ACS Omega
·
2025
·
IF 4.3
Juan Du,Kang-Li Yang,Zhi-Qing Yuan,Rui He,Shu-Juan Liu,Can-Cheng Li,Shou-tong Meng,Xu-yu Long,Qian Su,Qing Liao,Pei-ning Zhu
Postharvest fruit losses are largely driven by a short shelf-life resulting from ethylene-induced ripening, microbial spoilage, and moisture loss. In this study, a multifunctional coating was fabricated on Moso bamboo substrates via a simple two-step process. The coating integrates superhydrophobic, ethylene-scavenging, and antibacterial functions, utilizing rosin, nano-ZnO, Artemisia argyi powder, nano-CaCO3, and KMnO4. The bamboo with this coating acts as an indirect preservation platform, regulating the storage microenvironment to reduce ethylene accumulation, microbial proliferation, and water loss. The system is cost-effective, biosafe, and scalable for practical use. Shelf-life tests demonstrated significant extension for both climacteric and nonclimacteric fruits: bananas (from 5 to 21 days, ≥200%), strawberries (1–2 to 5 days, ≥150%), blueberries (5–7 to 15 days, ≥114%), cherry tomatoes (4–7 to 14 days, ≥100%), and sweet cherries (5–7 to 14 days, ≥100%). The synergistic effect of ethylene adsorption, moisture barrier, and contact-plus vapor-phase antibacterial action contributes to the broad-spectrum efficacy of this approach. These findings support this coating as a promising passive packaging material for fresh produce preservation.
研究领域:
食品科学
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材料科学
·
农业科技
·
纳米技术
·
采后生理学
·
包装工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
He-Xiang Zhao,Yan Wang,Jun-Jie Yang,Ji-Guo Zhang,Yuan-Ru Guo,Shujun Li,Qing-Jiang Pan
A bio-composite of cellulose@CaCO 3 (Cel@CaCO 3 ) has been prepared via a facile precipitation reaction route, in anticipation of solving the toxic lead ion pollution problem and satisfying the sustainable development. The microstructures along with the morphology were characterized by XRD, FT-IR, SEM and TEM. It is found that CaCO 3 forms the hydrogen bonding with cellulose in the composite, which makes it cover on the cellulose fibers. This would construct a suitable micro-environment for the Pb 2+ capture and removal due to the spatial confinement effect. The high performance has been achieved with the up-taken capacity of 602.3 mg·g −1 . When treating the wastewater with the Pb 2+ concentration less than 50 mg·g −1 , almost 100 % removal rate was obtained only within 10 min. The Pb 2+ ions were trapped on the surface of cellulose and appeared as the form of PbCO 3 . Consequently, the complete separation and recovery would be accomplishable without the secondary pollution, for the spent bio-composite filter was removed easily and conveniently. Notably, the treated water met the drinkable criterion. The roles of cellulose and removal mechanism have also been explained in details.
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DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Jiahui Yan,Haoyu Chen,Carlos F. Guimarães,Rui L. Reis,Zhihua Zhu,Tianyi Wang,Fenglan Zhang,Yaqian Lv,Qihui Zhou,Xiaoying Kong,Jinsheng Shi
Ion interference including copper (Cu + )/calcium (Ca 2+ ) overload activate cell-specific death channels, damage mitochondria and disrupt cellular homeostasis, showing great potential in anti-tumor therapy. However, the complex metabolic environment and the powerful self-protection of tumors cause clinical failure of ion interference. Thus, metabolic disruption is expected an innovative strategy for the enhancement of ion interference. Herein, CuS-α-CHCA&penthiopyrad@CaCO 3 -RGD nanoparticles (CCPCR NPs) are prepared to provide a Cu + /Ca 2+ dual-overload anti-tumor therapy assisted by metabolic-symbiosis-destruction strategy, realizing the collapse of tumor self-protection. Specifically, precise CuS and CaCO 3 delivery triggered irreversible Cu + /Ca 2+ dual-overload and reactive oxygen species (ROS) attack toward 4T1 cells. Meanwhile, α-CHCA and penthiopyrad disturbed the metabolic symbiotic environment by disrupting the TCA cycle and preventing lactate efflux to aggravate intracellular acidosis and promote Fenton-like reaction of Cu + , enhancing the sensitivity of tumor cells to copper death and Ca 2+ overload. Further, aided by the metabolism of symbiosis, the destroyed tumor cells further activate the polarization of M1 macrophages and the maturation and antigen cross-presentation of dendritic cells (DCs), which further eliminate tumor cells. In summary, an amplified anti-tumor dual-ion interference strategy assisted by metabolic symbiotic destruction is established, which is of great significance in improving the clinical effect of ion therapy for tumors.
研究领域:
肿瘤学
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药学
·
免疫学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
Geoenergy Science and Engineering
·
2023
·
IF 0
Hanyi Zhong,Shusen Li,Wenlei Liu,Zhengsong Qiu,Ying Guan,Weian Huang
Effective filtration loss control under high temperature and high salinity environments is a great challenge in oil and gas drilling engineering. In this study, a core-shell structural nano-composite (CSNC) using precipitated nano-CaCO 3 as the core material and cross-linked polymer between acrylamide (AM), 2-acrylamido-2-methylpropanesulfonic acid (AMPS), acrylic acid (AA) and methylene-bis-acrylamide (MBA) as the shell was prepared by reverse emulsion polymerization . The structure of CSNC was characterized with Fourier infrared spectrum (FT-IR), thermogravimetric analysis (TGA), scanning electron microscope (SEM), transmission electron microscope (TEM) and particle size distribution analysis. The filtration control properties of CSNC particles were investigated in both aqueous solution and bentonite suspension with various contents of NaCl and CaCl 2 respectively. The high temperature and high pressure (HTHP) filtration properties between CSNC and typical high temperature resistant filtration reducers were compared. The filtration controlling mechanism of CSNC particles were probed through zeta potential analysis, X-ray diffraction (XRD) analysis and filter cake morphologies observation. The results indicated that for the 4% w/v bentonite suspension treated with 3% w/v CSNC, the low temperature and low pressure (LTLP) filtration loss and filter cake thickness decreased by 84.2% and 76.1% respectively after thermal aging at 220 °C. When the bentonite suspension was contaminated with 30% w/v NaCl and 0.5% w/v CaCl 2 respectively, incorporation of 1% w/v CSNC reduced the filtration loss by 72.5% and 86.9% after thermal aging at 200 °C. The core-shell structure, cross-linked structure, and salt tolerant sulfonic acid groups on the outer surface of CSNC in combination contributed to extraordinary filtration loss control under stringent high temperature and high salinity conditions.
研究领域:
石油工程
·
材料科学
✓ 已验证
DOI
Gels
·
2022
·Vol. 8
·期 5
·322
·
IF 4.432
Zhichuan Tang,Zhengsong Qiu,Hanyi Zhong,Hui Mao,Kai Shan,Yujie Kang
Filtration loss control under high-temperature conditions is a worldwide issue among water-based drilling fluids (WBDFs). A core–shell high-temperature filter reducer (PAASM-CaCO3) that combines organic macromolecules with inorganic nanomaterials was developed by combining acrylamide (AM), 2-acrylamide-2-methylpropane sulfonic acid (AMPS), styrene (St), and maleic anhydride (MA) as monomers and nano-calcium carbonate (NCC). The molecular structure of PAASM-CaCO3was characterized. The average molecular weight of the organic part was 6.98 × 105and the thermal decomposition temperature was about 300 °C. PAASM-CaCO3had a better high-temperature resistance. The rheological properties and filtration performance of drilling fluids treated with PAASM-CaCO3were stable before and after aging at 200 °C/16 h, and the effect of filtration control was better than that of commonly used filter reducers. PAASM-CaCO3improved colloidal stability and mud cake quality at high temperatures.Keywords:filtration reducer;high temperature;water-based drilling fluid;nanomaterials;calcium carbonate
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产品关联
DOI
PubMed
高影响因子
Energy Technology
·
2022
·Vol. 10
·期 9
·2200163
·
IF 4.149
Yan Cui,Jiahui Chen,Jingyang Zhao,Zhen Ma,Yuming Tan,Jianjun Xue,Hanliang Xu,Junmin Nan
Based on a strategy of stabilizing the LiMn 2 O 4 (LMO) cathode interface, the high-temperature cycling and storage performance of 18 650-type LMO/graphite lithium-ion batteries (LIBs) is effectively improved. The LMO cathode is prepared using lithium carboxymethyl cellulose (CMCLi)–polyacrylic acid/acrylate copolymer composite binder and nanoscale CaCO 3 functional component (marked as binder C). Compared with the traditional oily binder, the dissolution of Mn 2+ from LMO cathode into the electrolyte can effectively decrease, and the structure stability of LMO cathode can increase. The batteries exhibit retention capacity of 80.3% at 1 C after 600 cycles at room temperature and 76.7% at 1 C after 200 cycles at temperature of 45 °C. The high-temperature storage performance is also improved and there are 81.1% and 73.5% residual capacities when the fully charged batteries are stored in 60 °C for 14 and 28 days. The enhanced performance is mainly attributed to the interfacial stability of LMO cathode due to the bonding ability of composite binders and the elimination of HF by CaCO 3 . These results reveal the application prospect of as-developed aqueous binders and provide a way to improve the performance of LMO-based LIBs through stable interface strategy.
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产品关联
DOI
高影响因子
ACS Nano
·
2024
·
IF 15.8
Xin Wan,Ying Zhang,Yiqun Wan,Mengmeng Xiong,Anqi Xie,Yongye Liang,Hao Wan
The biomimetic nanoparticles (NPs) possessing abilities of tumor targeting and multimodal therapy show great potential for efficient combat of colon cancer. Herein, we developed a multifunctional biomimetic nanoplatform (Fe3O4@PDA@CaCO3–ICG@CM) based on CaCO3-modified magnetic polydopamine (PDA) loaded with indocyanine green (ICG), which was encapsulated by a mouse lymphoma cell (EL4) membrane (CM) expressing functional proteins (i.e., lymphocyte function-associated antigen 1, LFA-1; transforming growth factor-β receptor, TGF-βR; programmed cell death protein 1, PD-1; and factor related apoptosis ligand, FasL). Under magnetic attraction and LFA-1/PD-1-mediated endocytosis, Fe3O4@PDA@CaCO3–ICG@CM efficiently targeted CT26 colon tumor cells. The released calcium ion (Ca2+) from the NPs triggered by acidic tumor microenvironment, the enhanced photothermal effect contributed by the combination of PDA and ICG, and FasL’s direct killing effect together induced tumor cells apoptosis. Moreover, the apoptosis of CT26 cells induced immunogenic cell death (ICD) to promote the maturation of dendritic cells (DCs) to activate CD4+/CD8+ T cells, thereby fighting against tumor cells, which could further be boosted by programmed death-ligand 1 (PD-L1) blockage and transforming growth factor-β (TGF-β) scavenging by Fe3O4@PDA@CaCO3–ICG@CM. As a result, in vivo satisfactory therapeutic effect was observed for CT26 tumor bearing-mice treated with Fe3O4@PDA@CaCO3–ICG@CM under laser irradiation and magnetic attraction, which could eradicate primary tumors and restrain distant tumors through dual tumor targeting-assisted multimodal therapy and eliciting adaptive antitumor immune response, generating the immune memory for inhibiting tumor metastasis and recurrence. Taken together, the multifunctional biomimetic nanoplatform exhibits superior antitumor effects, providing an insightful strategy for the field of nanomaterial-based treatment of cancer.
研究领域:
纳米技术
·
癌症研究
·
生物医学工程
·
免疫治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Lu Liu,Enling Hu,Haoyu Qiu,Qian Xu,Kun Yu,Ruiqi Xie,Fei Lu,Qi Wang,Bitao Lu,Qing Li,Guangqian Lan
Skin wound healing in dynamic environments remains challenging. Conventional gels are not ideal dressing materials for wound healing due to difficulties in completely sealing wounds and the inability to deliver drugs quickly and precisely to the injury. To tackle these issues, we propose a multifunctional silk gel that rapidly forms strong adhesions to tissue, has excellent mechanical properties, and delivers growth factors to the wound. Specifically, the presence of Ca 2+ in the silk protein leads to a solid adhesion to the wet tissue through a chelation reaction with water-trapping behavior; the integrated chitosan fabric and CaCO 3 particles ensure enhanced mechanical strength of the silk gel for better adhesion and robustness during wound repair; and the preloaded growth factor further promoted wound healing. The results showed the adhesion and tensile breaking strength were as high as 93.79 kPa and 47.20 kPa, respectively. MSCCA@CaCO 3 -aFGF could remedy the wound model in 13 days, with 99.41 % wound shrinkage without severe inflammatory responses. Due to strong adhesion properties and mechanical strength, MSCCA@CaCO 3 -aFGF can be a promising alternative to conventional sutures and tissue closure staples for wound closure and healing. Therefore, MSCCA@CaCO 3 -aFGF is expected to be a strong candidate for the next generation of adhesives.
研究领域:
生物医学工程
·
材料科学
·
组织工程
·
伤口愈合
✓ 已验证
DOI
PubMed
高影响因子
Asian Journal of Pharmaceutical Sciences
·
2024
·
IF 10.7
Xiaoju Guo,Xiaoxiao Chen,Jiayi Ding,Feng Zhang,Shunyang Chen,Xin Hu,Shiji Fang,Lin Shen,Chenying Lu,Zhongwei Zhao,Jianfei Tu,Gaofeng Shu,Minjiang Chen,Jiansong Ji
Chemotherapy plays a crucial role in triple-negative breast cancer (TNBC) treatment as it not only directly kills cancer cells but also induces immunogenic cell death. However, the chemotherapeutic efficacy was strongly restricted by the acidic and hypoxic tumor environment. Herein, we have successfully formulated PLGA-based nanoparticles concurrently loaded with doxorubicin (DOX), hemoglobin (Hb) and CaCO 3 by a CaCO 3 -assisted emulsion method, aiming at the effective treatment of TNBC. We found that the obtained nanomedicine (DHCaNPs) exhibited effective drug encapsulation and pH-responsive drug release behavior. Moreover, DHCaNPs demonstrated robust capabilities in neutralizing protons and oxygen transport. Consequently, DHCaNPs could not only serve as oxygen nanoshuttles to attenuate tumor hypoxia but also neutralize the acidic tumor microenvironment (TME) by depleting lactic acid, thereby effectively overcoming the resistance to chemotherapy. Furthermore, DHCaNPs demonstrated a notable ability to enhance antitumor immune responses by increasing the frequency of tumor-infiltrating effector lymphocytes and reducing the frequency of various immune-suppressive cells, therefore exhibiting a superior efficacy in suppressing tumor growth and metastasis when combined with anti-PD-L1 (αPD-L1) immunotherapy. In summary, this study highlights that DHCaNPs could effectively attenuate the acidic and hypoxic TME, offering a promising strategy to figure out an enhanced chemo-immunotherapy to benefit TNBC patients.
研究领域:
肿瘤学
·
药理学
·
纳米技术
·
免疫疗法
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）