ELECTROCHIMICA ACTA
·
2026
·
IF 5.6
Yuanyuan Liao,Jieran Xie,Lei Sun,Zongyi Huang,Jing Li,Feng Liu,Yongxiu Li
Oxygen evolution reaction (OER) is a critical challenge in electrochemical water splitting, necessitating the development of efficient catalysts. In this study, a room-temperature gas–liquid diffusion strategy is presented to synthesize rare earth-doped NiCo₂O₄ nanosheets on carbon paper (RE-NiCo₂O₄/CP, RE = La, Ce, Pr, Gd) as alkaline OER electrocatalysts. Among them, Ce-NiCo₂O₄/CP demonstrates catalytic activity, requiring an overpotential of only 265 mV to achieve a current density of 20 mA cm⁻² in 1 M KOH, which is lower than that of undoped NiCo₂O₄/CP (348 mV). Comprehensive characterization reveals that RE doping modulates the electronic structure of NiCo₂O₄, increasing the Co 3+ /Co 2+ ratio and optimizing intermediate adsorption. Notably, Ce doping facilitates the formation of highly active Ni(Co)OOH species during OER, further enhancing catalytic performance. Combination experiments and in-situ analysis confirmed that the increase in activity was due to the incorporation of rare earths, which enhanced the charge transfer of reaction intermediates and promoted the formation of highly active phases. This work not only presents a synthesis method for high-performance OER catalysts, but also elucidates the electronic modulation effect into the role of rare-earth elements in tuning electrocatalytic properties.
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高影响因子
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2026
·
IF 6.7
Aiyi Chen,Gensheng Mo,Weiyuan Xu,Yong Jian,Peijie Guan,Chenyang Zhang,Zhihan Yan,Yanqiang Huang,Lixiong Dai
Molecular Synergy : Two novel GBCAs, Gd-L1 and Gd-L2 , are constructed by integrating a macrocyclic inert Gd-DOTABA core with HSA-targeting biphenylalanine (BiP)-based dipeptides. • High Relaxivity : Both probes exhibit high longitudinal relaxivity ( r 1 = 20.7 and 23.3 mM −1 s −1 in 4.5% HSA at 1.4 T), driven by near-quantitative binding to human serum albumin (>90%). • Superior Kinetic Stability : The complexes demonstrate outstanding inertness, with acid dissociation half-lives 3-5 times longer than the clinical benchmark Gd-DOTA, ensuring a high safety profile. • Potent Low-Dose Efficacy : At merely one-third of the standard clinical dose (0.03 mmol/kg), both agents enable high-contrast tumor delineation and high-resolution angiography in vivo. • Favorable Safety : Comprehensive in vivo studies confirm excellent biocompatibility, efficient dual clearance, and no acute or subacute toxicity, supporting clinical translation potential. The development of gadolinium-based contrast agents (GBCAs) that simultaneously possess high relaxivity and excellent kinetic inertness remains an important challenge for safe and efficient magnetic resonance imaging (MRI). Herein, we report a rational molecular engineering strategy to construct two novel probes, Gd-L1 and Gd-L2 , by conjugating an unnatural biphenylalanine (BiP)-based dipeptide to a macrocyclic Gd-DOTABA scaffold. The introduced BiP-containing dipeptide enhances interaction with human serum albumin (HSA), leading to substantially improved relaxivity. Both complexes exhibit high longitudinal relaxivity ( r 1 = 10.3 and 9.4 mM −1 s −1 in water), which increases to 20.7 and 23.3 mM −1 s −1 in the presence of HSA. In addition, these complexes demonstrate favorable kinetic inertness, with acid dissociation half-lives 3–5 times longer than Gd-DOTA. At a reduced dose of 0.03 mmol/kg, both agents enable high-contrast tumor imaging and magnetic resonance angiography in vivo . Biodistribution, pharmacokinetic, and toxicity studies further support favorable clearance and biocompatibility. These findings demonstrate that unnatural dipeptide-functionalized Gd-DOTABA complexes represent promising macrocyclic albumin-interacting MRI contrast agents with enhanced imaging performance and favorable safety characteristics. Rational Design of Unnatural Dipeptide-Enabled Gd-DOTABA Probes: A Synergistic Approach for Stable, High-Relaxivity Gd Complexes Enabling Low-Dose Tumor and Vascular Imaging. Download: Download high-res image (476KB) Download: Download full-size image
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PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Xingbo Kang,Sihan Feng,Sai Huang,Qi Zhu,Ji-Guang Li
Bi 3+ ion presents strong UV excitation up to ∼430 nm and is almost not excitable by visible light, which makes it valuable in current lighting technologies. Morphologically uniform Sc 1- x VO 4 : x Bi 3+ ( x = 0–0.03, 0.005 interval) and RE 0.99 VO 4 :0.01Bi 3+ (RE = Sc, Lu, Y, Gd, Lu 0.5 Sc 0.5 , Y 0.5 Lu 0.5 , Gd 0.5 Y 0.5 ) micro/nanocrystals were successfully prepared in this work by hydrothermal reaction under 180 °C and pH = 8, without using any chelate or surfactant. The solid-solution vanadates were formed as microrods for Sc and nanocrystals for the other RE owing to different reaction pathways. The optimal Bi 3+ content for luminescence is 1 at% ( x = 0.01) and concentration quenching was analyzed to occur via electric dipole-dipole interaction. The peak wavelength of the excitation/emission band was found to almost linearly increase, accompanied by band broadening, with decreasing cell volume for the series of REVO 4 :0.01Bi 3+ , which was rationalized by considering the energy of metal-to-metal charge transfer (MMCT) and the character of the chemical bond (nephelauxetic effect). Notably, the REVO 4 :0.01Bi 3+ phosphors showed broadband luminescence (FWHM >165 nm) covering almost the entire visible light region in each case, and the center wavelength of emission can be widely and finely tuned from ∼557 to 639 nm by decreasing the size of RE 3+ on demand. Such luminescence performance may allow the micro/nanocrystals to find valuable application in UV-excited white LED lighting and others.
研究领域:
材料科学
·
光学
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高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2024
·
IF 5.8
Chunlin Zheng,Weiwei Qi,Mingqiang Ning,Lan Xiang,Tao Liu,Yuanyuan Li,Ganggang Lv,Qiang Wu,Qikui Man,Baogen Shen
Prussian blue analogs (PBA) derivatives have been researched extensively as electromagnetic wave (EMW) absorbers. However, the metallic components are typically transition-metal elements, which results in limited potential for optimization of their EMW absorbing performance. In this work, GdCo-PBA derivates with different carbon nanotubes (CNTs) morphologies and phase compositions were synthesized via tuning the pyrolysis rate and the dielectric loss capability can be tuned. As a result, the R-GdN/Co@CNTs achieved the minimum reflection loss ( RL min ) of −36.74 dB@1.7 mm and the maximum effective absorption bandwidth (EAB) of 5.61 GHz @ 2.0 mm due to the combined effect of the interconnected CNTs conduction network and the GdN phase in optimizing the impedance matching and enhancing the dielectric loss. Meanwhile, the radar cross section (RCS) simulation and electrochemical corrosion tests confirmed that GdCo-PBA derivatives can significantly reduce RCS values of 28.6 dBm 2 @ 15° and possessed satisfied anti-corrosion properties with a corrosion current density of 2.06 × 10 −5 A/cm 2 and polarization resistance of 2.57 × 10 4 Ω, which displayed significant potential for practical applications in extreme marine environments. This work presents a strategy for synthesizing lanthanide PBA derivates with the EMW absorbing and anti-corrosion properties.
研究领域:
材料科学
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电磁学
·
腐蚀与防护
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高影响因子
Journal of Materials Chemistry C
·
2024
·
IF 5.7
Kai Ding,Wenye Deng,Jinyang Li,Ni Ai,Yan Xue,Xianghui Chen,Pengjun Zhao,Weiwei Meng,Aimin Chang,Yongxin Xie
This study synthesized La0.9X0.1AlO3 (X = Eu, Gd, Ho, Tm) and LaAlO3 ceramics by a solid-state method. The characterization of the ceramics revealed that the high degree of lattice distortion induced by variations in the size, mass, and electronegativity of rare-earth elements enhances high-temperature stability, leading to aging drift rates between 0.4% and 2.3% after 500 h at 1000 °C. Furthermore, the emergence of intrinsic defects and dislocations alters the charge conduction mode in LaAlO3, resulting in significant linearity at temperatures above 1000 K. This study further elucidates the transition in the charge conduction mechanism from thermally activated conduction to hopping conduction, which is driven primarily by oxygen vacancies and dislocations. DFT calculations support these findings, demonstrating a reduction in the band gap and increased carrier concentration. This work paves the way for the development of advanced NTC thermistors for reliable temperature monitoring in challenging environments.
研究领域:
材料科学
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电子工程
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高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2021
·
IF 5.316
Lei Fu,Di Wu,Yanfei Xiao,Wanfang Zou,Jinfen Kuang,Yan Liang,Fu Du,Jiaqing Peng,Xinyu Ye
Blue phosphor Sr 5−x-y R y (PO 4 ) 3 Cl:xEu 2+ (R = La, Gd, Lu) was prepared via solid-state reaction process, in which R 3+ replaces part of Sr 2+ ions in the matrix to benefit Eu 2+ luminescence. The change of Eu 2+ /Eu 3+ values were studied by XPS , and the results shown that the incorporation of R 3+ in the matrix resulted in the values increase of Eu 2+ /Eu 3+ . And substitute R 3+ non-equivalently for Sr 2+ , the modified Sr 5−x-y R y (PO 4 ) 3 Cl:xEu 2+ phosphors show better luminescence intensity and thermal stability. The emission intensity of Sr 4.72 Lu 0.2 (PO 4 ) 3 Cl:0.08Eu 2+ is 1.97 times of Sr 4.95 (PO 4 ) 3 Cl:0.05Eu 2+ . Moreover, the thermal quenching of Eu 2+ photoluminescence could be reduced. Compared to the commercial BAM:Eu 2+ phosphor, the stabilities of all Sr 4.72 R 0.2 (PO 4 ) 3 Cl:0.08Eu 2+ (R=La 3+ , Gd 3+ and Lu 3+ ) phosphors are better than that of BAM:Eu 2+ at the temperatures below 100 °C. The luminescent intensity of Sr 4.72 Lu 0.2 (PO 4 ) 3 Cl:0.08Eu 2+ maintains 95% while BAM:Eu 2+ is only 88% of the initial intensity at 150 °C. By combining Sr 4.72 Lu 0.2 (PO 4 ) 3 Cl:0.08Eu 2+ , Y 3 (Al,Ga) 5 O 12 :Ce 3+ and CaAlSiN 3 :Eu 2+ with 400 nm near-ultraviolet LED chip, a white-light-emitting diode was obtained. The fabricated WLED device with CIE color coordinates x = 0.3896, y = 0.3788, low CCT (3775 K) and high Ra (95.1), has enormous potential application in full-spectrum lighting field.
研究领域:
材料科学
·
光学工程
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高影响因子
Journal of Materials Chemistry B
·
2021
·Vol. 9
·期 7
·1846-1857
·
IF 6.331
Yiyao Pu,Yuda Zhu,Zi Qiao,Nini Xin,Suping Chen,Jing Sun,Rongrong Jin,Yu Nie,Hongsong Fan
Based on widely used photoacoustic imaging (PAI) and photothermal properties of polydopamine (PDA), a multifunctional Gd–PDA-Ce6@Gd-MOF (GPCG) nanosystem with a core–shell structure and strong imaging ability was constructed. Benefitting from the metal–organic framework (MOF) structure, GPCG nanoparticles (NPs) showed enhanced magnetic resonance imaging (MRI) ability with high relaxation rates (r1 = 13.72 mM−1 s−1 and r2 = 216.14 mM−1 s−1). The MRI effect of Gd ions combined with the PAI effect of PDA, giving GPCG NPs a dual-modal imaging ability. The core, mainly composed of PDA and photodynamic photosensitizer chlorin e6 (Ce6), achieved photothermal/photodynamic therapy (PTT/PDT) synergistic performance. Besides, to overcome the unexpected release of Ce6, the MOF shell realized pH-sensitive release and a high local concentration. Through in vivo studies, we concluded that GPCG NPs show a good inhibitory effect on tumor growth. In conclusion, we successfully obtained a GPCG theranostic nanoplatform and paved the way for subsequent design of imaging guided therapeutic nanostructures based on metal-doped PDA.
研究领域:
纳米技术
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生物医学工程
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诊疗学
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影像与治疗
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PubMed
高影响因子
JOURNAL OF SOLID STATE CHEMISTRY
·
2019
·
IF 2.291
Peixi Hao,Linwen Jiang,Hanlei Zhao,Jiangtao Li,Shiwen Qiu,Hongbing Chen
The MFeO 3 : R 3+ (M = La, Gd; R = Eu, Er, Ho) nanocrystalline powders were successfully synthesized by the sol–gel combustion method using glycine-based gel at a low ignition temperature. The as-burnt products present honeycomb-like structure with many irregular continuous pores due to the releasing of a large amount of gas during the combustion reaction process. The lattice parameters and cell volumes of MFeO 3 :R 3+ (M = La, Gd; R = Eu, Er, Ho) nanocrystalline powders are compared in detail. The magnetic properties of all the samples were studied systematically. The results show that the doping of rare-earth ions enhanced greatly the coercivity of GdFeO 3 and LaFeO 3 as a result of the enhancement of magnetic anisotropy . The influence of doped rare-earth ions on the magnetic properties was summarized. The distinction of magnetism of MFeO 3 :R 3+ (M = La, Gd; R = Eu, Er, Ho) were explained in detail by the intrinsic magnetism of doped rare-earth ions. This work is significant for the application of rare-earth elements in other magnetic materials.
研究领域:
材料科学
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磁学
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高影响因子
ACS Applied Bio Materials
·
2020
·
IF 0
Bin Xia,Xu Yan,Wei-Wei Fang,Sheng Chen,ZhiLin Jiang,JinChen Wang,Tian-Ci Sun,Qing Li,Zhen Li,Yang Lu,Tao He,BaoQiang Cao,Chang-Tong Yang
Activatable cell-penetrating peptide (ACPP) conjugated polymeric nanoparticles containing gadolinium (Gd)-chelates and aggregation-induced emission fluorogens (AIEgens) have been synthesized and applied as a magnetic resonance imaging (MRI) and fluorescence imaging (FI) bimodal imaging probe with active tumor targeting. The polymeric nanoparticles have been generated by dissolving presynthesized linear block copolymers into water directly. With AIEgens, N-BP5-Gd-ACPPs showed tumor cell penetration, which can be characterized by in vitro FI. Preliminary in vivo experiments of Gd-chelated nanoparticles have demonstrated promising characteristics as a tumor-targeting MRI contrast agent with good biocompatibility. This study impacts the synthesis of functional copolymers and polymeric nanoparticles for their applications in bioimaging.
研究领域:
生物医学工程
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分子影像学
·
材料科学
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PubMed
Catalysts
·
2021
·Vol. 11
·期 3
·324
·
IF 4.146
Jinkun Guan,Lusha Zhou,Weiquan Li,Die Hu,Jie Wen,Bichun Huang
SO2poisoning is a great challenge for the practical application of Mn-based catalysts in low-temperature selective catalytic reduction (SCR) reactions of NOxwith NH3. A series of Gadolinium (Gd)-modified MnOx/ZSM-5 catalysts were synthesized via a citric acid–ethanol dispersion method and evaluated by low-temperature NH3-SCR. Among them, the GdMn/Z-0.3 catalyst with the molar ratio of Gd/Mn of 0.3 presented the highest catalytic activity, in which a 100% NO conversion could be obtained in the temperature range of 120–240 °C. Furthermore, GdMn/Z-0.3 exhibited good SO2resistance compared with Mn/Z in the presence of 100 ppm SO2. The results of Brunauer–Emmett–Teller (BET), X-ray photoelectron spectroscopy (XPS), temperature-programmed reduction of H2(H2-TPR) and temperature-programmed desorption of NH3(NH3-TPD) illustrated that such catalytic performance was mainly caused by large surface area, abundant Mn4+and surface chemisorbed oxygen species, strong reducibility and the suitable acidity of the catalyst. The in situ diffuse reflectance infrared Fourier transform spectra (DRIFTS) results revealed that the addition of Gd greatly inhibited the reaction between the SO2and MnOxactive sites to form bulk manganese sulfate, thus contributing to high SO2resistance. Moreover, in situ DRIFTS experiments also shed light on the mechanism of low-temperature SCR reactions over Mn/Z and GdMn/Z-0.3, which both followed the Langmuir–Hinshelwood (L–H) and Eley–Rideal (E–R) mechanism.Keywords:SO2poisoning;low temperature;NH3-SCR;in situ DRIFTS
研究领域:
催化化学
·
环境科学
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高影响因子
BIOMATERIALS
·
2015
·
IF 8.557
Ling'e Zhang,Leyong Zeng,Yuanwei Pan,Song Luo,Wenzhi Ren,An Gong,Xuehua Ma,Hongze Liang,Guangming Lu,Aiguo Wu
Inorganic photosensitizer coupled Gd-based upconversion luminescent (UCL) nanocomposites have potential application for both magnetic resonance imaging (MRI) and photodynamic therapy (PDT) of cancers using the light stability and biocompatibility of TiO 2 inorganic photosensitizer. However, TiO 2 inorganic photosensitizer could only be excited by ultraviolet (UV) light, which was harmful and weakly penetrable in tissues. In this work, folic acid (FA)-targeted NaGdF 4 :Yb/Tm@SiO 2 @TiO 2 nanocomposites (FA-Gd-Si-Ti NPs) were constructed and synthesized for both in vivo MRI and near infrared (NIR)-responsive inorganic PDT, in which TiO 2 component could be excited by NIR light due to the UCL performance of NaGdF 4 :Yb/Tm component converting NIR to UV light. The results showed the as-prepared FA-Gd-Si-Ti NPs had good biocompatibility in vitro and in vivo. Moreover, MR study indicated that FA-Gd-Si-Ti NPs were good T 1 -weighted MRI contrast agents with high longitudinal relaxivity (r 1 ) of 4.53 m m −1 s −1 , also in vivo MRI of nude mice showed “bright” signal in MCF-7 tumor. Under the irradiation of 980 nm laser at the power density of 0.6 W/cm 2 for 20 min, the viability of HeLa and MCF-7 cells incubated with FA-Gd-Si-Ti NPs could decrease from about 90 % to 35 % and 31%, respectively. Furthermore, in vivo PDT of MCF-7 tumor-bearing nude mice model showed that the inhibition ratio of tumors injected with FA-Gd-Si-Ti NPs reached up to 88.6% after 2-week treatment, compared with that of nude mice in control group. Based on the deep penetration of NIR light and the good biocompatibility of TiO 2 inorganic photosensitizer, the as-prepared FA-Gd-Si-Ti NPs could have potential applications in both MRI and NIR-responsive PDT of cancers in deep tissues.
研究领域:
生物医学工程
·
肿瘤学
·
材料科学
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PubMed
高影响因子
Nanoscale
·
2015
·Vol. 8
·期 2
·878-888
·
IF 7.394
Yuanwei Pan,Ling'e Zhang,Leyong Zeng,Wenzhi Ren,Xueshan Xiao,Jichao Zhang,Lili Zhang,Aiguo Li,Guangming Lu,Aiguo Wu
Multidrug resistance (MDR) of cancers is still a major challenge, and it is very important to develop visualized nanoprobes for the diagnosis and treatment of drug resistant cancers. In this work, we developed a multifunctional delivery system based on DOX-encapsulated NaYF4:Yb/Er@NaGdF4 yolk–shell nanostructures for simultaneous dual-modal imaging and enhanced chemotherapy in drug resistant breast cancer. Using the large pore volume of the nanostructure, the delivery system had a high loading efficiency and excellent stability. Also, an in vitro and in vivo toxicity study showed the good biocompatibility of the as-prepared yolk–shell nanomaterials. Moreover, by nanocarrier delivery, the uptake of DOX could be greatly increased in drug resistant MCF-7/ADR cells. Compared with free DOX, the as-prepared delivery system enhanced the chemotherapy efficacy against MCF-7/ADR cells, indicating the excellent capability for overcoming MDR. Furthermore, core–shell NaYF4:Yb/Er@NaGdF4 improved the upconversion luminescence (UCL) performance, and the designed delivery system could also be applied for simultaneous UCL and magnetic resonance (MR) imaging, which could be a good candidate as a dual-modal imaging nanoprobe. Therefore, we developed a multifunctional yolk–shell delivery system, which could have potential applications as a visualized theranostic nanoprobe to overcome MDR in breast cancer.
研究领域:
纳米技术
·
癌症研究
·
材料科学
·
生物医学工程
·
药物学
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PubMed
高影响因子
危险品化学品经营许可证（带存储）