FASEB JOURNAL
·
2026
·
IF 4.3
Wenbo Yuan,Qirui Zhao,Jing Hua,Lingyao Xu,Yufan Wang,Tongtong Xu,Zuchao Du,Liping Wu,Daxiang Cui
Ulcerative colitis (UC) is a chronic inflammatory bowel disease marked by sustained mucosal inflammation and epithelial barrier dysfunction, closely associated with aberrant NOD‐like receptor family pyrin domain‐containing 3 (NLRP3) inflammasome activation. Targeted oral therapies that simultaneously suppress inflammation and promote mucosal repair remain limited. We developed an orally administrable nanomicrocapsule system (PDA@Gel@GO) for colon‐targeted delivery of oridonin, a natural diterpenoid with anti‐inflammatory activity. The system was constructed by encapsulating galactosylated carboxymethyl chitosan–based oridonin nanomicelles (GO) within gelatin microspheres, followed by polydopamine coating to enhance gastrointestinal stability and mucosal adhesion. In a dextran sulfate sodium (DSS)‐induced UC mouse model, PDA@Gel@GO exhibited preferential accumulation in inflamed colonic tissues and significantly improved body weight loss, disease activity index, and colon shortening. Mechanistic studies demonstrated that PDA@Gel@GO treatment suppressed NLRP3 inflammasome activation, as evidenced by reduced expression of NLRP3, ASC, caspase‐1, and IL‐1β, accompanied by attenuation of oxidative stress and restoration of intestinal barrier proteins. Transcriptomic analysis further revealed activation of gene programs associated with epithelial regeneration, cell cycle progression, and DNA repair, suggesting coordinated inflammation resolution and mucosal repair. Collectively, this study presents a macrophage‐targeted, multilayered nanomicrocapsule platform that enhances the therapeutic efficacy of oridonin through precise colon targeting and integrated anti‐inflammatory and tissue‐protective effects, providing a promising strategy for precision treatment of UC. Mechanism of galactosylated carboxymethyl chitosan nanomicelle oral microcapsules delivering oridonin in alleviating colitis via targeting the NLRP3 inflammasome.
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DOI
PubMed
高影响因子
Symmetry-Basel
·
2025
·Vol. 17
·期 5
·773
·
IF 2.2
Qingfang Zhang,Yi Li,Xingyu Wang,Xiaoyu Zhang,Shuyi Liu,Hengyi Yuan,Xiaodong Yang,Da Li,Zeping Jin,Yujian Zhang,Yutong Liu,Zhengmai Bian
In recent years, flexible piezoresistive sensors based on polydimethylsiloxane (PDMS) matrix materials have developed rapidly, showing broad application prospects in fields such as human motion monitoring, electronic skin, and intelligent robotics. However, achieving a balance between structural durability and fabrication simplicity remains challenging. Traditional methods for preparing PDMS flexible substrates with high porosity and high stability often require complex, costly processes. Breaking through the constraints of conventional material systems, this study innovatively combines the high elasticity of polydimethylsiloxane (PDMS) with the stochastically distributed porous topology of a sponge-derived biotemplate through biomimetic templating replication technology, fabricating a heterogeneous composite system with an architecturally asymmetric spatial network. After 5000 loading cycles, uncoated samples experienced a thickness reduction of 7.0 mm, while PDMS-coated samples showed minimal thickness changes (2.0–3.0 mm), positively correlated with curing agent content (5:1 to 20:1). The 5:1 ratio sample demonstrated exceptional mechanical stability. As evidenced, the PDMS film-encapsulated architecturally asymmetric spatial network demonstrates superior stress dissipation efficacy, effectively mitigating stress concentration phenomena inherent to symmetric configurations that induce matrix fracture, thereby achieving optimal mechanical stability. Compared to the pre-test resistance distribution of 10–248 Ω, after 5000 cyclic loading cycles, the uncoated samples exhibited a narrowed resistance range of 10–50 Ω, while PDMS-coated samples maintained a broader resistance range (10–240 Ω) as the curing agent ratio increased (from 20:1 to 5:1), demonstrating that increasing the curing agent ratio helps maintain conductive network stability. The 5:1 ratio sample displayed the lowest resistance variation rate attenuation—only 3% after 5000 cycles (vs. 80% for uncoated samples)—and consistently minimal attenuation at all stages, validating superior electrical stability. Under 0–6 kPa pressure, the 5:1 ratio device maintained a linear sensitivity of 0.157 kPa−1, outperforming some existing works. Human motion monitoring experiments further confirmed its reliable signal output. Furthermore, the architecturally asymmetric spatial network of the device enables superior conformability to complex curvilinear geometries, leveraging its structural anisotropy to achieve seamless interfacial adaptation. By synergistically optimizing material composition and structural design, this study provides a novel technical method for developing highly durable flexible electronic devices.
研究领域:
材料科学
·
电子工程
·
仿生学
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DOI
高影响因子
DESALINATION
·
2024
·
IF 8.3
Ting Shu,Yuliang Zhang,Xiahui Liu,Zhuo Liu,Ying Qin,Fei Wang,Xueting Chang,Dongsheng Wang,Lihua Dong,Xiaobo Chen,Xijia Yin,Zecheng Qian
Solar interfacial evaporation technology is an effective and sustainable method for seawater desalination. It is crucial to achieve high photothermal conversion efficiency, rapid evaporation rate, and long-term stability. In this study, a vertically aligned porous aerogel evaporator is prepared using sodium alginate as the substrate material and graphene oxide (GO) and polypyrrole (PPy) as the photothermal materials through a directional freezing technology. The polypyrrole@graphene oxide-sodium alginate evaporator exhibits a high solar photothermal conversion efficiency as high as 98.6 % and an evaporation rate of up to 4.66 kg·m −2 ·h −1 under 1 sun. During the 144-hour desalination, the evaporator transports brine for evaporation in the daytime and removes salt residue from the evaporator surface at night. It has demonstrated a self-cleaning behavior and restored its desalination stability. Thus, this aerogel evaporator with a high evaporation rate and stable salt resistance shows great potential for practical applications in solar thermal conversion and seawater desalination.
研究领域:
材料科学
·
环境科学
·
能源科学
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DOI
高影响因子
Advanced Membranes
·
2022
·
IF 0
Ning Zhang,Hui Yu,Haoyu Cui,Hui Xiao,Xiaobin Jiang,Yan Dai,Xiaopeng Zhang,Junjiang Bao,Gaohong He
Graphene oxide (GO) films are highlighted to have great potential in water purification. The highly chemical and thermally stable polyacrylonitrile (PAN) competently constructs a superior substrate supporting the ultrathin GO laminates under various aqueous environments. However, the lack of available functional groups of PAN substrate, which inevitably leads to an undesirable water-induced peeling of the stacked GO laminates, greatly limits its practical application in constructing a stable GO composite membrane. A hydrolysis-condensation-induced bridge strategy is reported in which a bio-inspired molecular bridge generates a strong adhesion of PAN substrate to GO laminate, meanwhile interlaminar molecular bridges also form to generate a robust GO laminate with excellent resistance to swelling. Such GO composite membranes exhibit structural durability in the treatment of dye-containing wastewater for several days or even longer. The interfacial molecular bridge has little effect on the size-sieving and unique transport capability of the GO laminates. Comparable water permeability with the pristine GO laminates and nearly complete rejection to dyes (i.e. Congo red, methylene blue, and methyl orange) were obtained. The combination of easy fabrication, robust stability, and high performance make the PAN-supported GO membranes advantageous for practical application in textile wastewater purification.
研究领域:
材料科学
·
环境工程
·
化学工程
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DOI
SURFACE & COATINGS TECHNOLOGY
·
2025
·
IF 6.1
Hao Wang,Liuyan Zhang,Yingying Li,Yidong Huang,Jiarui Guo,Suye Li,Renyu Zhou,Binkai Yuan,Lichan Wu,Danting Wu,Gengzhe Shen,Guibin Tan,Fujian Guo
To provide effective surface protection for magnesium (Mg) alloy, a novel Zn-Ni-ZrN/GO composite coating was fabricated on the Mg substrate through an integrated cold spraying and electrodeposition approach. The ZrN/GO binary nanocomposite was introduced into the plating system for the first time, overcoming the performance limitations of conventional single-particle doping. This system achieved a triple synergistic mechanism of “hard-phase strengthening, soft-phase lubrication, and barrier-type anti-corrosion,” while simultaneously resolving the interfacial bonding challenge between Mg alloy and coatings. The microstructure, tribological behavior, and electrochemical corrosion properties of the coating were systematically investigated using a range of analytical techniques, including SEM, TEM, XRD, EDS, XPS, potentiodynamic polarization (PDP), electrochemical impedance spectroscopy (EIS), full immersion tests and wear tests. The results revealed that the Zn-Ni-ZrN/GO coating exhibited a dense and uniform microstructure, with ZrN/GO composite materials being well-dispersed in the Zn Ni matrix, forming a synergistic strengthening structure that promoted grain refinement. Tribological analysis showed that the Zn-Ni-ZrN/GO coating exhibited significantly lower friction coefficients and wear rates with a friction coefficient of 0.13 and a wear rate of 5.2 × 10 −6 mm 3 ·N −1 ·m −1 . In terms of corrosion resistance in a 3.5 wt% NaCl solution, the Zn-Ni-ZrN/GO coating exhibited the highest self-corrosion potential (Ecorr = −1.13 VSCE) and the lowest self-corrosion current density (icorr = 2.72 × 10 −6 A·cm −2 ). Overall, the Zn-Ni-ZrN/GO coating achieved synergistic optimization of wear and corrosion resistance through compositional design, significantly enhancing the wear and corrosion resistance of Mg alloy, and offering a new approach for the development of high-performance Zn-Ni-based protective coatings.
研究领域:
材料科学
·
表面工程
·
腐蚀与磨损防护
·
纳米复合材料
·
电沉积
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DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2023
·
IF 5.2
Tao He,Shuang Xiong,Haobin Han,Dalei Wang,Yueyue Wang,Chaoqing Dai,Wei Liu
The composite structure composed of GO and Ag has better sensing ability and is widely used as SERS substrates. However, there are few studies on the influence of external environment such as light on the stability of GO and Ag composite structure. In fact, GO can effectively prevent Ag from oxidation , so it is necessary to deeply study the mechanism of GO protection. In view of this, we prepare Ag microspheres on glass slides by one-step reduction method, and spin-coated with GO as surface enhanced Raman scattering (SERS) strips for the detection of organic molecules R6G . The detection limit is as low as 10 −12 M. The linearity of the detection results is significantly corrected by using the GO characteristic peak as the internal standard (IS). The effects of xenon lamp simulate sunlight irradiation on the SERS performance of Ag substrate and Ag/GO Raman strips are investigated comparatively. We find that the Ag/GO composite structure can maintain good stability without the influence of light compared to the Ag substrate. We discuss the dynamic variation of Ag and Ag/GO substrates during the light exposure. Bacterial inhibition experiments further demonstrate the protective effect of GO on Ag. The conclusions of this paper have potential applications for improving the stability of SERS substrates.
研究领域:
材料科学
·
分析化学
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DOI
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2018
·Vol. 165
·期 5
·B227
·
IF 3.662
Jiushang Zheng,Jianglin Diao,Yanzi Jin,Ailing Ding,Bin Wang,Lizhou Wu,Bo Weng,Jiucun Chen
Novel two-dimensional Ti3C2 MXene nanosheets were successfully prepared by etching Al from Ti3AlC2 in LiF/HCl system. In order to further improve the dispersing property and electrical conductivity of Ti3C2 nanosheets, Ti3C2/graphene oxide (Ti3C2-GO) nanocomposites were synthesized and applied for the fabrication of inkjet-printed hydrogen peroxide (H2O2) sensor. The results of electrochemical characterization show that the prepared sensor maintains the biological activity of hemoglobin (Hb) and can be applied to the practical detection. The printed sensors display a dynamic range from 2 μM to 1 mM and a detection limit of 1.95 μM with a high sensitivity and excellent selectivity for H2O2 determination. Therefore, the printable Ti3C2-GO nanocomposites are an excellent sensing platform for electrochemical determination.
研究领域:
材料科学
·
生物传感
·
电化学
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DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Wei Chen,Fanfei Deng,Min Xu,Jun Wang,Zhenbo Wei,Yongwei Wang
Graphene oxide and cuprous oxide ( G O/Cu 2 O) nanocomposite based quartz crystal microbalance (QCM) gas sensor via layer-by-layer self-assembly (LBLSA) method was developed for trimethylamine (TMA) gas sensing under concentrations of 5 ppm. The sensor response increased linearly with the concentration of TMA, which was consistent with the Saurebrey equation. It also had good sensitivity, reversibility, selectivity and stability in 60 days. The detection limit of 230 ppb was achieved which was the lowest detection levels among recently reported QCM gas sensor towards TMA under room temperature. The sensing mechanism of GO/Cu 2 O nanocomposite based QCM gas sensor towards TMA under low concentrations was proposed as follows: (1) an adsorption-desorption process via hydrogen bonding between the GO surface carboxyl groups and TMA molecules; (2) enhanced physical adsorption of TMA gas molecules via LBLSA method due to enlarged surface area and p-n junction of GO/Cu 2 O nanocomposite. This GO/Cu 2 O nanocomposite based QCM gas sensor may provide a foundation for the TMA gas sensors development in areas of environmental protection and food safety.
研究领域:
材料科学
·
环境科学
·
食品安全
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DOI
高影响因子
Journal of Materials Chemistry C
·
2023
·Vol. 11
·期 29
·9925-9936
·
IF 6.4
Zhaoling Huang,Siyuan Li,Hao Guo,Caiping Huang,Yuyu Bian,Yubing Gong,Jiaqiang Huang,Qi Zeng
Electrothermal materials with low energy consumption and high stability are in high demand for improving our daily life. Here we propose a novel high-performance flexible heater with a high heating rate through screen printing, based on multi-scale nanocomposites comprised of multilayer graphene oxide (ML-GO), carbon nanotubes (CNTs) and aluminum nitride (AlN). The results show that AlN can fill the gaps in the network structure, reducing the surface thermal resistance and film resistivity, which greatly improves the electrical and thermal conductivity of the flexible heater. The maximum temperature of the ML-GO/CNT/AlN heated film reaches 131.2 °C at 4.5 V, and the thin layer exhibits a low sheet resistance down to 10.27 ± 2.5 Ω sq−1. Meanwhile, the steady temperature and corresponding responsivity of the multi-scale flexible heater are 153% and 57.8% higher than those of the ML-GO-based flexible heater, respectively. Inspiringly, the fluctuation in the steady-state temperature curve is less than 0.8% under random mechanical bending and torsion force. During deicing, a high steady-state temperature can also be observed and the ultra-fast response time is far superior to those of most existing heaters. In addition to that, ML-GO/CNT/AlN heaters present a low driving voltage, excellent flexibility and stability, and can be integrated into various deicing conditions and wearable medical systems without being too picky about the used substrates. They also show great potential for application in various intelligent heating films and open up pathways for wearable heating applications.
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高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2023
·
IF 9.5
Jingjing Gu,Ziqiang Hong,Suixin Zhang,Yong Li,Rui Jia,Ruonan Tan,Hongwei Shao,Shichao Zhang,Xinxin Li,Jin Ran,Peng Cui
Graphene oxide (GO) membranes with uniform sub-nanometer interlayer channels have shown great promise in the ion sieving field. However, the lack of ion-transporting sites on the GO nanosheets usually leads to inferior ion permeation and selectivity. Although the intercalation of molecules with ionic groups into GO laminates is easily achieved to incorporate ion exchange sites, this approach inevitably enlarges the interlayer spacing, reducing the ionic sieving capacity. Thus, current methods are limited in breaking the permeation and selectivity “trade-off”. Herein, we report a confined intercalation strategy to inject ample sulfonic acid groups into GO laminates using sulfonated graphene quantum dots (SGQD) as intercalators. SGQD with abundant ion exchange sites assembles on the sp 2 domains of GO via π-π interactions and confers the GO membranes with continuous ion conduction pathways. Meanwhile, benefiting from the ultra-small size SGQD as well as its sheet morphology, it can well accommodate in the GO laminates. This strategy fulfills the incorporation of ionic sites without expanding channel width and destructing the two-dimensional (2D) regularity for GO laminates, resulting in simultaneous improvements in ion permeability and selectivity. Correspondingly, the resulting membranes show synergistically improving OH - dialysis coefficients of 3.5 × 10 −3 -8.2 × 10 −3 m h −1 and OH - /WO 4 2- separation factors of 56–116 compared with the GO membrane (0.9 × 10 −3 m h −1 and 8.4) for separating simulated NaOH/Na 2 WO 4 alkaline effluents. We believe the confined intercalating regulation can act as a versatile and fine way to modify 2D membranes for intensifying ion separation.
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高影响因子
Membranes
·
2023
·Vol. 13
·期 7
·622
·
IF 4.2
Mona Saad Binkadem
The effluents of industrial wastewater contain several toxic organic and inorganic pollutants that may contaminate clean and freshwater sources if untreated or poorly treated. These toxic pollutants include colors; hazardous compounds; surfactants; cosmetics; agrochemicals; pharmaceutical by-products; and agricultural, pharmaceutical, and medical contaminants. Treating wastewater has become a global problem. Many projects have been started in the last two decades to treat wastewater, resultant water pollution, and associated waste management problems. Adsorbants based on graphene oxide (GO) are viable wastewater treatment materials due to their adaptability, photocatalytic action, and capacity for self-assembly. Here, we report the fabrication of nanofibrous mats from polycaprolactone (PCL), carboxymethyl arabinoxylan (CMARX), and carboxyl-functionalized-graphene oxide using an electrospinning technique. The silver nanoparticles were loaded onto the mat to enhance their photocatalytic activity. These mats were characterized using different techniques, including Fourier transform infrared (FTIR), scanning electron microscope (SEM), and transmission electron microscope (TEM). The water contact angles were used to study their hydrophilic and hydrophobic behavior. The Langmuir isotherm model and adsorption kinetics were studied to evaluate their adsorption capabilities against methylene blue (MB). Sample 2 followed the Langmuir isotherm model (R2= 0.9939). Adsorption kinetics exhibited pseudo-second order behavior (R2= 0.9978) due to their maximum correlation coefficient values. MB has excellent adsorption at room temperature and the formation of the monolayer at the surface of the adsorption mat. An enhanced PO43−and MB adsorption was observed, providing recyclability up to 4–5 times. Hence, the fabricated nanofibrous mat would be a potential candidate for more effective wastewater treatment applications.Keywords:adsorption;bacterial cellulose;electrospinning;thin nanofibrous mat;wastewater treatment;environmental pollution treatment
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DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2023
·Vol. 191
·期 1
·1-11
·
IF 5.7
Shi Fengna,Hu Sheng,Li Jingfang,Wang Fang,Chen Naipin
A novel, green, and facile approach has been developed to construct an ultrasensitive flexible enzyme-less electrochemical sensor on the basis of chitosan and graphene oxide composites decorated with Cu nanoparticles supported on nickel foam (Nif/Cs/GO@Cu), in which GO functions as the intermediate between Nif and Cu nanoparticles. The Nif/Cs/GO@Cu sensing platform was successfully fabricated by the drop casting method to load Cs/GO onto Nif followed by an additionally electrodeposition to support Cu nanoparticles on Nif/Cs/GO. Impressively, the Nif/Cs/GO@Cu exhibited much higher electrocatalytic activity for glucose and UA oxidation as compared to that of Nif or Nif@Cu. For glucose and UA at about 0.6 V and 0.1 V (vs. Ag/AgCl), linearity could be obtained in the concentration ranges 5 µM–4 mM and 5–345 µM; the sensitivities were 16 and 2.5 µA µM −1 cm −2 , and the detection limits 83 nM and 0.3 µM, respectively. The improved performance of the composite electrode was ascribed to the synergistic effect of Cu nanoparticles, Nif and GO, in which GO provides high electron conductivity and large surface area to prevent the agglomeration of Cu nanoparticles; Cu nanoparticles and Nif offer abundant active sites towards analytes oxidation. Additionally, the method was applied to determine both analytes successfully in blood serum samples with excellent recovery and also opens up an attractive route to potential applications of the flexible nickel foam-based electrochemical sensor. Graphical Abstract
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PubMed
高影响因子
危险品化学品经营许可证（带存储）