RSC Advances
·
2018
·Vol. 8
·期 31
·17389-17398
·
IF 2.936
Yunquan Zheng,Qisheng Pan,Liuda Mo,Wenyi Zhang,Yunjian Duan,Chengqun Chen,Haijun Chen,Yanghao Guo,Xianai Shi,Jianmin Yang
Alzheimer's disease (AD) is an extremely complex disease, characterized by several pathological features including oxidative stress and amyloid-β (Aβ) aggregation. Blockage of Aβ-induced injury has emerged as a potential therapeutic approach for AD. Our previous efforts resulted in the discovery of Monascus pigment rubropunctatin derivative FZU-H with potential neuroprotective effects. This novel lead compound significantly diminishes toxicity induced by Aβ(1-42) in Neuro-2A cells. Our further mechanism investigation revealed that FZU-H inhibited Aβ(1-42)-induced caspase-3 protein activation and the loss of mitochondrial membrane potential. In addition, treatment of FZU-H was proven to attenuate Aβ(1-42)-induced cell redox imbalance and Tau hyperphosphorylation which caused by okadaic acid in Neuro-2A cells. These results indicated that FZU-H shows promising neuroprotective effects for AD.
研究领域:
神经科学
·
药理学
·
分子生物学
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产品关联
DOI
PubMed
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2019
·
IF 3.714
He Li,Xiang-Yi Tang,Chun-Jian Wu,Shu-Juan Yu
The 2,3-dihydro-3,5-dihydroxy-6-methyl-4(H)-pyran-4-one (DDMP) is one of the Mallard reaction product with intense bitter and strong antioxidant activity . Insight into DDMP formation pathways is important to manage Maillard reaction products quality. In this work, wet- and dry-heating glucose-amino acid model reactions were investigated to understand the DDMP formation pathways. Lysine and proline facilitated the DDMP generation in wet- and dry-heating system, respectively, suggesting the reaction intensity and amino acid properties are primary factors mediating DDMP generation. Fundamental mechanism on DDMP formation or inhibition was evaluated via quantitatively monitoring enolization products, which suggested that the formation of DDMP was facilitated at lower moisture content condition caused by more 1-deoxyglucosone (1-DG) generation via 2,3-enolization. However, increasing moisture content resulted in the decay of DDMP because of the transformation of 2,3-enolization to 1,2-enolization, which inhibited DDMP generation but transformed to form 5-hydroxymethylfurfural (HMF).
研究领域:
食品科学
·
生物化学
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DOI
高影响因子
JOURNAL OF POWER SOURCES
·
2024
·
IF 8.1
Zixuan Li,Dequan Bao,Wei Zhao,Wenxuan Xu,Yingheng Huang,Xiyong Chen,Hao Zhang,Xuhui Sun
Gel polymer electrolytes (GPEs) have emerged as a highly promising alternative to conventional liquid electrolytes for stable lithium-metal batteries (LIBs). However, their inherent poor mechanical properties and limited interfacial compatibility with lithium metal usually lead to unexpected growth of lithium dendrites , hindering commercial viability. Herein, an asymmetric polymer electrolyte with h-BN (HGPE) as protective layer was fabricated via a facile one-step coating strategy. Compared to pure GPE, the asymmetric polymer electrolytes exhibit significantly enhanced mechanical strength from 4.4 MPa to 7.4 MPa, effectively suppressing lithium dendrite growth. Furthermore, the HGPE improves interfacial compatibility with the anodes by preventing direct contact between GPE and lithium metals. The addition of h-BN also enhances the lithium-ion transfer number (t Li+ ), reaching 0.87 compared to 0.53 for pure GPE, attributed to the hindrance of anion movement by the protective layer. Consequently, the Li symmetric battery assembled with HGPE demonstrate exceptional long-term stability, maintaining performance over 1600 h at 0.1 mA cm −2 . Furthermore, the assembled Li|LiFePO 4 battery can deliver a high-capacity retention rate of 93.8 % after 500 cycles at room temperature, showcasing the promising potential of asymmetric polymer electrolytes for high-performance LMBs.
研究领域:
材料科学
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电化学
·
能源存储
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DOI
高影响因子
Food & Function
·
2024
·
IF 5.1
Qingqing Lv,Aolin Yang,Ziyu Han,Ruirui Yu,Junying Zhu,Zhan Shi,Chenggang Yang,Shimiao Dai,Mengru Hao,Yuqing Chen,Ji-Chang Zhou
Low selenium levels are closely associated with reduced cognitive performance and lipid dysregulation, yet the mechanism of action remains unclear. The physiological function of selenium is primarily mediated by selenoproteins. Selenoprotein H (SELENOH), as one of the selenium-containing proteins, has an unelucidated role in regulating cognitive status and lipid metabolism. In this study, we established a Selenoh gene knockout (HKO) mouse model to investigate whether Selenoh mediates the impact of selenium on cognitive function. We found that HKO mice showed a significant decline in cognition compared with the wild-type (HWT) littermates, and were not affected by deficient or excessive selenium, while no differences in anxiety and depression behavior were observed. HKO mice showed reduced myelin basic protein expression in hippocampal oligodendrocytes, with decreased glycolipid levels and increased phospholipid and sphingolipid levels in the hippocampus. Furthermore, the high-fat diet (HFD) exerted no effect on cognition and limited impact on the gene profile in the hippocampus of HKO mice. Compared with those of HWT mice, the myelination pathways in the hippocampus of HKO mice were downregulated as revealed by RNA-seq, which was further confirmed by the reduced expression levels of myelin-related proteins. Finally, HKO increased the expression of hippocampal fatty acid transporter (FATP) 4, and HFD increased the FATP4 expression in HWT mice but not in HKO mice. In summary, our study demonstrated that HKO induced cognitive decline by impairing myelination in oligodendrocytes with disrupted hippocampal lipid metabolism, which provided a novel viewpoint on the selenoprotein-mediated neurodegenerative diseases of selenium.
研究领域:
神经科学
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营养学
·
分子生物学
·
遗传学
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产品关联
DOI
PubMed
高影响因子
HIGH PERFORMANCE POLYMERS
·
2016
·
IF 1.045
Yongzhen Wang,Yanchao Yuan,Ying Zhao,Shumei Liu,Jianqing Zhao
A halogen-free flame retardant of 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide-containing H-benzimidazole (DHBI) was synthesized and subsequently used as co-curing agent of 4,4′-diamino-diphenylmethane for diglycidyl ether of bisphenol-A. The structure of DHBI was characterized by Fourier transform infrared (FTIR) spectroscopy, proton, carbon 13 and phosphorus-31 nuclear magnetic resonance, and mass spectroscopy. A series of cured epoxy resins (EPs) were prepared and their flame retardancy, thermal stability, flexibility, and dielectric properties were investigated. The resulting cured EP (EP-10) with 7.45 wt% of DHBI successfully achieved UL 94 V-0 rate with limited oxygen index of 35.6% and without dropping phenomenon. Compared with the cured pristine EP (EP-00), the glass transition temperature of EP-10 was increased by 6.9°C, accompanied with an enhancement of flexible strength by 13.1 MPa and a decrement of dielectric constant by 0.3 at the testing frequency of 1 MHz.
研究领域:
材料科学
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聚合物化学
·
消防安全工程
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产品关联
DOI
高影响因子
Bioresources and Bioprocessing
·
2018
·Vol. 5
·期 1
·1-11
·
IF 0
Liu Xin,Wang Weiwei,Hu Haiyang,Lu Xinyu,Zhang Lige,Xu Ping,Tang Hongzhi
Background Benzofuran and its derivatives contain central pharmacophores and are important structures in medicinal chemistry. Chemical synthesis of benzofuran rings often requires expensive catalysts and stringent operational conditions. Biosynthesis is recognized as a promising way to save energy and produce valuable compounds. Dioxin biodegradation pathways can form several benzofuran derivatives, and these pathways may be a better choice for further synthesis of important biological compounds. 2-Hydroxy-4-(3′-oxo-3′ H -benzofuran-2′-yliden)but-2-enoic acid (HOBB), a benzofuran derivative, can be biosynthesized from dibenzofuran (DBF) through co-metabolic degradation in a lateral dioxygenation pathway. Results Efficient biosynthesis of HOBB was observed using whole cells of Pseudomonas putida strain B6-2. After cultivation in LB medium containing biphenyl, the cells were suspended to an OD 600 of 5 to conduct biosynthesis in the presence of 0.5-mM DBF at pH 7 for 8 h. The bacterial cells were used twice to degrade approximately 0.70-mM DBF, and in batch process, accumulated about 0.29-mM HOBB. HOBB could be easily purified from the reaction with ethyl acetate using the neutral-acid extraction method, and 13.58 ± 0.31 mg of HOBB was obtained from 22.49 ± 0.74-mg DBF with an overall production yield of 60.4% (w/w). The product HOBB, which is a yellow powder, could be detected and identified by LC–MS, GC–MS, and NMR. Conclusions In this study, a new biological route was developed to produce HOBB from DBF using whole cells of P. putida B6-2 (DSM 28064). The biosynthesis of HOBB may contribute to studies of the DBF lateral pathway and provide a new green route for synthesizing benzofuran derivatives with pharmacological activities.
研究领域:
环境生物学
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药学
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微生物学
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DOI
Molecular Catalysis
·
2023
·
IF 4.6
Xiangquan Qin,Yiping Jiang,Jie Chen,Fuquan Yao,Longyi Jin,Zhiqi Cong
Selective hydroxylation of C( sp 3 )–H bonds is a long-standing challenge in the organic synthesis field. We herein report an artificial P450 peroxygenase system facilitated by ω-pyridyl fatty acyl amino acids that can hydroxylate broad-spectrum alkanes, including linear and cyclic alkanes and benzylic and allylic alkane chains. Compared with the previously reported dual-functional small molecule (DFSM) with imidazole as a catalytic group (Im-DFSM), pyridyl DFSM (Pyd-DFSM) produced substantially higher total turnover numbers (TTNs) for the hydroxylation of medium-chain alkanes and cycloalkanes (C6–C8), e.g., 12.0-fold and 17.1-fold increased TTNs of P450 mutant F87A/T268V for heptane and cycloheptane , respectively. In addition, Pyd-DFSM altered the enantioselectivity of benzylic hydroxylation, e.g., it almost inverted the configuration observed in the benzylic hydroxylation of ethylbenzene and tetralin . More importantly, Pyd-DFSM showed excellent regioselectivity for allylic hydroxylation over epoxidation of terminal alkenes and cycloalkenes , e.g., up to 94% allylic hydroxylation of 1-hexene was observed. This work significantly enhances the catalytic toolbox of the DFSM-facilitated P450 peroxygenase system; it not only substantially expands the chemical space of P450 enzymes, but also provides an alternative solution for the selective hydroxylation of C( sp 3 )–H bonds.
研究领域:
有机化学
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生物化学
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催化
·
酶工程
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DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2024
·Vol. 48
·期 8
·3573-3580
·
IF 2.7
Ruidong Li,Bo Zhao,Ganggang Chang,Shanchao Ke,Minjie Chen,Didi Dong,Chun Pu,Xiaoyu Yang
In the current investigation, the base-metal hollow multifunctional catalyst, Pd–IL@H-UiO-66-NH2, was fabricated utilizing a hydrothermal method followed by etching and supporting processes. The results of the effort demonstrate that Pd–IL@H-UiO-66-NH2 displays significantly enhanced activity and product selectivity in catalysis of the one-pot Knoevenagel condensation–hydrogenation reaction, as well as a high level of generality in promoting hydrogenation reactions of unsaturated hydrocarbons. The excellent properties of Pd–IL@H-UiO-66-NH2 are ascribed to its rationally designed spatial distribution of catalytically active sites within its hierarchical structure, which is comprised of surface wrinkles that increase hydrophobicity and exposure of the active sites, and hollow structures that serve as nanoreactors to enrich substrate interactions and improve mass transfer. Furthermore, the catalytic stability of Pd–IL@H-UiO-66-NH2 was shown to be largely maintained after its use in five successive catalytic cycles. The stability of the new tandem catalyst benefits from strong confinement effects associated with its hollow structure and electronic interactions between the Pd and ILs that effectively restrict leaching and aggregation of Pd nanoparticles (NPs).
研究领域:
催化
·
材料科学
·
化学工程
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产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Kok Bing Tan,Pan Tian,Xinxin Zhang,Jian Tian,Guowu Zhan,Jiale Huang,Qingbiao Li
The present study developed bifunctional catalyst for CO 2 hydrogenation into dimethyl ether (DME), whereby it consists of Pd/In 2 O 3 for CO 2 hydrogenation into methanol, and H-ZSM-5 for methanol dehydration into DME. The catalyst development was focused on the synthesis of Pd/In 2 O 3 via a green and low-cost synthesis method of carbonized alginate templating. Thus, microspherical-confined nano-Pd/In 2 O 3 was formed, whereby the localized nucleation growth was coordinated by the chemically entrapped In 3+ via ionic bond in the well-distributed alginate structure. It was found that hydrothermal temperature plays a key role in the development of this catalyst structure. The optimum hydrothermal temperature is 160 °C, as it is able to produce the highest amount of methanol. This catalyst was further integrated with H-ZSM-5 via different integration manners. It was found that mortar mixed method produces the highest amount of DME, as the close proximity causes stronger ion-exchange mechanism between the catalyst components, which facilitates higher oxygen vacancy density in the bifunctional catalyst. Under the optimum Pd/In 2 O 3 : H-ZSM-5 (PdIn-160–12: H-ZSM-5) mass ratio of 4:1, the highest STY DME of 79.7 g DME kg cat -1 h −1 with CO 2 conversion of 9% and DME selectivity of 44.1% can be achieved. In addition, the STY DME can be maintained even in 60 h on stream, demonstrating the excellent stability and performance of microspherical-confined nano-Pd/In 2 O 3 /H-ZSM-5 bifunctional catalyst synthesized via carbonized alginate templating strategy.
研究领域:
催化
·
化学工程
·
材料科学
·
环境化学
·
能源科学
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DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Tanjun Deng,Wenli Lu,Xiaoxian Zhao,Haoyu Wang,Yumeng Zheng,Ao Zheng,Zhengyu Shen
Chronic wounds with bacterial infection present formidable clinical challenges. In this study, a versatile hydrogel dressing with antibacterial and angiogenic activity composite of silk fibroin (SF), chondroitin sulfate (CS), and graphene oxide quantum dots (GOQDs) is fabricated. GOQDs@SF/CS (GSC) hydrogel is rapidly formed through the enzyme catalytic action of horseradish peroxidase. With the incorporation of GOQDs both gelation speed and mechanical properties have been enhanced, and the photothermal characteristics of GOQDs in GSC hydrogel enabling bacterial killing through photothermal treatment (PTT) at ~51 °C. In vitro studies show that the GSC hydrogels demonstrate excellent antibacterial performance and induces type H vessel differentiation of endothelial cells via the activated ERK1/2 signaling pathway and upregulated SLIT3 expression. While in vivo results show that the hydrogel significantly promotes type H vessels formation, which related to the collagen deposition, epithelialization and, ultimately accelerating the regeneration of infected skin defects. Collectively, this multifunctional GSC hydrogel, with dual action of antibacterial efficacy and angiogenesis promotion, emerges as an innovative skin dressing with potential for advancing in infected wound healing.
研究领域:
材料科学
·
生物医学工程
·
伤口愈合
·
组织工程
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纳米技术
·
生物材料
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产品关联
DOI
PubMed
高影响因子
GREEN CHEMISTRY
·
2019
·Vol. 21
·期 16
·4380-4387
·
IF 9.405
Kang Chen,Liuzhang Ouyang,Hao Zhong,Jiangwen Liu,Hui Wang,Huaiyu Shao,Yao Zhang,Min Zhu
LiBH4 has excellent application potential as an off- or on-board hydrogen carrier for its unparalleled hydrogen capacity (18.5 wt%). However, the difficulty in recycling “one-pass” LiBH4 and the resulting high cost hamper its large-scale applications. Here, we report a facile and low-cost method for LiBH4 regeneration by ball milling its hydrolysis by-product (LiBO2·2H2O) and Mg under ambient conditions, where expensive H− stored in LiBH4 is entirely converted from cheap H+ in coordinated water. This scenario is reported for the first time without hydrides employed as hydrogen sources for the reduction process. Moreover, the yields for LiBH4 synthesized by this method may reach 40%. The cost of LiBH4 regeneration exhibits a 5-fold reduction over a previous study using NaBH4 as a raw material. Significantly, the as-purified product displays even better physicochemical properties than commercial LiBH4, for example, superior hydrolysis kinetics. Overall, a one-step approach, combining hydrogen production and storage in a closed cycle, is proposed in this work. Furthermore, the formation mechanism of LiBH4 is illustrated and the intermediate product, LiBH3(OH), is successfully observed for the first time during the regeneration course.
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产品关联
DOI
高影响因子
POLYMER COMPOSITES
·
2022
·Vol. 43
·期 6
·3846-3857
·
IF 3.531
Wenhao Luo,Jinling Zeng,Yanrong Chen,Wenbin Dai,Yingbang Yao,Bing Luo,Fuzeng Zhang,Tingting Wang
Hexagonal boron nitride (h-BN) micro-platelets were surface-functionalized by sulfuric acid (SA). Such modified h-BN powders were mixed with thermoplastic polyether imide (PEI) to prepare flexible composite films using a solution casting method. After surface modification, the h-BN powders were uniformly dispersed in the PEI matrix. The thermal conductivity of the flexible composite materials was significantly improved, with a 60% increase over that of pure PEI. The mechanical properties of the composites were also measured and discussed. The Young's modulus of the h-BN/PEI composites was increased from 1.15 GPa for pure PEI to 1.62 GPa for the h-BN/PEI composite with a filling ratio 10 vol%. As compared to pure PEI film, the electrical breakdown strength of the composites with 5 vol% h-BN increased from 45.3 to 55.3 kV/mm. Our results show that the surface-modified h-BN filler is effective in improving the thermal conductivity and insulation performance of PEI-based composites.
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DOI
高影响因子
危险品化学品经营许可证（带存储）