ACS Applied Materials & Interfaces
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2025
·
IF 8.2
Zixuan Liu,Lujing Gao,Shuyi Han,Zaimei Zhang,Haoye Jiang,Ruiqi Liu,Yu Zhang,Hai Xu,Deqing Mei,Kai Tao
As the largest organ in the human body, the skin plays a crucial role in protecting tissues from external threats. Damage in the skin can not only lead to bleeding and increase the risk of infection and inflammation but also result in tissue necrosis and scar formations. Therefore, wound dressings of high efficiency and intrinsic biocompatibility are essential for defending the wound sites and promoting healing. However, the state-of-the-art wound dressings have intrinsic shortcomings in curing, which would exudate due to limited water absorption capacity and the adhesion side effect, which may cause secondary damages. There remains a gap in the availability of wound dressings that simultaneously integrate antibacterial, self-healing, biodegradable, and temperature-sensitive properties. Herein, a bioinspired supramolecular hydrogel-based wound dressing composed of a KYD (KYDYKYDYKK) self-assembly peptide-agar double-network is developed with the assistance of 3D printing. The reversible self-assembling dynamics of the KYD along with the existence of lysine residues endow the double-networks with the ability of self-healing and antibacterial properties, while the introduction of agar allows the bioinspired system to be temperature sensitive. In addition, the grid size of the bioinspired dressing is light-stimulated and adaptable, allowing for real-time control of air permeability. Combined with intrinsic biodegradability, the multifunctional supramolecular wound dressing enables sustainable drug releases. Consequently, the programmability of strength, flexibility, and performances in this design ensures customizability in a variety of wound conditions of the bioinspired supramolecular wound dressing, thus showing promising potential in enhancing clinical wound management and improving patient lifecare.
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Separations
·
2024
·Vol. 11
·期 6
·165
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IF 2.5
Ahmad Ali,Hangping Chen,He Xu,Shuo Wang,Shun Yao
Plants serve as reservoirs of bioactive compounds endowed by nature, rendering them promising subjects for investigating chemical diversity. Despite their potential, much remains untapped, whether in standardized extracts or isolated pure compounds. This unexplored terrain has paved the way for significant discoveries in pharmaceuticals. Notably, research has delved into the medicinal properties ofMallotus philippensis, a prominent plant in South Asia. Employing meticulous extraction techniques such as maceration, the fruit of this plant underwent initial antimicrobial screening, revealing encouraging results. Subsequent fractionation of the plant’s extracts via liquid–liquid extractions, utilizing dichloromethane and absolute ethanol, facilitated further analysis. Evaluating these fractions for antibacterial activity demonstrated efficacy against various pathogenic microorganisms, particularlyPseudomonas aeruginosaandEscherichia coli, notably by the ethanolic and dichloromethane extracts. Furthermore, a comprehensive phytochemical analysis unveiled the presence of alkaloids, flavonoids, saponins, glycosides, phenols, and tannins. An assessment of the extracts’ antioxidant potential via the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay showcased significant activity, with a radical scavenging rate of 97%. This underscores the significance of utilizing fruit remnants, which are often rich in valuable chemical constituents yet commonly discarded, thereby adding value to both the species and the environment. Further investigation focused on the composition ofMallotus philippensisfruit, encompassing volatile and non-volatile metabolites through HPLC-MS analysis. Additionally, this study introduced the application of ionic liquid-loaded polysulfone microcapsules to enrich target constituents from crude extracts. An exploration of the key separation conditions, results, and recycling performance of these microcapsules provided insights for future research endeavors. Overall, this comprehensive study ofMallotus philippensisfruit extracts establishes a foundation for the ongoing exploration and development of this medicinal plant.
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JOURNAL OF FOOD COMPOSITION AND ANALYSIS
·
2024
·
IF 4
Xiaoqi Weng,Jing Zhang,Yunxuan Duan,Jing Chen,Yuanting Zhu,Chen Xiao,Yong Zuo
In the present work, a new strategy for visual detection of nitrite in pickled mustards based on the principle of diazotization coupling reaction was proposed. Under acidic conditions, nitrite could induce the formation of the purplish red compound by reacting with sulfanilamide and N-ethylenediamine (NETH). The Euclidean distance (ED) presented a good linear relationship with nitrite concentration from 0.1 to 15 μg/mL (R 2 = 0.976). Additionally, the agar gel-based colorimetric test tube was further developed by combining the agar and reaction regents. The linear range of detection of colorimetric test tube for nitrite were 0.1–3 μL/mL and 5–20 μL/mL, respectively, demonstrating good quantitative analysis ability. The agar gel-based colorimetric test tube presented great selectivity and anti-interfering properties towards nitrite and was successfully applied for the detection of nitrite in different pickled mustards, demonstrating great practical application prospects. The proposed agar gel-based colorimetric test tube exhibits the advantages of simple preparation, convenient to carry, easy operation, fast reaction and data visualization, is beneficial for the real-time and on-site detection of nitrite, and is helpful for the food safety supervision of pickled mustards.
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Polymers
·
2024
·Vol. 16
·期 6
·840
·
IF 4.7
Li Tang,Xuemei Wu,Yue Xu,Youwei Li,Shaoji Wu,Liang Gong,Jianxin Tang
Bilayer hydrogel actuators, consisting of an actuating layer and a functional layer, show broad applications in areas such as soft robotics, artificial muscles, drug delivery and tissue engineering due to their inherent flexibility and responses to stimuli. However, to achieve the compatibility of good stimulus responses and high mechanical properties of bilayer hydrogel actuators is still a challenge. Herein, based on the double-network strategy and using the synchronous ultraviolet (UV) polymerization method, an upper critical solution temperature (UCST)-type bilayer hydrogel actuator was prepared, which consisted of a poly(acrylamide-co-acrylic acid)[MC] actuating layer and an agar/poly(N-hydroxyethyl acrylamide-co-methacrylic acid)[AHA] functional layer. The results showed that the tensile stress/strain of the bilayer hydrogel actuator was 1161.21 KPa/222.07%. In addition, the UCST of bilayer hydrogels was ~35 °C, allowing the bilayer hydrogel actuator to be curled into an “◎” shape, which could be unfolded when the temperature was 65 °C, but not at a temperature of 5 °C. Furthermore, hydrogel actuators of three different shapes were designed, namely “butterfly”, “cross” and “circle”, all of which demonstrated good actuating performances, showing the programmable potential of bilayer hydrogels. Overall, the bilayer hydrogels prepared using double-network and synchronous UV polymerization strategies realized the combination of high mechanical properties with an efficient temperature actuation, which provides a new method for the development of bilayer hydrogel actuators.
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高影响因子
Gels
·
2024
·Vol. 10
·期 2
·100
·
IF 5
Xue-Chun Yang,Jing-Tai Zhao
Photocatalysis is one of the effective ways to degrade pollutant antibiotics. Agar is used as the adsorption module to provide abundant pore structure. Carbon dots (CDs) are selected as light energy conversion components. Graphitic carbon nitride (g-C3N4) is used as the main material of the catalyst. Agar/CDs/g-C3N4-functionalized aerogel with a unique 3D pore structure is assembled. The Agar/CDs/g-C3N4aerogel shows the highest photocurrent density, which is 3.7 times that of agar, 2.4 times that of 3-g-C3N4and 1.6 times that of Agar/g-C3N4aerogel. Compared with 3-g-C3N4and Agar/g-C3N4aerogel, which can completely remove AMX after 75 min, Agar/CDs/g-C3N4aerogel can degrade amoxicillin (AMX) completely after 45 min of illumination. The reason is that Agar/CDs/g-C3N4aerogel has a larger specific surface area, richer functional groups, a wider spectral range, higher photocurrent density and better carrier migration and separation efficiency. It is a good strategy with which to combine the effects of each component in the ternary system for the efficient photocatalysis of organic pollutants.
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Applied Materials Today
·
2025
·
IF 6.9
Zhuoyuan Zheng,Yan Liu,Yawen Li,Jie Zhou,Genggui Fu,Baofeng Yang,Yusong Zhu
The burgeoning demand for wearable and implantable electronic devices has spurred the necessity for the development of flexible and safe energy storage systems. Rechargeable aqueous hybrid-ion batteries (RAHBs) are considered promising alternatives, thanks to their high operating voltage, high power density, and enhanced safety. In this study, we introduce a hydrogel polymer electrolyte designed for flexible quasi-solid-state aqueous lithium-zinc (Li-Zn) hybrid ion batteries. The hydrogel polymer electrolyte (HGPE) is fabricated from a blend of agar and polyacrylamide, gelled with a 1M ZnSO 4 /2M Li 2 SO 4 aqueous electrolyte solution. The resultant hydrogel polymer electrolyte (AP-HGPE) exhibits exceptional characteristics, including outstanding ionic conductivity, a broad electrochemical stability window, and a notable ion migration number. Additionally, the Zn/AP-HGPE/Zn symmetric cells have demonstrated stable cycling for 350 h at 1 mA cm -2 , verifying the consistent deposition and stripping behavior of ions. Leveraging these properties, the full battery (Zn/AP-HGPE/LiMn 2 O 4 ) presents remarkable cycle performance, retaining 80.5 % of its initial capacity after 500 cycles at 1 C, accompanied by exemplary rate performance. Furthermore, RAHB maintains its stable electrochemical performance even under torsion and bending, highlighting its viability for integration into flexible devices. This research represents a significant stride forward in the development of RAHBs that are stable, flexible and long-lasting.
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CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Bing Han,Fan Liu,Shuhang Hu,Xinyu Chen,Chenming Lin,In-Seop Lee,Cen Chen
Bacterial cellulose (BC) produced by Acetobacter xylinum has great advantages in wound dressing. However, the structural limitation under static culture, and lack of antibacterial properties restrict its application, especially for infectious wound healing. The present study reported an original wound dressing, which was composed of a Janus BC membrane with antibacterial nano-sized copper oxide (CuO) through polydopamine (PDA) conjugation to promote wound healing under infectious condition. The finished product (CuO/PDA/BC membrane) exhibited favorable air permeability, high hydrophilicity and good mechanical properties, as well as strong antibacterial effects by the sustained release of CuO and photothermal effect of CuO/PDA. Furthermore, CuO/PDA/BC membrane inhibited inflammatory response and promoted wound healing in an infectious wound model in vivo. These results suggested that our CuO/PDA/BC membrane had great potential as wound dressing for infectious wound healing.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
·
IF 9.4
Shiyu Xiong,Xingwei Ding,Ling Zhou,Ziqian Liu,Wenyan Jiang,Fanrong Ai,Kaiyong Cai
The management of diabetic wounds (DW) is a significant challenge within the medical field. Effectively regulating the levels of reactive oxygen species (ROS) at the wound site and orchestrating the inflammatory response are effective strategies for DW treatment. In this study, a novel hydrogel was developed by cross-linking polyboronic acid-modified carboxymethyl chitosan with herbal active ingredient rosmarinic acid (RA), an active herbal ingredient, through dynamic boronic esters formation. In this RA hydrogel (RAgel), RA serves both as an active pharmaceutical ingredient and as a linker for the creation of a dynamic covalent hydrogel, which can decrease the potential toxicity of chemical crosslinking agents and improve the utilization of RA. RAgel demonstrated potential for controlling RA loading and responsiveness to ROS and glucose levels in a diabetic wound environment. Additionally, the intrinsic antioxidant and antibacterial properties of RA were effectively preserved and enhanced upon integration into RAgel. Furthermore, RAgel not only promoted the migration of L929 cells, a key aspect of tissue repair, but also induced M2 polarization in macrophages,while inhibiting the secretion of pro-inflammatory cytokines. In a murine model of diabetic wound healing, RAgel significantly enhanced the proliferation of both the epidermal and granulation tissues. It also exerts a marked anti-inflammatory effect and promotes collagen deposition, thereby expediting the overall wound healing process. The reported RAgel formulation has potential to address the complex challenges associated with diabetic wound management.
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Environmental Science-Water Research & Technology
·
2024
·
IF 3.5
Qin Long,Haonan Wu,Junfeng Li,Yuting Lin,Xiaoqing Zhou,Yi Huang,Peicong Zhang,Qin Zou,Rui Zhang
Effectively removing emulsions and dyes simultaneously from the mixed wastewater is challenging. In this study, we chose wood fiber as a supporting material. ZnO was uniformly grown on the surface of the wood fiber by a one-step hydrothermal method. After freeze-drying, ZnO/wood fiber composite was successfully created, which was kelp-shaped wood fiber (width dimensions of 25-50 μm) loaded with short rod-shaped ZnO (diameter dimensions of 5-25 nm and length dimensions of 15-100 nm). The composite was hydrophilic and oleophobic and had excellent antibacterial characteristics (>99.94%). The effectiveness of the composite in the separation of oil-in-water emulsions stabilized with a surfactant could reach 99.31%, owing to the ZnO enhanced emulsion breaking and separation capabilities. In addition, ZnO may interact electrostatically with dye molecules, allowing for 99.92% efficiency in dye adsorption during emulsion separation. Then, ZnO provided ZnO/wood fiber composite photocatalytic degradation of dyes, which allowed for repeated recycling of ZnO/wood fiber composite, resulting in 98.80% emulsion interception and 99.90% dye removal after five cycles. The environment friendly ZnO/wood fiber composite has remarkable multifunctionality for emulsion separation, dye adsorption, self-cleaning, and antibacterial properties, which provides a novel treatment option for mixed emulsion and dye wastewater.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Rui Zeng,Ying Liu,Yue Lu,Chao Chang,Jine Wu
In order to overcome the technical challenges of poor stability and weak antibacterial effects of individual essential oil in food preservation applications, the present study aimed to encapsulate cinnamon and clove essential oil compound by using spray-drying technique. The combination of cinnamon and clove essential oils was determined to have good synergistic bacteriostatic effects by the checkerboard dilution method, and the best bacteriostatic effect could be obtained when the volume ratio was 7:3 for compounding. Microcapsules were prepared using hydroxypropyl-β-cyclodextrin (HPCD) as wall material and compound essential oil as core material, the optimal conditions for the microcapsule preparation process through a one-way test were: homogenizing speed of 8000 r/min, wall material addition of 2 %, HPCD to EO ratio of 1:3, EO to T-80 ratio of 1.5:1, and homogenizing time of 8 min. The physicochemical properties of the prepared compound essential oil microcapsules (EOM) were characterized, and the results showed that the EOM was successfully encapsulated in HPCD with good physicochemical properties, and the encapsulation rate of the prepared microcapsules was measured to be 65.82 ± 4.00 %. The thermal stability of the encapsulated EOM was improved, and volatilization of the essential oils was effectively inhibited. In addition, the EOM showed antibacterial activity against the five types of bacteria tested, and the number of surviving bacteria decreased by about 17–18 % after 72 h. The preservation experiment of low salt pickles showed that the EOM was more effective in maintaining the quality and prolonging the shelf life of the pickles compared with commercial sodium benzoate, which also demonstrated the potential application of EOM in preserving low-salt pickles. This study provides a feasible and new technical strategy for more effective application of plant essential oils in food preservation.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Zhaoqian Zhang,Hongxia An,Qiaoxia Hu,Junping Miao,Genghao Gong,Yunxia Hu
Dopamine-assisted co-deposition is a promising approach for preparing nanofiltration (NF) membranes due to its simplicity, controllability, and versatility. However, limited research has been conducted on the functionalization and membrane formation mechanism of polydopamine (PDA) co-deposition membranes. In this study, lysozyme (Lys) was selected as one model protein and co-deposited with dopamine to prepare antibacterial NF membranes. The effects of the mass ratio of PDA/Lys and deposition time on the selective layer structure and membrane performance, and membrane-forming mechanism were systematically investigated. Results prove that addition of lysozyme into a dopamine solution promotes the rapid formation of a dense selective layer, and the maximum density of the PDA/Lys co-deposition layer reaches 1.53 g·cm −3 with the optimal 1:0.50 mass ratio of dopamine and lysozyme, and the resulting membranes have the effective pore size of 1.5 nm in diameter. The optimal PDA/Lys membranes can achieve high methyl blue (MB) rejection (98.2 %) and low salt rejection (13.1 % for NaCl) while maintaining high water permeance (42.4 L·m −2 ·h −1 ·bar −1 ) and demonstrating excellent long-term operational stability. Moreover, the NF membranes made from co-deposition of PDA and Lys exhibited outstanding antibacterial properties with 92 % bacterial-killing efficiency. Our work provides a simple method for utilizing functional proteins to prepare antibacterial NF membranes, and offers new insights into the membrane-forming mechanism of dopamine-assisted co-deposition membranes.
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ANALYTICA CHIMICA ACTA
·
2024
·
IF 5.7
Jinmeng Fan,Yanjie Pu,Yuedong Wang,Yong Cui,Chao Wang
Phenolic compounds are typical organic pollutants which cause severe human health problems due to their teratogenesis, carcinogenesis, neurotoxicity, immunotoxicity and endocrine disruption. Natural laccase is a multicopper oxidase existing in bacteria, plants, and insects, which can accelerate the transformation of phenolic compounds to their less hazardous oxidized products under mild conditions without harmful byproducts. Despite eco-environmentally friendly property of laccase, it still faces constraints of widespread application attribute to its high cost, complex preparation, and vulnerability. Therefore, exploring laccase mimics with high catalytic activity attracts a lot of attention and endeavors. In this research, copper-based nanozymes were prepared with coordination of copper ions and imidazole for mimicking the active sites of natural laccase via solvothermal method. The obtained Cu-based (Cu-Im) nanozymes exhibited multiple redox valence states of Cu and laccase-mimicking coordination structures, which endow Cu-Im with high laccase-like activity. During the process of catalytic oxidation reactions, singlet oxygen and superoxide anions generated from oxygen. Encouraged by the catalytic property, Cu-Im was utilized in degradation and detection of phenolic and catecholamine compounds. The catalytic degradation of compounds by Cu-Im showed good conversion and substrate versatility, which can be used as a kind of potential materials for phenolic pollutant degradation and remediation. Simultaneously, colorimetric sensors of phenols and catecholamines based on Cu-Im in solution system and POCT pad platform were constructed which indicated wide linear range and low limit of detection for both detection strategies. The Cu-Im-based sensor was a promising method for sensitive, fast, convenient, and qualitative-quantitative colorimetric analysis of phenols and catecholamines. The outcomes of this research elucidate Cu-Im is a satisfactory substitute for natural laccase, which will have broad application prospects in laccase-related fields, such as environmental recovery, pollution monitoring, and diagnosis of neurological diseases etc.
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