JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2025
·Vol. 36
·期 12
·1-14
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IF 2.8
Mei Rui,Yan Feng,Hu Sizheng,Gong Zonggui,Guo Haoxuan,Wang Qijing,Zheng Xinghua
With the increasingly urgent safety requirement of lithium-ion batteries, more and more attention has been paid to Li 7 La 3 Zr 2 O 12 (LLZO)-based solid electrolytes with high ion conductivity and excellent electrochemical performance. Unfortunately, owing to the serious “Li-loss” and the abnormal grain growth (AGG) during the long-time high-temperature sintering process, it is difficult to achieve the high-quality LLZO electrolyte with uniform and fine grains, high density and excellent electrochemical performance. In this work, Ga/Mo co-doped LLZO solid-state electrolytes have been prepared by traditional sintering (TS) and two-step sintering (TSS). And the sintering mechanism, phase stability, microstructure evolution, and electrochemical performance have been systematically investigated. A small amount of Ga/Mo doping not only promotes the formation of the cubic garnet LLZO phase, but also enhances the stability of cubic phase. High density of 92.3% and uniform microstructure without AGG have been achieved via a small amount of Ga doping and TSS. Li 6.3 Ga 0.1 La 3 Zr 1.8 Mo 0.2 O 12 electrolytes, prepared by TSS of 1200 °C/15 min-1100 °C/8 h, exhibits high ion conductivity of 2.59 × 10 –4 S·cm −1 and critical current density (CCD) value of 0.5 mA·cm −2 , low electric conductivities of 4.77 × 10 –9 S·cm −1 , which suggests it is a potential electrolyte to apply in all-solid-state batteries.
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Materials Today Bio
·
2025
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IF 10.2
Mingxia Zhou,Linping Lu,Xinyu Xu,Yefan Zhou,Huan Fang,Xue Wang,Dongxu Li,Xiaoyan Li,Jiaqi Hua,Jiahe Liu,Yingxia Li,Libin Jiang,Qiuju Miao,Hongtao Wen,Jing He,Shenyu Yang
Ulcerative colitis (UC), a prevalent form of inflammatory bowel disease (IBD), manifests as chronic diarrhea, abdominal pain, and bloody mucoid stools. Current treatment approaches for UC are typically limited by inadequate targeted delivery, premature gastrointestinal degradation, and systemic off-target effects. To address these challenges, we engineered PL&GA@EUK, EUK-134 nanozymes encapsulated in polylysine (PL) and glycyrrhizic acid (GA) coacervate droplets. PL&GA@EUK exhibited potent superoxide dismutase- and catalase-mimetic activities, scavenging hydroxyl radicals and demonstrating anti-inflammatory efficacy in both in vivo and in vitro models. In mice with dextran sulfate sodium-induced colitis, oral administration of PL&GA@EUK for 14 days significantly ameliorated the disease activity index and colonic damage. By maintaining the integrity of the intestinal mucosal barrier and modulating redox homeostasis, it protects the intestinal epithelial cells against ferroptosis, ultimately attenuating colitis progression. 16S rDNA sequencing revealed that PL&GA@EUK significantly enriched beneficial commensals, while suppressing opportunistic pathogens. Metabolomic analysis further indicated that it modulates lipid peroxidation-associated metabolites by regulating the biosynthesis of polyunsaturated fatty acids. Crucially, PL&GA@EUK achieved enhanced colon-targeted delivery with minimal systemic toxicity, thereby overcoming the key limitations of conventional treatments. The multifaceted mechanism of PL&GA@EUK, involving reactive oxygen species scavenging, gut microbiome remodeling, and ferroptosis suppression, underscores its immense promise for the clinical management of IBD.
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PubMed
高影响因子
Acta Biomaterialia
·
2024
·
IF 9.4
Qingrong Li,Cong Zhang,Mengmei Zhu,Jie shan,Haisheng Qian,Yan Ma,Xianwen Wang
Inflammatory bowel disease (IBD) may arise due to disruption of mucosal barriers as a result of dysregulation of the intestinal flora and excessive oxidative stress. The creation of nanomaterials with only microbiota-regulating effects often leads to inadequate therapeutic outcomes caused by the disruption of a healthy microbial balance and the emergence of tissue harm caused by excessive oxidative stress. This report describes the multifunctional activity of ultrasmall W-GA nanodots, which can precisely regulate the intestinal microbiome by inhibiting the abnormal expansion of Enterobacteriaceae during colitis and alleviating the damage caused by oxidative stress to the reconstructive microflora, ultimately restoring intestinal barrier function. W-GA nanodots have been synthesized through a simple coordination reaction and can be dispersed in various solvents in vitro , demonstrating favorable safety profiles in cells, significant clearance of reactive oxygen and nitrogen species (RONS), and increased cell survival in models of oxidative stress induced by hydrogen peroxide (H 2 O 2 ). Through oral or intravenous administration, the W-GA nanodots were shown to be highly safe when tested in vivo , and they effectively reduced colon damage in mice with DSS-induced colitis by restoring the integrity of the intestinal barrier. W-GA nanodots have enabled the integration of microflora reprogramming and RONS clearance, creating a potent therapeutic strategy for treating gut inflammation. Consequently, the development of W-GA nanodots represents a promising strategy for enhancing the formation and preservation of the intestinal barrier to treat IBDs by suppressing the growth of Enterobacteriaceae , a type of facultative anaerobic bacterium, and facilitating the effective removal of RONS. Ultimately, this leads to the restoration of the intestinal barrier's functionality. Statement of Significance An increasing number of nanoparticles are under development for treating inflammatory bowel disease. Although they can alleviate inflammation symptoms by regulating reactive oxygen and nitrogen species (RONS) and microbiota, their understanding of the mechanism behind microbiota regulation is limited. This study synthesized W-GA nanodots using a straightforward one-pot synthesis method. Simple synthesis holds significant promise for clinical applications, as it encompasses multiple nanoenzyme functions and also exhibits Enterobacteriaceae inhibitory properties.Thus, it contributes to ameliorating the current medical landscape of inflammatory bowel disease.
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PubMed
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ACS Applied Optical Materials
·
2026
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IF 3.4
Shichao Rao,Wentao Niu,Zhongwei Man,Xiulin Xie,Zhe Yin,Yue Qin,Shuaibing Wang,Ouyang Lin,Aiwei Tang
The advancement of environmentally benign I–III–VI colloidal quantum dots (QDs) has established a promising materials platform to replace cadmium-based counterparts. However, in practical device architectures, especially blue-emitting devices, abundant surface nonradiative recombination centers and imbalanced carrier injection often lead to suboptimal device performance, thereby hindering their deployment in display technologies. Herein, we employ a zinc iodide (ZnI2) post-treatment for the Cu–Ga–Zn–S (CGZS) QDs film strategy, effectively passivating surface defects and nonradiative sites, thereby enhancing device performance. The treated QDs facilitate the formation of an interface dipole, which effectively elevates the overall energy levels of the QDs while simultaneously reducing the hole injection barrier, leading to an enhanced hole injection efficiency. Working in concert, these effects facilitate balanced carrier injection and optimize exciton recombination, thereby boosting the device efficiency and operational stability. Consequently, the peak external quantum efficiency (EQE) exhibits a favorable improvement, increasing from 1.01% in the pristine device to 1.90% after treatment. This work offers an effective approach to achieving balanced carrier injection in quantum-dot light-emitting diodes (QLEDs) and establishes a solid foundation for the development of high-performance, cadmium-free, blue-emitting QLEDs.
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Molecular Catalysis
·
2026
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IF 4.3
Xiaofei Ma,Shijiao Hao,Hui Jiang,Weiqian Qi,Hefang Wang
Cu-Al mixed oxide catalysts (CxA-LDO), prepared via calcination of layered double hydroxides (LDHs) precursors, were investigated for the transesterification of propylene carbonate (PC) with methanol to dimethyl carbonate (DMC). Characterization demonstrated that calcination temperature and the Cu/Al molar ratio critically influence the surface basicity properties and structural stability. Under optimized conditions (80 °C, 2 h, 2.0 wt% loading, MeOH/PC = 10:1), the C 0.5 A-400-LDO catalyst achieved 57.93% PC conversion and 57.29% DMC yield (TON = 28.94). Surface basicity was identified as the key governing factor for the reaction. This conclusion is supported by a strong correlation observed between the reaction rate and the number of total basic sites. However, the catalyst deactivated significantly over six cycles (PC conversion dropped from 57.93% to 47.2%), which ICP-AES analysis unambiguously attributed to significant copper leaching (8.1 wt.% net loss) rather than sintering. Kinetic analysis revealed a complex reaction mechanism that could be simplified to pseudo-first-order reaction behavior. The activation energies were determined to be Ea( k + ) = 51.61 kJ·mol -1 for the forward reaction and Ea(k - ) = 55.34 kJ·mol -1 for the reverse reaction. Concurrently, a hybrid genetic algorithm-optimized backpropagation (GA-BP) neural network was developed. Compared to conventional BP, the GA-BP model demonstrated superior predictive accuracy (R 2 = 0.997 for training set and 0.977 for testing set) and exhibited significantly reduced error metrics. This study not only contributes to the fundamental understanding of base-catalyzed transesterification but also introduces a synergistic experimental-computational strategy applicable to rational catalyst design.
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MOLECULAR PHARMACEUTICS
·
2026
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IF 4.9
Jie Li,Yuhui Luo,Chengyu Luo,Zixin Yang,Fei Luo,Huajian Gu,Fei Chen,Zongxi He,Suping Li
Abstract Carbonic anhydrase IX (CA IX) is a key biomarker for tumor hypoxia and a promising target for molecular imaging. In this study, we developed [68Ga]Ga-DOTA-L3, a novel small-molecule CA IX-targeted PET tracer. The radiolabeling was optimized to consistently achieve a radiochemical purity of >98% (10 μg precursor, 90 °C, pH 4.5, 10 min), with excellent stability in saline and FBS up to 240 min. In vivo studies demonstrated rapid blood clearance and predominant renal excretion. Surface plasmon resonance analysis demonstrated high-affinity binding of the DOTA-L3 precursor toward CA IX (Kd = 7.60 ± 0.37 nM) with highest affinity observed for CA IX among the tested isoforms. MicroPET/CT imaging (30−240 min p.i.) showed robust tumor accumulation in OSRC-2 (SUVmean = 1.47 ± 0.21) and HT-29 (SUVmean = 1.03 ± 0.12) xenografts, while minimal uptake was observed in CA IX-low FTC-238 tumors (SUVmean = 0.21 ± 0.05) at 60 min p.i. PET-derived tumor uptake showed a strong linear correlation with CA IX expression levels (R2 = 0.976, P < 0.001) across the three tumor models. High tumor-to-muscle and tumor-to-blood ratios further confirm favorable imaging contrast (T/M = 27.53 ± 1.89 and T/B = 24.61 ± 2.35 at 240 min p.i. for OSRC-2 model). These results support [68Ga]Ga-DOTA-L3 as a promising candidate for non-invasive assessment of CA IX-associated hypoxia and as a scaffold for future theranostic development.
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ACS Applied Materials & Interfaces
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2026
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IF 7.8
Fan Gao,Ying Nie,Annett Dorner-Reisel,Tao Wang
The antibacterial property of fullerenes and their derivatives is highly dependent on light irradiation, which limits their biomedical applications. In this work, we report a novel type of nanoparticle composed of Fullerenol and gallium (Ga). The morphological features and chemical structures of the nanoparticles were characterized, and their assembly mechanism was further elucidated. Moreover, the antioxidant activity, osteogenic performance, and antibacterial effect of the Fullerenol-Ga under dark conditions were systematically investigated. The results show that the average diameter of individual Fullerenol-Ga nanoparticles is 10-30 nm. The assembly process between Fullerenol molecules and Ga3+ proceeds through a coupled mechanism of electrostatic adsorption and coordination crosslinking. The obtained Fullerenol-Ga exhibit remarkable scavenging ability against both DPPH and ABTS radicals, and effectively reduces the overall intracellular ROS level as well. Furthermore, high concentrations of nanoparticles can significantly promote the proliferation of MC3T3-E1 cells, enhance ALP activity, and upregulate the expression of early osteogenic related genes. Due to the unique "Trojan horse" antibacterial mechanism of Ga3+, the Fullerenol-Ga achieves an antibacterial rate of over 95% against both Escherichia coli and Staphylococcus aureus at a concentration of 150 μg/mL. Based on the multifaceted performance described above, this Fullerenol-Ga synergistic therapeutic system shows great potential as an additive for the surface modification of orthopedic implant materials.
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Advanced Optical Materials
·
2026
·
IF 7.2
Chen Lin,Mengxin Liu,Yuhui Liu,Xin Su,Xinan Shi,Daocheng Pan
Quantum-sized SnO 2 nanoparticles have been widely employed as electron transport layer (ETL) in high-efficiency quantum dot light-emitting diodes (QLEDs) owing to their attractive properties, such as high stability, wide bandgap, and excellent optical transparency. However, the device performance of SnO 2 -based QLEDs is still significantly lower to those of ZnO-based devices, suggesting considerable room for improvement. Here, we demonstrate the use of Ga-doped SnO 2 nanoparticles with tunable mobility and conductivity for constructing high-performance SnO 2 -based QLEDs. The influences of Ga-doping concentration on the mobility and conductivity of SnO 2 nanoparticles are systematically investigated. The mobility and conductivity of Ga-doped SnO 2 nanocrystals can be tuned over two orders of magnitude by varying Ga-doping level. This p-type doping strategy effectively suppresses excessive electron transport in the SnO 2 nanocrystals, thereby promoting more balanced charge injection within the QLED structure. As a result, red-emitting inverted QLEDs incorporating 3.5 at% Ga-doped SnO 2 nanocrystals achieve an average external quantum efficiency (EQE) of 17.36% and a peak EQE of 20.04%. These results suggest that Ga-doped SnO 2 nanocrystals are excellent candidates for the fabrication of high-performance QLEDs.
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ACS Sustainable Chemistry & Engineering
·
2026
·
IF 7.6
Gexing Meng,Ting Huang,Zhenpan Chen,Huibin Liu,Shixin Wu,Lanqi Ning,Jijie Wang,Fangfang Zhao,Kuiyi You,He’an Luo
Perovskite oxides have emerged as promising oxygen carriers for chemical looping dry reforming of methane (CL-DRM) due to their potentially larger oxygen storage capacity (OSC), easily tunable compositions, and redox properties. However, it is still very challenging to properly modulate the activity of surface and lattice oxygen species in perovskite-type oxygen carriers to well balance their capability of C(sp3)–H bond activation and syngas selectivity. Herein, Ga-doped LaCoO3 (LaGa0.5Co0.5O3) featured with a three-dimensionally ordered macroporous (3DOM) morphology was discovered to show a superior syngas yield of 10.60 mmol gmaterial–1 with ∼85% selectivity that is about 7- and 1.7-fold those of unmodified LaCoO3 (1.40 mmol gmaterial–1) and LaGa0.5Co0.5O3 (5.74 mmol gmaterial–1) oxygen carriers, respectively, combined with an improved CO productivity of 3.84 mmol gmaterial–1 in the CL-DRM. The incorporation of the Ga dopant was proven to be useful to further suppress the formation of coke from CH4 cracking during the partial oxidation of methane (POM) half-reaction, leading to enhanced CO selectivity. The XPS results revealed that the chemical looping reactions based on the LaGa0.5Co0.5O3 oxygen carrier were driven by both the Co0/Co2+/Co3+ and Ga0/Ga3+ redox pairs. As further proven by the CH4-TPR and H2-TPR characterizations, the constructed 3DOM morphology can effectively promote redox reactions between different valence cobalt species and gallium species due to its increased surface anchoring sites for redox-active centers and facilitated mass transfer (e.g., gas diffusion and ion migration) within the internal pores and skeleton. Our work demonstrates that lattice modification coupled with surface engineering through doping and morphology control can effectively enhance the CL-DRM performance of LaGaxCo1–xO3 oxygen carriers, which provides a promising strategy to design other high-performance oxygen carriers beyond the cobalt-based perovskite oxygen carriers discussed in our work.
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CERAMICS INTERNATIONAL
·
2026
·
IF 6
Jun Yu,Xianwei Zhao,Yongjun Chen,Azhu Wang,Pei Li,Yuzhe Wang,Haining Chen,Huicong Liu,Hui Ye,Weiping Li
Ga-doped zinc oxide (GZO) has attracted considerable interest for applications in electronic transport owing to its superior electrical properties. In this study, we report a low-temperature (<100°C) aqueous open-system route for the in-situ synthesis of GZO powders. The efficient substitutional doping of Ga 3+ into the ZnO lattice is achieved via a formation, in-situ transformation and dissolution–reprecipitation pathway of ε-Zn(OH) 2 or ZnGa-layered double hydroxide (ZnGa-LDH) intermediates, which simultaneously endows the products with unique flower-like or bundle-like morphologies. Chemical equilibrium calculations and time-dependent experiments reveal that the ionic species Zn(NH 3 ) 4 2+ and Ga(OH) 4 - , formed in the aqueous solution under high ammonia concentration, serve as reactive monomers that facilitate the formation and transformation of the intermediate phases. Electrical measurements combined with UV-Vis-NIR, EPR, and PL spectroscopic analyses indicate that Ga doping introduces shallow donor-type defects alongside zinc vacancy-related acceptor defects into the ZnO lattice, narrowing the optical bandgap and enhancing the electrical conductivity of the resulting powders. The GZO powder with a nominal doping ratio of 5% exhibits the lowest resistivity (Surface resistivity measured by the four-probe method is 3.43 × 10 4 Ω/□). This work provides a new pathway for the controllable preparation of functional conductive oxide powders.
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ADVANCED FUNCTIONAL MATERIALS
·
2026
·
IF 19.9
Shuxia Wei,Xuejun Xu,Zongjie Su,Hongyi Lu,Yue Liu,Han Xu,Qianqian Gao,Yunfeng Wang,Ming Li,Tianyu Xing,Siyu Wang,Haoran Li,Li Wu,Yi Zhang
The open-circuit voltage ( V OC ) deficit remains a primary bottleneck hindering the efficiency of solution-processed Cu(In,Ga)(S,Se) 2 (CIGSSe) solar cells, largely due to the uncontrolled elemental diffusion during high-temperature selenization that prevents the formation of a beneficial bandgap gradient. Here, we propose a novel and highly effective low-temperature surface treatment strategy to overcome this long-standing challenge. By spin-coating a gallium-thiourea complex solution onto the pre-fabricated CIGSSe absorber, we construct a strategic Cu-poor, Ga-rich surface layer. Such design widens the surface bandgap, leading to an optimized band alignment at the CIGSSe/CdS heterojunction with a reduced conduction band offset (0.15 eV) and an enlarged valence band offset (1.13 eV). This synergistic effect drastically suppresses interface recombination. As a consequence, we achieve a champion device with a V OC of 0.692 V—the highest value reported to date for solution-processed CIGSSe—and a power conversion efficiency of 16.65% (17.93% with an MgF 2 anti-reflection layer). This work presents a simple yet powerful pathway for targeted front interface engineering, paving the way for high-efficiency, low-cost chalcopyrite photovoltaics.
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APPLIED THERMAL ENGINEERING
·
2022
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IF 6.465
Jiashu Zheng,Xiaoxiang Li,Wenkui Xing,Benwei Fu,Chengyi Song,Wen Shang,Peng Tao,Tao Deng
With the increasing power density and continuously added functionalities, normal operation of portable electronic devices such as USB flash disks and smart phones calls for facile and efficient thermal management. Ga-based liquid metals have attracted intensive research attention for thermal management applications because of their high thermal conductivity and low toxicity, but as a type of phase change materials they still suffer from large supercooling and leakage issues. Herein, this work reports direct incorporation of high-loading miscible Ga 2 O 3 particles within Ga liquid metals to prepare non-leakage phase change composites for transient heat absorption. By loading 16.7 wt% of Ga 2 O 3 particles, paste-like liquid metal composites with a high thermal conductivity (∼21 W/m·K), a low interfacial thermal resistance (∼3.5 mm 2 ·K·W −1 ), a small supercooling degree (∼8.8 °C) and a large volumetric latent heat (∼308 J/cm 3 ) were obtained. These advantageous features enable application of the prepared liquid metal phase change composites for high-performance temporary heat absorption of intermittent-use electronic devices such as USB flash disks. Moreover, the attached phase change composites can be easily peeled off from electronic devices, and Ga liquid metals and Ga 2 O 3 particles can be readily recycled by immersing the composites within acidic or basic solutions. The facile direct hand-mixing fabrication process, broadly tailorable supercooling degree and form-stability properties, reusability and recyclability would make the prepared liquid metal composites suitable for phase change-based thermal management applications.
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