JOURNAL OF NANOBIOTECHNOLOGY
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2025
·Vol. 23
·期 1
·791
·
IF 12.6
Qiao Wenyu,Yang Luling,Liu Yu,Zhang Huaiyuan,Zheng Zhihuan,Gu Tianheng,Zhu Jiaxi,Hu Xinyi,Li Gangze,Zhang Yuxia,Xiao Meng,Zhang Lin
Excessive accumulation of reactive oxygen species (ROS) and dysbiosis of the gut microbiota are pivotal contributors to the pathogenesis of inflammatory bowel disease (IBD) and associated fibrosis. In this study, a microfluidic approach was utilized to fabricate a multifunctional therapeutic microsphere system by encapsulating hollow mesoporous cerium oxide nanoparticles (HCeO 2 ) loaded with KP1 short peptides-specific inhibitors of the TGF-β/Smad signaling pathway. The resulting composite formulation (KP1@HCeO₂@SAM) was designed to achieve synergistic antioxidant, anti-inflammatory, and antifibrotic effects. The developed microspheres exhibited prolonged intestinal retention and effectively modulated gut microbiota composition, increasing the relative abundance of probiotic species by over sevenfold. Moreover, they demonstrated remarkable reactive oxygen species (ROS) scavenging efficiency (> 95%) and significant inhibition of fibrotic signaling cascades. In dextran sulfate sodium (DSS)-induced murine colitis models, treatment with the microspheres led to a substantial reduction in Disease Activity Index (DAI) (> 76%), restoration of intestinal barrier integrity (> 90%), and mitigation of fibrotic progression, as indicated by a 66% decrease in α-SMA expression. These findings establish a novel and integrative therapeutic platform for the effective management of IBD. Graphical abstract
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SENSORS AND ACTUATORS B-CHEMICAL
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2024
·
IF 8
Heng Guan,Yizhuo Fan,Wei Wang,Qilin Wang,Yu Chen,Shengping Ruan
As a ternary metal oxide with a suitable band gap and double catalytic center, MnWO 4 has a broad application prospect in the fields of electrochemistry, catalysis, and gas detection. In this study, MnWO 4 @C composite was synthesized by a one-step hydrothermal method and its sensitivity property to xylene was investigated. The carbon microspheres with favorable ion adsorption ability effectively inhibit the agglomeration of the reaction ions, thus producing uniformly dispersed nanoscale MnWO 4 particles with large specific surface area, which could expose more reaction sites for the high valence W 6+ with good redox ability as well as Mn 2+ catalytic activation center with d-orbit. The MnWO 4 @C composite material possesses enhanced gas adsorption and high catalytic activity. The response of the MnWO 4 @C composite (53.4, 100 ppm) is 25 times larger than that of MnWO 4 to xylene, and the modified material shows properties of lower detection limit (2 ppm), good operating temperature (157 ℃) and significant selectivity to xylene. This work provides an effective strategy to improve the sensitive activity of MnWO 4 .
研究领域:
材料科学
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气体传感器技术
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催化材料
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ChemistrySelect
·
2025
·Vol. 10
·期 27
·e01763
·
IF 2
Junjie Tang,Shiyu Peng,Guizhi Tang,Yuxue Mo,Chen Wang
Graphical This paper presents a urchin-like graphitized carbon-coated SnO₂ (GC-SnO₂) composite. Its spine-like carbon structure with branched networks alleviates stress concentration in SnO₂ anodes during cycling, enabling efficient ion transport. This design enhances high-rate performance and structural stability of lithium-ion batteries. Tin dioxide (SnO₂) has emerged as a promising anode for lithium-ion batteries (LIBs) due to its high theoretical capacity and natural abundance. However, it suffers from severe volume expansion during lithiation/delithiation processes and limited rate capability. To address these challenges, this work rationally designed an urchin-like-graphitized carbon (GC)-SnO₂ microsphere composite (denoted for GC-SnO 2 ) through hydrothermal synthesis followed by controlled annealing. The hierarchical architecture consists of hollow SnO 2 nanospheres encapsulated within branched graphitized carbon protrusions, forming a hierarchically porous network. This structural design enables three key advantages: (1) accelerated Li + diffusion through interconnected channels, (2) stress buffering via spiny carbon branches to mitigate SnO 2 pulverization, and (3) enhanced conductivity through conformal GC coating. Benefiting from these synergistic features, the GC-SnO 2 anode exhibits outstanding cyclability, maintaining 765 mA h g −1 after 100 cycles at 0.2 A g −1 . Notably, it achieves 538 mA h g −1 at 2 A g −1 over 1000 cycles, surpassing bare SnO 2 (89 mA h g −1 ) and exceeding the performance of most reported SnO 2 -based anodes. This work provides an effective strategy for designing stress-tolerant oxide/carbon composites toward high-energy-density LIBs.
研究领域:
材料科学
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储能
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纳米技术
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电化学
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复合材料
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NEW JOURNAL OF CHEMISTRY
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2025
·
IF 2.5
Fang Wang,Ziqi Xu,Lingqi Deng,Jiaqi Liu
In this study, chitosan (CS) microspheres incorporated with polyacrylamide (PAM)/gelatin (Gel) hydrogel were fabricated using sodium tripolyphosphate (TPP) as cross-linking agent. The addition of TPP based on the optimal CS microsphere concentration, significantly enhanced hydrogel mechanical properties. Specifically, the composite hydrogel exhibited an elongation at break and tensile strength of 900% and 268.26 kPa, respectively, compared to 135.56 kPa and 419.03% for the PAM/Gel hydrogel. Furthermore, compressive strength at 70% strain was 2.1 times greater than that of the unmodified hydrogel. The composite hydrogel's network structure, rich in non-covalent bonds such as electrostatic interactions, hydrogen bonds, π-π interactions, and metal coordination bonds, exhibits excellent self-healing and self-adhesion properties. Following 18 hours of self-healing at room temperature, 92.2% of the original tensile strength was recovered. Additionally, the PAM/Gel/CS hydrogels exhibited powerful self-adhesive ability. Even after five bonding cycles to porcine skin, a substantial adhesion strength of 36.43 kPa was maintained, corresponding to 54% of the initial strength. Finally, in vitro studies revealed a controlled and sustained release profile for both 5-Fluorouracil (5-FU) and Tetracycline hydrochloride (TH) from the composite hydrogel. The observed increase in water uptake under acidic conditions of PAM and chitosan further accelerate drug release. Therefore, this dual-drug delivery hydrogel system, exhibiting excellent mechanical properties, suggests promise for pH-responsive therapeutic applications.
研究领域:
药学
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材料科学
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生物医学工程
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高分子化学
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药物递送
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ADVANCED FUNCTIONAL MATERIALS
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2024
·
IF 18.5
Zhigang Chen,Xiao Wang,Juan Liu,Kaizheng Liu,Shun Li,Mingming Wu,Zhongqing Wu,Zhenming Wang,Yu Shi,Changshun Ruan
The physical microtopography, in an effective and stable manner, can powerfully confer biomaterials with enhanced osteoconduction for the repair of critical-sized bone defects. However, the realization of the osteoconductive microtopography within a 3D porous scaffold is still unmet. Herein, this work presents a stone-cottage-inspired printing strategy to build microsphere patterned scaffolds with a tunable microtopography for accelerated bone regeneration. The customized composite inks of poly (lactic- co -glycolic acid) microspheres as “Stone” and alginate hydrogels as “Mortar” endow the fibers of as-printed scaffolds with a stable and tunable groove-ridge microstructure. Owing to this microtopography, microsphere patterned scaffolds significantly promote cell recruitment, immune response, angiogenesis, and osteogenesis. Meanwhile, compared to 55 and 85 µm, 25 µm width of groove-ridge microstructure displays the most osteoconduction for repair of critical bone defects. Mechanistically, while cells prefer to adhere to microstructure with a bigger width and higher modulus in the early phase, this microstructure should also act as a barrier for cell growth and its smaller width is more beneficial for cell communication and differentiation in the later phase. Overall, it provides a robust strategy to fabricate the osteoconductive microtopography within a 3D scaffold, broadening the manipulation of physical morphology in tissue engineering.
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CATALYSIS TODAY
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2025
·
IF 5.3
Yacong Yang,Ya Zhao,Fengyan Shi,Zitao Chen,Weiguang Zhao,Yue Gao,Yingchun Miao,Yuning Huo
Micromotors with autonomous motion by multiple driving forces have attracted wide attentions. In this work, we successfully constructed MnO 2 -carbon microspheres (Mn-Cs) composite micromotors with synergistic photothermal-bubbly driving effect. The uniform MnO 2 loading and the stable combination of MnO 2 with Cs in Mn-Cs composite facilitated to improve the photothermal conversion performance. The regular morphology and large specific surface area of Mn-Cs were beneficial for the in-situ photocatalytic decomposition of H 2 O 2 under light irradiation. Notably, the photothermal conversion effect of Mn-Cs could further promote the decomposition of H 2 O 2 . The low thermal conductivity of air was beneficial for expanding the temperature gradient between the micromotor surface and the environment. As a result, the speed of optimal 1.0-Mn-Cs sample under the light irradiation and addition of H 2 O 2 (75.2 μm/s) was 14.3 and 5.88 times higher than that individual light irradiation (5.27 μm/s) and addition of H 2 O 2 (12.8 μm/s), respectively. It was indicative of the great significance of synergistic photothermal-bubbly driving effect. This study provided a new strategy for developing synergistically driven micromotors to reduce chemical fuel dependence, and showed a significant prospect in green, economic and sustainable applications.
研究领域:
材料科学
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纳米技术
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化学工程
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物理化学
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2025
·
IF 5.6
Die Hu,Xuexun Zhang,Shiwen Gong,Wentao Ma,Bo Cheng,Jing Yang,Lesan Yan,Binbin Li,Tong Qiu,Xinyu Wang
With the wide application of soft tissue fillers, implant material-induced inflammatory reactions have become a key factor affecting the therapeutic efficacy. This study developed an injectable filler with enhanced anti-inflammatory and antioxidant effects by adsorbing glycyl-L-histidyl-L-lysine copper complex (GHK-Cu) onto hydroxyapatite microspheres (HAPs), marking the first combination of HAPs and GHK-Cu to address inflammation caused by soft tissue fillers. GHK-Cu was successfully loaded onto HAPs by electrostatic adsorption. HAPs were then mixed with carboxymethyl cellulose (CMC), glycerol (GLY), and water to form GHK-Cu@CMHA gel. The study focus on the effective combination of HAPs as a carrier for sustained GHK-Cu delivery and the anti-inflammatory properties of GHK-Cu. GHK-Cu@CMHA exhibits sustained release properties for 7 days, which ensures prolonged therapeutic effects, minimizes peptide waste and reduces injection frequency, with good flowability and injectability. In the model of LPS-induced inflammation model in vivo and in vitro, GHK-Cu@CMHA gel reduced levels of inflammatory factors and Reactive oxygen species (ROS) levels decreased, while superoxide dismutase (SOD) activity was enhanced. In this process, H&E staining and Masson staining revealed significant collagen deposition. These findings further confirm that GHK-Cu@CMHA is a novel injectable soft tissue filler with good anti-inflammatory and antioxidant properties, which holds well potential for inflammation inhibition.
研究领域:
生物材料
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组织工程
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生物医学工程
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药剂学
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炎症研究
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纳米技术
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CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Hang Liu,Junlong Liu,Yanchang Liu,Zhihao Qu,Siye Tian,Yuhong Zhang
In this work, the ZnO microsphere is prepared by hydrothermal method and modified with different concentrations of Eu. The morphology of ZnO:Eu sample shows flower-like microspheres with many nanosheets. The gas performance of ZnO:Eu microsphere is investigated for detecting NO 2 . Compared with pure ZnO, the response of ZnO:2 % Eu sensor is increased by 8 times, and the optimal operating temperature of that is decreased to 130 °C. Especially, the gas sensing properties of ZnO:2 % Eu sensor is enhanced under UV excitation. The recovery time of ZnO:Eu sensor is reduced by 1200 s, and the response is increased by 3.6 times under UV excitation. The above results show an increase in sensor response due to doping Eu and UV excitation. At last, the possible gas mechanism of ZnO:Eu is discussed with and without UV excitation. This finding provides important guidance for UV-assisted sensors to enhance NO 2 response.
研究领域:
材料科学
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环境监测
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SEPARATION AND PURIFICATION TECHNOLOGY
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2024
·
IF 8.1
Yong Li,Lin Zhang,Ziyi Zhang,Tongdong Shen,Kun-Yi Andrew Lin,Shaoping Tong
Cobalt-magnesium oxide–carbon microsphere composite (Co-MgO-CMS), Cobalt-carbon nanosheet composite (Co-CNS), and magnesium oxide–carbon nanorod composite (MgO-CNR) were synthesized by the MOFs self-sacrificing template method. And they were used as the catalysts for catalytic ozonation of thiamphenicol (20 mg/L) in water at an initial pH of 7.0. The phase of Co-MgO-CMS is mainly composed of metallic cobalt, magnesium oxide and carbon according to X-ray diffraction and transmission electron microscopy analyses. Thiamphenicol removal efficiency is enhanced through Co-MgO-CMS catalytic ozonation (75.4 %, in 6 min), compared with those in ozonation alone (39.8 %), Co-CNS catalytic ozonation (43.2 %), MgO-CNR catalytic ozonation (65.1 %) and Mg-Co binary oxide (Mg 2 CoO y ) catalytic ozonation (69.0 %). Self-increasing of solution pH, protonated hydroxyl groups and electron transfer on metallic Co and lattice Co 2+ are advantageous for the ozone decomposition into reactive oxygen species in Co-MgO-CMS catalytic ozonation. Owing to the metallic Co in Co-MgO-CMS, the electron transfer ability of Co-MgO-CMS is better than that of Mg 2 CoO y according to the in situ electrochemical test. Moreover, electron transfers directly from metallic Co to ozone. While protonated hydroxyl groups are the key for electron transfer on lattice Co 2+ . A possible degradation pathway for thiamphenicol in Co-MgO-CMS catalytic ozonation is proposed according to the detected intermediates. This work provides insight into improvement on electron transfer ability of concerted acid-base catalyst in heterogeneous catalytic ozonation.
研究领域:
环境科学
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催化化学
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JOURNAL OF MOLECULAR LIQUIDS
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2025
·
IF 5.2
Xiujun Wang,Zhe Sun,Jian Zhang,Shenwen Fang,Jiaqi Huang
Polymer microspheres have been used in the field of heterogeneous reservoir profile control, but their temperature and salt resistance still need to be improved. In this paper, N’N-dimethylacrylamide (DMA) and sodium styrene sulfonate (NaSS) were used as monomers, divinylbenzene (DVB) was used as cross-linker, and inverse emulsion polymerization was adopted to preparation the ultra-high temperature resistant polymer microsphere. After the investigation of the influences of emulsification shear time, monomer concentration, mass ratio of DMA to NaSS, and DVB addition on the polymerization result, a kind of polymer microspheres (PNS microspheres) that could maintain long-term stability in different brines (including seawater) at 150 °C for 45 days was prepared. The temperature and salt resistance of PNS microspheres are significantly better than that of polyacrylamide microspheres. The size of PNS microspheres is about 30 μm, and they can expand by about 2–4 times in low salinity brine at 150 °C, while they do not expand in seawater. Plugging effect experiment results showed that PNS microspheres can achieve a plugging rate of over 90 % for porous media with a water permeability ≤ 600 mD. T 2 spectrum of PNS microsphere displacement effect presented that it can effectively block the large pore throats and achieve micro fluid flow diversion, while oil displacement effect showed it can improve oil recovery of about 20 %. This work provides a viable candidate material expected to be applied for profile control in offshore high-temperature heterogeneous reservoirs.
研究领域:
石油工程
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材料科学
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Science Advances
·
2024
·Vol. 10
·期 26
·
IF 11.7
Ruifeng Luo,Jinwei Liu,Qian Cheng,Mitsuhiko Shionoya,Cheng Gao,Ruibing Wang
Oral medication for ulcerative colitis (UC) is often hindered by challenges such as inadequate accumulation, limited penetration of mucus barriers, and the intricate task of mitigating excessive ROS and inflammatory cytokines. Here, we present a strategy involving sodium alginate microspheres (SAMs) incorporating M2 macrophage membrane (M2M)–coated Janus nanomotors (denominated as Motor@M2M) for targeted treatment of UC. SAM provides a protective barrier, ensuring that Motor@M2M withstands the harsh gastric milieu and exhibits controlled release. M2M enhances the targeting precision of nanomotors to inflammatory tissues and acts as a decoy for the neutralization of inflammatory cytokines. Catalytic decomposition of H2O2 by MnO2 in the oxidative microenvironment generates O2 bubbles, propelling Motor@M2M across the mucus barrier into inflamed colon tissues. Upon oral administration, Motor@M2M@SAM notably ameliorated UC severity, including inflammation mitigation, ROS scavenging, macrophage reprogramming, and restoration of the intestinal barrier and microbiota. Consequently, our investigation introduces a promising oral microsphere formulation of macrophage-biomimetic nanorobots, providing a promising approach for UC treatment.
研究领域:
药学
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纳米技术
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胃肠病学
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生物医学工程
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高影响因子
Regenerative Biomaterials
·
2024
·
IF 5.6
Zhou Xiaosong,Guo Min,Wang Zongliang,Wang Yu,Zhang Peibiao
Bioactive microspheres coated with acellular matrix (aECM) have received extensive attention in bone tissue engineering. In this work, biomimetic microspheres with different aECM ratios, uniform size and controllable size were prepared easily by blending natural porcine dermal aECM and poly (lactic-co-glycolic acid) (PLGA) using electrohydrodynamic spraying and solidification actuated by solvent extraction (ESASE) method. In this work, the appropriate polymer concentration and preparation voltage were investigated, and the surface morphology of the microspheres were observed by scanning electron microscope. Sirius red was used to visualize aECM exposure on the surface of the microspheres. The in vitro and in vivo experiments was carried out to evaluate the bioactivity and osteogenic properties of the microspheres. The results showed that the morphology and size of PLGA microspheres had little influence on the aECM blending. In vitro experiments showed that the higher the content of aECM, the better the cell adhesion performance. In vivo, rat calvarial defect models were observed and characterized at 4 and 8 weeks postoperatively, and the values of BV/TV of 50aECM/PLGA were 47.57 ± 1.14% and 72.92 ± 2.19%, respectively. The results showed that the skull healing effect was better in aECM-containing microspheres. In conclusion, aECM/PLGA composite microspheres can increase cell adhesion performance through the addition of aECM. Moreover, in vivo experiments have proved that aECM/PLGA microspheres is beneficial to bone repair, which means the aECM/PLGA microspheres is a promising bone tissue engineering material.
研究领域:
组织工程
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生物材料
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生物医学工程
·
再生医学
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