterial systems can improve microbial survival and activity. The E2 degradation rate for the mixed culture system was 94% under conditions in which E2 was the sole source of carbon and growth energy, while the degradation rates of the R. equi DSSKP-R-001 and C. testosteroni QYY20150409 single strains were 86% and 76%, respectively. Comparing and analyzing the degradation products of E2, intermediate cross-metabolism products were observed in the culture containing the two bacteria. The metabolic products of benzene were essentially removed during the process of E2 degradation in the mixed culture, which showed stronger degradation ability than cultures of the individual strains. The results from this investigation on the degradation of E2 by individual and mixed bacterial cultures provide a theoretical basis for the microbial remediation of environmental oestrogens.
研究领域:
环境科学
·
微生物学
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ADVANCED POWDER TECHNOLOGY
·
2014
·
IF 1.642
Renping Cao,Kangbin Chen,Qianglin Hu,Wensheng Li,Hui Ao,Chunyan Cao,Tao Liang
A series of Sr (1 − x − y − z ) MoO 4 : x Eu 3+ , y Bi 3+ , z R + (R + = Li + , Na + , and K + ) phosphors are prepared through solid-state reaction method in air. Eu 3+ doped SrMoO 4 phosphor can show red emission at ∼616 nm under excitation 275 nm and 397 nm light due to the 5 D 0 → 7 F 2 transition of Eu 3+ ion, and its emission intensity can be enhanced after co-doping Bi 3+ owing to energy transfer between Bi 3+ and Eu 3+ ions. The mechanism of energy transfer is discussed by the schematic energy level diagrams of Bi 3+ and Eu 3+ ions. The optimal composition in Eu 3+ and Bi 3+ co-doped SrMoO 4 phosphors is determined to be (Sr 0.92 Eu 0.05 Bi 0.03 )MoO 4 . The emission intensity of SrMoO 4 :Eu 3+ , Bi 3+ phosphor is found to be further improved by using Li + , Na + , and K + ions as charge compensators. These experiment results in the paper are helpful to develop novel and high-efficiency phosphors for white light-emitting diodes.
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ENZYME AND MICROBIAL TECHNOLOGY
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2014
·
IF 2.966
Chuan-Yang Shang,Wei-Xun Li,Rui-Feng Zhang
ZnO nanowires were successfully introduced into a macroporous SiO 2 by in situ hydrothermal growth in 3D pores. The obtained composites were characterized by SEM and XRD, and used as supports to immobilize Candida antarctica lipase B (CALB) through adsorption. The high specific surface area (233 m 2 /g) and strong electrostatic interaction resulted that the average loading amount of the composite supports (196.8 mg/g) was 3–4 times of that of macroporous SiO 2 and approximate to that of a silica-based mesoporous material. Both adsorption capacity and the activity of the CALB immobilized on the composite supports almost kept unchanged as the samples were soaked in buffer solution for 48 h. The chiral resolution of 2-octanol was catalyzed by immobilized CALB. A maximum molar conversion of 49.1% was achieved with 99% enantiomeric excess of ( R )-2-octanol acetate under the optimal condition: a reaction using 1.0 mol/L ( R , S )-2-octanol, 2.0 mol/L vinyl acetate and 4.0 wt.% water content at 60 °C for 8 h. After fifteen recycles the immobilized lipase could retain 96.9% of relative activity and 93.8% of relative enantioselectivity .
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危险品化学品经营许可证（带存储）