JOURNAL OF POLYMER SCIENCE
·
2023
·Vol. 61
·期 24
·3276-3287
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IF 3.4
Jinglei Xing,Ge Zhu,Xingzhong Fang,Guofei Chen
To meet the needs of high heat-resistant and colorless polyimide (CPI) films, a series of poly(amide-imide) (PAI) films were synthesized by copolymerization of 1,2,3,4-cyclobutanetetracarboxylic dianhydride (CBDA), terephthaloyl chloride (TPC), 4,4′-(hexafluoroisopropylidene)diphthalic anhydride (6FDA) and 2,2′-bis(trifluoromethyl)benzidine (TFDB) with the addition of lithium chloride (LiCl) for ionic coordination. The coordination of Li cations with carbonyl groups significantly reduced the coefficient of thermal expansion (CTE) and improved the mechanical properties. Moreover, by adjusting the ratio of CBDA and TPC, all PAI films exhibited high glass transition temperature ( T g ), low CTE and high transparency. Among these PAI films, PAI-6-2Li exhibited excellent comprehensive performance with a high T g of 363 °C, low CTE of 6.4 ppm/K, high transmittance of 84% at 400 nm and tensile modulus of 7.2 GPa, which was expected to be used in the field of flexible displays. Graphical
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2023
·Vol. 24
·期 18
·13695
·
IF 5.6
Jia Sun,Zuying Zhou,Yang Zhou,Ting Liu,Yueting Li,Zipeng Gong,Yang Jin,Lin Zheng,Yong Huang
The purpose of this study was to elucidate the metabolic action patterns ofP. forrestiiagainst rheumatoid arthritis (RA) using metabolomics, and to obtain its potential effective substances for treating RA. First, the therapeutic effects ofP. forrestiiagainst RA were confirmed; second, the chemical composition ofP. forrestiiwas analyzed, and 17 prototypes were absorbed into blood; subsequently, plasma metabolomics studies using UPLC-Triple-TOF-MS/MS and GC-MS were performed to disclose the metabolomics alterations in groups, which revealed 38 altered metabolites after drug intervention. These metabolites were all associated with the arthritis pathophysiology process (−log(p) > 1.6). Among them, sorted by variable important in projection (VIP), the metabolites affected (VIP ≥ 1.72) belonged to lipid metabolites. Finally, Pearson’s analysis between endogenous metabolites and exogenous compounds was conducted to obtain potential pharmacological substances for theP. forrestiitreatment of RA, which showed a high correlation between five blood-absorbed components andP. forrestii-regulated metabolites. This information provides a basis for the selection of metabolic action modes forP. forrestiiclinical application dosage, and potential pharmacological substances that exerted anti-RA effects ofP. forrestiiwere discovered. The study provided an experimental basis for further research on pharmacoequivalence, molecular mechanism validation, and even the development of new dosage forms in the future.Keywords:Periploca forrestiiSchltr.;rheumatoid arthritis;network pharmacology;metabolomics;pharmacodynamic substances
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JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
·
2023
·
IF 3.4
Taixiang Gao,Hongxiong Zhang,Qinqing Li,Feng Zhao,Nan Wang,Wenbin He,Junlong Zhang,Rui Wang
Fuzi decoction (FZD) is clinically used to treat chronic heart failure (CHF) in China, but the mechanism underlying FZD treatment in CHF remains unclear. Here, we investigated the potential mechanism underlying FZD treatment of CHF in rats. First, the compounds in FZD-containing serum of rats were identified, and 16 S rRNA sequencing and GC–MS-based untargeted metabolomics analysis were then performed. The levels of fecal short-chain fatty acids (SCFAs) were determined and compared, and fecal microbiota transplantation (FMT) was used to verify the role of the gut microbiota . Our results identified 27 in FD-containing serum. FZD increased the Firmicutes -to- Bacteroidetes ratio and the Lactobacillus abundance and affected the β diversity of the gut microbiota in rats with CHF. Differential species analysis showed that Lactobacillus and Prevotella were biomarkers of FZD treatment of CHF. Untargeted metabolomics analysis revealed that FZD affected valine , leucine and isoleucine biosynthesis; galactose metabolism; and aminoacyl-tRNA biosynthesis in rats with CHF. Furthermore, FZD significantly increased the acetic acid, propionic acid , butyric acid and isopentanoic acid levels in the feces of rats with CHF. Correlation analysis showed that the butyric acid and Lactobacillus levels had the strongest correlation in the control, sham and high-dose FZD (HFZD) groups, and many microbiota components were closely related to differentially abundant metabolites. FMT revealed that the fecal microbiota obtained from the HFZD group changed the heart rate; the brain natriuretic peptide (BNP), acetic acid, propionic acid, butyric acid, and metabolite levels; and the gut microbiota in rats with CHF. In summary, our study revealed that the mechanism of action of FZD in CHF treatment may be related to improvements in the gut microbiota, elevations in the SCFA content and the regulation of valine, leucine, and isoleucine biosynthesis; galactose metabolism; and other metabolic pathways.
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FOOD CHEMISTRY
·
2023
·
IF 8.8
Youfang Huang,Yueyue Zhang,Yilin Yu,Xiaochong Song,Xiaojia Huang
Specific capture is a beneficial tactic in simultaneous monitoring of sulfonamides (SAs) and quinolones (QLs). For this purpose, a new magnetic molecularly imprinted adsorbent based on double-template molecules (DT-MIP@MNA) was facilely prepared by “one-pot” hydrothermal technique and utilized as the adsorbent of magnetic solid-phase extraction (MSPE). Molecular simulation technique was employed to quickly screen functional monomer. The recognition factors of prepared adsorbent towards templates sulfamethazine and nalidixic acid were 5.89 and 2.90, respectively, and the corresponding adsorption capacities were as high as 8.85 mg/g and 8.97 mg/g, respectively. Under the optimized parameters, the proposed DT-MIP@MNA/MSPE was combined with HPLC to simultaneously and selectively monitor trace SAs and QLs residuals in water and milk samples. The achieved limits of detection were 0.012–0.028 μg/L and 0.015–0.032 μg/kg for water and milk samples, respectively. The current supplied a sensitive, reliable and anti-interference method for simultaneously monitoring trace SAs and QLs in food.
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FOOD CHEMISTRY
·
2023
·
IF 8.8
Hua Huang,Jinqiang Yan,Huaxue Yan,Biao Jiang
Surface wax crystals play important roles in protecting plants from pest and disease invasions, and UV irradiation. The wax crystals are less probed individually from the fruit surfaces. Herein the morphologies, chemicals and an efficient method to sample the wax blooms of white wax gourd were addressed. Various crystalloids such as rodlets, platelets, fragments, and granules were observed, which stacked as fine wax film covering on wax gourd fruit surface. The wax blooms were effectively removed by cryo-adhesive after consecutive manipulating set by a high-end device with cylinders. Wax crystals were dominated by triterpenols and triterpenol acetates over 61 % of total crystals, followed by vey-long-chain aliphatics. Accordingly, the high-end device with cryo-adhesive provides an efficient approach to selectively probe the wax crystals from those fruits covering wax blooms. The elucidation of morphologies and chemical compositions of wax crystals may help to better understand their regulations on fruit quality traits.
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CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Yanxiao Yang,Yunfeng Guo,Zhe Qiu,Weihua Gong,Yonggui Wang,Yanjun Xie,Zefang Xiao
Metal-organic frameworks (MOFs) are characterised by high porosity levels and controllable structures, making them ideal adsorbents for wastewater. However, obtaining substrate materials with mechanical stability, excellent pore accessibility, and good processability for compositing MOF crystal powders to adsorb multiple pollutants in complex aqueous environments is challenging. In this study, porous MOFs@ modified cellulose sponge (MCS) composites were fabricated using MCS as a scaffold to provide anchoring sites for the coordination of Zr 4+ ions and further in situ synthesis of MOFs, namely UiO-66@MCS and UiO-66-NH 2 @MCS, which effectively removed heavy metal ions and organic dyes. MOFs@MCS composites exhibit excellent water and dimensional stability, maintaining the pore structure by ambient drying during reuse. Compared with UiO-66@MCS composite, UiO-66-NH 2 @MCS composite exhibited a higher adsorption capacity of 224.5 mg·g −1 for Hg 2+ and 400.9 mg·g −1 for methylene blue (MB). The adsorption of Hg 2+ onto the MOFs@MCS composites followed the Langmuir and pseudo-second-order models, whereas the Freundlich and pseudo-second-order models were more suitable for MB adsorption. Moreover, the MOFs@MCS composites exhibited excellent reusability and were selective for the removal of Hg 2+ . Overall, this approach effectively combines Zr-based MOFs with mechanically and dimensionally stable porous cellulose sponges, rendering the approach suitable for purifying complex wastewater.
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PROGRESS IN ORGANIC COATINGS
·
2023
·
IF 6.6
Jinglong Pan,Xi Liu,Xiangkang Cao,Xiaoze Ma,Yunfei Hu,Guangyi Cai,Xinxin Zhang,Zehua Dong
Environmentally friendly antifouling coatings have received increasing attention in the field of marine infrastructures. In this work, a carboxy-betaine salicylate surface-modified silica nanofiller (QAs-SA@SiO 2 NPs) was synthesized and doped in polyurethane coatings (PU) to gain durable antifouling properties. The modified silica NPs were prepared by the covalent bond grafting method and then dispersed in PU paint to produce a kind of composite anti-fouling coating (QAs-SiO 2 PU). It is noted that the QAs-SiO 2 PU coating can adjust the release rate of salicylate according to environmental pH value. Once the salicylate layer was dissolved, the inner amphoteric carboxy-betaine molecules would be exposed to form a hydrated layer on QAs-SA@SiO 2 NPs, thus realizing a step-by-step antifouling performance. The experimental results show that the 7 wt% addition of QAs-SA@SiO 2 filler in the PU coating can reduce protein adhesion by 99.1 %, bacterial adhesion by 99.8 %, and chlorella adhesion by 95.0 %, presenting a significant mussels-repellence ability compared to the pristine PU coating. This work may provide a promising approach to designing eco-friendly and durable marine anti-fouling and anti-corrosion coatings.
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SYNTHETIC METALS
·
2021
·
IF 3.266
Yanyu Gao,Wei Zhang,Dongxu Li,Xiaoxue Lin,Xin Qiao,Haijun Niu,Wen Wang
Electrochromic (EC) materials have captured intense attentions in the field of smart window, label screen and camouflage recently. The structure of EC active group is crucial to the properties of product. In this study, novel PAs with EC and memory properties were developed by polycondensation of asymmetry triarylamine N, N ' -bis(4-aminophenyl)-N-isopropyl-N ' -phenylbenzene-1,4-diamine (IPATAA) with five different dicarboxylic monomers. An isopropyl group of the IPATAA molecule is linked to a nitrogen atom to increase electron density and solubility. Furthermore, PAs are apt to be processed into a film by spin-coating or printing. After electro-oxidation, PAs films change from colorless to blue. The coloring time and bleaching time is 2.8–4.1 s and 2.6–4.5 s, respectively. The highest coloring efficiency of PAs film is 366 cm 2 C −1 . Memory devices made using the PAs show non-volatile memory characteristics such as lower switching threshold voltages (<1.08 V) and better switching current ratios (>2 × 10 4 ).
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Catalysis Science & Technology
·
2021
·Vol. 11
·期 10
·3527-3538
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IF 6.119
Kaixin Li,Limin Deng,Shun Yi,Yabo Wu,Guangjie Xia,Jun Zhao,Dong LU,Yonggang Min
Hydrogen-bonding (HB) induced by the water solvation shell is vital in chemical and biological systems. Herein, HBs related to the binding behavior of protonic ionic liquids (PILs) with water molecules were found to dominate in the acid catalysis of the glycosidic bond in hydrolysis. Spectroscopic techniques, including temperature-related NMR and solvatochromic UV/vis, were employed to investigate the distinct HB interactions of the PILs in the continuous solvent phase. The results revealed that both the sulfonic groups and the N-containing groups synergistically govern the deprotonation of the PILs and consequently the reaction efficiency of the PILs via HBs. Furthermore, the intermolecular HBs between the PIL and the solvent clusters were found to be responsible for the superior catalytic activity of the PILs over the conventional sulfuric acid. A linear correlation between the hydrolysis rate (k–k0) and catalyst concentration was established in the PILs and sulfuric acid. Their linearization indicates a secondary proton release from the anion of PILs, which was not observed in the case of sulfuric acid. Computational studies showed that the PIL-catalysed mechanism obeyed the dynamic “one-step” protonation of the glycosidic bond by the surrounding explicit solvent water molecules. A lower free energy barrier was obtained by the PILs in comparison with sulfuric acid. The reasons behind this were concluded to be the easy secondary proton release from the PILs by the consecutive nucleophilic activation of water molecules via HBs, offering a more acidic solution for reactant protonation, and the other was the background positive charge of solvent water molecules induced by HBs, stabilizing the transition state in the process.
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JOURNAL OF ELECTRONIC MATERIALS
·
2021
·Vol. 50
·期 6
·3078-3083
·
IF 1.938
Wu Wanyi,Wang Mengkun,Huang Huihui,Gu Wenxian,Yan Chengzhan,Chen Guang,Yin Dewu,Jin Huile,Wang Jichang,Wang Shun
In this work, hierarchically porous carbon spheres co-doped by iron and nitrogen were synthesized via in situ dehalogenation. The rich porous structure and relatively high specific surface area (210 m 2 /g) facilitate the formation of an ultra-fine Fe 2 N active phase and FeN 4 active centers within the carbon matrix. Transmission electron microscopy and X-ray photoelectron spectroscopy analysis further reveal the presence of a dominant Fe 2 N phase and minor FeN 4 bonds in the as-prepared Fe-N-C-pd-800 samples. Because of this, the oxygen reduction reaction (ORR) process can more readily take place on Fe 2 N than on FeN 4 , and the Fe 2 N phase enriched Fe-N-C-pd-800 carbon spheres exhibit a promising onset potential ( E onset =1.02 V) and half-wave potential ( E 1/2 =0.86 V) in alkaline media. In addition, Fe-N-C-pd-800 also shows excellent methanol resistance and long-cycling stability.
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ENERGY & FUELS
·
2021
·
IF 3.605
Yongjiang Yuan,Tingyu Zhang,Zhe Wang
A highly stable anion exchange membrane (AEM) is constructed by linking bipyridine to a polyetheretherketone (PEEK) polymer. First, PEEK is prepared by the polycondensation reaction; N-bromosuccinimide and benzoyl peroxide are used for the bromination reaction; and then pyridine or 4,4′-bipyridine is connected to PEEK by the Friedel–Crafts alkylation reaction. The successful preparation of the target product was confirmed by the collaborative analysis of the Fourier transform infrared spectrum and 1H nuclear magnetic resonance spectrum. The ionic conductivity test showed that the highest hydroxide conductivity of PyBPEEK-50% and BiPyBPEEK-50% at 80 °C reached 36.99 and 32.05 mS cm–1, respectively, which proved that they can meet the basic requirements. The alkali stability test showed that the ionic conductivity of the membrane could still reach 88.46% after 750 h of immersion in 1 M NaOH at room temperature, which proved that the cross-linking structure composed of 4,4′-bipyridine effectively weakened the attack of OH– on AEMs. In addition, the cross-linked structure effectively balances the loss of mechanical properties as a result of water absorption and membrane swelling. The swelling rate of BiPyBPEEK-50% at 80 °C is only 4.4%, and the tensile strength can reach 66 MPa. Therefore, to avoid the introduction of too many uncontrollable factors in the complicated synthesis process, this work used a simple method to synthesize AEMs based on the bipyridine cross-linked structure and compared its performance gains and losses through non-cross-linked membranes. The potential application value of this method in the field of fuel cells is verified.
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ChemSusChem
·
2021
·Vol. 14
·期 11
·2341-2351
·
IF 8.928
Bo Zhou,Fan Song,Xinyue Ma,Lijun Wang
Graphical The batch is back : A scalable green catalyst system based on a TiO 2 nanoparticle–exfoliated montmorillonite composite catalyst with hard Lewis acid sites and abundant accessible Brønsted acid sites is developed for the rapid preparation of furfural acetals, which are a promising biofuel with high octane value, high calorific value, and high oxidation resistance. Furfural acetals with high octane value, high calorific value and high oxidation resistance are considered promising biofuels or fuel precursors with huge potential demand. However, there are few studies on efficient scalable catalyst systems, including continuous-flow catalyst systems, for their preparation. In this work, TiO 2 nanoparticles supported on exfoliated montmorillonite, with strong Lewis acid sites and abundant accessible Brønsted acid sites, is used to catalyze the acetalization reactions of biomass-derived furfural and alcohols. Low dosage of the catalyst made the reaction reach equilibrium in a very short time (TOF=690–1305 min −1 ) at room temperature with the acetal as the only product. In continuous-flow reactions, the catalyst showed a stable product output with conversion close to that for the batch reaction with a short catalyst-reactant contact time of 150 s. Contrast experiments revealed that both Lewis and Brønsted acid sites on the catalyst were indispensable for maximizing the catalytic performance, and simultaneously activating both furfural and alcohol on the adjacent Lewis and Brønsted acid sites was proposed to be responsible for the high catalytic performance.
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