Nature Synthesis
·
2026
·
IF 22.6
Jia Xiaoke,Chen Li,Xiong Kun,Wang Yujie,Zhou Linjie,Xu Xiaohui,Li Shuang,Wang Mao,Thomas Arne,Cheng Chong
Covalent organic frameworks (COFs) are promising photocatalysts for hydrogen peroxide (H 2 O 2 ) production, yet their rational design remains challenging. Although machine learning has advanced the prediction of properties of porous materials, its application to COF-based photocatalysis faces two major challenges: the representation of multilevel structural features and the limited availability of training datasets. Here we present a comprehensive computational framework, termed ‘information co-evolution’, that accelerates the discovery of efficient COF structures for H 2 O 2 photosynthesis. This framework integrates two pathways: to mitigate data limitations, we introduce data augmentation techniques and ensemble modelling; concurrently, to address the structural encoding challenge, we introduce a cross-level feature fusion strategy that integrates these fragment descriptors with mechanism-driven physical descriptors. These strategies collectively reduced the validation root mean square error from 4.70 to 3.31. Among over 10,000 candidates, our framework can successfully identify high-performance COFs for H 2 O 2 photosynthesis, for example, COF-343 achieves a H 2 O 2 photosynthetic rate of 12,978.7 μmol h −1 g −1 . The model interpretation further unveiled critical structural motifs, offering information for the rational design of COF photocatalysts beyond traditional trial-and-error methods.
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SCIENCE
·
2026
·Vol. 391
·期 6792
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IF 47.3
Liping Cai,Qing Zhang,Tianxiong Yao,Xiaoxiao Zou,Lei Xie,Siyu Yang,Yanyuan Xiao,Fei Huang,Zhiwei Peng,Jiawen Yang,Jianzhen Huang,Qiqi Jing,Ziqi Ling,Min Zheng,Chuanmin Qiao,Jinyuan Wu,Jiaqi Chen,Tao Jiang,Qin Liu,Min Liu,Zhe Chen,Jingquan Li,Hui Jiang,Haoyun Jiang,Zuoquan Chen,Yaya Liao,Yizhong Huang,Longyun Li,Yunyan Zhou,Zhou Zhang,Chao Yin,Yu Ye,Hui Yang,Biao Chen,Zhong Wang,Huanfa Gong,Dong Chen,Cong Huang,Xinkai Tong,Zhimin Zhou,Hao Fu,Yingchun Sun,Xiao Sun,Min Yan,Lin Wu,Shuqi Xiong,Yaxiang Wang,Xinke Xie,Mengqing Zhou,Xiaodong Liu,Xianhua Xie,Fusheng Wu,Zifeng Liu,Mei Ge,Sanya Xiong,Chenyu Li,Tao Shen,Yuxin Liu,Xi Tang,Xiaolong Chang,Siyi Liu,Chuangang Yu,Naixiang Yu,Zikang Hu,Dengshuai Cui,Jiahong Zhong,Sha Liu,Jianchao Hu,Yang Wen,Weiwei Zhou,Guanyue Wei,Shiyao Lin,Yiwen Xiahou,Liqing Chen,Jianjun Li,Ruirong Liu,Xiaoyun Chen,Yujie Shu,Feng Chen,Chao Wei,Xiaofen Hu,Yong Li,Yong Hou,Qingjie Zeng,Jun Gao,Ying Su,Jing Li,Junwu Ma,Yuanmei Guo,Congying Chen,Shijun Xiao,Huashui Ai,Zhiyan Zhang,Weiwei Liu,Qiang Yang,Yuyun Xing,Lin Rao,Bin Yang,Lusheng Huang
Although massive cell atlases are already available, it is still a challenge to obtain an atlas of all tissues within a single body, especially in fetuses and pregnant mothers. We present a transcriptomic atlas of 2.56 million single cells covering 115 and 119 tissues from one fetal pig and its pregnant mother, respectively. We found that a cluster of heart capillary endothelial cells with enhanced fatty acid transit capability was enriched for pregnancy but restored after gestation. We also deciphered that l -leucine transport insufficiency in the trophoblast causes fetal growth restriction by reducing a muscle type II myofiber subcluster. Our “all-from-one” strategy enabled the identification of tissue cell type–specific transcription factors and provided insights into pregnancy heart adaptation and fetal growth restriction.
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Nature Communications
·
2026
·
IF 18.1
Wang Chang-ting,Lin Canjie,Xu Kai,Liu Yang,Lao Zhongtao,Cao Jianping,Liu Bei,Baqais Amal,Bin Bandar Khaled,Aldrees Saud,Alhussaini Mohammed A.,Leu Shao-Yuan,Ghaffour Noreddine,Gan Qiaoqiang,Wang Wenbin,Wang Peng
Downward solar evaporation with multistage configurations is a promising off-grid solution for high-efficiency potable water production. However, a major, yet often overlooked, barrier to practical application is the significant, unquantified performance gap between laboratory benchmarks and field operation, arising from the complex environmental factors. To diagnose this gap, this work first introduces the Environmental Robustness Index (ERI), the ratio of field-to-lab normalized water productivity ( P’ ), as an essential metric. A comprehensive framework is then developed to precisely quantify the effect of key environmental factors, including wind, sky cooling, and ambient temperature, on the ERI. Guided by the framework, we present the spectrally selective air lock strategy as a universal principle to suppress environmental heat losses and improve ERIs. Implementing this strategy significantly enhances downward solar evaporator’s ERIs from 0.55 to 0.98, effectively closing the gap. This study establishes a framework for solar evaporation to move beyond reporting P’ lab alone and utilize ( P’ lab , ERI) as the dual metrics for advancing real-world applicability.
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Nano-Micro Letters
·
2026
·Vol. 18
·期 1
·303
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IF 38.5
Zhu Huang,Wang Ting,Gao Shihuan,Geng Wei,Ma Tian,Cheng Liang,Han Xianglong,Deng Jiuhong,Gao Shanshan,Cheng Chong
The phage-inspired de novo design of the artificial peroxidase (IrNC@TiO 2 ) features robust subnanometer cluster sites and a sea-urchin-like topography.
The potent enzymatic activity of Ir clusterzymes and the topological advantages of the spiky substrate endow IrNC@TiO 2 with the ability to effectively capture and eradicate planktonic Streptococcus mutans while inhibiting biofilm formation.
IrNC@TiO 2 can significantly inhibit tooth-surface biofilm development, prevent enamel demineralization, and reduce caries incidence in anticaries experiments
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Journal of Energy Chemistry
·
2026
·
IF 15.6
Suli Chen,Zhengrui Miao,Junhong Guo,Haiying Che,Zi-Feng Ma,Tianxi Liu
Gel polymer electrolytes hold significant promise for next-generation solid-state sodium metal batteries (SMBs) due to their high ionic conductivity and favorable interfacial contact with electrodes. However, their practical application is limited by inherent flammability, inferior mechanical properties, and poor interfacial compatibility with sodium metal anodes. Herein, we introduce a rationally designed covalently crosslinked nanoconfinement strategy to in situ build a mechanically robust asymmetric flame-retardant composite gel electrolyte (AFCGE) to achieve highly stable SMBs, where a chemically crosslinked covalent organic framework (COF) network is constructed on a glass fiber matrix along with synchronously polymerized flame-retardant polymers. The in situ formed COF network provides innate nanochannels that spatially confine polymer growth, which not only enhances mechanical robustness but also significantly promotes local Na + transport kinetics and facilitates uniform sodium deposition at the anode side, thereby effectively suppressing dendrite growth. Thus, the AFCGE exhibits high ionic conductivity, excellent mechanical properties, superior flame retardancy, and outstanding interfacial stability. Na/Na symmetric cell achieves an ultralong cycling lifespan exceeding 4000 h with low polarization at 0.1 mA cm −2 . Quasi-Solid-state SMBs further demonstrate excellent electrochemical performance, and no thermal runaway or electrolyte leakage occurs in pouch cells, underscoring their potential for safe and durable energy storage.
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Analytical Methods
·
2026
·
IF 3
Jiajia Wang,Chun Kan,Demeng Qian,Mingping Gao,Ayang Zhou,Bao-Kang Jin
CA-125, as a tumor marker for ovarian cancer, plays an importance role for rapid and sensitive detection in early diagnosis. Herein, a label-free electrochemical immunosensor based on COF/PTh/MB nanocomposite was constructed for the detection of CA-125.The TAPB-DMTP-COF material, with its large surface area and stable porous framework, was used as the substrate. However, its poor conductivity hindered electron transfer. To address this, conductive polymer PTh was combined with the COF to enhance the composite's conductivity. Meanwhile, MB was used as a signal probe, and differential pulse voltammetry (DPV) was adopted to measure the electrochemical signal. Under optimized experimental conditions, the proposed immunosensor exhibited excellent performance for the CA-125 detection, with a detection range of 1 mU/mL-10000 mU/mL, and a low detection limit of 0.34 mU/mL (S/N = 3), providing a potential platform for clinical application.
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Nature Communications
·
2026
·
IF 18.1
Dong Tengteng,Xu Xiaohui,Chen Li,Yang Jiani,Guo Mengchao,Zhou Mi,Xu Min,Xue Weichao,Ren Xiancheng,Li Shuang,Cheng Chong
Covalent organic frameworks with three-dimensional networks and interconnected porous structures show promising advantages for hydrogen peroxide photocatalysis. However, 3D COFs are typically constructed from 3D-oriented knots with less conjugation and insufficient light absorption, which significantly inhibits their performance. Herein, we present a universal defect engineering approach by systematically replacing T d knots with trigonal planar ligands and modifying linear linkers with electron-withdrawing/donating groups to achieve simultaneous enhancement of light absorption and precise electronic tuning of 3D donor-acceptor structures. Experimental results and theoretical analysis reveal that the optimized 3D COF with planar ligands induced defects and fluorine functional groups (COF-300-D-F), which achieve an H 2 O 2 production rate of 19.09 mmol g −1 h −1 and apparent quantum yield of 11.95% at 400 nm with benzyl alcohol as sacrificial agent. Moreover, the material maintains long-term stability during continuous operation exceeding 96 hours and exhibits high activity in photocatalytic benzylamine coupling reactions.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Rongchuan Yue,Yanxu Liu,Yangchun Li,Yao Zhang,Jing Luo,Yijuan Huang,Kun Wang,Junqi Gou,Yonghong Zhang,Chenshi Rao
In this study, an injectable conductive hydrogel (MeGG/PN@PP@G-8) based on a gellan gum/chitosan dual network (MeGG/PN) was designed and constructed. PEDOT: PSS imparts electrical coupling to the material, while the G-8 small molecule provides anti-inflammatory and anti-fibrotic activity. This system reduced ROS levels by 93.7% under H₂O₂-induced oxidative stress and increased the proportion of RAW264.7 macrophages toward the M2 phenotype by threefold, thereby shaping an immune microenvironment conducive to repair. In a rat myocardial infarction model, MeGG/PN@PP@G-8 patch treatment reduced IL-1β, IL-6, and TNF-α expressions by 96.1%, 95.3%, and 94.9%, respectively, nearly returning to sham group levels. Furthermore, treatment with the hydrogel reduced fibrosis area and enhanced angiogenesis and sarcomere remodeling. Transcriptome analysis further revealed that the material simultaneously inhibits pro-pathogenic pathways such as NF-κB/TNF and TGF-β/SMAD, while activating PI3K-Akt, ECM receptors, and angiogenic genes, achieving multi-pathway synergistic effects of anti-inflammatory, anti-fibrotic, pro-regenerative, and electrophysiological repair. The “wet adhesion-electrical coupling-drug synergy” strategy proposed in this study provides an innovative material platform and mechanistic basis for tissue regeneration and functional recovery after myocardial infarction.
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COMPOSITES COMMUNICATIONS
·
2026
·
IF 8.6
Fuhao Liu,Shifa Su,Zhenhua Wang,Shanhu Niu,Dawei Li,Na Zhang,Chuanhui Gao
To meet the demand for lightweight, high-performance and green sustainable materials, basalt fiber-reinforced polyamide 66 (BF/PA66) composites show great application potential in aerospace and automobile manufacturing. However, poor interfacial compatibility between basalt fibers (BF) and PA66 matrix limits their comprehensive performance. In this study, BF surfaces were modified with amino (KH-550), epoxy (KH-560) and mercapto (KH-590) silane coupling agents to enhance interfacial bonding. Systematic tests were conducted on composites with 15 wt% fiber content. The results showed that all silane coupling agents were successfully grafted onto BF surfaces via Si-O-Si covalent bonds, improving fiber surface roughness and reactivity. KH-550 modification achieved the optimal performance: tensile, flexural and impact strengths increased by 25.12%, 45.57% and 46.08% respectively compared with pure PA66, with the strongest interfacial binding energy (−7.84 kcal/mol). Additionally, KH-550 reduced water absorption by 38.89% and improved thermal stability. This study provides an efficient and eco-friendly method for interfacial regulation of BF/PA66 composites.
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PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
·
2026
·
IF 7.9
Zilin Nie,Yang Liu,Quanhua Xie,Lu Ran,Tianyi Hu,Haixing Chang,Hassan Karimi-Maleh,Wenliang Fan,Haiyan Yao,Nianbing Zhong
Glyphosate is a persistent herbicide that contaminates water and poses health risks, yet conventional removal methods remain limited. Photocatalysis offers a promising alternative but is hindered by issues such as charge recombination, poor light utilization, and the formation of phosphate (PO 4 3- ) by-products. In this study, a coupled system is constructed, comprising ZnIn 2 S 4 nanocage (ZIS-HNCs)/BiOCl mesoporous single-crystal nanosheet (BiOCl MSCN) heterojunction–photocatalytic optical and Fe-modified zeolite fibers, to completely remove glyphosate from aqueous environments. Light radiated from the hollow optical fibers excites the ZIS-HNCs/BiOCl MSCN photocatalyst to generate electron–hole pairs. The formation of a heterojunction between ZIS-HNCs and BiOCl MSCN accelerates interfacial charge transfer, increases the production of holes and electrons, and consequently enhances their performance in degrading glyphosate. PO 4 3- produced from photocatalytic degradation is removed in situ by the Fe-modified zeolite fibers through Fe–O–P coordination and electrostatic adsorption. This suppresses the quenching of photogenerated electron–hole pairs by PO 4 3- , further enhancing the efficiency of glyphosate degradation and inhibiting the formation of phosphate by-products. The photocatalysis–ion adsorption coupling strategy provides a novel and effective approach for the simultaneous removal of pesticide residues from aquatic environments.
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ENVIRONMENTAL RESEARCH
·
2026
·
IF 8.2
Yong Chen,Huiping Zeng,Jiaxin Xu,Sibo Fu,Yuliang Zhu,Fanxu Zeng,Luyao Teng,Jiahao Wu,Fanhao Meng,Dong Li,Jie Zhang
This work simplified the structure of waste iron-containing sludge from groundwater treatment plants to explore its mechanism of activating periodate(PI) for degrading organic pollutants in water. The pH during preparation was used to regulate the crystallinity and the doping of transition metal Mn in the precursor solution to prepare catalysts similar to the waste iron-containing sludge. Sulfadiazine (SDZ) was selected as the model contaminant, and it was found that the efficiency of the prepared catalyst to remove the contaminants was 100% in 10min by activating PI. Combining electrochemical and performance experiment results, it was found that the amorphous part of the material can optimize the electronic structure and enhance the electron transfer ability. However, Mn doping can also reduce the electron transfer resistance, and the synergistic effect of Fe-Mn bimetal occupied a more important part in the entire catalytic system. According to the results of Electron paramagnetic resonance (EPR) and quenching experiments, it was found that although a variety of free radicals were produced, the active substances that contributed the most were IO 3 • and 1 O 2 . The materials showed certain environmental adaptability in the subsequent experiments. This study provides theoretical support for removing organic pollutants from waste iron-containing sludge and provides some basic insights for bimetal synergistic activation of PI.
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Journal of Agriculture and Food Research
·
2026
·
IF 7.2
Qile Zhang,Zhengming Zhou,Yiu Ming Cheung,Hoi Wa Yeung,Minghui Li,Chufeng He,Jian Zhu,Wing Tak Wong
Global arable land is shrinking. Public health burdens from metabolic and intestinal disorders are rising. Developing functional cereal crops for marginal lands is now a critical research priority. This study investigated a novel resistant starch (RS)-enriched Seawater Rice (SR). We compared its benefits to Waxy Rice (WR) and Normal Rice (NR). SR had the highest RS content and WR was dominated by rapidly digestible starch. In an oral glucose tolerance test, SR uniquely reduced acute postprandial glycemic spikes. In vitro fermentation showed SR distinctly altered gut microbiota. SR downregulated pathogenic Escherichia-Shigella and enriched beneficial Bifidobacterium and Ligilactobacillus . In Dextran sodium sulfate (DSS)-induced colitis mouse model, SR alleviated body weight loss and enhanced intestinal barrier function. It also restored key short-chain fatty acids (SCFAs) levels. WR and NR showed no protective effects. These findings highlight SR’s RS-driven superiority via the gut microbiota-SCFA axis, supporting its potential as a functional food for glycemic control and colitis prevention.
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