IONICS
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2017
·Vol. 23
·期 9
·2377-2385
·
IF 2.062
Pan Guangxing,Song Yonghai,Miao Longfei,Wang Li
A novel ascorbic acid (AA) electrochemical biosensor based on ferrocene dicarboxylic acid (Fc(COOH) 2 )/zeolitic imidazolate framework-8 (ZIF-8)/three-dimensional (3D) kenaf stem-derived macroporous carbon (3D-KSCs) was proposed for the first time. The formation and properties of Fc(COOH) 2 /ZIF-8/3D-KCSs nanocomposites were characterized by scanning electron microscopy, Fourier transform-infrared spectroscopy, N 2 adsorption/desorption isotherms, X-ray powder diffraction, and energy dispersive X-ray spectroscopy. The results showed that a large number of short rod-like ZIF-8/Fc(COOH) 2 was arrayed on the 3D-KSCs surface via a simple one-step hydrothermal method. Fc(COOH) 2 was firmly encapsulated into the pores of ZIF-8 simultaneously during the synthesis process of ZIF-8. The Fc(COOH) 2 /ZIF-8/3D-KCSs nanocomposites were employed to prepare integrated Fc(COOH) 2 /ZIF-8/3D-KSCs electrode directly for electrochemical AA sensing, and the integrated electrode showed better performance for AA detection than traditional enzyme-based biosensors and nonenzymatic sensors. A wide detection range of 0.06 μM~5.01 mM and a low detection limit of 0.017 μM were obtained with good stability and selectivity. The work also sheds new light on developing ZIF-8-based nanocomposites for electrochemical sensing.
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产品关联
DOI
高影响因子
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
·
2024
·
IF 5.6
Cong Wu,Qi Jiang,Hui Zhong,Xudong Zhou,Leping Liu,Tong Pan,Chao Liu,Wei Wang,Wenbing Sheng
An oxidising and substituting one-pot reaction strategy has been developed to synthesise dihydromyricetin derivatives with the aim of enhancing the inhibitory activity of dihydromyricetin against SARS-CoV-2. Different ω-methoxy-ω-oxeylkyl was introduced in C7-OH site and yielded eight analogs, all of them showed good inhibitory activity against SARS-CoV-2 3CLpro with IC50 values ranging from 0.72 to 2.36 μM. In the Vero E6-cell, compound 3 has a good activity of anti-SARS-CoV-2 virus (Omicron virus BA.5) in the prevention model, with an EC50 of 15.84 μM, and so do compound 10 in the therapeutic model, with an EC50 of 11.52 μM. The results suggest that the introduction of long chain ω-oxeylkyl at C7-OH facilitate the inhibition of viral replication in the therapeutic model, which is consistent with the binding energies predicted from molecular docking conclusions. It implies that dihydromyricetin derivatives have the potential to become effective inhibitors of SARS-CoV-2 Omicron and other viruses.
研究领域:
药物化学
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病毒学
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生物信息学
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DOI
PubMed
高影响因子
Journal of Energy Chemistry
·
2024
·
IF 14
Xuejun Xu,Rutao Meng,Yue Liu,Han Xu,Jianpeng Li,Yi Zhang
Solution-processed chalcopyrite solar cells are widely regarded as a promising alternative method in reducing the cost compared with vacuum-based techniques. It is noted that the absorber layer usually needs to be prepared under a high insert pressure (∼1.6 atm) to suppress element loss or under a mild pressure but additional surface etching is needed for fabricating high efficient solar cell. Herein, a copper gradient structured precursor is proposed to prepare CuIn(S,Se) 2 (CISSe) film under a mild pressure (1.1 atm). The designed gradient Cu not only promotes crystal grain growth and tailors the defects, but also avoids the surface etching of the formed CISSe film for the fabrication of high efficient solar cells. Further, Cu gradient design decreases the conduction band offset of heterojunction, boosting the carriers transport across the p-n heterojunction. Accordingly, a 13.35% efficient CISSe solar cell, comparable to the high efficient CISSe solar cell prepared by this method under high pressure or with film surface etching, is fabricated. This work provides a facile pathway to fabricate high efficient solution-processed chalcopyrite solar cell, avoiding high selenization pressure and film etching, and shows huge potential for solution-processed copper-based solar cells.
研究领域:
材料科学
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可再生能源
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DOI
高影响因子
ENVIRONMENTAL TOXICOLOGY
·
2018
·Vol. 34
·期 2
·141-149
·
IF 2.491
Xia Wang,Baida Kong,Bingnan He,Lai Wei,Jianbo Zhu,Yuanxiang Jin,Yudong Shan,Weitao Wang,Chunqiang Pan,Zhengwei Fu
8:2 Fluorotelomer alcohol (8:2 FTOH) is widely used in houseware and industrial goods and is ubiquitous in the surrounding environment. 8:2 FTOH has been linked to hepatoxicity, nephrotoxicity, and reproductive toxicity, as well as endocrine-disrupting effects. However, as of yet, the research regarding immunotoxicity of 8:2 FTOH remains largely limited. In the present study, adult male C57BL/6 mice were administered with 10, 30, and 100 mg/kg/d 8:2 FTOH by gavage for 28 days to investigate its immunotoxicity in vivo. The results showed that exposure to 8:2 FTOH caused increases in liver weight and histological changes in the liver, including vacuolation, cell swelling, immune cell infiltration, karyopyknosis and nuclear swelling. No histological change in either the spleen or the thymus was observed after administration of 8:2 FTOH. In addition, exposure to 8:2 FTOH reduced the concentration of IL-1β in serum, and mRNA levels of IL-1β, IL-6 , and TNF-α in both the thymus and spleen. CXCL-1 mRNA expression was downregulated in both the liver and thymus after 8:2 FTOH administration, while only IL-1β mRNA expression was upregulated in the liver. Moreover, the exposure of primary cultured splenocytes to 8:2 FTOH inhibited the ConA-stimulated proliferation of splenocytes at concentrations of 30 and 100 μM, and the LPS-stimulated proliferation of splenocytes at 100 μM. Furthermore, 8:2 FTOH inhibited the level of secreted IFN-γ in ConA-stimulated splenocytes. The results obtained in the study demonstrated that 8:2 FTOH posed potential immunotoxicity and liver injury in mice. Our findings will provide novel data for the health risk assessment of 8:2 FTOH.
研究领域:
毒理学
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免疫学
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环境健康
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DOI
PubMed
高影响因子
JOURNAL OF RARE EARTHS
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2018
·
IF 2.524
Yaqian Chen,Huanping Wang,Xiaoting Zhang,Zhen Xiao,Qinghua Yang,Ruoshan Lei,Degang Deng,Lihui Huang,Shiqing Xu
(Y 0.87 La 0.1 Zr 0.03 ) 2 O 3 nanopowders doped with various concentrations of Tm 3+ and Ho 3+ were prepared by the citrate method. The standard cubic Y 2 O 3 phase can be matched in the Tm 3+ /Ho 3+ co-doped (Y 0.87 La 0.1 Zr 0.03 ) 2 O 3 nanopowders. The nanopowders exhibit average particle sizes of 40, 60, 80 and 100 nm after calcinated at 900, 1000, 1100 and 1200 °C, respectively. The energy transfer from Tm 3+ to Ho 3+ and the optimum fluorescence emission around 2 μm were investigated. Results indicate that the emission bands at around 1.86 and 1.95 μm correspond to 3 F 4 → 3 H 6 transition of Tm 3+ and 5 I 7 → 5 I 8 transition of Ho 3+ , respectively. Better spectral properties were achieved in Tm 3+ /Ho 3+ co-doped (Y 0.87 La 0.1 Zr 0.03 ) 2 O 3 nanopowders with the average size of 100 nm obtained at the conditions of the treatment of precursors calcinated at 1200 °C for 2 h doped with 1.5 mol% Tm 3+ and 1 mol% Ho 3+ .
研究领域:
材料科学
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光学
·
纳米技术
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DOI
高影响因子
Polymer Chemistry
·
2020
·Vol. 11
·期 41
·6650-6657
·
IF 5.342
Shanshan Chen,Tingting Sun,Zhigang Xie,Dewen Dong,Ning Zhang
Mobile divalent zinc, Zn(II), is an essential cofactor involved in mammalian biological processes. To understand the intrinsic action mechanism of mobile zinc, the development of a Zn2+-selective fluorescent probe that can detect mobile zinc via biological imaging is of great significance. We present here a novel Zn2+-selective fluorescent sensor based on poly(2-oxazoline) (POx) cylindrical molecular brushes with good water solubility and biocompatibility. The POx molecular brushes were end-capped by a Zn2+-responsive functionality, which can give efficient blue emission upon coordination with zinc ions. Fluorescence investigation indicates that the POx molecular brushes exhibit superior selectivity toward Zn2+ in comparison with most competitive heavy and transition metal ions. Due to the ease of cellular uptake that results from their unique molecular contour, POx molecular brushes are capable of detecting intracellular Zn2+ ions as demonstrated by living cell fluorescence studies.
研究领域:
生物化学
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材料科学
·
分析化学
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DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2019
·
IF 4.561
Hui Guo,Yu Dong,Tiantian Ping,Xiaoqin Shi,Shufeng Shen
Densities and viscosities for the binary liquid mixtures of monoethanolamine (MEA) with 2-alkoxyethanols (2-ethoxyethanol (EGEE) and 2-butoxyethanol (EGBE)) were measured over the entire concentration range at temperatures of 293.15–353.15 K and atmospheric pressure. From the experimental results, the excess molar volume ( V E ), viscosity deviations (∆ η ) and excess Gibbs free energy of activation of viscous flow (∆ G ⁎E ) were calculated and the excess/deviations properties for the studied binary systems were fitted with the Redlich-Kister equation to estimate the binary interaction parameters. The results were analyzed in terms of intermolecular interactions between unlike molecules and intramolecular interactions within like associated molecules. The densities and viscosities of CO 2 -loaded solutions were also measured and correlated with the proposed correlations. The calculated values of density and viscosity for the binary/ternary systems are in good agreement with the experimental values, with AADs within 0.2% for density and 3.2% for viscosity. The FTIR spectral analysis for the binary mixtures of MEA with 2-alkoxyethanols at various concentrations suggests the presence of weak interactions between component molecules in the systems, and also supports the findings of excess properties.
研究领域:
物理化学
·
分子相互作用
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DOI
高影响因子
ACS Omega
·
2022
·
IF 4.132
Jialu Huang,Zhiming Ni,Xiaofan Song,Han Li,Xiaolei Chen,Aichuang Zhang,Hu Yang,Yuan Liu,Peng Zhu,Ping Hua,Xiaolei Yuan
PdPb nanocrystals have drawn considerable attention due to their excellent catalytic properties, while their practical applications have been impeded by the severe degradation of activity, which is caused by the adsorption of intermediates (especially CO) during the operation. Herein, we first present porous PdPb alloys with the incorporation of amorphous Pb(OH)2 species as highly active and stable electrocatalysts. Alloying Pd with Pb species is initially proposed to optimize the Pd–Pd interatomic distance and adjust the d-band center of Pd. Importantly, the amorphous Pb(OH)2 species are beneficial to promoting the formation of OHad and the removal of COad. Therefore, PdPb-Pb(OH)2 catalysts show a mass activity of 3.18 A mgPd–1 and keep excellent stability for the ethanol oxidation reaction (EOR). In addition, further CO stripping and a series of CO poisoning experiments indicate that PdPb-Pb(OH)2 composites possess much better CO tolerance benefiting from the tuned electronic structure of Pd and surface incorporation of Pb(OH)2 species.
研究领域:
材料科学
·
电化学
·
催化
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Xiaona Sun,Chunqing Ai,Chengrong Wen,Haoran Peng,Jingfeng Yang,Yuna Cui,Shuang Song
Fucoidan is a highly sulfated polysaccharide with a wide range of bioactivities, including anti-pathogenic activity. However, the relationship between structure and activity of fucoidan in inhibiting pathogen infections remains unclear. Here, different-molecular-weight fucoidans were prepared by photocatalytic degradation followed by membrane ultrafiltration, and their chemical structures and anti-pathogenic microbiota activity were compared. Results showed that photocatalytic degradation could effectively degrade fucoidan while its structure block and sulfate groups were not destroyed obviously. Fucoidan (90.8 kDa) of 5 mg/mL could inhibit the growth of S. aureus , S. typhimurium and E. coli , but its degradation products, Dfuc1 (19.2 kDa) and Dfuc2 (5.5 kDa), demonstrated lower inhibitory effect. In addition, compared to Dfuc1 and Dfuc2, fucoidan showed stronger capability to prevent the adhesion of S. aureus , L. monocytogenes , V. parahaemolyticus and S. typhimurium to HT-29 cells. Moreover, the inhibitory effect against SARS-CoV-2 and the binding activity to S protein were also positively correlated to molecular weight. These results indicate that natural fucoidan with higher molecular weight are more effective to inhibit these pathogenic bacteria and SARS-CoV-2, providing a better understanding of the relationship between structure and activity of fucoidan against pathogenic microbiota.
研究领域:
微生物学
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生物化学
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病毒学
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DOI
PubMed
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2021
·
IF 4.464
Mingguang Ma,Jing Lu,Ling Wang,Xia Qiu,Tingting Xu,Sufan Wang,Yinggui Zhu
In this work, we first reported the electrochemiluminescence (ECL) properties of 2-hydroxynicotinic acid (2-HNA) with 0.09 M K 2 S 2 O 8 in 0.5 M H 3 BO 3 – Na 2 B 4 O 7 buffer solution. The effects of the type of co-reactant, the concentration of K 2 S 2 O 8 and the pH of the buffer solution on the ECL intensity of this system were investigated. And the possible mechanism of 2-HNA/ K 2 S 2 O 8 system has been speculated by fluorescence spectrum and ECL spectrum. Besides, we found that phloxine B (PB) can significantly enhance the ECL intensity of the 2-HNA/ K 2 S 2 O 8 system. It is speculated that an electrochemiluminescence resonance energy transfer (ECL-RET) process may occur between 2-HNA and PB, so that PB enhanced the ECL of the 2-HNA system. Combining the ultraviolet spectrum and density functional theory (DFT) calculations further proved the rationality of this speculation. Based on this, a new method of ECL detection of PB with high sensitivity and high selectivity was established.
研究领域:
分析化学
·
电化学
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DOI
高影响因子
Catalysis Science & Technology
·
2020
·Vol. 10
·期 13
·4412-4423
·
IF 5.721
Qiang Liu,Zhenbo Zhao,Masahiko Arai,Chao Zhang,Ke Liu,Ruhui Shi,Peixuan Wu,Zhuangqing Wang,Weiwei Lin,Haiyang Cheng,Fengyu Zhao
The transformation of γ-valerolactone (GVL) into 1,4-pentanediol (1,4-PDO) and 2-methyltetra-hydrofuran (2-MTHF) in the presence of H2, one of the useful biomass conversion and utilization processes, was investigated with monometallic Cu/Al2O3 and bimetallic ZnCu/Al2O3 catalysts. A 10 wt% Cu-loaded monometallic catalyst produced 1,4-PDO and 2-MTHF in comparable quantities at a medium conversion (∼50%). When Zn was added in a range of Zn/Cu molar ratios of up to 2, in contrast, the catalysts yielded 1,4-PDO in a high selectivity of about 97% at low and high conversion levels. In addition, the 1,4-PDO selectivity over the ZnCu/Al2O3 catalysts remained almost unchanged during recycled runs. That is, the addition of Zn to Cu/Al2O3 switched the product selectivity and improved the catalyst stability and reusability. Furthermore, the physicochemical properties of the catalysts were characterized by several methods including XRD, TEM, TPR, XPS, FTIR of adsorbed pyridine, and so on. On the basis of those results, the relationships between the catalytic performance (activity, selectivity, and reusability) and the catalyst structural features were discussed.
研究领域:
催化化学
·
生物质转化
·
材料科学
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DOI
高影响因子
MOLECULES
·
2024
·Vol. 29
·期 14
·3396
·
IF 4.2
Zhengyang Wang,Shuting Wang,Yuexing Zhang,Mingliang Ma
A series of fluorescent molecules with 1,1-dimethylnaphthalene-2(1H)-one as the core were synthesized to overcome aggregation quenching and emit bright green fluorescence. The low molecular weight of these molecules led to them to smoothly pass through the cell membrane and penetrate deep into the nucleus to emit the corresponding fluorescence. Among them, NC-4-Br and NC-5-3O have good optical and in vitro properties and showed potential for use as fluorescent probes.
研究领域:
生物化学
·
分子生物学
·
医学成像
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DOI
PubMed
高影响因子
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