JOURNAL OF MOLECULAR LIQUIDS
·
2022
·
IF 6.633
Bolun Mei,Xin Fang,Yi Yu,Yicun Xing,Li Xu,Guoji Liu
The solid–liquid equilibrium data of 1-nitronaphthalene in twelve pure solvents (methanol, ethanol, n -propanol, i-propanol, n -butanol, i-butanol, acetone, acetonitrile, dichloromethane, methyl acetate, ethyl acetate and cyclohexane) were systematically determined by isothermal saturation method in the temperatures ranging from 273.15 K to 308.15 K under atmospheric pressure (0.1 MPa). Molecular electrostatic potential surface and Hirshfeld surface analysis were applied to obtain the visual analysis of crystal structure and the overall charge distribution. The effect of solvent multiple physicochemical factors including polarity, hydrogen bond donor, hydrogen bond acceptor and cohesive energy density of solvent was explored to the solubility behavior. Then the experimental solubility data were correlated by the modified Apelblat equation, λ h equation, Van't Hoff equation and Wilson model, the ARD% was used to check the accuracy of the four equations and the modified Apelblat showed the best fitting. Furthermore, the mixing thermodynamic properties were calculated based on Wilson model, which indicates the dissolution of 1-nitronaphthalene is a spontaneous, endothermic and entropy-driving process. Finally, molecular dynamic simulations were employed to further analyze the dissolution behavior from solute-solvent interaction perspective.
研究领域:
化学工程
·
物理化学
·
计算化学
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DOI
高影响因子
VETERINARY MICROBIOLOGY
·
2022
·
IF 3.246
Hongyan Luo,Mengru Li,Zhishuang Yang,Dekang Zhu,Pei Li
A novel chromosomally-located β-lactamase gene, bla RASA-1 , was identified in Riemerella anatipestifer RA-CH-1. The RASA-1, encoded by bla RASA-1 , was a class A extended-spectrum β-lactamase (ESBL), which shared 42.7% and 40.5% identities with the RAA-1 and CGA-1 β-lactamase, respectively. Overexpression of RASA-1 in Escherichia coli confers broad resistance to β-lactams and the purified native RASA-1 revealed ESBL-like hydrolysis activity. Blasting in GenBank showed that bla RASA-1 was exclusively detected in Riemerella anatipestifer . Moreover, sequence analysis revealed that this gene was located within the multi-resistance region of Riemerella anatipestifer genome.
研究领域:
微生物学
·
抗药性研究
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DOI
高影响因子
Materials
·
2025
·Vol. 18
·期 5
·1131
·
IF 3.2
Tian Zhao
HKUST-1 (HKUST = Hong Kong University of Science and Technology) is one of the most recognized metal-organic frameworks (MOFs) based on copper and trimesate, extensively studied for a variety of applications, such as gas storage, separation, adsorption, electrocatalysis, drug delivery, sensor and photodegradation, etc. In this work, we introduce a novel nanofused HKUST-1, referred to as N-CuBTC (BTC = trimesate), which has been synthesized with the hydrothermal method at room temperature (typical synthesis temperature is from 80~120 °C). The resulting N-CuBTC features an irregular particle morphology, with numerous crystals clustering together and edges that have fused, creating a hierarchical pore structure. In contrast to the traditional micro-sized octahedral HKUST-1 (named as M-CuBTC), N-CuBTC displays a unique clumped morphology, where the HKUST-1 crystals are seamlessly integrated into a cohesive structure. This innovative formation significantly enhances mass transfer capabilities and porosity accessibility. Consequently, N-CuBTC demonstrates markedly improved catalytic performance in the cyanosilylation of aldehydes.
研究领域:
材料科学
·
催化化学
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DOI
PubMed
高影响因子
Biomass Conversion and Biorefinery
·
2022
·
IF 4.05
Li Keying,Zhu Hengji,Zhao Yu,Yan Jingwei,Zhang Jiajian,Lin Xiuhua,Fan Liwei,Lu Zexiang
The solvent has an important impact on liquefaction conversion from biomass to efficiently obtain fuels and chemicals. In this paper, the catalytic liquefaction of woody biomass was studied using fir sawdust as raw material and concentrated sulfuric acid as catalyst in GVL/1-octanol mixed solvent with mechanical stirring and oil bath heating. The influence of GVL on liquefaction yield was discussed, and the liquefaction productions were characterized by some analysis methods to analyze the liquefaction mechanism. The results show that adding GVL benefits to improving liquefaction yield and generating high value-added monophenol because of the enhancement of the surface wettability of biomass and the inhibition of polymerization of mononuclear aromatics with other degradation products. The maximum liquefaction yield of 76.07% was obtained under the suitable conditions of fir sawdust 10 g, temperature 150 ℃, reaction time 60 min, mass ratio of sawdust/solvent 1:6, catalyst concentration 0.6 mol·L −1 , and mass ratio of GVL/1-octanol 4:6. The mechanism study reveals that aromatics originated by lignin degradation as well as small molecule ketones from cellulose and hemicellulose degradation. GVL/1-octanol as an eco-friendly solvent system exhibits a promising prospect of application in woody biomass conversion. Graphical abstract
研究领域:
生物化学
·
可再生能源
·
绿色化学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Kai An,Hongyan Jia,Ruobing Cheng,Yong Guo,Xiaohui Liu,Yanqin Wang
Pt-based bimetallic catalysts have gained more and more attention in propane dehydrogenation (PDH), but still suffer from the high cost and poor stability. In this work, a PtCu@S-1 catalyst with an extremely low loading of Pt (0.047 wt%) is prepared by in-situ hydrothermal synthesis and employed in PDH. An excellent productivity (propylene yield: 471.8 molC 3 H 8 ⋅ g Pt -1 ⋅ h −1 ) is achieved at 600 °C with a weight hour space velocity of 25.80 h −1 . After 50 h of reaction at 600 ℃, 0.047Pt0.19Cu@S-1 catalyst still remains sinter-free, with a deactivation rate of only 0.006 h −1 . Various characterizations show that Cu 0 co-existed with Pt 0 in PtCu@S-1 catalyst plays an important role, greatly improved catalyst reactivity and stability. At high weight hour space velocity (44.5 h −1 ), the propylene productivity can reach 1056.4 molC 3 H 8 ⋅ g Pt -1 ⋅ h −1 . This work provides a new way for the design of extremely low Pt-loaded PDH catalysts with excellent performance at high temperatures.
研究领域:
催化化学
·
材料科学
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产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Haonan Zhang,Changhe Lu,Shuai Wang,Qinhua Zhang,Qiang Zhou,Shuxu Zhu,Chong Qi,Mingbo Wu,Wenting Wu
The utilization of O 2 for propylene epoxidation is a highly desirable reaction due to its 100 % atom economy. However, achieving this reaction under mild conditions presents a significant challenge. In this paper, we present a tandem reaction system that combines 4,4′-dibromobenzophenone (BP) modified carbon nitride (g-C 3 N 4 ) with titanium silicalite zeolite (TS-1) to enable the selective photooxidation of propylene into propylene oxide at room temperature, using O 2 as the oxygen source. The achieved production rate of propylene oxide was an impressive 1195 μmol/g cat. /h, with a selectivity exceeding 99 %. Furthermore, the catalyst exhibited no significant deactivation after 5 cycles. Spectra and in-situ capture experiments revealed that the reaction involved a two-step system, with photocatalytic production of H 2 O 2 and propylene epoxidation facilitated by H 2 O 2 ·H 2 O 2 was generated through O 2− and 1 O 2 pathways, with an in-situ utilization efficiency of H 2 O 2 reaching 82 %. This work presents a novel approach for the direct epoxidation of propylene using O 2 .
研究领域:
化学工程
·
环境科学
·
材料科学
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产品关联
DOI
高影响因子
APPLIED CATALYSIS A-GENERAL
·
2024
·
IF 4.7
Cong Wang,Gang Li,Zheng Huang,Anfeng Peng
Alkyl-aluminum, which is sensitive to air, has been a major obstacle to the development of ethylene oligomerization. Herein, LiAlH 4 is used as an effective alkyl-aluminum substitute. The performance of LiAlH 4 itself in the reaction is investigated, proving that it possesses moderate activity. Further addition of Versailles/Santa Barbara-1 (VSB-1) catalysts with different morphologies can effectively improve the reaction, in which VSB-1/LiAlH 4 presents the activity of 32.1 g ‧ g LiAlH4 −1 ·h −1 (154.1 g ‧ g VSB-1 −1 ‧h −1 ) and the selectivity of 1-butene, 1-hexene and 1-octene in all products could reach 51.4 %, 18.9 % and 7.9 %, respectively. The co-catalytic system is stable and the VSB-1 catalyst therein can be effectively reused at least three times under the suitable treatment conditions. In addition, the product analysis of the co-catalyzed system reveals that the addition of VSB-1 catalyst tended to produce 1-butene, 1-hexene and 1-octene at 20 bar. Based on above result, a possible reaction mechanism is proposed.
研究领域:
化学工程
·
催化科学
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产品关联
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 113
·112445-112450
·
IF 3.289
Shanni Hong,Na Sun,Min Liu,Jine Wang,Renjun Pei
Galectin-1 is closely related with immune systems, and its overexpression may cause tumor metastasis. Owing to the better stability of antisense oligonucleotides than siRNA, we constructed a chimera of aptamer–antisense oligonucleotide (Apt–AS) for silencing the galectin-1 gene specifically. For studying the endocytosis pathways of Apt–AS by aptamer targeted delivery, we marked the 3′ terminus of Apt–AS with Alexa Flour 488 (Apt–AS488) so as to trace the pathways through the confocal microscope. Furthermore, Apt–AS was used to silence the expression of galectin-1. The results showed Apt–AS entered cells by a caveolae mediated endocytosis pathway, and the aptamer–antisense chimeras did not impair the antisense gene silencing efficiency. Moreover Apt–AS could improve the cellular uptake and selectively entered cells.
研究领域:
分子生物学
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癌症研究
·
基因工程
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产品关联
DOI
高影响因子
RESEARCH ON CHEMICAL INTERMEDIATES
·
2017
·Vol. 43
·期 8
·4697-4710
·
IF 1.369
Sun Hao,Huang Xin,Wang Fang,Gu Zhenggui
Selective isomerization of 1-methylnaphthalene was carried out in a fixed-bed reactor over HBEA catalysts modified by acid and tetraethoxysilane treatments, respectively. Catalysts were characterized by X-ray diffraction, NH 3 temperature-programmed desorption, N 2 physisorption, inductively coupled plasma analysis, thermogravimetric analysis and Fourier transform infrared spectrometry after adsorption of pyridine. The results demonstrated that tetraethoxysilane treatment successfully passivated external active sites of the zeolite, but had little effect on the selectivity of isomerization reaction and catalytic stability. Dealumination of HBEA zeolite by treatment with oxalic and hydrochloric acids can lead to higher surface area and pore volume. Sufficiently strong Brönsted acidic sites were found to be responsible for the isomerization activity. Furthermore, a decrease in the number of Lewis acidic sites in acid-modified zeolites were advantageous to suppress the hydride transfer and subsequent side reactions that form coke, leading to higher 2-methylnaphthalene selectivity and longer catalytic life.
研究领域:
化学工程
·
催化科学
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产品关联
DOI
高影响因子
ChemNanoMat
·
2022
·Vol. 8
·期 10
·e202200268
·
IF 3.82
Mengmeng Liu,Jingjing Li,Pengfei Wang,Shuai Chen,Zhengping Dong,Fengwei Zhang
Graphical The encapsulation of Pt/TiO 2 -450H catalyst with SMSI into zeolite silicalite-1 (S-1) is reported. The resulting Pt/TiO 2 @S-1 catalyst dispalyed superior catalytic performance especially for halogenated nitroaromatics and without degradation in selectivity after 7 cycles. It is attributed to the high surface area, SMSI effect in confined space and the pore structure of S-1 with selective adsorption of substrates. The encapsulation of metal nanoparticles (NPs)-based active sites and homogeneous catalysts in nanoporous materials has been of highly research focus for tuning their catalytic activity, selectivity and stability. Although the catalysts with strong metal-support interaction (SMSI) hold the reversible encapsulation feature in a certain atmosphere, there is still a lack of systematic research on them in a real confined environment. Herein, we present a highly selective and stable Pt/TiO 2 @S-1 catalyst, which is prepared by in-situ growth of classical silicalite-1 on the external surface of Pt/TiO 2 -450H pre-catalyst with SMSI effect. Encouragingly, the encapsulated 20Pt/TiO 2 @S-1 catalyst demonstrates unprecedented catalytic performance for various nitroaromatics and without any degradation in selectivity after 7 cycles (>99%) for the hydrogenation of 1-chloro-4-nitrobenzene. Such situation is attributed to the high surface area, SMSI effect in confined space as well as the pore structure of silicalite-1 with selective adsorption of substrates.
研究领域:
催化
·
化学工程
·
材料科学
·
环境化学
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DOI
高影响因子
Theranostics
·
2025
·Vol. 15
·期 6
·2360
·
IF 13.3
Bin Li,Jingyi Liu,Wanyu He,Yanlin Zhou,Man Zhao,Cong Xia,Xiaoyue Pan,Zhihua Ji,Ruoyu Duan,Hui Lian,Kai Xu,Guoying Yu,Lan Wang
Rationale: Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a critical syndrome with a mortality rate of up to 40%, and it is characterized by a prominent inflammatory cascade. The inflammasome and pyroptosis play crucial regulatory roles in regulating various inflammatory-related diseases by serving as pivotal signaling platforms for inflammatory responses and mediating the release of substantial quantities of inflammatory factors. Our previous studies confirmed that GC-1, a clinical-stage thyroid hormone analog, effectively mitigated pulmonary fibrosis by restoring mitochondrial function in epithelial cells. However, the potential effects of GC-1 on macrophage inflammasome assembly and pyroptosis in lung injury as well as the underlying mechanisms, remain unclear. Methods: The effects of GC-1 on lung injury, oxidative damage and inflammation were evaluated in two murine models of ALI (LPS- or HCl-induced models) by assessing lung pathology, the concentrations of IL-1β and IL-18 in BAL fluid, inflammasome and the levels of inflammasome- and pyroptosis-related proteins. Additionally, the impact of GC-1 on ROS-mediated inflammasome assembly and pyroptosis was investigated by examining ROS levels, Nrf2 signaling, and inflammasome adaptor protein ASC levels in mouse alveolar macrophages and human THP-1 macrophages treated with LPS and ATP. The Nrf2 inhibitor ML385 and the mitochondrial-ROS inhibitor Mito-TEMPO were used to further elucidate the effect of GC-1 on the Nrf2-p53-ASC pathway. Results: GC-1 significantly alleviated inflammation and lung injury in ALI model mice, as indicated by pulmonary pathology, inflammatory cytokine levels, ROS production and pyroptosis rates. Consistently, GC-1 inhibited ASC recruitment and oligomerization in macrophages, which suppressed the gasdermin D-mediated release of IL-1β and IL-18. These findings indicated a reduction in inflammasome assembly and pyroptosis initiation. Further research revealed that GC-1 may mitigate oxidative stress induced by mitochondrial damage through Nrf2 signaling, thereby inhibiting the expression of ROS-activated p53 and the target gene ASC. This protective effect of GC-1 could be reversed by ML385 and mimicked by Mito-TEMPO. Conclusions: This study presents a novel mechanism for treating ALI in which GC-1 inhibits macrophage ROS-mediated inflammasome assembly and pyroptosis through Nrf2-p53-ASC pathway. These findings highlight the promising potential of the use of GC-1 as an anti-inflammatory and antioxidant drug in the treatment of ALI/ARDS.
研究领域:
药理学
·
免疫学
·
呼吸医学
·
炎症研究
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产品关联
DOI
PubMed
高影响因子
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
·
2018
·Vol. 34
·期 9
·1-10
·
IF 2.1
Peng Huasong,Tan Jian,Bilal Muhammad,Wang Wei,Hu Hongbo,Zhang Xuehong
Phenazine-1-carboxamide (PCN) is one of the major biocontrol agents produced by plant growth-promoting rhizosphere (PGPR) pseudomonads including Pseudomonas chlororaphis . In this study, a combined strategy of genetic modification and statistical experimental designs was applied to obtain mutants of P. chlororaphis strains with high-yield PCN production. To achieve this, the lon gene was knocked out in wild-type P. chlororaphis HT66 and the breeding mutant P3 strain with a non-scar deletion strategy. The resulting HT66Δ lon and P3Δ lon mutants produced a significantly higher PCN production in shake-flask cultures which was 5- and 9-folds greater than their native counterparts. The potential ability of strain P3 Δlon for PCN production was further optimized by statistical designs. A two-level Plackett–Burman (PB) experimental design with six variables was employed to scrutinize medium components that significantly influence PCN production. Notably, glycerol, tryptone, and soy peptone were identified to be the most significant factors ( p < 0.05). Response surface methodology (RSM) based on the central composite design (CCD) was adopted to determine these factors optimal levels and their interactive effects between culture components for PCN production. The predicted maximum PCN production was 9002 mg/L, whereas an actual PCN production of 9174 mg/L was recorded in the validation experiments using the optimal medium containing glycerol 37.08 mL/L, tryptone 20.00 g/L, and soy peptone 25.03 g/L, which was nearly threefolds higher than without optimization and 20-folds higher than the wild-type strain. In conclusion, the results revealed that P. chlororaphis display a high potential for industrial-scale production for phenazine biopesticides.
研究领域:
微生物学
·
生物技术
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）