SENSORS AND ACTUATORS B-CHEMICAL
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2023
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IF 8.4
Huixian Jia,Yujie Liu,Wei Tang,Chenghui Liu,Xinrui Duan
Multiplexed fluorescence imaging is mainly applied to cellular imaging. However, the application of an analogous technique to mammals remains challenging due to the presence of substantial scattering and autofluorescence in biological tissues in the visible (350–700 nm) and near-infrared I region (NIR-I, 700–900 nm). Herein, we report multiplexing excitation and single-channel detection in the near-infrared II region (NIR-II) with two fluorescent probes for dual-color imaging in vivo. The first one, FNIR-1090 was constructed on Pr-1099 derivative by attaching with 1-Ethylpiperazine through the SRN1 displacement reaction. The second one, IR-765 was synthesized by a one-step reaction between the Vilsmeier–Haack reagent with 2-(3,5,5-trimethylcyclohex-2-enylidene) malononitrile (TEMO). It is noteworthy that the absorption spectrum of FNIR-1090 is almost completely separated from that of IR-765, which facilitates dual-color in vivo imaging. The two dyes can be used for high-contrast dual-channel vivo imaging of different tissues. All these prominent performances show the great promise of FNIR-1090 and IR-765 in non-invasive, real-time, and dual-color NIR-II imaging (>900 nm) in vivo.
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Journal of Materials Chemistry B
·
2020
·Vol. 8
·期 36
·8323-8336
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IF 5.344
Li Yang,Xiaojiao Zhu,Tianren Xu,Fusen Han,Gang Liu,Yingcui Bu,Jie Zhang,Feng Zhang,Hongping Zhou,Yi Xie
Exploiting two-dimensional nanomaterials as photo-based theranostic agents is promising for the highly efficient ablation of deep-tissue-buried tumors. However, they are limited by their poor absorption in the second near-infrared-light (NIR-II) bio-window (1000–1300 nm) and intrinsic nonbiodegradability. Herein, defect-rich sulfur-doped Ni(OH)2 (S-Ni(OH)2) nanosheets decorated with bovine serum albumin (BSA) as a novel theranostic agent is developed, which can accomplish multimodal-imaging-guided photothermal ablation of mouse cancers in the NIR-II bio-window. Sulfur doping extends the absorption spectra of Ni(OH)2 nanosheets from the visible to NIR-II bio-window, affording highly efficient photothermal conversion (58.20% for 1064 nm), entailing it to become an excellent contrast agent for photoacoustic imaging. Further, because of their intrinsic paramagnetic property, they can be applied for magnetic resonance imaging. Owing to the abundant defective sites in S-Ni(OH)2 nanosheets, they exhibit response to the tumor microenvironment, resulting in effective biodegradation and excretion from the body. In vivo toxicity experiments indicated that S-Ni(OH)2-BSA NSs delivered no appreciable toxicity and good biocompatibility. This work provides an avenue for the rational design of effective theranostics agents.
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CHEMICAL ENGINEERING JOURNAL
·
2021
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IF 13.273
Xiangqi Liu,Wei Feng,Huijing Xiang,Baihui Liu,Mujie Ye,Meng Wei,Rui Dong,Yu Chen,Kuiran Dong
Chemodynamic therapy, which produces cytotoxic hydroxyl radicals through intratumoral Fenton reactions, has been extensively explored in nanomedicine for cancer treatment. However, the limited endogenous hydrogen peroxide (H 2 O 2 ) levels, which serve as the reactant, weakens the anticancer effect of the Fenton reaction. In this work, a cascade catalytically reactive nanosystem has been constructed for the treatment of epithelial and embryonal tumors with high synergetic efficacy through the integration of natural glucose oxidase (GOD) and polyethylene glycol (PEG) onto the surface of Fe 3 S 4 nanoplates (abbreviated as Fe 3 S 4 -PEG-GOD NPs). The GOD component consumes glucose in tumor and produces a large amount of H 2 O 2 , which provides rich substrates for the Fenton reaction catalyzed by the Fe catalytic center of the nanoplates. The intriguing photothermal conversion efficiency (45%) of the constructed composite nanocatalysts in the second near infrared (NIR-II) biowindow allows for photothermal treatment to substantially strengthen and synergize the anticancer effects of nanocatalysts both in vitro and in vivo. This synergy occurs through generation of a hyperthermic effect necessary for promoting the sequential catalytic reaction. The synergistic anticancer effect has been verified in both epithelial and embryonal tumor mouse models, and provides justification for the biomedical use of multifunctional nanocatalysts for versatile tumor nanotherapeutics.
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BIOMATERIALS
·
2020
·
IF 10.317
Zihan Mei,Duyang Gao,Dehong Hu,Huichao Zhou,Teng Ma,Liang Huang,Xin Liu,Rongqin Zheng,Hairong Zheng,Ping Zhao,Jianqiao Zhou,Zonghai Sheng
Multidrug-resistant Staphylococcus aureus (MRSA) seriously endanger human health. The development of efficient methods to eliminate the infections and monitor the treatment process are of great significance. Near-infrared-II (NIR-II) photoacoustic (PA) imaging and photothermal therapy (PTT) are highly integrated theranostic platforms with superior performance including a low imaging background, increased tissue penetration depth, and high photothermal threshold. Herein, we report an activatable near-infrared II (NIR-II) phototheranostic strategy using miniature Au/Ag nanorods (NRs) for the photochemical synergistic therapy of MRSA infections and in situ monitoring of the treatment progress. Au/Ag NRs were efficiently activated by ferricyanide solution and allowed to continuously release free Ag + to eliminate MRSA, triggering NIR-II photothermal and PA performance enhancement. The activated NIR-II photothermal effect in turn accelerated the release of free Ag + from Au/Ag NRs for the synergistic elimination of gram-positive Staphylococcus aureus and promoted wound healing. No photothermal damages or free Ag + -induced side effects were observed in treated mice. After synergistic treatment, a 20-fold NIR-II PA signal increase with a maximum signal-to-noise measurement of 9.5 was observed between the implanted site and normal tissue, enabling sensitive monitoring of Ag + release process. The prepared Au/Ag NRs were stable and biocompatible, showing great potential for activatable NIR-II phototheranostic application.
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RSC Advances
·
2018
·Vol. 8
·期 48
·27382-27389
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IF 2.936
Chengwan Xia,Diya Xie,Lang Xiong,Qian Zhang,Yang Wang,Zezheng Wang,Yuxin Wang,Bin Li,Chao Zhang
Herein, we reported nitroxide radical-modified CuS nanoparticles (CuS–NO˙ NPs), and they exhibited a typical absorption peak at 1182 nm. Due to such a long wavelength absorbance, CuS–NO˙ NPs exhibited excellent therapeutic outcome and low damage to normal tissues. Besides, we simultaneously achieved CuS–NO˙ NPs for MRI and CT dual-modal imaging, which successfully provided a new strategy for imaging-guided tumor treatment, thus increasing potential clinical applications for cancer treatment.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-19
·
IF 14.7
He Liangrui,Wang Liyang,Yu Xujiang,Tang Yizhang,Jiang Zhao,Yang Guoliang,Liu Zhuang,Li Wanwan
The poor 5-year survival rate for bladder cancers is associated with the lack of efficient diagnostic and treatment techniques. Despite cystoscopy-assisted photomedicine and external radiation being promising modalities to supplement or replace surgery, they remain invasive or fail to provide real-time navigation. Here, we report non-invasive fractionated photodynamic therapy of bladder cancer with full-course real-time near-infrared-II imaging based on engineered X-ray-activated nanotransducers that contain lanthanide-doped nanoscintillators with concurrent emissions in visible and the second near-infrared regions and conjugated photosensitizers. Following intravesical instillation in mice with carcinogen-induced autochthonous bladder tumours, tumour-homing peptide-labelled nanotransducers realize enhanced tumour regression, robust recurrence inhibition, improved survival rates, and restored immune homeostasis under X-ray irradiation with accompanied near-infrared-II imaging. On-demand fractionated photodynamic therapy with customized doses is further achieved based on quantifiable near-infrared-II imaging signal-to-background ratios. Our study presents a promising non-invasive strategy to confront the current bladder cancer dilemma from diagnosis to treatment and prognosis.
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ACS Applied Electronic Materials
·
2025
·
IF 4.7
Ting Zhang,Xiaoqian Zhang,Qinan Mao,Fangyi Zhao,Heyi Yang,Xinyue Li,Jiasong Zhong
Lanthanide doping has been instrumental in tuning the emissions of double perovskite halides (DPHs) into the near-infrared (NIR) region. However, the limited penetration depth of UV excitation and typically low photoluminescence quantum yield (PLQY) of these materials restrict their utility in biomedical applications. In this paper, Cr3+-doped lead-free DPHs (Cs2NaScCl6:Cr3+) have been explored, featuring a broadband NIR emission spanning 800–1300 nm and an impressive PLQY of 76.9%. Oriented toward biological applications, we employ Yb3+ as a codopant to be introduced into Cs2NaScCl6:Cr3+. The novel Cs2NaScCl6:Cr3+,Yb3+ crystal powder displays a red-shifted emission (peaking at 995 nm) with a remarkably narrower full width at half-maximum (fwhm) of 51 nm. Importantly, the efficient energy transfer between Cr3+ and Yb3+ enables Cs2NaScCl6:Cr3+,Yb3+ to maintain a PLQY of 46.1% upon 780 nm excitation. Leveraging its NIR-I excitable and NIR-II emissive properties, Cs2NaScCl6:Cr3+,Yb3+ presents great potential in biodetection and bioimaging applications. Its superior energy transfer efficiency, high PLQY, and favorable spectral characteristics position this material as a promising candidate for advanced biomedical techniques requiring deep tissue penetration and high imaging contrast.
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Nano Today
·
2024
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IF 13.2
Hui Huang,Wendi Xuan,Jiakang Hai,Xue Wang,Meng Chen,Guobing Hong,Xinyue Dai,Lili Xia,Wei Feng,Yu Chen
Bioorthogonal reaction refers to chemical reactions that occur within a biological system without interfering the normal biochemical process, offering the unprecedented versatility in engineering chemical reactions within cells. However, the precise regulation of bioorthogonal reaction in living systems is mired by the complexity of the physiological environment and the toxicity of catalysts. Herein, considering the deeper tissue penetration and reduced phototoxicity compared to visible light and ultraviolet, a second near infrared (NIR-II) light-activated Cu-based bioorthogonal reaction is developed to achieve precise spatiotemporal control and effective switching for Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) mediated chemical transformations in tumor, reducing the off-target effects. The catalytic activity of Cu catalyst through valence state interconversion between Cu(II) and Cu(I) can be precisely regulated in a reversible manner under NIR-II light irradiation-induced photoelectron transfer, which controls the extent of desired drug synthesis in bioorthogonal reaction. Meanwhile, the adverse effects of Cu(I) can be substantially mitigated within normal tissues due to their oxygen-rich condition. By utilizing NIR-II light and oxygen level, the Cu bioorthogonal catalyst achieves a balance between catalytic activity and biocompatibility. The ability to achieve precise spatiotemporal control and reversible catalysis makes this NIR-II light-mediated CuAAC platform an efficient and adaptable tool for bioorthogonal chemistry in living systems.
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International Journal of Nanomedicine
·
2024
·
IF 6.6
Bei Li,Yuting Luo,Geng Liu,Maling Gou,Lei Feng,Xiwen Ye,Jianrong Xu,Yaotian Fan,Zhen You
Introduction Hepatocellular carcinomas (HCC) have a high morbidity and mortality rate, and is difficult to cure and prone to recurrence when it has already developed. Therefore, early detection and efficient treatment of HCC is necessary.Methods In this study, we synthesized a novel NDI polymer with uniform size, long-term stability, and high near-infrared two-zone (NIR-II) absorption efficiency, which can greatly enhance the effect of photothermal therapy (PTT) after intravenous injection into Huh-7-tumor bearing mice.Results The in vitro and in vivo studies showed that NDI polymer exhibited excellent NIR-guided PTT treatment, and the antitumor effect was approximately 88.5%, with obvious antimetastatic effects.Conclusion This study developed an NDI polymer-mediated integrated diagnostic and therapeutic modality for NIR-II fluorescence imaging and photothermal therapy.
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Bioactive Materials
·
2024
·
IF 18
Tian Zhang,Dongsheng Tang,Pengfei Wu,Shaoping Jiang,Yuquan Zhang,Abid Naeem,Yong Li,Chunhui Li,Bo Hu,Shuai Guo,Caixia Sun,Haihua Xiao,Ran Yan,Yuhua Weng,Yuanyu Huang
Immune checkpoint blockade (ICB) therapy is a widely favored anti-tumor treatment, but it shows limited response to non-immunogenic “cold” tumors and suffers from drug resistance. Photodynamic therapy (PDT), as a powerful localized treatment approach, can convert a “cold tumor” into a “hot tumor” by inducing immunogenic cell death (ICD) in tumor cells, thereby enhancing tumor immunogenicity and promoting tumor immunotherapy. However, the effectiveness of PDT is largely hindered by the limited penetration depth into tumor tissues. To address these issues, we proposed an all-in-one drug system with NIR-II photo-accelerated PDT effects, efficient immune checkpoint gene silencing, and a facile manufacturing process. The so-called all-in-one drug system comprises a multi-modal designed polymer PPNP and siRNA. PPNP is an amphipathic polymer that includes the near infrared-II (NIR-II) photosensitizer Aza-boron-dipyrromethene (Aza-BODIPY), a glutathione (GSH)-cleavable linker, and a cationic monomer derived from cholesterol. PPNP can self-assemble and efficiently load siRNA. Under laser irradiation, PPNP triggers a potent ICD cascade, causing the on-demand release of siPD-L1, reshaping the tumor's immunosuppressive microenvironment, effectively inhibiting the growth of various tumors, and stimulating the immune memory. This study represents a generalized platform for PDT and gene silencing, designed to modulate immune-related signaling pathways for improved anticancer therapy.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-16
·
IF 15.7
Li Yibin,Qu Fei,Wan Fang,Zhong Cheng,Rao Jingyi,Liu Yijing,Li Zhen,Zhu Jintao,Li Zhong’an
Near-infrared (NIR)-II fluorescence imaging-guided photodynamic therapy (PDT) has shown great potential for precise diagnosis and treatment of tumors in deep tissues; however, its performance is severely limited by the undesired aggregation of photosensitizers and the competitive relationship between fluorescence emission and reactive oxygen species (ROS) generation. Herein, we report an example of an anionic pentamethine cyanine (C5T) photosensitizer for high-performance NIR-II fluorescence imaging-guided PDT. Through the counterion engineering approach, a triphenylphosphine cation (Pco) modified with oligoethylene glycol chain is synthesized and adopted as the counterion of C5T, which can effectively suppress the excessive and disordered aggregation of the resulting C5T-Pco by optimizing the dye amphipathicity and enhancing the cyanine-counterion interactions. Dynamic tuning of fluorescence characteristics and ROS generation is achieved at the aggregate level, resulting in an impressive type I ROS generation under 760 nm light irradiation, accompanied by efficient NIR-II fluorescence emission excited at 808 nm. As a result, excitation wavelength selective NIR-II fluorescence imaging-guided PDT has been successfully demonstrated for tumor diagnosis and therapeutics of female mice.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2024
·
IF 5.8
Tong Feng,Yuanlin Jin,Zhangwen Long,Dacheng Zhou,Xiaqing Jiang,Bitao Liu,Jianbei Qiu
Phosphor conversion light-emitting diode (PC-LED) technology has become a focal point of research for portable near-infrared light sources in recent years. One of the crucial aspects is to develop phosphor materials that can be effectively stimulated by commercial available blue light. Unfortunately, efficient phosphors in the NIR-II that can be excited by commercial blue light are particularly scarce. In this study, Mg 4 Ta 2 O 9 :0.04Cr 3+ ,0.03Yb 3+ ,0.07Li + (MTO:0.04Cr 3+ ,0.03Yb 3+ ,0.07Li + ) phosphor was synthesized using the high temperature solid phase method, and its emission spectrum covered the first and second near-infrared windows (700–1200 nm). The internal quantum efficiency (IQE) and external quantum efficiency (EQE) are 88.7 % and 45.6 %, respectively, due to the synergistic effect of energy transfer and Li-ion modification. Additionally, the doping of Yb 3+ ions and Li + ions enhances the thermal stability of luminescence. The thermal stability of MTO:0.04Cr 3+ ,0.03Yb 3+ ,0.07Li + and MTO:0.04Cr 3+ ,0.03Yb 3+ is 9.81 % and 14.43 % higher, respectively, than that of MTO:0.04Cr 3+ ,0.03Yb 3+ and MTO:0.04Cr 3+ . To evaluate its potential applications, we developed a prototype PC-LED utilizing MTO:0.04Cr 3+ ,0.03Yb 3+ ,0.07Li + phosphor as an emission emitter which demonstrated advantages in biomedical imaging, night vision, and non-destructive testing.
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